MITANI Takakazu

Graduate School of Agriculture

Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology 

Associate Professor 


  • Ph.D., Osaka Prefecture University

Research Keyword

    Food factor, Nutrition, Target protein, Obesity

Field Of Study

  • Nutritional biochemistry
  • Food sciences, molecular nutrition
  • Food sciences, functional food science


  • 2019 - 2024
    Shinshu University, Faculty of Agriculture, Assistant Professor

Educational Background

  • 2010 - 2013, Osaka Prefecture University, Graduate School of Life and Environmental Scienves, Environmental Sciences and Technology
  • 2008 - 2010, Osaka Prefecture University, Graduate School of Life and Environmental Sciences, Environmental Sciences and Technology

Member History

  • 2024
    参与, Japan Society of Nutrition and Food Science, Chubu


  • 2023
    日本農芸化学会中部支部, 日本農芸化学会中部支部奨励賞(学術奨励賞)
    カカオ豆抽出物が脂肪細胞の褐色化を誘導する分子機構の解析, Japan society


  • Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet.
    Yonemoto E, Ihara R, Tanaka E, Mitani T.
    Bioscience, Biotechnology, and Biochemistry, 2024, Refereed
    Last, Corresponding
  • BTB and CNC homology 1 deficiency disrupts intestinal IgA secretion through regulation of polymeric immunoglobulin receptor expression
    Hamada R, Yonezawa A, Matsumoto K, Mitani T, Takagi T, Muto A, Igarashi K, Naito Y, Higashimura Y.
    American Journal of Physiology-Gastrointestinal and Liver Physiology, 2024, Refereed, Not invited電子ジャーナル
  • Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes  
    Watanabe S, Haruyama R, Umezawa K, Tomioka I, Nakamura S, Katayama S, Mitani T (corresponding author).
    Journal of Nutirtional Biochemistry, 121, 109433, 28 Aug. 2023, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway.
    Yamamoto M, Miyoshi M, Morioka K, Mitani T, Takaya T.
    Biochemical and Biophysical Research Communications, 664, 1-8, 05 Jul. 2023, Refereedリポジトリ電子ジャーナル
  • 25-Hydroxyvitamin D increases insulin-stimulated glucose uptake by enhancing adipocyte differentiation
    Nakashima M, Mitani T (corresponding author).
    Journal of Nutritional Science and Vitaminology, 68(5), 420-428, Oct. 2022, Refereed
    Last, Corresponding
  • Isolation, identification, and in vivo evaluation of the novel antihypertensive peptide, VSKRLNGDA, derived from chicken blood cells
    Wongngama W, Roytrakulb S, Mitani T, Katayama S, Nakamura S, Yongsawatdigula J.
    Process Biochemistry, 115, 169-177, 15 Feb. 2022, Refereed
  • Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria.
    Ikeda T, Watanabe S, Mitani T (corresponding author).
    Bioscience, Biotechnology, and Biochemistry,, 29 Nov. 2021, Refereed
    Last, Corresponding
  • Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARgamma activation-dependent manner
    Tanaka E, Mitani T (corresponding author), Nakashima M, Yonemoto E, Fujii H, Ashida H.
    The Journal of Nutritional Biochemistry, 100, 108898, 05 Nov. 2021, Refereed
  • Production and characterization of chicken blood hydrolysate with antihypertensive properties
    Wongngam W, Mitani T, Katayama S, Nakamura S, Yongsawatdigul J.
    Poultry Science, 99(10), 5163-5174, 27 Jul. 2020, Refereed電子ジャーナル
  • Enzymatically synthesized glycogen prevents UVB-induced cell damage in normal human epidermal keratinocytes
    Yoshioka Y, Kitakaze T, Mitani T, Furuyashiki T, Ashida H.
    Journal of Clinical Biochemistry and Nutrition, 67(1), 36-42, 05 May 2020, Refereed電子ジャーナル
  • Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes
    Mitani T, Watanabe S, Wada K, Fujii H, Nakamura S, Katayama S
    Biochemical and biophysical research communications, 522(3), 770-775, 30 Nov. 2019, Refereed
  • Oral immunotherapy with a phosphorylated hypoallergenic allergen ameliorates allergic responses more effectively than intact allergen in a murine model of buckwheat allergy.
    Katayama S, Yamaguchi D, Suzuki Y, Athamneh AMA, Mitani T, Satoh R, Teshima R, Mine Y, Nakamura S.
    Molecular Nutrition & Food Research, 62(21), e1800303, 14 Sep. 2018, Refereed電子ジャーナル
  • Soybean-derived glycine-arginine dipeptide administration promotes neurotrophic factor expression in the mouse brain
    Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.
    Journal of Agricultural and Food Chemistry, 66(30), 7935-7941, 01 Aug. 2018, Refereed
  • Long-term diet supplementation with lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8.
    Corpuz HM, Ichikawa S, Arimura M, Mihara T, Kumagai T, Mitani T, Nakamura S, Katayama S.
    Nutrients, 10(6), E762, 13 Jun. 2018, Refereed電子ジャーナル
  • Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
    Mitani T, Takaya T, Harada N, Katayama S, Yamaji R, Nakamura S, Ashida H
    Archives of Biochemistry and Biophysics, 646, 98-106, 15 May 2018, Refereed
