KADOTA Shin

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences 

Senior Assistant Professor 

Researcher Information

Field Of Study

  • Life sciences, Cell biology
  • Life sciences, Cardiology

Career

  • 2017
    Shinshu University
  • 2016 - 2017
    Shinshu University
  • 2013 - 2016
    Department of Pathology, University of Washington
  • 2010 - 2013
    日本学術振興会 特別研究員(DC1)
  • 2004 - 2009
    市立岸和田市民病院 循環器科
  • 2003 - 2004
    京都大学医学部付属病院 内科研修医

Educational Background

  • 2009 - 2013, Kyoto University, 医学研究科
  • 1997 - 2003, Kyoto University, Faculty of Medicine, Department of Medical Science
Research activity information

Paper

  • Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
    Hideki Kobayashi; Shugo Tohyama; Hajime Ichimura; Noburo Ohashi; Shuji Chino; Yusuke Soma; Hidenori Tani; Yuki Tanaka; Xiao Yang; Naoko Shiba; Shin Kadota; Kotaro Haga; Taijun Moriwaki; Yuika Morita-Umei; Tomohiko C Umei; Otoya Sekine; Yoshikazu Kishino; Hideaki Kanazawa; Hiroyuki Kawagishi; Mitsuhiko Yamada; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
    Circulation, Apr. 2024リポジトリ電子ジャーナル
  • Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.
    Naoko Shiba; Xiao Yang; Mitsuto Sato; Shin Kadota; Yota Suzuki; Masahiro Agata; Kohei Nagamine; Masaki Izumi; Yusuke Honda; Tomoya Koganehira; Hideki Kobayashi; Hajime Ichimura; Shinichiro Chuma; Junichi Nakai; Shugo Tohyama; Keiichi Fukuda; Daigo Miyazaki; Akinori Nakamura; Yuji Shiba
    Molecular therapy. Nucleic acids, 34, 102060-102060, Dec. 2023リポジトリ電子ジャーナル
  • Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
    Yuki Tanaka; Shin Kadota; Jian Zhao; Hideki Kobayashi; Satomi Okano; Masaki Izumi; Yusuke Honda; Hajime Ichimura; Naoko Shiba; Takeshi Uemura; Yuko Wada; Shinichiro Chuma; Tsutomu Nakada; Shugo Tohyama; Keiichi Fukuda; Mitsuhiko Yamada; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba
    Stem cell research & therapy, 14(1), 240-240, Sep. 2023, Refereed
    Lead, Correspondingリポジトリ電子ジャーナル
  • Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.
    Silvia Marchiano; Kenta Nakamura; Hans Reinecke; Lauren Neidig; Michael Lai; Shin Kadota; Filippo Perbellini; Xiulan Yang; Jordan M Klaiman; Leslie P Blakely; Elaheh Karbassi; Paul A Fields; Aidan M Fenix; Kevin M Beussman; Anu Jayabalu; Faith A Kalucki; Akiko Futakuchi-Tsuchida; Gerhard J Weber; Sarah Dupras; Hiroshi Tsuchida; Lil Pabon; Lili Wang; Björn C Knollmann; Steven Kattman; R Scott Thies; Nathan Sniadecki; W Robb MacLellan; Alessandro Bertero; Charles E Murry
    Cell stem cell, 30(4), 396-414, Apr. 2023, Refereedリポジトリ電子ジャーナル
  • Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration.
    Hideki Kobayashi; Shugo Tohyama; Hideaki Kanazawa; Hajime Ichimura; Shuji Chino; Yuki Tanaka; Yota Suzuki; Jian Zhao; Naoko Shiba; Shin Kadota; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
    Journal of molecular and cellular cardiology, 174, 77-87, Nov. 2022, Refereedリポジトリ電子ジャーナル
  • Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.
    Yasushi Takemoto; Shin Kadota; Itsunari Minami; Shinya Otsuka; Satoshi Okuda; Masahiro Abo; Louvy Lynn Punzalan; Yan Shen; Yuji Shiba; Motonari Uesugi
    Angewandte Chemie (International ed. in English), Aug. 2021, Refereedリポジトリ電子ジャーナル
  • β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
    Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E. Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
