HIGUCHI Yumiko

School of Medicine Department of Health Sciences Biomedical Laboratory Sciences 

Senior Assistant Professor 

Research activity information

Paper

  • T cell clonal expansion and STAT3 mutations: a characteristic feature of acquired chronic T cell-mediated pure red cell aplasia
    Kawakami, Fumihiro; Kawakami, Toru; Yamane, Taku; Maruyama, Masae; Kobayashi, Jun; Nishina, Sayaka; Sakai, Hitoshi; Higuchi, Yumiko; Hamanaka, Kazutoshi; Hirokawa, Makoto; Nakao, Shinji; Nakazawa, Hideyuki; Ishida, Fumihiro;
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 115(6), 816-825, Jun. 2022WebofScience電子ジャーナル
  • Novel variant fibrinogen gamma p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
    Yoda, Masahiro; Kaido, Takahiro; Kamijo, Tomu; Taira, Chiaki; Higuchi, Yumiko; Arai, Shinpei; Okumura, Nobuo;
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 114(3), 325-333, Sep. 2021WebofScience電子ジャーナル
  • Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients
    Fujimura, Satoshi; Higuchi, Yumiko; Usami, Yoko; Yamaura, Makoto; Higuchi, Tsukasa; Terasawa, Fumiko; Okumura, Nobuo;
    CLINICA CHIMICA ACTA, 512, 127-134, Jan. 2021WebofScience電子ジャーナル
  • A Novel Amino Acid Substitution, Fibrinogen B beta p.Pro234Leu, Associated with Hypofibrinogenemia Causing Impairment of Fibrinogen Assembly and Secretion
    Kaido, Takahiro; Yoda, Masahiro; Kamijo, Tomu; Arai, Shinpei; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nobuo;
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(24), Dec. 2020WebofScience電子ジャーナル
  • Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative
    Yoda, Masahiro; Kaido, Takahiro; Taira, Chiaki; Higuchi, Yumiko; Arai, Shinpei; Okumura, Nobuo;
    THROMBOSIS RESEARCH, 196, 152-158, Dec. 2020WebofScience電子ジャーナル
  • A Case of Severe Enhanced-Fibrinolytic-Type DIC with Two Fibrinogen Gene Mutations Not Associated with Fibrinogenopenia
    依田 将宏;海藤 貴大;上條 途夢;新井 慎平;平 千明;樋口 由美子;長田 眞;塚田 唯子;奥村 伸生
    臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌, 68(5), 390-397, May 2020リポジトリ
  • Heterozygous variant fibrinogen gamma A289V (Kanazawa III) was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens
    Kaido, Takahiro; Yoda, Masahiro; Kamijo, Tomu; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nobuo;
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 42(2), 190-197, Apr. 2020WebofScience電子ジャーナル
  • Comparison of molecular structure and fibrin polymerization between two B beta-chain N-terminal region fibrinogen variants, B beta p.G45C and B beta p.R74C
    Kaido, Takahiro; Yoda, Masahiro; Kamijo, Tomu; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nobuo;
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020WebofScience電子ジャーナル
  • High frequency of STAT3 gene mutations in T-cell receptor (TCR)gamma delta-type T-cell large granular lymphocytic leukaemia: implications for molecular diagnostics
    Yamane, Taku; Kawakami, Toru; Sekiguchi, Nodoka; Kobayashi, Jun; Ueki, Toshimitsu; Kobayashi, Hikaru; Kawakami, Fumihiro; Nishina, Sayaka; Sakai, Hitoshi; Oshimi, Kazuo; Higuchi, Yumiko; Nakazawa, Hideyuki; Ishida, Fumihiro;
