OHKANDA Junko

Academic Assembly School of Science and Technology Institute of Agriculture

Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology 

Professor 

Research Keyword

    protein-protein interactions, intrinsically disordered proteins and regions, Pharmaceutical and plant hormones, Antitumor agents, Signaling pathways, Posttranslational modification, Natural products, Peptides, 14-3-3 proteins, fusicoccin

Field Of Study

  • Chemical Biology
  • Chemical biology, Bioorganic chemistry

Mail Address

    johkanda★shinshu-u.ac.jp

Career

  • 2022
    Chemistry A European Journal, Editorial board member (Wiley-VCH)
  • 2017
    Bioorganic Chemistry Editorial board member (Elsevier)
  • 2016
    Professor, Shinshu University
  • 2013 - 2016
    Associate Professor, ICR, Kyoto University
  • 2005 - 2013
    Associate Professor, ISIR, Osaka University
  • 2004 - 2005
    Lecturer, Tokyo Gakugei University
  • 2003 - 2003
    Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA)
  • 1998 - 2003
    Postdoctral Associate, Department of Chemistry, Yale University
  • 1991 - 1997
    Assistant Professor, Seikei University
  • 1990 - 1991
    Researcher, Ricoh Co. Ltd.

Educational Background

  • 1990, M. Sc., Ochanomizu University

Member History

  • 2022
    Scientific Program Committee, International Chemical Biology Society

Award

  • 2017
    公益財団法人 長瀬科学技術振興財団, Nagase Foundation Research Award

Paper

  • Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors
    Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda
    Bioorganic & Medicinal Chemistry Letters, 98, Jan. 2024, Refereed電子ジャーナル
  • Isoform-selective fluorescent labeling of 14-3-3sigma by acrylamide-containing fusicoccins
    Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda
    Chemistry A European Journal, 29(41), Jul. 2023, Refereed電子ジャーナル
  • Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3 phoospholigand interactions
    Nanami Ogino, Ryoma Masuda, LouvyLynn Punzalan, Emi Yamashita, Shota Igaue, Yoshihisa Inoue, Junko Ohkanda
    Bioorg. Med. Chem., 73, 117020, 18 Sep. 2022電子ジャーナル
  • Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY
    Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii
    Protein Expr. Purif., 196-196, 106089, 18 Mar. 2022
  • Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B
    Yosei Nagaoka, Prakash Parvatkar, Go Hirai, Junko Ohkanda
    Bioorg. Med. Chem. Lett., 48, 128265, 12 Jul. 2021電子ジャーナル
  • Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
    Hosoya, Yusuke; Ohkanda, Junko;
    MOLECULES, 26(8), Apr. 2021リポジトリ電子ジャーナル
  • Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
    Ohkanda, Junko;
    Chemistry Letters, 50(1), 57-67, Jan. 2021リポジトリ電子ジャーナル
  • Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
    Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda
    Chemical Communications, 56, 11203-11206, 21 Aug. 2020, Refereed電子ジャーナル
  • Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates
    Masuda, Ryoma; Kawasaki, Yuuya; Igawa, Kazunobu; Manabe, Yoshiyuki; Fujii, Hiroshi; Kato, Nobuo; Tomooka, Katsuhiko; Ohkanda, Junko;
    CHEMISTRY-AN ASIAN JOURNAL, 15, 742-747, 2020WebofScience電子ジャーナル
  • A NOVEL CONDENSED HETEROCYCLIC QUINONE WITH A DIBENZOFURANOBISTHIADIAZOLE SKELETON
    Sugawara, Kazuma; Nojo, Wataru; Ishigaki, Yusuke; Ohkanda, Junko; Suzuki, Takanori;
    Heterocycles, 101(1), 99-103, 2020リポジトリ電子ジャーナル
  • Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine
    Kawaguchi, Yoshimasa; Ise, Shoko; Azuma, Yusuke; Takeuchi, Toshihide; Kawano, Kenichi; Toan Khanh Le; Ohkanda, Junko; Futaki, Shiroh;
    Bioconjugate chemistry, 30(2), 454-460, Feb. 2019WebofScience電子ジャーナル
  • A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf
    Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;
    CHEMISTRY-A EUROPEAN JOURNAL, 25(59), 13531-13536, 2019WebofScience電子ジャーナル
  • Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity
    Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;
    CHEMISTRY-A EUROPEAN JOURNAL, 24(60), 16066-16071, 2018WebofScience電子ジャーナル
  • A Strategy of Designing Mid-sized Synthetic Molecules that Recognize Interfaces of Protein protein Interactions
