Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences 



  • Doctor of Medicine

Research Keyword

    Aging, Model mice, Amyloidosis

Field Of Study

  • Aging Biology
  • Amyloidosis



Mail Address



  • 2019
  • 2018
  • 1986 - 1988
    アメリカ合衆国国立衛生研究所(NIH)心肺血液研究所分子病分野Visiting Fellow

Educational Background

  • 1978, Kyoto University, Faculty of Agriculture
  • 1984, Kyoto University, 医学
  • 1980, Kyoto University, 農学


  • Suppression of mouse AApoAII amyloidosis progression by daily supplementation with oxidative stress inhibitors.
    Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi1 Y, Sawashita J, Mori M, Higuchi K.
    Oxid Med Cell Longev., 2019, 126327, 2019リポジトリ
  • Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
    Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K.
    Oxid Med Cell Longev, 2018, 3181759, Jun. 2018リポジトリ
  • Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.
    Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto K, Mori M, Higuchi K, Sawashita J.
    Exp Anim., 67(2), 105-115, May 2018
  • Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure.
    Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K.
    Sci Rep, 8(1), 5620, Apr. 2018
  • Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis.
    Miyahara H, Sawashita J, Ishikawa E, Yang M, Ding X, Liu Y, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K.
    J Proteomics, 172, 111-121, Feb. 2018
  • SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.
    Akiguchi I, Pallàs M, Budka H, Akiyama H, Ueno M, Han J, Yagi H, Nishikawa T, Chiba Y, Sugiyama H, Takahashi R, Unno K, Higuchi K, Hosokawa M.
    Neuropathology, (37), 293-305, Aug. 2017, Refereed
  • Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.
    Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J.
    Sci Rep. :, 7(1), 8253, 2017
  • Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.
    Li L, Sawashita J, Ding X, Yang M, Xu Z, Miyahara H, Mori M, Higuchi K.
    PLOS ONE, 12(2), e0172402, 2017
  • The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation
    Yoshinaga T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Nishio S, Kanizawa Y, Hachiya N, Tanaka T, Kokudo N, Higuchi K, Ikeda S
    J Pathol, in press, 2016
  • Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis.
    Yang M, Liu F, Higuchi K, Sawashita J, Fu X, Zhang L, Zhang L, Fu L, Tong Z, Higuchi K.
    Yang M, Liu F, Higuchi K, Sawashita J, Fu X, Zhang L, Zhang L, Fu L, Tong Z, Higuchi K., 7(24), 35843-35852, 2016
  • The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aα-chain amyloidosis associated with a novel frameshift variant
    Yazaki M, Yoshinaga T, Sekijima Y, Nishio S, Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi K, Ikeda S
    Amyloid, 22(2), 142-144, 2015
  • NFκB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training
    Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
    Int J Sports Med, 36(9), 769-775, 2015
  • A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice
    Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M
    Exp Anim, 64(2), 171-179, 2015
  • C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice
    Sawashita J, Zhang B, Hasegawa K, Mori M, Naiki H, Kametani F, Higuchi K
    Proc Natl Acad Sci U S A, 12(8), E836-845, 2015
  • Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart
    Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding X, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K
    Lab Invest, 95(3), 320-333, 2015
  • The factors affecting adherence to a long-term interval walking training program in middle-aged and older people
    Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, Nose H; Shinshu University Genetic Research Consortium
    J Appl Physiol (1985), 118(5), 595-603, 2015
  • Transmission of Systemic AA Amyloidosis in Animals
    Murakami, T; Ishiguro, N; Higuchi, K
    VETERINARY PATHOLOGY, 51(2), 363-371, Mar. 2014WebofScienceリポジトリ電子ジャーナル
  • AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
    Mori, M; Tiang, G; Higuchi, K