    BRITISH JOURNAL OF HAEMATOLOGY, 2020WebofScience電子ジャーナル
  • gamma D318Y fibrinogen shows no fibrin polymerization due to defective "A-a" and "B-b" interactions, whereas that of gamma K321E fibrinogen is nearly normal
    Kamijo, Tomu; Mukai, Saki; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nobuo;
    THROMBOSIS RESEARCH, 182, 150-158, Oct. 2019WebofScience電子ジャーナル
  • In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination
    Shimodaira, Shigetaka; Yanagisawa, Ryu; Koya, Terutsugu; Hirabayashi, Koichi; Higuchi, Yumiko; Sakamoto, Takuya; Togi, Misa; Kato, Tomohisa, Jr.; Kobayashi, Takashi; Koizumi, Tomonobu; Koido, Shigeo; Sugiyama, Haruo;
    Vaccines, 7(3), Sep. 2019WebofScience電子ジャーナル
  • Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (B beta Ala68Thr), showed almost entirely normal polymerization
    Kamijo, Tomu; Nagata, Kazuhiro; Taira, Chiaki; Higuchi, Yumiko; Arai, Shinpei; Okumura, Nobuo;
    THROMBOSIS RESEARCH, 172, 1-3, Dec. 2018WebofScience電子ジャーナル
  • Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (B beta Ala68Thr), showed almost entirely normal polymerization
    Kamijo, Tomu; Nagata, Kazuhiro; Taira, Chiaki; Higuchi, Yumiko; Arai, Shinpei; Okumura, Nobuo;
    THROMBOSIS RESEARCH, 172, 1-3, Dec. 2018WebofScience電子ジャーナル
  • フィブリノゲン蓄積病を呈する異常フィブリノゲン産生細胞の繊維状封入体形成と小胞体ストレス応答
    上條 途夢;大久保 奈緒;平 千明;樋口 由美子;新井 慎平;奥村 伸生
    臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌, 66(10), 1058-1064, Oct. 2018リポジトリ
  • Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors
    Hirabayashi, Koichi; Yanagisawa, Ryu; Saito, Shoji; Higuchi, Yumiko; Koya, Terutsugu; Sano, Kenji; Koido, Shigeo; Okamoto, Masato; Sugiyama, Haruo; Nakazawa, Yozo; Shimodaira, Shigetaka;
    Anticancer Research, 38(4), 2227-2234, Apr. 2018WebofScience電子ジャーナル
  • Clinical effect and immunological response in patients with advanced malignant glioma treated withWT1-pulsed dendritic cell-based immunotherapy: A report of two cases
    Sakai, K., Shimodaira, S., Maejima, S., Sano, K., Higuchi, Y., Koya, T., Sugiyama H. & Hongo, K.
    Interdisciplinary Neurosurgery, 9, 24-29, Sep. 2017, Refereedリポジトリ
  • Interferon-alpha-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
    Koya, Terutsugu; Yanagisawa, Ryu; Higuchi, Yumiko; Sano, Kenji; Shimodaira, Shigetaka;
    SCIENTIFIC REPORTS, 7, 2017WebofScience電子ジャーナル
  • WT1 Peptide Vaccine is Unaffected by Airport Screening X-Irradiation
    Higuchi Y, Kawakubo M, Yuzawa M, Sano K and Shimodaira S.
    Vaccines & Immunother., 3(1), Sep. 2016
  • Quality Verification of Dendritic Cell-Based Cancer Vaccine
    Shigetaka Shimodaira, Terutsugu Koya, Yumiko Higuchi, Masato Okamoto, Shigeo Koido
    Pharm Anal Acta, Jul. 2016
  • Efficacy of dendritic cell-based cancer immunotherapy
    Shigetaka Shimodaira, Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto, Shigeo Koido.
    Biochem Anal Biochem, May 2016
  • An update on Dendritic Cell-Based Cancer Immunotherapy
    Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Yanagisawa R, Okamoto M and Koido S