  • Methylxanthine derivative-rich cacao extract suppresses differentiation of adipocytes through down-regulation of PPARγ and C/EBPs
    Yamashita Y*, Mitani T*, Wang L, Ashida H. (*Co-first Author)
    Journal of Nutritional Science and Vitaminology, 64(2), 151-160, 30 Apr. 2018, Refereed
  • Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.
    Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N, Palaga T.
    SCIENTIFIC REPORTS, 8(1), 5625, 04 Apr. 2018, Refereed
  • Rutinosylated ferulic acid attenuates food allergic response and colitis by up-regulating regulatory T cells in mouse models.
    Katayama S, Ohno F, Mitani T, Akiyama H, Nakamura S.
    Journal of Agricultural and Food Chemistry, 65(49), 10730-10737, 13 Dec. 2017, Refereed電子ジャーナル
  • Caffeine-stimulated intestinal epithelial cells suppress lipid accumulation in adipocytes
    Mitani T, Nagano T, Harada K, Yamashita Y, Ashida H
    Journal of Nutritional Science and Vitaminology, 63(5), 333-340, 08 Dec. 2017, Refereed
  • Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1
    Mitani T, Watanabe S, Yoshioka Y, Katayama S, Nakamura S, Ashida H
    Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1864(12), 2438-2448, 28 Sep. 2017, Refereed
  • Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities
    Heng MY, Katayama S, Mitani T, Ong ES, Nakamura S.
    Food Chemistry, 221, 1388-1393, 15 Apr. 2017, RefereedWebofScience電子ジャーナル
  • Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus.
    Lebetwa N, Mitani T, Nakamura S, Katayama S
    Journal of the Science of Food and Agriculture, 97(6), 1939-1944, 01 Apr. 2017, Refereed電子ジャーナル
  • Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress.
    Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H.
    FREE RADICAL BIOLOGY AND MEDICINE, 106, 355-367, 28 Feb. 2017, Refereed
  • Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells
    Yoshioka Y, Li X, Zhang T, Mitani T, Yasuda M, Nanba F, Toda T, Yamashita Y, Ashida H.
    Journal of Clinical Biochemistry and Nutrition, 60(2), 108-114, 06 Dec. 2016, Refereed
  • Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
    Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, Yamaji R.
    SCIENTIFIC REPORTS, 6, 23001, 10 Mar. 2016, Refereed
  • Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia
    Mitani T, Minami M, Harada N, Ashida H, Yamaji R.
    Cellular Signalling, 27(10), 1994-2001, Oct. 2015, Refereed
  • Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model
    Ashida H, Harada K, Mishima S, Mitani T, Yamashita Y, Matsumura F.
    Pesticide Biochemistry and Physiology, 120, 14-20, May 2015, RefereedWebofScience電子ジャーナル
  • Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer
    Mitani T, Harada N, Tanimori S, Nakano Y, Inui H, Yamaji R.
    Journal of Nutritional Science and Vitaminology, 60(4), 276-282, Aug. 2014, Refereed
  • Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells
    Mitani T, Ito Y, Harada N, Nakano Y, Inui H, Ashida H, Yamaji R.
    Journal of Nutritional Science and Vitaminology, 60(2), 122-128, Apr. 2014, Refereed
  • Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4 '-amino-3,5-dihydroxy-trans-stilbene
    Ito Y*, Mitani T*, Harada N, Isayama A, Tanimori S, Takenaka S, Nakano Y, Inui H, Yamaji R. (*Co-first Author)
    Journal of Nutritional Science and Vitaminology, 59(4), 358-364, Aug. 2013, Refereed
  • Coordinated action of hypoxia-inducible factor-1 alpha and beta-catenin in androgen receptor signaling
    Mitani T, Harada N, Nakano Y, Inui H, Yamaji R.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 287(40), 33594-33606, 28 Sep. 2012, Refereed
  • Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2 alpha through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms
    Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, Nakano Y.
    Biochemical and biophysical research communications, 413(2), 201-205, 23 Sep. 2011, RefereedWebofScience電子ジャーナル
  • Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1 alpha in a low androgen environment
    Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, Inui H.
    Journal of Steroid Biochemistry and Molecular Biology, 123(1-2), 58-64, Jan. 2011, Refereed
  • A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor
    Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H,
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(9), 1965-1968, Sep. 2010, RefereedWebofScience電子ジャーナル
  • Involvement of three glutamine tracts in human androgen receptor transactivation
    Harada N, Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, Inui H.
    Journal of Steroid Biochemistry and Molecular Biology, 118(1-2), 77-84, Jan. 2010, RefereedWebofScience電子ジャーナル


