KADOTA Shin
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
School of Medicine Department of Regenerative Science and Medicine
Senior Assistant Professor
Researcher Information
Career
Research activity information
Paper
- Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Hideki Kobayashi; Shugo Tohyama; Hajime Ichimura; Noburo Ohashi; Shuji Chino; Yusuke Soma; Hidenori Tani; Yuki Tanaka; Xiao Yang; Naoko Shiba; Shin Kadota; Kotaro Haga; Taijun Moriwaki; Yuika Morita-Umei; Tomohiko C Umei; Otoya Sekine; Yoshikazu Kishino; Hideaki Kanazawa; Hiroyuki Kawagishi; Mitsuhiko Yamada; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Circulation, 150(8), 611-621, Aug. 2024, Refereed
- Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.
Naoko Shiba; Xiao Yang; Mitsuto Sato; Shin Kadota; Yota Suzuki; Masahiro Agata; Kohei Nagamine; Masaki Izumi; Yusuke Honda; Tomoya Koganehira; Hideki Kobayashi; Hajime Ichimura; Shinichiro Chuma; Junichi Nakai; Shugo Tohyama; Keiichi Fukuda; Daigo Miyazaki; Akinori Nakamura; Yuji Shiba
Molecular therapy. Nucleic acids, 34, 102060-102060, Dec. 2023, Refereed - Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
Yuki Tanaka; Shin Kadota; Jian Zhao; Hideki Kobayashi; Satomi Okano; Masaki Izumi; Yusuke Honda; Hajime Ichimura; Naoko Shiba; Takeshi Uemura; Yuko Wada; Shinichiro Chuma; Tsutomu Nakada; Shugo Tohyama; Keiichi Fukuda; Mitsuhiko Yamada; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba
Stem cell research & therapy, 14(1), 240-240, Sep. 2023, Refereed
Lead, Corresponding - Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.
Silvia Marchiano; Kenta Nakamura; Hans Reinecke; Lauren Neidig; Michael Lai; Shin Kadota; Filippo Perbellini; Xiulan Yang; Jordan M Klaiman; Leslie P Blakely; Elaheh Karbassi; Paul A Fields; Aidan M Fenix; Kevin M Beussman; Anu Jayabalu; Faith A Kalucki; Akiko Futakuchi-Tsuchida; Gerhard J Weber; Sarah Dupras; Hiroshi Tsuchida; Lil Pabon; Lili Wang; Björn C Knollmann; Steven Kattman; R Scott Thies; Nathan Sniadecki; W Robb MacLellan; Alessandro Bertero; Charles E Murry
Cell stem cell, 30(4), 396-414, Apr. 2023, Refereed - Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration.
Hideki Kobayashi; Shugo Tohyama; Hideaki Kanazawa; Hajime Ichimura; Shuji Chino; Yuki Tanaka; Yota Suzuki; Jian Zhao; Naoko Shiba; Shin Kadota; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Journal of molecular and cellular cardiology, 174, 77-87, Nov. 2022, Refereed - Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.
Yasushi Takemoto; Shin Kadota; Itsunari Minami; Shinya Otsuka; Satoshi Okuda; Masahiro Abo; Louvy Lynn Punzalan; Yan Shen; Yuji Shiba; Motonari Uesugi
Angewandte Chemie (International ed. in English), Aug. 2021, Refereed - ヒトES細胞由来心筋細胞は生体内で成熟した心室筋細胞に変化し移植後不整脈の抑制に関与する
市村 創; 門田 真; 桑原 宏一郎; 瀬戸 達一郎; 柴 祐司
血管, 44(1), 45-45, Jun. 2021 - β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E. Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC: Basic to Translational Science, 5(11), 1057-1069, Nov. 2020, Refereed - Heart regeneration using pluripotent stem cells.
Shin Kadota; Yuki Tanaka; Yuji Shiba
Journal of cardiology, 76(5), 459-463, Nov. 2020, Invited
Lead - Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Hajime Ichimura; Shin Kadota; Toshihide Kashihara; Mitsuhiko Yamada; Kuniaki Ito; Hideki Kobayashi; Yuki Tanaka; Naoko Shiba; Shinichiro Chuma; Shugo Tohyama; Tatsuichiro Seto; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
Scientific reports, 10(1), 11883-11883, Jul. 2020, Refereed, Not invited
Corresponding - ラット心筋内におけるヒトES細胞由来心筋細胞の経時的変化
市村 創; 門田 真; 茅野 周治; 御子柴 透; 小松 正樹; 田中 晴城; 山本 高照; 大橋 伸朗; 福家 愛; 和田 有子; 柏原 俊英; 山田 充彦; 柴 祐司; 瀬戸 達一郎
日本心臓血管外科学会学術総会抄録集, 50回, O10-2, Mar. 2020 - Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment.
