植村 健 (ウエムラ タケシ)   

学術研究院(総合人間科学系(基盤研究支援センター))

基盤研究支援センター 

教授 

学位

  • 博士(医学), 東京大学

研究キーワード

    中枢神経, シナプス, 脳神経回路網形成, 神経発達障害

研究分野

  • 神経科学一般, 分子神経生物学・神経科学一般

電話番号

    0263-37-3108

メールアドレス

    tuemura★shinshu-u.ac.jp

経歴

  • 2023年
    信州大学基盤研究支援センター 教授
  • 2017年
    信州大学基盤研究支援センター 准教授
  • 2014年
    信州大学学術研究院医学系 准教授
  • 2013年
    信州大学医学部 講師
  • 2007年
    東京大学大学院医学系研究科 助教
  • 2005年
    東京大学大学院医学系研究科 助手
  • 2003年
    東京大学大学院医学系研究科 研究拠点形成特任研究員

学歴

  • 2003年, 東京大学
  • 1997年, 東京理科大学

論文

  • Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
    Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H
    Nanomaterials, 2023年01月WebofScience電子ジャーナル
  • Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
    Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N
    Elife, 2023年01月WebofScience電子ジャーナル
  • Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
    Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;
    CELL REPORTS, 39(1), 110624, 2022年WebofScience電子ジャーナル
  • IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
    Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;
    BIOLOGICAL PSYCHIATRY, 91(9), 821-831, 2022年WebofScience電子ジャーナル
  • Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
    Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
    ADVANCED SCIENCE, 2201214, 2022年WebofScience電子ジャーナル
  • Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
    Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 2021年07月WebofScience電子ジャーナル
  • Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
    Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
    The Journal of Biochemistry, Apr 5;mvab046., 2021年電子ジャーナル
  • Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
    Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
    Biochemical and biophysical research communications, 534, 179-185, 2021年WebofScience電子ジャーナル
  • Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
    Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 12(1), 1848, 2021年WebofScience電子ジャーナル
  • Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
    Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;
    BIOMEDICINES, 8(11), 2020年11月WebofScience電子ジャーナル
  • Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
    Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;
    EXPERIMENTAL GERONTOLOGY, 141, 2020年11月WebofScience電子ジャーナル
  • Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
    Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;
    Nanomaterials, 10(7), 2020年07月WebofScience電子ジャーナル
  • Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
    Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu
    SCIENTIFIC REPORTS, 10(1), 2020年02月28日リポジトリ
  • Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
    Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;
    BMC CANCER, 20(1), 2020年WebofScience電子ジャーナル
  • DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
    Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;
    Biochemical and biophysical research communications, 524(3), 621-628, 2020年WebofScience電子ジャーナル
  • Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
    Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;
    Elife, 9, 2020年WebofScience電子ジャーナル
  • Carbon fibers for treatment of cancer metastasis in bone
    Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;
    RSC Advances, 10(55), 33071-33079, 2020年WebofScience電子ジャーナル
  • Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
    Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;
    MOLECULAR PSYCHIATRY, 24(7), 1093-1093, 2019年07月WebofScience電子ジャーナル
  • Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
    Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;
    OncoTargets and Therapy, 12, 2513-2518, 2019年WebofScience電子ジャーナル
  • Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
    Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai
    NATURE COMMUNICATIONS, 9, 269, 2018年, 査読有りWebofScience電子ジャーナル
  • MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
    Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M
    Cell Rep, 24, 95-106, 2018年, 査読有り電子ジャーナル
  • Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
    Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 9, 2018年WebofScience電子ジャーナル