    JACC: Basic to Translational Science, 5(11), 1057-1069, Nov. 2020, Refereedリポジトリ電子ジャーナル
  • Heart regeneration using pluripotent stem cells.
    Shin Kadota; Yuki Tanaka; Yuji Shiba
    Journal of cardiology, 76(5), 459-463, Nov. 2020, Invited
    Leadリポジトリ電子ジャーナル
  • Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
    Hajime Ichimura; Shin Kadota; Toshihide Kashihara; Mitsuhiko Yamada; Kuniaki Ito; Hideki Kobayashi; Yuki Tanaka; Naoko Shiba; Shinichiro Chuma; Shugo Tohyama; Tatsuichiro Seto; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
    Scientific reports, 10(1), 11883-11883, Jul. 2020, Refereed, Not invited
    Correspondingリポジトリ電子ジャーナル
  • ラット心筋内におけるヒトES細胞由来心筋細胞の経時的変化
    市村 創; 門田 真; 茅野 周治; 御子柴 透; 小松 正樹; 田中 晴城; 山本 高照; 大橋 伸朗; 福家 愛; 和田 有子; 柏原 俊英; 山田 充彦; 柴 祐司; 瀬戸 達一郎
    日本心臓血管外科学会学術総会抄録集, 50回, O10-2, Mar. 2020
  • Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment.
    Kadota S; Shiba Y
    Current cardiology reports, 21(8), 73, Jun. 2019, Invited
    Leadリポジトリ電子ジャーナル
  • Long-Term Culture In Vitro Enhanced Maturation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in vivo
    Shin Kadota; Yuki Tanaka; Yuji Shiba
    CIRCULATION, 138, Nov. 2018, Refereed, Not invited
    LeadWebofScienceリポジトリ
  • Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells
    Shin Kadota; Naoko Shiba; Yuji Shiba
    CIRCULATION JOURNAL, 81(12), 1764-1765, Dec. 2017, Invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
    Tatsuki Ogasawara; Satomi Okano; Hajime Ichimura; Shin Kadota; Yuki Tanaka; Itsunari Minami; Motonari Uesugi; Yuko Wada; Naoto Saito; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
    SCIENTIFIC REPORTS, 7(1), 8630, Aug. 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
    Shin Kadota; Lil Pabon; Hans Reinecke; Charles E. Murry
    STEM CELL REPORTS, 8(2), 278-289, Feb. 2017, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
    Shin Kadota; John Carey; Hans Reinecke; James Leggett; Sam Teichman; Michael A. Laflamme; Charles E. Murry; Michael Regnier; Gregory G. Mahairas
    EUROPEAN JOURNAL OF HEART FAILURE, 17(8), 772-781, Aug. 2015, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets
    Shin Kadota; Itsunari Minami; Nobuhiro Morone; John E. Heuser; Konstantin Agladze; Norio Nakatsuji
    European Heart Journal, 34(15), 1147-1156, Apr. 2013, Refereed, Not invited
    Leadリポジトリ電子ジャーナル
  • A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions
    Itsunari Minami; Kohei Yamada; Tomomi G. Otsuji; Takuya Yamamoto; Yan Shen; Shinya Otsuka; Shin Kadota; Nobuhiro Morone; Maneesha Barve; Yasuyuki Asai; Tatyana Tenkova-Heuser; John E. Heuser; Motonari Uesugi; Kazuhiro Aiba; Norio Nakatsuji
    CELL REPORTS, 2(5), 1448-1460, Nov. 2012, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Curvature-dependent excitation propagation in cultured cardiac tissue
    S. Kadota; M. W. Kay; N. Magome; K. Agladze
    JETP Letters, 94(11), 824-830, Feb. 2012, Refereed, Not invited
    Leadリポジトリ電子ジャーナル
  • [Embryonic stem cell research].
    Kadota S; Aiba K; Nakatsuji N
    Nihon rinsho. Japanese journal of clinical medicine, 69(12), 2109-2113, Dec. 2011, Not invited
    Leadリポジトリ
  • The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus
    Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 148(1), 59-63, Apr. 2011, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • A case of marked ST depression and myocardial injury as a result of disulfiram-ethanol reaction