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 21(1), 1-8, Mar. 2014WebofScienceリポジトリ電子ジャーナル
  • Novel frame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10
    Unno K, Yamamoto H, Toda M, Hagiwara S, Iguchi K, Hoshino M, Takabayashi F, Hasegawa-Ishii S, Shimada A, Hosokawa M, Higuchi K, Mori M
    Biochem Biophys Res Commun, 454(1), 89-94, 2014
  • The toxicity mechanisms of action of Aβ25-35 in isolated rat cardiac myocytes
    Zhang B, Bian X, He P, Fu X, Higuchi K, Yang X, Li D
    MOLECULES, 19(8), 12242-12257, 2014
  • Senile systemic amyloidosis (Japanese)
    Yazaki M, Higuchi K
    Brain Nerve, 266(7), 817-826, 2014
  • Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice
    Tian G, Sawashita J, Kubo H, Nishio SY, Hashimoto S, Suzuki N, Yoshimura H, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S, Higuchi K
    Antioxid Redox Signal, 20(16), 2606-2620, 2014
  • Diversity and complexity of the mouse Saa1 and Saa2 genes
    Mori M, Tian G, Ishikawa A, Higuchi K
    Exp Anim, 63(1), 99-106, 2014WebofScienceリポジトリ電子ジャーナル
  • Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene
    Mori, M; Gotoh, S; Taketani, S; Hiai, H; Higuchi, K
    EXPERIMENTAL EYE RESEARCH, 112, 45-50, Jul. 2013WebofScienceリポジトリ電子ジャーナル
  • An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats
    Luo, H; Higuchi, K; Matsumoto, K; Mori, M
    GENES AND IMMUNITY, 14(3), 192-197, 2013WebofScienceリポジトリ電子ジャーナル
  • Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
    Tanisawa, K; Mikami, E; Fuku, N; Honda, Y; Honda, S; Ohsawa, I; Ito, M; Endo, S; Ihara, K; Ohno, K; Kishimoto, Y; Ishigami, A; Maruyama, N; Sawabe, M; Iseki, H; Okazaki, Y; Hasegawa-Ishii, S; Takei, S; Shimada, A; Hosokawa, M; Mori, M; Higuchi, K; Takeda, T; Higuchi, M; Tanaka, M
    BMC GENOMICS, 14, 248, 2013WebofScienceリポジトリ電子ジャーナル
  • Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1
    Tomozawa, Hiroshi; Nishio, Ayako; Higuchi, Keiichi; Matsumoto, Kiyoshi; Mori, Masayuki
    EXPERIMENTAL ANIMALS, 60(2), 151-160, Apr. 2011WebofScienceリポジトリ電子ジャーナル
  • Exercise Effects on Methylation of ASC Gene
    Nakajima, K.; Takeoka, M.; Mori, M.; Hashimoto, S.; Sakurai, A.; Nose, H.; Higuchi, K.; Itano, N.; Shiohara, M.; Oh, T.; Taniguchi, S.
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 31(9), 671-675, Sep. 2010WebofScienceリポジトリ電子ジャーナル
  • BN.MES-Cyba(mes) Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia
    Tomozawa, Hiroshi; Nishio, Ayako; Okuhara, Yuji;Higuchi, Keiichi; Matsumoto, Kiyoshi; Mori, Masayuki
    EXPERIMENTAL ANIMALS, 59(4), 469-478, Jul. 2010WebofScienceリポジトリ電子ジャーナル
  • Mouse model to study human A beta M-2 amyloidosis: generation of a transgenic mouse with excessive expression of human beta(2)-microglobulin
    Zhang, Pengyao; Fu, Xiaoying; Sawashita, Jinko; Yao, Junjie; Zhang, Beiru; Qian, Jinze; Tomozawa, Hiroshi; Mori, Masayuki; Ando, Yukio; Naiki, Hironobu; Higuchi, Keiichi
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 17(2), 50-62, Jun. 2010WebofScience電子ジャーナル
  • Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
    Qian, Jinze; Yan, Jingmin; Ge, Fengxia; Zhang, Beiru; Fu, Xiaoying; Tomozawa, Hiroshi; Sawashita, Jinko; Mori, Masayuki; Higuchi, Keiichi
    PLOS PATHOGENS, 6(5), e1000914, May 2010WebofScienceリポジトリ電子ジャーナル
  • Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases
    Mori, Masayuki; Higuchi, Keiichi; Sakurai, Akihiro; Tabara, Yasuharu; Miki, Tetsuro; Nose, Hiroshi
    JOURNAL OF PHYSIOLOGY-LONDON, 587(23), 5577-5584, Dec. 2009WebofScienceリポジトリ電子ジャーナル
  • Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese
    Sawashita, Jinko; Onitsuka, Sayaka; Gen-no, Hirokazu; Ishikawa, Shinobu; Iino, Fumie; Tateishi, Norihiko; Murakami, Takeo; Seki, Yoichi; Nagaiwa, Toshiyuki; Hanaoka, Masaaki; Hama, Sumio; Nose, Hiroshi; Higuchi, Keiichi
    EXPERIMENTAL GERONTOLOGY, 44(10), 666-675, Oct. 2009WebofScienceリポジトリ電子ジャーナル
  • Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
    Sawashita, Jinko; Kametani, Fuyuki; Hasegawa, Kazuhiro; Tsutsumi-Yasuhara, Shinobu; Zhang, Beiru; Yan, Jingmin; Mori, Masayuki; Naiki, Hironobu; Higuchi, Keiichi