    Immunome Res, 12(1), Mar. 2016
  • Enzyme-Linked Immunosorbent Spot Assay for the Detection Of Wilms’ Tumor 1-Specific T Cells Induced by Dendritic Cell Vaccination Cell Vaccination
    Yumiko Higuchi, Terutsugu Koya, Miki Yuzawa, Naoko Yamaoka, Yumiko Mizuno, Kiyoshi Yoshizawa, Koichi Hirabayashi, Takashi Kobayashi 3, Kenji Sano, and Shigetaka Shimodaira
    Biomedicines , 3, 304-315, Dec. 2015
  • Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms’ Tumor 1 in Patients with Advanced Colorectal Cancer
    Shigetaka Shimodaira, Kenji Sano, Koichi Hirabayashi, Terutsugu Koya , Yumiko Higuchi, Yumiko Mizuno, Naoko Yamaoka, Miki Yuzawa, Takashi Kobayashi, Kenichi Ito, and Tomonobu Koizumi
    3, 1004-1018, Dec. 2015
  • Standard WT1 Expression Using Immunohistochemistry
    Shigetaka Shimodaira Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto, Shigeo Koido.
    J Mol Biomark Diagn, (7), 266, Dec. 2015
  • Dendritic cell-based immunotherapy targeting Wilms' tumor 1 in patients with recurrent malignant glioma
    Sakai, Keiichi; Shimodaira, Shigetaka; Maejima, Shinya; Udagawa, Nobuyuki; Sano, Kenji; Higuchi, Yumiko; Koya, Terutsugu; Ochiai, Takanaga; Koide, Masanori; Uehara, Shunsuke; Nakamura, Midori; Sugiyama, Haruo; Yonemitsu, Yoshikazu; Okamoto, Masato; Hongo, Kazuhiro;
    JOURNAL OF NEUROSURGERY, 123(4), 989-997, Oct. 2015WebofScience電子ジャーナル
  • Future Prospective of Cancer Vaccination Technology in Japan
    Shimodaira S, Hirabayashi K, Kobayashi T, Higuchi Y and Yokokawa K
    Pharmaceut Reg Affairs, 4(2), Jul. 2015
  • Induction of Antigen-Specific Cytotoxic T Lymphocytes by Chemoradiotherapy in Patients Receiving Wilms’ Tumor 1-Targetted Dendritic Cell Vaccinations for Pancreatic Cancer
    Shimodaira S, Kobayashi T, Hirabayashi K, Horiuchi K, Koya T, Mizuno Y, Yamaoka N, Yuzawa M, Ishikawa S, Higuchi Y, Sano K, Ito K, and Koizumi T
    J Radiol, 4(4), Jul. 2015
  • Smoking influences the yield of dendritic cells for cancer immunotherapy
    Shimodaira S, Higuchi Y, Koya T, Kobayashi T, Yanagisawa R
    Pharmaceut Reg Affairs, 4(133), Apr. 2015
  • Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: a case report and review of the literature
    Saito, Shoji; Yanagisawa, Ryu; Yoshikawa, Kentaro; Higuchi, Yumiko; Koya, Terutsugu; Yoshizawa, Kiyoshi; Tanaka, Miyuki; Sakashita, Kazuo; Kobayashi, Takashi; Kurata, Takashi; Hirabayashi, Koichi; Nakazawa, Yozo; Shiohara, Masaaki; Yonemitsu, Yoshikazu; Okamoto, Masato; Sugiyama, Haruo; Koike, Kenichi; Shimodaira, Shigetaka;
    CYTOTHERAPY, 17(3), 330-335, Mar. 2015WebofScience電子ジャーナル
  • A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2
    Shigemura, Tomonari; Agematsu, Kazunaga; Yamazaki, Takashi; Sakashita, Kazuo; Nakayama, Yoshiko; Higuchi, Yumiko; Matsuda, Kazuyuki; Koike, Kenichi;
    RHEUMATOLOGY, 50(7), 1342-1344, Jul. 2011WebofScience電子ジャーナル
  • WT1 AND MUC1-PULSED DENDRITIC CELL VACCINATION THERAPY FOR NON-SMALL-CELL LUNG CANCER
