UEMURA Takeshi

Academic Assembly School of Humanities and Social Sciences Institute of Humanities

Research Center for Advanced Science and Technology 

Professor 

Research Keyword

    CNS, synapse, neural circuit formation, neurodevelopmental disorders

Field Of Study

  • Neuroscience-general, Molecular Neuroscience / General neuroscience

TEL

    +81-263-37-3108

Paper

  • Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
    Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H
    Nanomaterials, Jan. 2023WebofScience電子ジャーナル
  • Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
    Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N
    Elife, Jan. 2023WebofScience電子ジャーナル
  • Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
    Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;
    CELL REPORTS, 39(1), 110624, 2022WebofScience電子ジャーナル
  • IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
    Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;
    Biological Psychiatry, 91(9), 821-831, 2022WebofScience電子ジャーナル
  • Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
    Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
    ADVANCED SCIENCE, 2201214, 2022WebofScience電子ジャーナル
  • Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
    Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), Jul. 2021WebofScience電子ジャーナル
  • Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
    Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
    The Journal of Biochemistry, Apr 5;mvab046., 2021電子ジャーナル
  • Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
    Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
    Biochemical and biophysical research communications, 534, 179-185, 2021WebofScience電子ジャーナル
  • Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
    Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 12(1), 1848, 2021WebofScience電子ジャーナル
  • Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
    Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;
    BIOMEDICINES, 8(11), Nov. 2020WebofScience電子ジャーナル
  • Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
    Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;
    EXPERIMENTAL GERONTOLOGY, 141, Nov. 2020WebofScience電子ジャーナル
  • Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
    Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;
    Nanomaterials, 10(7), Jul. 2020WebofScience電子ジャーナル
  • Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
    Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu
    SCIENTIFIC REPORTS, 10(1), 28 Feb. 2020リポジトリ
  • Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
    Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;
    BMC CANCER, 20(1), 2020WebofScience電子ジャーナル
  • DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
    Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;
    Biochemical and biophysical research communications, 524(3), 621-628, 2020WebofScience電子ジャーナル
  • Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
    Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;
    Elife, 9, 2020WebofScience電子ジャーナル
  • Carbon fibers for treatment of cancer metastasis in bone
    Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;
    RSC Advances, 10(55), 33071-33079, 2020WebofScience電子ジャーナル
  • Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
    Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;
    MOLECULAR PSYCHIATRY, 24(7), 1093-1093, Jul. 2019WebofScience電子ジャーナル
  • Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
    Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;
    OncoTargets and Therapy, 12, 2513-2518, 2019WebofScience電子ジャーナル
  • Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
    Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai
    NATURE COMMUNICATIONS, 9, 269, 2018, RefereedWebofScience電子ジャーナル
  • MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
    Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M
    Cell Rep, 24, 95-106, 2018, Refereed電子ジャーナル
  • Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
    Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 9, 2018WebofScience電子ジャーナル
  • In situ screening for postsynaptic cell adhesion molecules during synapse formation
    Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T
    JOURNAL OF BIOCHEMISTRY, 162, 295-302, 2017, RefereedWebofScience電子ジャーナル
  • Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
    Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;
    SCIENTIFIC REPORTS, 6, 2016WebofScienceリポジトリ電子ジャーナル
  • Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
    Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;
    NATURE COMMUNICATIONS, 6, Apr. 2015WebofScienceリポジトリ電子ジャーナル
  • Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
    Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;
    SCIENTIFIC REPORTS, 5, 2015WebofScience電子ジャーナル
  • Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
    Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;
    ULTRAMICROSCOPY, 143, 52-66, Aug. 2014WebofScience電子ジャーナル
  • Striatal dopamine D1 receptor is essential for contextual fear conditioning
    Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M
    SCIENTIFIC REPORTS, 4, 3976, 2014電子ジャーナル
  • IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
    Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;
    SCIENTIFIC REPORTS, 4, 2014WebofScienceリポジトリ電子ジャーナル
  • Striatal dopamine D1 receptor is essential for contextual fear conditioning
    Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;
    SCIENTIFIC REPORTS, 4, 2014WebofScienceリポジトリ電子ジャーナル
  • Synapse formation in the brain
    Mishina M, Yoshida T, Yasumura M, Uemura T
    Cortical Development, 282, 229-248, 2013
  • Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
    Kishioka A, Uemura T, Fukushima F, Mishina M
    Mol. Brain, 6, 17, 2013WebofScienceリポジトリ電子ジャーナル
  • Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
    Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
    Frontiers in Neural Circuits, 6(90), doi: 10.3389/fncir.2012.00090, 2012, Refereed電子ジャーナル
  • GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
    Lee SJ, Uemura T, Yoshida T, Mishina M
    J Neurosci, 32(13), 4688-4701, 2012電子ジャーナル
  • Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
    Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
    J Neurosci, 32(8), 2588-2600, 2012電子ジャーナル
  • Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
    Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
    J Neurochem, 121(5), 705-716, 2012電子ジャーナル
  • IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
    Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
    J Neurosci, 31(88), 13485-13499, 2011電子ジャーナル
  • Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
    Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
    Biochem Biophys Res Commun, 406(4), 627-632, 2011電子ジャーナル
  • Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
    Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
    Cell, 141(6), 1068-1079, 2010電子ジャーナル
  • The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
    Uemura T, Mishina M
    Biochem Biophys Res Commun, 377(4), 1315-1319, 2008電子ジャーナル
  • Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
    Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina
    Neurosci Lett, 433(2), 146-151, 2008電子ジャーナル
  • Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
    Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M
    J Neurosci, 27(44), 12096-12108, 2007電子ジャーナル
  • Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
    Uemura T, Mori H, Mishina M
    Mol Cell Neurosci, 26(2), 330-341, 2004電子ジャーナル
  • Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
    Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D
    J Biol Chem, 278(7), 4431-4434, 2003電子ジャーナル
  • Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
    Uemura T, Mori H, Mishina M
    Biochem Biophys Res Commun, 296(2), 492-496, 2002電子ジャーナル

Books and other publications

  • 実験医学増刊 32 10
    深井周也, 植村 健, 吉田知之, シナプス形成を誘導する膜受容体の機能と構造
    92-97 2014
  • 生物物理 53
    植村健, シナプスオーガナイザーによるシナプス形成の制御機構
    90-93 2013
    ISBN:https://doi.org/10.2142/biophys.53.090
  • 細胞工学 30 2
    植村健, 三品昌美, シナプス形成とグルタミン酸受容体δ2サブユニット
    186-191 2011

Affiliated academic society

  • 日本神経科学学会

Research Themes

  • Elucidation of molecular mechanism of brain circuit formation and function, and of pathophysiology of neurodevelopmental disorders caused by abnormalities in brain circuit formation