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1794(10), 1517-1529, Oct. 2009WebofScienceリポジトリ電子ジャーナル
  • Hereditary Pancreatitis Model WBN/Kob Rat Strain Has a Unique Haplotype in the Pdwk1 Region on Chromosome 7
    Mori, Masayuki; Fu, Xiaoying; Chen, Lei; Zhang, Guohong; Higuchi, Keiichi
    EXPERIMENTAL ANIMALS, 58(4), 409-413, Jul. 2009WebofScienceリポジトリ電子ジャーナル
  • Dysfunction in ABCB1A Has Only a Weak Effect on Susceptibility to Dextran Sulfate Sodium-Induced Colitis in SAM Strains
    Zhang, Guohong; Fu, Xiaoying; Takeda, Toshio; Higuchi, Keiichi; Mori, Masayuki
    EXPERIMENTAL ANIMALS, 58(4), 421-425, Jul. 2009WebofScienceリポジトリ電子ジャーナル
  • Apolipoprotein A-II accelerates reactive AA amyloidosis.
    Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K.
    Amyloid, 24(sup1), 147-148, May 2007, Refereed電子ジャーナル
  • Spontaneous hypomorphic mutations in antioxidant enzymes of mice (2003)
    Guo Z, Higuchi K, Mori M.
    Free Radic Biol Med., 2003
  • Amyloidosis modifier genes in less amyloidogenic A/J mouse strain.
    Guo Z, Mori M, Fu X, Yao J, Xing Y, Korenaga T, Li G, Matsushita T, Hosokawa M, Higuchi K.
    Lab Invest, 2003
  • Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse.
    Umezawa M, Tatematsu K, Korenaga T, Fu X, Matushita T, Okuyama H, Hosokawa M, Takeda T, Higuchi K.
    J Lipid Res., 44(4), 762-769, 2003WebofScience
  • Diurnal rhythm disorder of behavioral activity in SAMP1 mice is partially normalized by spontaneous wheel running.
    Yanagidaira, Y; Higuchi, K; Nose, H
    PHYSIOLOGY&BEHAVIOR, 80(2-3), 195-201, 2003WebofScience電子ジャーナル
  • Induction of protein conformational change in mouse senile amyloidosis.
    Xing Y, Nakamura A, Korenaga T, Guo Z, Yao J, Fu X, Matsushita T, Kogishi K, Hosokawa M, Kametani F, Mori M, Higuchi K. (2002).
    J Biol Chem., 277(36), 33164-33169, 2002WebofScience
  • Amyloid Fibril Proteins.
    Xing Y, Higuchi K
    Mech Ageing Dev., 123(12), 1625-1636, 2002WebofScience
  • Transmission of Mouse Senile Amyloidosis
    Y. Xing, A. Nakamura, T. Chiba 他2名
    Lab. Invest, 81, 493-499, 2001
  • Chromosome 13Locus, Pbd2, Regulates Bone Density in Mice
    M. Shimizu, K. Higuchi, M. Matsushita 他5名
    J. Bone Miner. Res, 16, 1972–1982, 2001
  • 老化促進マウス(SAM)の解析
    樋口京一、森 政之
    BIO Clinica, 16, 57-61, 2001
  • Extra-Hepatic Expression of Apolipoprotein A-II mRNA Revealed by In Situ Hybridization Analysis; Possible Contribution to Mouse Senile Amyloidosis
    L. Fu, I. Matuyama, T. Chiba 他6名
    J. Histochem. Cytochem, 49, 739-748, 2001
  • Spontaneous Loss-of-Function Mutations of the 8-Oxoguanine DNA Glycosylase Gene in Mice and Exploration of the Possible Implication of the Gene in Senescence
    M. Mori, S. Toyokuni, S. Kondo合計7名
    Free Rad. Biol. Med, 30, 1130-1136, 2001
  • Genetic Analysis of Lifespan in Hybrid Progeny Derived From the SAMP1 Mouse Strain with Accelerated Senescence
    Z. Guo, E. Toichi, M. Hosono 他4 名
    Mech. Ageing Dev., 118, 35-44, 2000
  • Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality
    Wang, J; Matsushita, T; Kogishi, K; Xia, C; Ohta, A; Chiba, T; Nakamura, A; Kondo, H; Mori, M; Hosokawa, M; Higuchi, K
  • Mouse Senile Amyloid Deposition Is Suppressed by Adenovirus-Mediated Overexpression of Amyloid-Resistant Apolipoprotein A-II
    T. Chiba, K. Kogishi, J. Wang 他7名
    Am. J. Pathol., 155, 1319-1326, 1999
  • Senescence-Accelerated Mouse
    K. Higuchi, M. Hosokawa, T. Takeda.
    Methods Enzymol, 309, 674-686, 1999

Books and other publications

  • SAM(老化促進モデルマウス)『モデル動物の作成と維持』
    樋口京一、森 政之。, Single work
    エル・アイ・シー(東京), 2004
  • 分子生物学・免疫学キーワード辞典(第2版)
    樋口京一、森 政之, Joint work
    医学書院, 2003
  • 「分子シャペロンによる細胞機能制御」;アミロイド線維タンパク質、シュプリンガー・フェアラーク東京、単著、永田和宏・森正敬・吉田賢右編、pp164-174, 総頁数219頁中11頁を担当.
    Single work
  • 「Les Amyloidoses」: Model of Amyloidosis of Senescence, Flammarion Medicine Science , 共著、G. Grateuau ,MD. Benson 他2名編集、K. Higuchi, H. Naiki, M. Hosokawa, T. Takada . pp138-145, 総頁数585頁中8頁を担当.
    Single work

Research Themes

  • マウス特に老化促進モデルマウス(SAM)を用いた老化、寿命、老化病態の遺伝的要因の解析