  • In situ screening for postsynaptic cell adhesion molecules during synapse formation
    Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T
    JOURNAL OF BIOCHEMISTRY, 162, 295-302, 2017年, 査読有りWebofScience電子ジャーナル
  • Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
    Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;
    SCIENTIFIC REPORTS, 6, 2016年WebofScienceリポジトリ電子ジャーナル
  • Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
    Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 6, 2015年04月WebofScienceリポジトリ電子ジャーナル
  • Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
    Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;
    SCIENTIFIC REPORTS, 5, 2015年WebofScience電子ジャーナル
  • Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
    Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;
    ULTRAMICROSCOPY, 143, 52-66, 2014年08月WebofScience電子ジャーナル
  • Striatal dopamine D1 receptor is essential for contextual fear conditioning
    Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M
    SCIENTIFIC REPORTS, 4, 3976, 2014年電子ジャーナル
  • IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
    Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;
    SCIENTIFIC REPORTS, 4, 2014年WebofScienceリポジトリ電子ジャーナル
  • Striatal dopamine D1 receptor is essential for contextual fear conditioning
    Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;
    SCIENTIFIC REPORTS, 4, 2014年WebofScienceリポジトリ電子ジャーナル
  • Synapse formation in the brain
    Mishina M, Yoshida T, Yasumura M, Uemura T
    Cortical Development, 282, 229-248, 2013年
  • Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
    Kishioka A, Uemura T, Fukushima F, Mishina M
    Mol. Brain, 6, 17, 2013年WebofScienceリポジトリ電子ジャーナル
  • Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
    Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
    Frontiers in Neural Circuits, 6(90), doi: 10.3389/fncir.2012.00090, 2012年, 査読有り電子ジャーナル
  • GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
    Lee SJ, Uemura T, Yoshida T, Mishina M
    J Neurosci, 32(13), 4688-4701, 2012年電子ジャーナル
  • Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
    Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
    J Neurosci, 32(8), 2588-2600, 2012年電子ジャーナル
  • Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
    Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
    J Neurochem, 121(5), 705-716, 2012年電子ジャーナル
  • IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
    Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
    J Neurosci, 31(88), 13485-13499, 2011年電子ジャーナル
  • Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
    Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
    Biochem Biophys Res Commun, 406(4), 627-632, 2011年電子ジャーナル
  • Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
    Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
    Cell, 141(6), 1068-1079, 2010年電子ジャーナル
  • The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
    Uemura T, Mishina M
    Biochem Biophys Res Commun, 377(4), 1315-1319, 2008年電子ジャーナル
  • Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
    Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina
    Neurosci Lett, 433(2), 146-151, 2008年電子ジャーナル
  • Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
    Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M
    J Neurosci, 27(44), 12096-12108, 2007年電子ジャーナル
  • Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
    Uemura T, Mori H, Mishina M
    Mol Cell Neurosci, 26(2), 330-341, 2004年電子ジャーナル
  • Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
    Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D
    J Biol Chem, 278(7), 4431-4434, 2003年電子ジャーナル
  • Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
    Uemura T, Mori H, Mishina M
    Biochem Biophys Res Commun, 296(2), 492-496, 2002年電子ジャーナル

書籍等出版物

  • 実験医学増刊 32 10
    深井周也, 植村 健, 吉田知之, シナプス形成を誘導する膜受容体の機能と構造
    92-97 2014年
  • 顕微鏡 49 1
    植村 健;, 大気圧走査電子顕微鏡を用いたシナプス構造と分子局在の解析 (特集 大気圧走査電子顕微鏡(ASEM))
    日本顕微鏡学会, 7-9 2014年
  • 生物物理 53
    植村健, シナプスオーガナイザーによるシナプス形成の制御機構
    90-93 2013年
    ISBN:https://doi.org/10.2142/biophys.53.090
  • 細胞工学 30 2
    植村健, 三品昌美, シナプス形成とグルタミン酸受容体δ2サブユニット
    186-191 2011年

所属学協会

  • 日本神経科学学会
  • 日本薬理学会
  • Society of Neuroscience

共同研究・競争的資金等の研究課題

  • 脳神経回路網形成と機能制御の分子基盤とそれらの破綻が引き起こす神経発達障害の病態の解明