OBA Takaaki

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

Shinshu University Hospital Clinical Division of Breast and Endocrine Surgery 

Senior Assistant Professor 

Researcher Information


  • 博士(医学), 信州大学

Mail Address

Research activity information


  • Significance of skeletal muscle index-to-body mass index ratio as a predictor of postsurgical bleeding after mastectomy in patients with breast cancer.
    Morikawa H, Oba T, Kiyosawa N, Iji R, Amitani M, Chino T, Shimizu T, Ono M, Kanai T, Maeno K, Ito KI.
    Breast Cancer., 2023電子ジャーナル
  • Development of a predictive score for post-hemithyroidectomy hypothyroidism using skeletal muscle index, remnant thyroid index, and thyroid-stimulating hormone levels: a retrospective cohort study.
    Amitani M, Oba T, Kiyosawa N, Iji R, Morikawa H, Chino T, Shimizu T, Ono M, Kanai T, Maeno K, Ito KI.
    Quant Imaging Med Surg, 2023電子ジャーナル
  • Eribulin promotes proliferation of CD8+ T cells and potentiates T cell-mediated anti-tumor activity against triple-negative breast cancer cells.
    Shimizu T, Oba T, Oshi M, Ito KI.
    Breast Cancer Res Treat., 2023電子ジャーナル
  • The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2022 edition.
    Terada M, Ito A, Kikawa Y, Koizumi K, Naito Y, Shimoi T, Ishihara M, Yamanaka T, Ozaki Y, Hara F, Nakamura R, Hattori M, Miyashita M, Kondo N, Yoshinami T, Takada M, Matsumoto K, Narui K, Sasada S, Iwamoto T, Hosoda M, Takano Y, Oba T, Sakai H, Murakami A, Higuchi T, Tsuchida J, Tanabe Y, Shigechi T, Tokuda E, Harao M, Kashiwagi S, Mase J, Watanabe J, Nagai SE, Yamauchi C, Yamamoto Y, Iwata H, Saji S, Toyama T.
    Breast Cancer, 2023電子ジャーナル
  • Fluctuations in Gut MicrobiomeComposition During Immune Checkpoint Inhibitor Therapy.
    Sarkar J, Cortes Gomez E, Oba T, Chen H, Dy GK, Segal BH, Ernstoff MS, Ito F.
    World J Oncol., 2023電子ジャーナル
  • Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell LungCancer Patients Treated with Chemo-Immunotherapy.
    Abdelfatah E, Long MD, Kajihara R, Oba T, Yamauchi T, Chen H, Sarkar J, Attwood K, Matsuzaki J, Segal B, DyGK, Ito F.
    Cancer Res Commun, 2023電子ジャーナル
  • Changes in thepathophysiology of primary hyperparathyroidism and analysis of postoperative recurrence cases at a regional corehospital in Japan: experience of 35 years in Shinshu University Hospital.
    Kanai T, Oba T, Morikawa H, Amitani M, Chino T, Shimizu T, Ono MT, Maeno K, Ito KI, Ito T.
    Ann Palliat Med., 2023電子ジャーナル
  • The Advantage of Using an Optical See-Through Head-Mounted Displayin Ultrasonography-Guided Needle Biopsy Procedures: A Prospective Randomized Study.
    Shimizu T, Oba T (co-first author), Ito KI.
    J Clin Med, 2023電子ジャーナル
  • Neutrophil-to-lymphocyte ratio is associated with the proportion of poorly differentiated components in papillarythyroid carcinoma.
    Oba T, Kazuma M, Kiyosawa N, Morikawa H, Amitani M, Chino T Shimizu T, Ono M, Ito T, Kanai T, Ito KI.
    J Surg Res, 2023電子ジャーナル
  • A Case of a Cystic Parathyroid Adenoma with Marked Hyperparathyroidism but Difficult Preoperative Diagnostic Imaging
    KUBOTA Satoshi, SHIMADA Yasuho, TAKAYAMA Shohei, OBA Takaaki, ITO Ken-ichi, KOMATSU Mitsuhisa
    The Shinshu Medical Journal, 70(3), 189-194, Jun. 2022電子ジャーナル
  • CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1(+) CD8(+) T cells
    Yamauchi, Takayoshi; Hoki, Toshifumi; Oba, Takaaki; Kajihara, Ryutaro; Attwood, Kristopher; Cao, Xuefang; Ito, Fumito;
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 71(1), 137-151, Jan. 2022WebofScience電子ジャーナル
  • The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time
    Ono, Mayu; Oba, Takaaki; Shibata, Tomohiro; Ito, Ken-Ichi;