Kadota S; Shiba Y
Current cardiology reports, 21(8), 73, Jun. 2019, Invited
Lead - Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells
Shin Kadota; Naoko Shiba; Yuji Shiba
CIRCULATION JOURNAL, 81(12), 1764-1765, Dec. 2017, Invited
Lead
- Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Tatsuki Ogasawara; Satomi Okano; Hajime Ichimura; Shin Kadota; Yuki Tanaka; Itsunari Minami; Motonari Uesugi; Yuko Wada; Naoto Saito; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
SCIENTIFIC REPORTS, 7(1), 8630, Aug. 2017, Refereed, Not invited - In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
Shin Kadota; Lil Pabon; Hans Reinecke; Charles E. Murry
STEM CELL REPORTS, 8(2), 278-289, Feb. 2017, Refereed, Not invited
Lead - Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
Shin Kadota; John Carey; Hans Reinecke; James Leggett; Sam Teichman; Michael A. Laflamme; Charles E. Murry; Michael Regnier; Gregory G. Mahairas
EUROPEAN JOURNAL OF HEART FAILURE, 17(8), 772-781, Aug. 2015, Refereed, Not invited
Lead - Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets
Shin Kadota; Itsunari Minami; Nobuhiro Morone; John E. Heuser; Konstantin Agladze; Norio Nakatsuji
European Heart Journal, 34(15), 1147-1156, Apr. 2013, Refereed, Not invited
Lead - A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions
Itsunari Minami; Kohei Yamada; Tomomi G. Otsuji; Takuya Yamamoto; Yan Shen; Shinya Otsuka; Shin Kadota; Nobuhiro Morone; Maneesha Barve; Yasuyuki Asai; Tatyana Tenkova-Heuser; John E. Heuser; Motonari Uesugi; Kazuhiro Aiba; Norio Nakatsuji
CELL REPORTS, 2(5), 1448-1460, Nov. 2012, Refereed, Not invited - Curvature-dependent excitation propagation in cultured cardiac tissue
S. Kadota; M. W. Kay; N. Magome; K. Agladze
JETP Letters, 94(11), 824-830, Feb. 2012, Refereed, Not invited
Lead - The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus
Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito
INTERNATIONAL JOURNAL OF CARDIOLOGY, 148(1), 59-63, Apr. 2011, Refereed, Not invited
Lead, Corresponding - A case of marked ST depression and myocardial injury as a result of disulfiram-ethanol reaction
Keisuke Shioji; Masayasu Izuhara; Shin Kadota; Osamu Baba; Hirokazu Mitsuoka; Takashi Uegaito; Mitsuo Matsuda
Journal of Cardiology Cases, 1(3), e137-e140, Jun. 2010, Refereed, Not invited - A case of right atrial angiosarcoma: The utility of PET and CT fusion imaging in detecting a malignant cardiac tumor
Shin Kadota; Mitsuo Matsuda; Nao Umei; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Takuma Satsu; Masahiko Onoe; Eiji Kadota
Journal of Cardiology Cases, 1(2), e84-e87, Apr. 2010, Refereed, Not invited
Lead, Corresponding - Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function
Osamu Baba; Masayasu Izuhara; Shin Kadota; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda
JOURNAL OF CARDIOLOGY, 54(3), 402-408, Dec. 2009, Refereed, Not invited - Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosis
Masayasu Izuhara; Keisuke Shioji; Shin Kadota; Osamu Baba; Yuzo Takeuchi; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda
CIRCULATION JOURNAL, 72(11), 1762-1767, Nov. 2008, Refereed, Not invited - The importance of serial cardiac troponin measurement for evaluating the response to immunosuppressive therapy for myocarditis
Shin Kadota; Yuzo Takeuchi; Masayasu Izuhara; Osamu Baba; Keisuke Shioji; Takashi Uegaito; Eiji Kadota; Mitsuo Matsuda
JOURNAL OF CARDIOLOGY, 52(2), 154-158, Oct. 2008, Refereed, Not invited
Lead - Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation
Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Soji Moriwaki; Keisuke Shioji; Yuzo Takeuchi; Takashi Uegaito
JOURNAL OF CARDIOLOGY, 51(3), 171-178, Jun. 2008, Refereed, Not invited
Lead - Cardiac tamponade due to a ruptured solitary mediastinal varix: A case report
Toshio Kaneda; Masahiko Onoe; Soji Moriwaki; Shin Kadota; Osamu Baba; Mitsuo Matsuda; Eiji Kadota; Toshihiko Saga
HEART SURGERY FORUM, 10(3), E199-E201, Jun. 2007, Refereed, Not invited - Ischemic duodenitis
H. Seno; S. Mikami; K. Komatsu; S. Kadota; S. Yazumi; T. Chiba
Endoscopy, 37(1), 91, Jan. 2005, Refereed, Not invited - Intestinal decontamination using povidone-iodine compromises small bowel storage quality
DW Olson; S Kadota; A Cornish; KL Madsen; J Zeng; LD Jewell; DL Bigam; TA Churchill
TRANSPLANTATION, 75(9), 1460-1462, May 2003, Refereed, Not invited - Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
Shin Kadota; John Carey; Hans Reinecke; James Leggett; Sam Teichman; Michael A. Laflamme; Charles E. Murry; Michael Regnier; Gregory G. Mahairas
Lead - Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets
Shin Kadota; Itsunari Minami; Nobuhiro Morone; John E. Heuser; Konstantin Agladze; Norio Nakatsuji
Lead - The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus
Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito - A case of right atrial angiosarcoma: The utility of PET and CT fusion imaging in detecting a malignant cardiac tumor
Shin Kadota; Mitsuo Matsuda; Nao Umei; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Takuma Satsu; Masahiko Onoe; Eiji Kadota - Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function
Osamu Baba; Masayasu Izuhara; Shin Kadota; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda - Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation
Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Soji Moriwaki; Keisuke Shioji; Yuzo Takeuchi; Takashi Uegaito - Intestinal decontamination using povidone-iodine compromises small bowel storage quality
DW Olson; S Kadota; A Cornish; KL Madsen; J Zeng; LD Jewell; DL Bigam; TA Churchill
MISC
- 多能性幹細胞由来生物学的ペースメーカーの開発
門田 真
医科学応用研究財団研究報告, 38, 54 - 57, Feb. 2021 - 【不整脈治療の最新デバイステクノロジーとリードマネジメント】ペースメーカ バイオペースメーカ
門田 真; 柴 祐司
循環器ジャーナル, 68(3), 422 - 427, Jul. 2020, Not invited - 多能性幹細胞由来心臓ペースメーカーの開発
門田 真
先進医薬研究振興財団研究成果報告集, 2019年度, 180 - 181, Mar. 2020 - ヒト多能性幹細胞由来心筋細胞を用いたバイオペースメーカーの開発
門田 真
福田記念医療技術振興財団情報, (31), 89 - 92, Dec. 2018, Not invited - iPS細胞を用いた新しい心不全治療法開発
門田 真; 柴 祐司
心臓, 49(12), 1203 - 1207, 2017 - Cardiac Regeneration Using Pluripotent Stem Cells
門田 真; 柴 祐司
信州医学雑誌 = The Shinshu medical journal, 65(3), 143 - 152, 2017 - [Embryonic stem cell research].
Kadota S; Aiba K; Nakatsuji N
Nihon rinsho. Japanese journal of clinical medicine, 69(12), 2109 - 2113, Dec. 2011, Not invited
Lead
Lectures, oral presentations, etc.
- 多能性幹細胞由来心筋細胞移植の現状と可能性
門田 真; 柴 祐司
第23回日本再生医療学会総会, Mar. 2024, InvitedDMD遺伝子ABD1領域の変異による心筋症に対するエクソンスキッピング治療の検討
柴直子; 楊暁; 門田真; 鈴木陽太; 縣正大; 長峰広平; 佐藤充人; 中村昭則; 柴祐司
日本再生医療学会総会(Web), 2024カニクイザルiPS細胞由来心筋細胞移植における生体イメージングによるグラフト生着評価法の確立
茅野 周治; 市村 創; 小林 秀樹; 門田 真; 瀬戸 達一郎; 遠山 周吾; 柴 祐司
日本胸部外科学会定期学術集会, Oct. 2023, (一社)日本胸部外科学会心筋成熟化の再生医療へのインパクト
門田 真
第22回日本再生医療学会総会, Mar. 2023, InvitediPS由来神経細胞を用いたCACNA1E遺伝子変異による発達性てんかん性脳症の病態解明
鈴木陽太; 柴直子; YANG Xiao; 門田真; 堀内哲吉; 柴祐司
日本再生医療学会総会(Web), 2023長期培養したヒト人工多能性幹細胞由来心筋細胞(hiPSC-CM)は,CRYABを介して移植グラフトの血管新生を促進する
田中夕祈; 門田真; 柴祐司
日本血管生物医学会学術集会プログラム・抄録集, 2023Cardiac regeneration research using iPS cell-derived cardiomyocytes
門田 真
第86回日本循環器学会学術集会, Mar. 2022, Invited多能性幹細胞由来心筋細胞の成熟化について
門田 真
第50回日本心脈管作動物質学会, Jul. 2021, InvitedヒトES細胞由来心筋細胞は生体内で成熟した心室筋細胞に変化し移植後不整脈の抑制に関与する