    Ohkanda, Junko;
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 75(7), 735-745, Jul. 2017WebofScience
  • たんぱく質間相互作用を制御する合成分子の創製
    大神田 淳子;
    京都大学化学研究所スーパーコンピュータシステム研究成果報告書, 2016, 7-7, Mar. 2017リポジトリ
  • Protein-guided self-assembly for controlling protein-protein interactions
    Junko Ohkanda
    Journal of the Society of Japanese Women Scientists, 17, 1-7, 2017
  • Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions
    Parvatkar, Prakash; Kato, Nobuo; Uesugi, Motonari; Sato, Shin-ichi; Ohkanda, Junko;*
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(50), 15624-15627, 2015WebofScience電子ジャーナル
  • RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation
    Harada, Kazuo*; Aoyama, Shoko; Matsugami, Akimasa; Kumar, Penmetcha K. R.; Katahira, Masato; Kato, Nobuo; Ohkanda, Junko;
    ChemBioChem, 15(6), 794-798, 2014WebofScience電子ジャーナル
  • Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions
    Ohkanda, Junko;*
    CHEMICAL RECORD, 13(6), 561-575, Dec. 2013WebofScience電子ジャーナル
  • Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
    Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;
    ACS Chemical Biology, 8(9), 1869-1875, Sep. 2013WebofScience電子ジャーナル
  • Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors
    Machida, Shinnosuke; Tsubamoto, Mai; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
    Bioorganic & medicinal chemistry, 21(14), 4004-4010, 2013WebofScience電子ジャーナル
  • A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
    Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;
    CHEMISTRY & BIOLOGY, 20(4), 583-593, 2013WebofScience電子ジャーナル
  • Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase
    Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko;*
    Chemical Communications, 49(49), 5535-5537, 2013WebofScience電子ジャーナル
  • Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein
    Maki, Toshio; Kawamura, Akie; Kato, Nobuo; Ohkanda, Junko;*
    MOLECULAR BIOSYSTEMS, 9(5), 940-943, 2013WebofScience電子ジャーナル
  • A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
    Kawakami, Koshi; Hattori, Miho; Inoue, Takatsugu; Maruyama, Yuriko; Ohkanda, Junko; Kato, Nobuo; Tongu, Miki; Yamada, Takaya; Akimoto, Miho; Takenaga, Keizo; Sassa, Takeshi; Suzumiy, Junji; Honma, Yoshio;
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 12(7), 791-800, Sep. 2012WebofScience
  • Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c
    Yamaguchi, Yoshinobu; Kato, Nobuo; Azuma, Hideki; Nagasaki, Takeshi; Ohkanda, Junko;*
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(6), 2354-2358, 2012WebofScience電子ジャーナル
  • Phosphopeptide-Dependent Labeling of 14-3-3 zeta Proteins by Fusicoccin-Based Fluorescent Probes
    Takahashi, Michiko; Kawamura, Akie; Kato, Nobuo; Nishi, Tsuyoshi; Hamachi, Itaru; Ohkanda, Junko;*
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(2), 509-512, 2012WebofScience電子ジャーナル
  • Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases
    Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;*
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(4), 958-963, 2011WebofScience電子ジャーナル
  • Design and functional evaluation of dual prenyltransferase inhibitors for simultaneous recognition of active site and exterior protein surface
    Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238, 2009WebofScience
  • Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins
    Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;
    ORGANIC LETTERS, 11(14), 3044-3047, 2009WebofScience電子ジャーナル
  • Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
    Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;
    JOURNAL OF MEDICINAL CHEMISTRY, 52(12), 3703-3715, 2009WebofScience電子ジャーナル
  • Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes
    Ohkanda, Junko; Satoh, Ritsuko; Kato, Nobuo;
    Chemical Communications, (45), 6949-6951, 2009WebofScience電子ジャーナル
  • Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
    Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;
    CHEMISTRY-A EUROPEAN JOURNAL, 14(5), 1392-1401, 2008WebofScience電子ジャーナル
  • Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
    Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;
    Oncogene, 26(5), 633-640, Feb. 2007WebofScience電子ジャーナル
  • ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces
    Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, 2007WebofScience
  • Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
    Ohkanda, J; Strickland, CL; Blaskovich, MA; Carrico, D; Lockman, JW; Vogt, A; Bucher, CJ; Sun, JZ; Qian, YM; Knowles, D; Pusateri, EE; Sebti, SM; Hamilton, AD;
    Organic & Biomolecular Chemistry, 4(3), 482-492, 2006WebofScience電子ジャーナル
  • In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
    Carrico, D; Ohkanda, J; Kendrick, H; Yokoyama, K; Blaskovich, MA; Bucher, CJ; Buckner, FS; Van Voorhis, WC; Chakrabarti, D; Croft, SL; Gelb, MH; Sebti, SM; Hamilton, AD;
    Bioorganic & medicinal chemistry, 12(24), 6517-6526, 2004WebofScience電子ジャーナル
  • Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
    Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; Van Voorhis, WC; Gelb, MH; Sebti, SM; Hamilton, AD;
    JOURNAL OF MEDICINAL CHEMISTRY, 47(2), 432-445, 2004WebofScience電子ジャーナル
  • In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
    Bordier, BB; Ohkanda, J; Liu, P; Lee, SY; Salazar, FH; Marion, PL; Ohashi, K; Meuse, L; Kay, MA; Casey, JL; Sebti, SM; Hamilton, AD; Glenn, JS;
    JOURNAL OF CLINICAL INVESTIGATION, 112(3), 407-414, Aug. 2003WebofScience電子ジャーナル
  • The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
    Bolick, SCE; Landowski, TH; Boulware, D; Oshiro, MM; Ohkanda, J; Hamilton, AD; Sebti, SM; Dalton, WS;
    Leukemia, 17(2), 451-457, Feb. 2003WebofScience電子ジャーナル
  • Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice
    Sun, JZ; Ohkanda, J; Coppola, D; Yin, H; Kothare, M; Busciglio, B; Hamilton, AD; Sebti, SM;
    CANCER RESEARCH, 63(24), 8922-8929, 2003WebofScience
  • A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
    Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;
    Proceedings of the National Academy of Sciences of the United States of America, 100(25), 15149-15153, 2003WebofScience電子ジャーナル
  • The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status
    Crespo, NC; Delarue, F; Ohkanda, J; Carrico, D; Hamilton, AD; Sebti, SM;
    CELL DEATH AND DIFFERENTIATION, 9(7), 702-709, Jul. 2002WebofScience電子ジャーナル
  • CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect
    Ohkanda, J;
    SEIKAGAKU, 74(1), 46-50, Jan. 2002WebofScience
  • Synthesis of linear and cyclic hexapeptides with N epsilon-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-beta-alanyl as the repeating unit and properties of their iron(III) complexes
    Katoh, A; Inoue, Y; Nagashima, H; Hikita, Y; Ohkanda, J; Saito, R;
    Heterocycles, 58, 371-381, 2002WebofScience
  • Toward Chagas disease chemotherapeutics: Development of simple compounds active against Trypanosoma cruzi.
    Lockman, JW; Ohkanda, J; Yokoyama, K; Eastman, RT; Buckner, FS; Gelb, MH; Hamilton, AD;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U17-U17, 2002WebofScience
  • Design, synthesis and evaluation of peptidomimetic farnesyltransferase inhibitor ester pro-drugs as potent antiparasitic agents.
    Carrico, D; Ohkanda, J; Gelb, MH; Blaskovich, MA; Sebti, SM; Hamilton, AD;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U28-U28, 2002WebofScience
  • Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches.
    Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U30-U30, 2002WebofScience
  • Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold
    Ohkanda, J; Lockman, JW; Kothare, MA; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
    JOURNAL OF MEDICINAL CHEMISTRY, 45(1), 177-188, 2002WebofScience電子ジャーナル
  • 3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-
    Katoh, A; Hikita, Y; Harata, M; Ohkanda, J; Tsubomura, T; Higuchi, A; Saito, R; Harada, K;
    Heterocycles, 55(11), 2171-2187, 2001WebofScience
  • The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
    Crespo, NC; Ohkanda, J; Yen, TJ; Hamilton, AD; Sebti, SM;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 276(19), 16161-16167, 2001WebofScience
  • Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
    Ohkanda, J; Lockman, JW; Yokoyama, K; Gelb, MH; Croft, SL; Kendrick, H; Harrell, MI; Feagin, JE; Blaskovich, MA; Sebti, SM; Hamilton, AD;
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(6), 761-764, 2001WebofScience
  • Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Lantry, LE; Zhang, ZQ; Yao, RS; Crist, KA; Wang, Y; Ohkanda, J; Hamilton, AD; Sebti, SM; Lubet, RA; You, M;
    CARCINOGENESIS, 21(1), 113-116, Jan. 2000WebofScience
  • Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
    Kothare, MA; Ohkanda, J; Lockman, JW; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
    Tetrahedron, 56(50), 9833-9841, 2000WebofScience
  • Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
    Adnane, J; Bizouarn, FA; Chen, Z; Ohkanda, J; Hamilton, AD; Munoz-Antonia, T; Sebti, SM;
    Oncogene, 19(48), 5525-5533, 2000WebofScience
  • Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent
    Katoh, A; Yoshida, T; Ohkanda, J;
    Heterocycles, 52(2), 911-920, 2000WebofScience
  • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
    Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;
    CANCER RESEARCH, 59(19), 4919-4926, 1999WebofScience
  • Novel nonthiol inhibitors of farnesyl transferase show potent antitumor properties.
    Ohkanda, J; Blaskovich, M; Sun, J; Sebti, SM; Hamilton, AD;
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 218, U984-U984, 1999WebofScience
  • Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
    Vasudevan, A; Qian, YM; Vogt, A; Blaskovich, MA; Ohkanda, J; Sebti, SM; Hamilton, AD;
    JOURNAL OF MEDICINAL CHEMISTRY, 42(8), 1333-1340, 1999WebofScience
  • Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis
    Katoh, A; Fujimoto, T; Takahashi, M; Ohkanda, J;
    Heterocycles, 50(1), 299-308, 1999WebofScience電子ジャーナル
  • Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes
    Katoh, A; Kitamura, Y; Fujii, H; Horie, Y; Satoh, T; Ohkanda, J; Yokomori, Y;
    Heterocycles, 49, 281-296, 1998WebofScience電子ジャーナル
  • New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
    Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;
    JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, (22), 3859-3864, 1998WebofScience電子ジャーナル
  • Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization
    Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;
    Biochemical and biophysical research communications, 252(1), 111-116, 1998WebofScience電子ジャーナル
  • N-hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation
    Ohkanda, J; Shibui, H; Katoh, A;
    Chemical Communications, (3), 375-376, 1998WebofScience電子ジャーナル
  • N-hydroxyamide-containing heterocycles: Synthesis, reactivities, and iron(III)-chelating properties
    Ohkanda, J; Katoh, A;
    REVIEWS ON HETEROATOM CHEMISTRY, 18, 87-118, 1998WebofScience
  • Functionalized N-hydroxyamide-containing heterocycles - Synthesis, reaction, and metal-chelating property
    Ohkanda, J; Katoh, A;
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 55(6), 524-534, Jun. 1997WebofScience
  • Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the influence of their structures upon the enantioselective reduction
    Katoh, A; Naruse, S; Ohkanda, J; Yamamoto, H;
    Heterocycles, 45(8), 1441-1446, 1997WebofScience電子ジャーナル
  • Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine
    Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;
    JOURNAL OF ORGANIC CHEMISTRY, 62(11), 3618-3624, 1997WebofScience
  • Structural analysis of N-(omega-phenylalkyl)substituted quinoxalin-2(1H)-ones and -thiones
    Katoh, A; Yoshida, T; Ohkanda, J; Nishio, T;
    Heterocycles, 44, 357-366, 1997WebofScience電子ジャーナル
  • N-hydroxyamide-containing heterocycles .7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones
    Ohkanda, J; Kumasaka, T; Takasu, A; Hasegawa, T; Katoh, A;
    Heterocycles, 43(4), 883-889, 1996WebofScience
  • Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability
    Katoh, A; Ishida, S; Ohkanda, J; Washizu, M;
    Heterocycles, 43(3), 589-599, 1996WebofScience
  • Synthesis of 2,3-disubstituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids
    Katoh, A; Takahashi, M; Ohkanda, J;
    Chemistry Letters, (5), 369-370, 1996WebofScience
  • The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin
    Ohkanda, J; Katoh, A;
    Chemistry Letters, (6), 423-424, 1996WebofScience
  • N-hydroxyamide-containing heterocycles .6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxycarbonylating agent
    Katoh, A; Kondoh, S; Ohkanda, J;
    HETEROCYCLIC COMMUNICATIONS, 2(2), 141-144, 1996WebofScience
  • N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .5. SYNTHESIS OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, ALIPHATIC DIAMINE, AND 1,1,1-TRIS(CARBOXYETHOXYMETHYL)ETHANE, AND PROPERTIES OF THEIR FERRIC COMPLEXES
    Ohkanda, J; Katoh, A;
    Tetrahedron, 51(47), 12995-13002, 1995WebofScience
  • N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .4. SYNTHESIS AND FE-III-CHELATING PROPERTIES OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, AMINO-ACID-RESIDUES, AND TRIS(2-AMINOETHYL)AMINE
    Ohkanda, J; Katoh, A;
    JOURNAL OF ORGANIC CHEMISTRY, 60(6), 1583-1589, 1995WebofScience
  • SYNTHESIS OF 2(1H)-PYRIMIDINONE-CONTAINING ALPHA-AMINO-ACID DERIVATIVES BY CHEMICAL MODIFICATION OF L-GLUTAMIC ACID
    KATOH, A; INOKAWA, M; OHKANDA, J; MITSUHASHI, K;
    CHEMICAL & PHARMACEUTICAL BULLETIN, 42(7), 1514-1517, Jul. 1994WebofScience
  • N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .3. THE RING TRANSFORMATION OF 1-BENZYLOXY-2(1H)-PYRIMIDINONES INTO 2-ISOXAZOLINES WITH HYDROXYLAMINE
    KATOH, A; OHKANDA, J; TAMURA, A; YOSHIIKE, Y; MITSUHASHI, K;
    Heterocycles, 37(2), 1141-1146, 1994WebofScience
  • N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .2. SYNTHESIS AND IRON(III) COMPLEX-FORMING TENDENCY OF 1-HYDROXY-2(1H)-PYRIMIDINONE AND 1-HYDROXY-2(1H)-PYRAZINONE
    OHKANDA, J; TOKUMITSU, T; MITSUHASHI, K; KATOH, A;
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 66(3), 841-847, Mar. 1993WebofScience
  • A CONVENIENT SYNTHESIS OF 3-(ARYL)SUBSTITUTED 2,4(1H,3H)-PTERIDINEDIONES AND THEIR ABSORPTION AND FLUORESCENCE SPECTROSCOPIC CHARACTERISTICS
    KATOH, A; OHKANDA, J; SATO, H; SAKAMOTO, T; MITSUHASHI, K;
    Heterocycles, 35(2), 949-954, 1993WebofScience
  • N-HYDROXYAMIDE-CONTAINING HETEROCYCLES - NEW EFFECTIVE ADDITIVES FOR PEPTIDE-SYNTHESIS BY THE DICYCLOHEXYLCARBODIIMIDE METHOD
    KATOH, A; OHKANDA, J; ITOH, Y; MITSUHASHI, K;
    Chemistry Letters, (10), 2009-2012, Oct. 1992WebofScience
  • STRUCTURAL ASPECTS OF THE MECHANICAL AND THERMAL-DISSOCIATION OF THE CENTRAL BOND IN 2,2'-BIS(2,3,4-TRIARYLCHROMENYL)S
    OHKANDA, J; MORI, Y; MAEDA, K; OSAWA, E;
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, (1), 59-63, Jan. 1992WebofScience
  • ISOLATION OF THE INTERMEDIATES AND IMPROVED SYNTHESIS OF PYRIDO[1',2'/1,2]IMIDAZOL[4,5-B]PYRAZINES AND PYRIDO[1',2'/1,2]IMIDAZOL]4,5-B]QUINOXALINES
    KATOH, A; UEDA, SH; OHKANDA, J; HIROTA, M; KOMINE, H; MITSUHASHI, K;
    Heterocycles, 34(10), 1965-1972, 1992WebofScience
  • UNUSUAL SUBSTITUENT EFFECT BY THE ALPHA-ACETYL GROUP ON THE TYPE-II PHOTOREACTION OF VALEROPHENONES - STRONG WAVELENGTH DEPENDENCE OF QUANTUM YIELDS
    HASEGAWA, T; OHKANDA, J; KOBAYASHI, M; YOSHIOKA, M;
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 64(3), 299-306, 1992WebofScience

Books and other publications

  • Chemical approach toward controlling of transient protein interactions, published in Middle Molecular Strategy
    Junko Ohkanda, Contributor, Chemical approach toward controlling of transient protein interactions
    Springer, Singapore, 77-96 14 Jul. 2021, Refereed
    ISBN:978-981-16-2457-5
  • Self-assembled receptors for protein surface recognition, published in Comprehensive Supramolecular Chemistry II
    Junko Ohkanda, Self-Assembled Receptors for Protein Surface Recognition
    Elsevier, Oxford, 351-369 2017

Affiliated academic society

  • The Chemical Society of Japan
  • The Pharmaceutical Society of Japan
  • American Chemical Society
  • The Society of Synthetic Organic Chemistry, Japan
  • International Chemical Biology Society

Research Themes

  • Design of synthetic molecules that regulate protein interactions