    Keisuke Shioji; Masayasu Izuhara; Shin Kadota; Osamu Baba; Hirokazu Mitsuoka; Takashi Uegaito; Mitsuo Matsuda
    Journal of Cardiology Cases, 1(3), e137-e140, Jun. 2010, Refereed, Not invitedリポジトリ電子ジャーナル
  • A case of right atrial angiosarcoma: The utility of PET and CT fusion imaging in detecting a malignant cardiac tumor
    Shin Kadota; Mitsuo Matsuda; Nao Umei; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Takuma Satsu; Masahiko Onoe; Eiji Kadota
    Journal of Cardiology Cases, 1(2), e84-e87, Apr. 2010, Refereed, Not invitedリポジトリ電子ジャーナル
  • Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function
    Osamu Baba; Masayasu Izuhara; Shin Kadota; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda
    JOURNAL OF CARDIOLOGY, 54(3), 402-408, Dec. 2009, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosis
    Masayasu Izuhara; Keisuke Shioji; Shin Kadota; Osamu Baba; Yuzo Takeuchi; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda
    CIRCULATION JOURNAL, 72(11), 1762-1767, Nov. 2008, Refereed, Not invitedWebofScienceリポジトリ
  • The importance of serial cardiac troponin measurement for evaluating the response to immunosuppressive therapy for myocarditis
    Shin Kadota; Yuzo Takeuchi; Masayasu Izuhara; Osamu Baba; Keisuke Shioji; Takashi Uegaito; Eiji Kadota; Mitsuo Matsuda
    JOURNAL OF CARDIOLOGY, 52(2), 154-158, Oct. 2008, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation
    Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Soji Moriwaki; Keisuke Shioji; Yuzo Takeuchi; Takashi Uegaito
    JOURNAL OF CARDIOLOGY, 51(3), 171-178, Jun. 2008, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Cardiac tamponade due to a ruptured solitary mediastinal varix: A case report
    Toshio Kaneda; Masahiko Onoe; Soji Moriwaki; Shin Kadota; Osamu Baba; Mitsuo Matsuda; Eiji Kadota; Toshihiko Saga
    HEART SURGERY FORUM, 10(3), E199-E201, Jun. 2007, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Intestinal decontamination using povidone-iodine compromises small bowel storage quality
    DW Olson; S Kadota; A Cornish; KL Madsen; J Zeng; LD Jewell; DL Bigam; TA Churchill
    TRANSPLANTATION, 75(9), 1460-1462, May 2003, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
    Shin Kadota; John Carey; Hans Reinecke; James Leggett; Sam Teichman; Michael A. Laflamme; Charles E. Murry; Michael Regnier; Gregory G. Mahairas
    Lead
  • Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets
    Shin Kadota; Itsunari Minami; Nobuhiro Morone; John E. Heuser; Konstantin Agladze; Norio Nakatsuji
    Lead
  • The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus
    Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito
  • A case of right atrial angiosarcoma: The utility of PET and CT fusion imaging in detecting a malignant cardiac tumor
    Shin Kadota; Mitsuo Matsuda; Nao Umei; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Takuma Satsu; Masahiko Onoe; Eiji Kadota
  • Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function
    Osamu Baba; Masayasu Izuhara; Shin Kadota; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda
  • Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation
    Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Soji Moriwaki; Keisuke Shioji; Yuzo Takeuchi; Takashi Uegaito
  • Intestinal decontamination using povidone-iodine compromises small bowel storage quality
    DW Olson; S Kadota; A Cornish; KL Madsen; J Zeng; LD Jewell; DL Bigam; TA Churchill