    Kobayashi, Takashi; Koizumi, Tomonobu; Tateishi, Kazunari; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Hanaoka, Masayuki; Kubo, Keishi; Shimodaira, Shigetaka; Yanagisawa, Ryu; Muramatsu, Saori; Higuchi, Yumiko; Goto, Takahumi; Ishikawa, Shinsuke;
    JOURNAL OF THORACIC ONCOLOGY, 6(6), S1266-S1267, Jun. 2011WebofScience
  • Simple polymerase chain reaction for the detection of mutations and deletions in the epidermal growth factor receptor gene: Applications of this method for the diagnosis of non-small-cell lung cancer
    Uhara, Miho; Matsuda, Kazuyuki; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nubuo; Yamauchi, Kazuyoshi;
    CLINICA CHIMICA ACTA, 401(1-2), 68-72, Mar. 2009WebofScience電子ジャーナル
  • CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient
    Yotsumoto, Mihoko; Ichikawa, Naoaki; Ueno, Mayumi; Higuchi, Yumiko; Asano, Naoko; Kobayashi, Hikaru;
    INTERNAL MEDICINE, 48(7), 559-562, 2009WebofScience電子ジャーナル
  • CD38 expression by hematopoietic stem cells of newborn and juvenile mice.
    Higuchi Y, Zeng H, Ogawa M.
    Leukemia, 17(1), 171-174, Jan. 2003
  • Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method
    Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T.
    Electrophoresis, 21, 3016-3019, Sep. 2000
  • Thrombopoietin enhances neutrophil production by bone marrow hematopoietic progenitors with the aid of stem cell factor in congenital neutropenia
    Sawai N, Koike K, Mwamtemi HH, Ito S, Kurokawa Y, Sakashita K, Kinoshita T, Higuchi T, Takeuchi K, Shiohara M, Kamijo T, Higuchi Y, Miyazaki H, Kato T,Kobayashi M, Miyake M, Yasui K, Komiyama A.
    Jounal of Leukocyte Biology., 68(1), 137-143, Jul. 2000
  • Plasminogen Kanagawa-I,a novel missense mutation, is caused by the amino acid substitution G732R
    Higuchi Y, Furihata K, Ueno I, Ishikawa S, Okumura N, Tozuka M, Sakurai N.
    BRITISH JOURNAL OF HAEMATOLOGY, 103, 867-870, Sep. 1998
  • Establishment of a GM-CSF-dependent megakaryoblastic cell line with the potential to differentiate into an eosinophilic lineage in response to retinoic acids
    Ma F, Koike K, Higuchi T, Kinoshita T, Takeuchi K, Mwamtemi HH, Sawai N, Kamijo T, Shiohara M, Horie S, Kawa S, Sasaki Y, Hidaka E, Yamagami O, Yamashita
    British Journal of Haematology., 100(2), 427-435, Feb. 1998
  • Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
    Higuchi T,Koike K,Sawai N,Mwamtemi HH, Takeuchi K,Shiohara M, Kikuchi T, Yasui K, Ito S, Yamagami O, Sasaki Y, Okumura N, Kato T, Miyazaki H, Ikeda M, Yamada M, Komiyama A.
    BRITISH JOURNAL OF HAEMATOLOGY, 99, 509-516, Dec. 1997
  • Fibrinogen Matsumoto III: a variant with 275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (364Asp→His) and Matsumoto II (308Asn→Lys)
    Terasawa F, Okumura N, Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T.
    THROMBOSIS AND HAEMOSTASIS, 81(5), 763-766, May 1995

Books and other publications

  • Dendritic Cell-Based Cancer ImmunotherapyTargeting Wilms’ Tumor 1 for Pediatric Cancer
    Shigetaka Shimodaira, Koichi Hirabayashi, Ryu Yanagisawa,Yumiko Higuchi, Kenji Sano, Tomonobu Koizumi
    Codon Publications, Mar. 2016