市村 創; 門田 真; 桑原 宏一郎; 瀬戸 達一郎; 柴 祐司
血管, Jun. 2021, 日本心脈管作動物質学会ラット心筋内におけるヒトES細胞由来心筋細胞の経時的変化
市村 創; 門田 真; 茅野 周治; 御子柴 透; 小松 正樹; 田中 晴城; 山本 高照; 大橋 伸朗; 福家 愛; 和田 有子; 柏原 俊英; 山田 充彦; 柴 祐司; 瀬戸 達一郎
日本心臓血管外科学会学術総会抄録集, Mar. 2020, (NPO)日本心臓血管外科学会多能性幹細胞由来心筋細胞を用いた心筋再生医療
門田 真
第40回日本炎症・再生医学会, Jul. 2019, InvitediPS細胞由来心筋細胞の培養期間延長による移植後細胞生着および成熟化促進について
田中夕祈; 門田真; 和田有子; 瀬戸達一郎; 桑原宏一郎; 柴祐司
日本分子生物学会年会プログラム・要旨集(Web), 2019Long-Term Culture In Vitro Enhanced Maturation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in vivo
Shin Kadota; Yuki Tanaka; Yuji Shiba
CIRCULATION, Nov. 2018, LIPPINCOTT WILLIAMS & WILKINS, Not invitedヒアルロン酸ハイドロゲルを用いた多能性幹細胞由来心筋細胞の新規移植法の検討
岡野怜己; 小笠原達樹; 市村創; 門田真; 田中夕祈; 南一成; 上杉志成; 和田有子; 齋藤直人; 岡田健次; 桑原宏一郎; 柴祐司
日本薬学会年会要旨集(CD-ROM), 2018Transplantation of regenerated cardiomyocyte and arrhythmia
門田 真
第10回アジア太平洋不整脈学会学術集会（APHRS2017）, Sep. 2017, InvitedCardiac regeneration using human pluripotent stem cells
門田 真
第80回日本循環器学会総会・学術集会, Mar. 2016, InvitedBB-R12, a Novel Gene Therapy for Heart Failure
Sam L. Teichman; Shin Kadota; Michael Regnier; Charles E. Murry; Michael Laflamme; Gregory G. Mahairas
CIRCULATION, Nov. 2014, LIPPINCOTT WILLIAMS & WILKINS, Not invitedPE-087 The Influence of Hyperglycemia on Admission and Post-load Insulin Response for Patients with Acute Coronary Syndrome without Treated Diabetes Mellitus(PE015,ACS/AMI (Clinical/Pathophysiology) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Kadota Shin; Matsuda Mitsuo; Izuhara Masayasu; Baba Osamu; Mitsuoka Hirokazu; Shioji Keisuke; Uegaito Takashi
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2009, Japanese Circulation SocietyPJ-168 Post-load Reduced Insulin Level is Associated with High Mortality Rates in Patients with No Previous Diagnosis of Diabetes Mellitus(PJ029,Diabetes 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Kadota Shin; Matsuda Mitsuo; Izuhara Masayasu; Baba Osamu; Mitsuoka Hirokazu; Shioji Keisuke; Uegaito Takashi
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2009, Japanese Circulation SocietyPostload Reduced Insulin Level Is Associated With High Mortality Rates in Patients With no Previous Diagnosis of Diabetes Mellitus
Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2009, ELSEVIER SCIENCE INC, Not invitedPJ-426 The Cardio-Ankle Vascular Index (CAVI), the Novel Aortic Stiffness Parameter, is Related with the Carotid Artery Sclerosis(Cerebrovascular circulation/Stroke(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Shioji Keisuke; Izuhara Masayasu; Kadota Shin; Baba Osamu; Takeuchi Yuzo; Uegaito Takashi; Mutsuo Satoru; Matsuda Mitsuo
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2008, Japanese Circulation Society,PJ-845 Post-load hyperinsulinemia is a significant determinant factor in association with multivessel coronary artery disease in patients with impaired glucose tolerance(Diabetes / Obesity / Metabolic syndrome(16)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Matsuda Mitsuo; Izuhara Masayasu; Kadota Shin; Baba Osamu; Shioji Keisuke; Takeuchi Yuzo; Uegaito Takashi; Mutsuo Satoru
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2008, Japanese Circulation Society,OE-258 Long-term Effect of Statin Therapy for Patients with Acute Myocardial Infarction Treated with Stent Implantation(Acute myocardial infarction, clinical (diagnosis/treatment)-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Kadota Shin; Izuhara Masayasu; Baba Osamu; Moriwaki Soji; Shioji Keisuke; Takeuchi Yuzo; Uegaito Takashi; Matsuda Mitsuo
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2007, Japanese Circulation Society,