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 147(11), 3211-3224, Nov. 2021WebofScience電子ジャーナル
  • In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models
    Oba, Takaaki; Makino, Kenichi; Kajihara, Ryutaro; Yokoi, Toshihiro; Araki, Ryoko; Abe, Masumi; Minderman, Hans; Chang, Alfred E.; Odunsi, Kunle; Ito, Fumito;
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5), e002432, May 2021WebofScience電子ジャーナル
  • HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells
    Oba T, Ono M, Matoba H, Uehara T, Hasegawa Y, Ito KI.
    Breast Cancer Res Treat., 186(1), 37-51, Feb. 2021
  • Prognostic Nutritional Index Is Superior to Neutrophil-to-lymphocyte Ratio as a Prognostic Marker in Metastatic Breast Cancer Patients Treated With Eribulin
    Oba, Takaaki; Maeno, Kazuma; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Ito, Ken-ichi;
    Anticancer Research, 41(1), 445-452, Jan. 2021WebofScience電子ジャーナル
  • Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer.
    Watanabe T, Oba T, Tanimoto K, Shibata T, Kamijo S, Ito KI.
    PLOS ONE, 2021
  • Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature.
    11. Shimizu T, Oba T, Chino T, Soma A, Ono M, Ito T, Kanai T, Maeno K, Sato Y, Uehara T, Ito KI.
    Thyroid Res, 2021電子ジャーナル
  • Fibroadenoma in a young male breast: A case report and review of the literature.
    Morikawa H, Nobuoka M, Amitani M, Shimizu T, Ohno K, Ono M, Oba T, Ito T, Kanai T, Maeno K, Uehara T, Ito KI.
    Clin Case Rep., 2021電子ジャーナル
  • Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors
    Oba, Takaaki; Kajihara, Ryutaro; Yokoi, Toshihiro; Repasky, Elizabeth A.; Ito, Fumito;
    CANCER RESEARCH, 81(24), 6183-6195, 2021WebofScience電子ジャーナル
  • Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression
    Patel, Ankit; Oba, Takaaki; Kajihara, Ryutaro; Yokoi, Toshihiro; Abrams, Scott I.; Ito, Fumito;
    JOURNAL OF IMMUNOLOGY, 207(5), 1298-1309, 2021WebofScience電子ジャーナル
  • Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer
    Yokoi, Toshihiro; Oba, Takaaki; Kajihara, Ryutaro; Abrams, Scott, I; Ito, Fumito;
    SCIENTIFIC REPORTS, 11(1), 21992, 2021WebofScience電子ジャーナル
  • T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
    Yamauchi, Takayoshi; Hoki, Toshifumi; Oba, Takaaki; Jain, Vaibhav; Chen, Hongbin; Attwood, Kristopher; Battaglia, Sebastiano; George, Saby; Chatta, Gurkamal; Puzanov, Igor; Morrison, Carl; Odunsi, Kunle; Segal, Brahm H.; Dy, Grace K.; Ernstoff, Marc S.; Ito, Fumito;
    NATURE COMMUNICATIONS, 12(1), 1402, 2021WebofScience電子ジャーナル
  • Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer
    Oba, Takaaki; Maeno, Kazuma; Amitani, Masatsugu; Shimizu, Tadafumi; Ohno, Koichi; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Uehara, Takeshi; Ito, Ken-Ichi;
    Endocrine journal, 68(11), 1329-1336, 2021WebofScience
  • Multicenter retrospective study on the use of Curebest (TM) 95GC Breast for estrogen receptor-positive and node-negative early breast cancer
    Tsukamoto, Fumine; Arihiro, Koji; Takahashi, Mina; Ito, Ken-ichi; Ohsumi, Shozo; Takashima, Seiki; Oba, Takaaki; Yoshida, Masayuki; Kishi, Kazuki; Yamagishi, Keisuke; Kinoshita, Takayuki;
    BMC CANCER, 21(1), 1077, 2021WebofScience電子ジャーナル
  • MEN1に伴う原発性副甲状腺機能亢進症術後の長期成績
  • Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.
    Oba T, Long M, Ito KI, Ito F.
    Sci Rep
  • Neputrophil-to-lymphocyte radio is associated with the proportion of poorly differentiated components in papillary thyroid cartinoma.
    Oba T,Kazuma M, kiyosawa N, Morikawa H, Amitani M, Chino T, Shimizu T, Ono M, Ito T, Kanai T, Ito KI.
    J Surg Res, 287, 47-54