樋口 京一 (ヒグチ ケイイチ)
先鋭領域融合研究群 バイオメディカル研究所
特任教授
研究者情報
研究キーワード
- 老化, モデル動物, アミロイドーシス
電話番号
- 0263-37-2691
メールアドレス
- keiichih★shinshu-u.ac.jp
経歴
研究活動情報
論文
- Suppression of mouse AApoAII amyloidosis progression by daily supplementation with oxidative stress inhibitors.
Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi1 Y, Sawashita J, Mori M, Higuchi K.
Oxid Med Cell Longev., 2019, 126327, 2019年
- Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K.
Oxid Med Cell Longev, 2018, 3181759, 2018年06月 - Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.
Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto K, Mori M, Higuchi K, Sawashita J.
Exp Anim., 67(2), 105-115, 2018年05月 - Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure.
Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K.
Sci Rep, 8(1), 5620, 2018年04月 - Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis.
Miyahara H, Sawashita J, Ishikawa E, Yang M, Ding X, Liu Y, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K.
J Proteomics, 172, 111-121, 2018年02月 - SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.
Akiguchi I, Pallàs M, Budka H, Akiyama H, Ueno M, Han J, Yagi H, Nishikawa T, Chiba Y, Sugiyama H, Takahashi R, Unno K, Higuchi K, Hosokawa M.
Neuropathology, (37), 293-305, 2017年08月, 査読有り - Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.
Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J.
Sci Rep. :, 7(1), 8253, 2017年 - Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.
Li L, Sawashita J, Ding X, Yang M, Xu Z, Miyahara H, Mori M, Higuchi K.
PLOS ONE, 12(2), e0172402, 2017年 - The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation
Yoshinaga T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Nishio S, Kanizawa Y, Hachiya N, Tanaka T, Kokudo N, Higuchi K, Ikeda S
J Pathol, in press, 2016年 - Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis.
Yang M, Liu F, Higuchi K, Sawashita J, Fu X, Zhang L, Zhang L, Fu L, Tong Z, Higuchi K.
Yang M, Liu F, Higuchi K, Sawashita J, Fu X, Zhang L, Zhang L, Fu L, Tong Z, Higuchi K., 7(24), 35843-35852, 2016年 - The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aα-chain amyloidosis associated with a novel frameshift variant
Yazaki M, Yoshinaga T, Sekijima Y, Nishio S, Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi K, Ikeda S
Amyloid, 22(2), 142-144, 2015年 - NFκB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training
Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
Int J Sports Med, 36(9), 769-775, 2015年 - A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice
Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M
Exp Anim, 64(2), 171-179, 2015年 - C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice
Sawashita J, Zhang B, Hasegawa K, Mori M, Naiki H, Kametani F, Higuchi K
Proc Natl Acad Sci U S A, 12(8), E836-845, 2015年 - Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart
Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding X, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K
Lab Invest, 95(3), 320-333, 2015年 - The factors affecting adherence to a long-term interval walking training program in middle-aged and older people
Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, Nose H; Shinshu University Genetic Research Consortium
J Appl Physiol (1985), 118(5), 595-603, 2015年 - Transmission of Systemic AA Amyloidosis in Animals
Murakami, T; Ishiguro, N; Higuchi, K
VETERINARY PATHOLOGY, 51(2), 363-371, 2014年03月
- AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
Mori, M; Tiang, G; Higuchi, K
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 21(1), 1-8, 2014年03月 - Novel frame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10
Unno K, Yamamoto H, Toda M, Hagiwara S, Iguchi K, Hoshino M, Takabayashi F, Hasegawa-Ishii S, Shimada A, Hosokawa M, Higuchi K, Mori M
Biochem Biophys Res Commun, 454(1), 89-94, 2014年 - The toxicity mechanisms of action of Aβ25-35 in isolated rat cardiac myocytes