  • Anti-obesity Effect of Food Factors Based on Target Proteins: Novel Molecular Function of Methylxanthines
    Mitani Takakazu
    化学と生物「解説」, 60(11), 586 - 593, 2022, Refereed, Invited
    Lead, Corresponding
  • 肝臓のミトコンドリア活性化に及ぼす大豆イソフラボンの効果とその分子機構に関する研究
    21, 173 - 179, 01 Jun. 2019
    Lead, Last, Corresponding
  • 多機能性を持つMoonlighting Proteins (特集 タンパク質・酵素の隠された機能について,探索とその技術)
    原田直樹, 三谷塁一, 山地亮一
    生化学, 87(3), 279 - 285, 2015, Invited
  • 抗酸化物質としてのレスベラトロールの多機能性
    三谷塁一, 原田直樹, 山地亮一
    ビタミン, 86(12), 687 - 689, 25 Dec. 2012, Invited

Lectures, oral presentations, etc.

  • 肥満関連疾患の予防に資する食品成分とその標的分子に関する研究
    第78回日本栄養・食糧学会大会(奨励賞受賞講演)(福岡), May 2024, Invited
  • 食品成分の標的タンパク質の同定とそれに基づく機能性発現メカニズムに関する研究
    日本農芸化学会2024年度大会(奨励賞受賞講演)(東京), Mar. 2024, Invited
  • カカオ豆抽出物が脂肪細胞の褐色化を誘導する分子機構の解析
    米本 英都、三谷 塁一
    2023年度日本農芸化学会 中部・関西支部合同大会(三重), Sep. 2023, Not invited
  • Not invited

Affiliated academic society

  • 2021
    Japanese society for Food Factors
  • 2009
    Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • 2009
    The Japanese Biochemical Society
  • 2013
    The Molecular Biology Society of Japan
  • 2012
    The Japan Society of Nutirtion and Food Science
  • 2014
    The vitamin Society of Japan

Academic Contribution Activities

  • Peer review
    Bioscience Reports, Jan. 2022 - Dec. 2022
  • Peer review
    Bioscience, Biotechnology, and Biochemistry, Jan. 2022 - Dec. 2022
  • Peer review
    International Journal of Molecular Sciences, Jan. 2021 - Dec. 2021
  • Peer review
    Molecules, Jan. 2021 - Dec. 2021
  • Peer review
    Bioscience, Biotechnology, and Biochemistry, Jan. 2021 - Dec. 2021
  • Peer review
    Antioxidants, Jan. 2020 - Dec. 2020
  • Peer review
    Molecules, Jan. 2020 - Dec. 2020
  • Peer review
    Bioscience, Biotechnology, and Biochemistry, Jan. 2020 - Dec. 2020
  • Peer review
    Bioscience, Biotechnology, and Biochemistry, Jan. 2019 - Dec. 2019