MISC

  • 【不整脈治療の最新デバイステクノロジーとリードマネジメント】ペースメーカ バイオペースメーカ
    門田 真; 柴 祐司
    循環器ジャーナル, 68(3), 422 - 427, Jul. 2020, Not invitedリポジトリ
  • ヒト多能性幹細胞由来心筋細胞を用いたバイオペースメーカーの開発
    門田 真
    福田記念医療技術振興財団情報, (31), 89 - 92, Dec. 2018, Not invited
  • iPS細胞を用いた新しい心不全治療法開発
    門田 真; 柴 祐司
    心臓, 49(12), 1203 - 1207, 2017リポジトリ電子ジャーナル
  • Cardiac Regeneration Using Pluripotent Stem Cells
    門田 真; 柴 祐司
    信州医学雑誌 = The Shinshu medical journal, 65(3), 143 - 152, 2017リポジトリ
  • BB-R12, a Novel Gene Therapy for Heart Failure
    Sam L. Teichman; Shin Kadota; Michael Regnier; Charles E. Murry; Michael Laflamme; Gregory G. Mahairas
    CIRCULATION, 130, Nov. 2014, Not invitedWebofScienceリポジトリ
  • PE-087 The Influence of Hyperglycemia on Admission and Post-load Insulin Response for Patients with Acute Coronary Syndrome without Treated Diabetes Mellitus(PE015,ACS/AMI (Clinical/Pathophysiology) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Kadota Shin; Matsuda Mitsuo; Izuhara Masayasu; Baba Osamu; Mitsuoka Hirokazu; Shioji Keisuke; Uegaito Takashi
    Circulation journal : official journal of the Japanese Circulation Society, 73, 420 - 420, 01 Mar. 2009リポジトリ
  • PE-253 Assessment of the Relation between Plasma B-type Natriuretic Peptide (BNP) Concentrations and Serum Amino-terminal proBNP (Nt-proBNP) Concentrations(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Baba Osamu; Matsuda Mitsuo; Uegaito Takashi; Shioji Keisuke; Mitsuoka Hirokazu; Kadota Shin; Izuhara Masayasu
    Circulation journal : official journal of the Japanese Circulation Society, 73, 462 - 463, 01 Mar. 2009リポジトリ
  • PJ-168 Post-load Reduced Insulin Level is Associated with High Mortality Rates in Patients with No Previous Diagnosis of Diabetes Mellitus(PJ029,Diabetes 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Kadota Shin; Matsuda Mitsuo; Izuhara Masayasu; Baba Osamu; Mitsuoka Hirokazu; Shioji Keisuke; Uegaito Takashi
    Circulation journal : official journal of the Japanese Circulation Society, 73, 588 - 588, 01 Mar. 2009リポジトリ
  • Postload Reduced Insulin Level Is Associated With High Mortality Rates in Patients With no Previous Diagnosis of Diabetes Mellitus
    Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10), A347 - A347, Mar. 2009, Not invitedWebofScienceリポジトリ
  • PJ-426 The Cardio-Ankle Vascular Index (CAVI), the Novel Aortic Stiffness Parameter, is Related with the Carotid Artery Sclerosis(Cerebrovascular circulation/Stroke(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Shioji Keisuke; Izuhara Masayasu; Kadota Shin; Baba Osamu; Takeuchi Yuzo; Uegaito Takashi; Mutsuo Satoru; Matsuda Mitsuo
    Circulation journal : official journal of the Japanese Circulation Society, 72, 619 - 619, 01 Mar. 2008リポジトリ
  • PJ-845 Post-load hyperinsulinemia is a significant determinant factor in association with multivessel coronary artery disease in patients with impaired glucose tolerance(Diabetes / Obesity / Metabolic syndrome(16)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Matsuda Mitsuo; Izuhara Masayasu; Kadota Shin; Baba Osamu; Shioji Keisuke; Takeuchi Yuzo; Uegaito Takashi; Mutsuo Satoru
    Circulation journal : official journal of the Japanese Circulation Society, 72, 724 - 724, 01 Mar. 2008リポジトリ
  • OE-258 Long-term Effect of Statin Therapy for Patients with Acute Myocardial Infarction Treated with Stent Implantation(Acute myocardial infarction, clinical (diagnosis/treatment)-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Kadota Shin; Izuhara Masayasu; Baba Osamu; Moriwaki Soji; Shioji Keisuke; Takeuchi Yuzo; Uegaito Takashi; Matsuda Mitsuo
    Circulation journal : official journal of the Japanese Circulation Society, 71, 215 - 215, 01 Mar. 2007リポジトリ
  • Ischemic duodenitis
    H. Seno; S. Mikami; K. Komatsu; S. Kadota; S. Yazumi; T. Chiba
    Endoscopy, 37(1), 91, Jan. 2005, Not invitedリポジトリ電子ジャーナル

Affiliated academic society

  • THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
  • Japanese College of Cardiology
  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE
  • The Japanese Circulation Society