Zhang B, Bian X, He P, Fu X, Higuchi K, Yang X, Li D
MOLECULES, 19(8), 12242-12257, 2014年 - Senile systemic amyloidosis (Japanese)
Yazaki M, Higuchi K
Brain Nerve, 266(7), 817-826, 2014年 - Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice
Tian G, Sawashita J, Kubo H, Nishio SY, Hashimoto S, Suzuki N, Yoshimura H, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S, Higuchi K
Antioxid Redox Signal, 20(16), 2606-2620, 2014年 - Diversity and complexity of the mouse Saa1 and Saa2 genes
Mori M, Tian G, Ishikawa A, Higuchi K
Exp Anim, 63(1), 99-106, 2014年 - Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene
Mori, M; Gotoh, S; Taketani, S; Hiai, H; Higuchi, K
EXPERIMENTAL EYE RESEARCH, 112, 45-50, 2013年07月 - An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats
Luo, H; Higuchi, K; Matsumoto, K; Mori, M
GENES AND IMMUNITY, 14(3), 192-197, 2013年 - Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
Tanisawa, K; Mikami, E; Fuku, N; Honda, Y; Honda, S; Ohsawa, I; Ito, M; Endo, S; Ihara, K; Ohno, K; Kishimoto, Y; Ishigami, A; Maruyama, N; Sawabe, M; Iseki, H; Okazaki, Y; Hasegawa-Ishii, S; Takei, S; Shimada, A; Hosokawa, M; Mori, M; Higuchi, K; Takeda, T; Higuchi, M; Tanaka, M
BMC GENOMICS, 14, 248, 2013年 - Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1
Tomozawa, Hiroshi; Nishio, Ayako; Higuchi, Keiichi; Matsumoto, Kiyoshi; Mori, Masayuki
EXPERIMENTAL ANIMALS, 60(2), 151-160, 2011年04月 - Exercise Effects on Methylation of ASC Gene
Nakajima, K.; Takeoka, M.; Mori, M.; Hashimoto, S.; Sakurai, A.; Nose, H.; Higuchi, K.; Itano, N.; Shiohara, M.; Oh, T.; Taniguchi, S.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 31(9), 671-675, 2010年09月 - BN.MES-Cyba(mes) Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia
Tomozawa, Hiroshi; Nishio, Ayako; Okuhara, Yuji;Higuchi, Keiichi; Matsumoto, Kiyoshi; Mori, Masayuki
EXPERIMENTAL ANIMALS, 59(4), 469-478, 2010年07月 - Mouse model to study human A beta M-2 amyloidosis: generation of a transgenic mouse with excessive expression of human beta(2)-microglobulin
Zhang, Pengyao; Fu, Xiaoying; Sawashita, Jinko; Yao, Junjie; Zhang, Beiru; Qian, Jinze; Tomozawa, Hiroshi; Mori, Masayuki; Ando, Yukio; Naiki, Hironobu; Higuchi, Keiichi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 17(2), 50-62, 2010年06月 - Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
Qian, Jinze; Yan, Jingmin; Ge, Fengxia; Zhang, Beiru; Fu, Xiaoying; Tomozawa, Hiroshi; Sawashita, Jinko; Mori, Masayuki; Higuchi, Keiichi
PLOS PATHOGENS, 6(5), e1000914, 2010年05月 - Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases
Mori, Masayuki; Higuchi, Keiichi; Sakurai, Akihiro; Tabara, Yasuharu; Miki, Tetsuro; Nose, Hiroshi
JOURNAL OF PHYSIOLOGY-LONDON, 587(23), 5577-5584, 2009年12月 - Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese
Sawashita, Jinko; Onitsuka, Sayaka; Gen-no, Hirokazu; Ishikawa, Shinobu; Iino, Fumie; Tateishi, Norihiko; Murakami, Takeo; Seki, Yoichi; Nagaiwa, Toshiyuki; Hanaoka, Masaaki; Hama, Sumio; Nose, Hiroshi; Higuchi, Keiichi
EXPERIMENTAL GERONTOLOGY, 44(10), 666-675, 2009年10月 - Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
Sawashita, Jinko; Kametani, Fuyuki; Hasegawa, Kazuhiro; Tsutsumi-Yasuhara, Shinobu; Zhang, Beiru; Yan, Jingmin; Mori, Masayuki; Naiki, Hironobu; Higuchi, Keiichi
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1794(10), 1517-1529, 2009年10月 - Hereditary Pancreatitis Model WBN/Kob Rat Strain Has a Unique Haplotype in the Pdwk1 Region on Chromosome 7
Mori, Masayuki; Fu, Xiaoying; Chen, Lei; Zhang, Guohong; Higuchi, Keiichi
EXPERIMENTAL ANIMALS, 58(4), 409-413, 2009年07月 - Dysfunction in ABCB1A Has Only a Weak Effect on Susceptibility to Dextran Sulfate Sodium-Induced Colitis in SAM Strains
Zhang, Guohong; Fu, Xiaoying; Takeda, Toshio; Higuchi, Keiichi; Mori, Masayuki
EXPERIMENTAL ANIMALS, 58(4), 421-425, 2009年07月 - Apolipoprotein A-II accelerates reactive AA amyloidosis.
Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K.
Amyloid, 24(sup1), 147-148, 2007年05月, 査読有り - Spontaneous hypomorphic mutations in antioxidant enzymes of mice (2003)
Guo Z, Higuchi K, Mori M.
Free Radic Biol Med., 2003年 - Amyloidosis modifier genes in less amyloidogenic A/J mouse strain.
Guo Z, Mori M, Fu X, Yao J, Xing Y, Korenaga T, Li G, Matsushita T, Hosokawa M, Higuchi K.
Lab Invest, 2003年 - Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse.
Umezawa M, Tatematsu K, Korenaga T, Fu X, Matushita T, Okuyama H, Hosokawa M, Takeda T, Higuchi K.
J Lipid Res., 44(4), 762-769, 2003年 - Diurnal rhythm disorder of behavioral activity in SAMP1 mice is partially normalized by spontaneous wheel running.
Yanagidaira, Y; Higuchi, K; Nose, H
PHYSIOLOGY&BEHAVIOR, 80(2-3), 195-201, 2003年 - Induction of protein conformational change in mouse senile amyloidosis.
Xing Y, Nakamura A, Korenaga T, Guo Z, Yao J, Fu X, Matsushita T, Kogishi K, Hosokawa M, Kametani F, Mori M, Higuchi K. (2002).
J Biol Chem., 277(36), 33164-33169, 2002年 - Amyloid Fibril Proteins.
Xing Y, Higuchi K
Mech Ageing Dev., 123(12), 1625-1636, 2002年 - Transmission of Mouse Senile Amyloidosis
Y. Xing, A. Nakamura, T. Chiba 他2名
Lab. Invest, 81, 493-499, 2001年 - Chromosome 13Locus, Pbd2, Regulates Bone Density in Mice
M. Shimizu, K. Higuchi, M. Matsushita 他5名
J. Bone Miner. Res, 16, 1972–1982, 2001年 - 老化促進マウス（SAM）の解析
樋口京一、森 政之
BIO Clinica, 16, 57-61, 2001年 - Extra-Hepatic Expression of Apolipoprotein A-II mRNA Revealed by In Situ Hybridization Analysis; Possible Contribution to Mouse Senile Amyloidosis
L. Fu, I. Matuyama, T. Chiba 他6名
J. Histochem. Cytochem, 49, 739-748, 2001年 - Spontaneous Loss-of-Function Mutations of the 8-Oxoguanine DNA Glycosylase Gene in Mice and Exploration of the Possible Implication of the Gene in Senescence
M. Mori, S. Toyokuni, S. Kondo合計7名
Free Rad. Biol. Med, 30, 1130-1136, 2001年 - Genetic Analysis of Lifespan in Hybrid Progeny Derived From the SAMP1 Mouse Strain with Accelerated Senescence
Z. Guo, E. Toichi, M. Hosono 他4 名
Mech. Ageing Dev., 118, 35-44, 2000年 - Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality
Wang, J; Matsushita, T; Kogishi, K; Xia, C; Ohta, A; Chiba, T; Nakamura, A; Kondo, H; Mori, M; Hosokawa, M; Higuchi, K
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 55(9), B432-B439, 2000年 - Mouse Senile Amyloid Deposition Is Suppressed by Adenovirus-Mediated Overexpression of Amyloid-Resistant Apolipoprotein A-II
T. Chiba, K. Kogishi, J. Wang 他７名
Am. J. Pathol., 155, 1319-1326, 1999年 - Senescence-Accelerated Mouse
K. Higuchi, M. Hosokawa, T. Takeda.
Methods Enzymol, 309, 674-686, 1999年
書籍等出版物
- SAM(老化促進モデルマウス)『モデル動物の作成と維持』
樋口京一、森 政之。, 単著
エル・アイ・シー（東京）, 2004年 - 分子生物学・免疫学キーワード辞典（第2版）
樋口京一、森 政之, 共著
医学書院, 2003年 - 「分子シャペロンによる細胞機能制御」；アミロイド線維タンパク質、シュプリンガー・フェアラーク東京、単著、永田和宏・森正敬・吉田賢右編、pp164-174, 総頁数219頁中11頁を担当.
単著
2001年 - 「Les Amyloidoses」: Model of Amyloidosis of Senescence, Flammarion Medicine Science , 共著、G. Grateuau ,MD. Benson 他2名編集、K. Higuchi, H. Naiki, M. Hosokawa, T. Takada . pp138-145, 総頁数585頁中8頁を担当.
単著
2000年
