
野口 卓郎 (ノグチ タクロウ)
医学部附属病院 信州がんセンター
講師
研究者情報
研究キーワード
- 臨床腫瘍学, 腫瘍免疫学, がんゲノム医療, バイオインフォマティクス
経歴
研究活動情報
受賞
論文
- Multicenter phase II trial of trastuzumab and docetaxel for HER2-positive salivary gland cancer.
Satoshi Kano; Naomi Kiyota; Ichiro Kinoshita; Yuichiro Tada; Kei Ijichi; Tomoko Yamazaki; Yasushi Shimizu; Yutaka Hatanaka; Hitoshi Tsuda; Shojiroh Morinaga; Yoshihiro Matsuno; Yoichi M Ito; Naoki Nishimoto; Keiko Kobayashi; Toshiyuki Isoe; Takuro Noguchi; Akihiro Homma; Hirotoshi Dosaka-Akita
Japanese journal of clinical oncology, 55(10), 1131-1140, 2025年10月

- Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer.
Shotaro Ito; Jun Sakakibara-Konishi; Mineyoshi Sato; Tetsuaki Shoji; Megumi Furuta; Hirofumi Takahashi; Kosuke Tsuji; Daisuke Morinaga; Masahiro Kashima; Hidenori Kitai; Junko Kikuchi; Eiki Kikuchi; Kanako C Hatanaka; Yutaka Hatanaka; Kyoko Hida; Takuro Noguchi; Satoshi Konno
Cancer medicine, 14(13), e71034, 2025年07月

- Actionable Gene Alterations Identified in Patients With Malignant Melanoma by Targeted Sequencing in Japan.
Takuro Noguchi; Shin Ariga; Rika Moku; Junko Kikuchi; Toraji Amano; Takuya Maeda; Kosuke Ishikawa; Taku Maeda; Akihiko Shiiya; Tomohiro Goda; Yoshihito Ohhara; Kanako Hagio; Yusuke Saito; Kanako C Hatanaka; Yutaka Hatanaka; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita
JCO precision oncology, 9, e2400437, 2025年01月

- Polymorphisms of the PD-L1 gene 3'-untranslated region are associated with the expression of PD-L1 in non-small cell lung cancer.
Yoshihito Ohhara; Utano Tomaru; Ichiro Kinoshita; Kanako C Hatanaka; Takuro Noguchi; Yutaka Hatanaka; Toraji Amono; Yoshihiro Matsuno; Hirotoshi Dosaka-Akita
Genes, chromosomes & cancer, 63(1), e23216, 2024年01月

- EGFR変異陽性肺癌におけるCD24発現の検討
椎谷 研彦; 野口 卓郎; 外丸 詩野; 有賀 伸; 高島 雄太; 品川 尚文; 木下 一郎; 松野 吉宏; 榊原 純; 秋田 弘俊
日本病理学会会誌, 112(1), 247-247, 2023年03月 - EGFR inhibition in EGFR-mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment.
Akihiko Shiiya; Takuro Noguchi; Utano Tomaru; Shin Ariga; Yuta Takashima; Yoshihito Ohhara; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Tomonobu Koizumi; Yoshihiro Matsuno; Naofumi Shinagawa; Jun Sakakibara-Konishi; Hirotoshi Dosaka-Akita
Cancer science, 2022年12月

- Notch pathway regulates osimertinib drug-tolerant persistence in EGFR-mutated non-small-cell lung cancer.
Hirofumi Takahashi; Jun Sakakibara-Konishi; Megumi Furuta; Tetsuaki Shoji; Kosuke Tsuji; Daisuke Morinaga; Eiki Kikuchi; Junko Kikuchi; Takuro Noguchi; Kanako C Hatanaka; Yutaka Hatanaka; Naofumi Shinagawa; Satoshi Konno
Cancer science, 2022年11月

- Expression of karyopherin alfa 2 and karyopherin beta 1 correlate with poor prognosis in gastric cancer.
Yoshihito Ohhara; Ichiro Kinoshita; Akira Suzuki; Makoto Imagawa; Jun Taguchi; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Hideyuki Seki; Junichi Suzuki; Hirotoshi Dosaka-Akita
Oncology, 2022年10月

- Suitability of Oral Rehydration Solution (ORS) for Use in the Cisplatin Short Hydration Method.
Yoshitaka Saito; Yoh Takekuma; Masaki Kobayashi; Naofumi Shinagawa; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Mitsuru Sugawara
Anticancer research, 42(6), 3185-3193, 2022年06月

- Primary mediastinal germ cell tumors - A retrospective analysis of >30 years of experience in a single institution.
Tomonobu Koizumi; Shintaro Kanda; Ryo Nihonmatu; Daisuke Gomi; Nodoka Sekiguchi; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Hiroshi Yamamoto; Tetsu Takeda
Thoracic cancer, 12(6), 807-813, 2021年03月

- CCR4-positive peripheral T-cell lymphoma presenting as eosinophilic pneumonia and developing from prolonged pustular psoriasis.
Nodoka Sekiguchi; Masamichi Komatsu; Takashi Ichiyama; Aya Kobayashi; Daisuke Gomi; Toshirou Fukushima; Takashi Kobayashi; Takuro Noguchi; Hideyuki Nakazawa; Naoko Asano; Fumihiro Ishida; Tomonobu Koizumi
The Journal of international medical research, 49(2), 300060521996165-300060521996165, 2021年02月

- Phase II trial of combination treatment with S-1/cetuximab in patients with platinum-ineligible recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Jun Taguchi; Yasushi Shimizu; Shin Ariga; Tomohiro Goda; Yoshihito Ohhara; Rio Honma; Takuro Noguchi; Satoshi Takeuchi; Ichiro Kinoshita; Toraji Amano; Takatsugu Mizumachi; Satoshi Kano; Miki Takahara; Takahisa Abe; Akihiro Homma; Hirotoshi Dosaka-Akita
International journal of clinical oncology, 26(1), 51-58, 2021年01月

- Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T-cell-dependent manner.
Tomoaki Muramatsu; Takuro Noguchi; Daisuke Sugiyama; Yoshie Kanada; Kaori Fujimaki; Sachiko Ito; Momokazu Gotoh; Hiroyoshi Nishikawa
International immunology, 33(1), 39-48, 2021年01月, 査読有り

- Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget's disease: Four cases and a review.
Nodoka Sekiguchi; Sae Kubota; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Shintaro Kanda; Tomonobu Koizumi; Tomomi Miyake; Takushi Shirai; Ryuhei Okuyama
The Journal of dermatology, 2020年07月, 査読有り

- National incidence and initial therapy for thymic carcinoma in Japan: based on analysis of hospital-based cancer registry data, 2009-2015.
Tomonobu Koizumi; Kengo Otsuki; Yuriko Tanaka; Takuro Noguchi; Toshirou Fukushuima; Takashi Kobayashi; Takesumi Ozawa; Nodoka Sekiguchi; Kazutoshi Hamanaka
Japanese journal of clinical oncology, 50(4), 434-439, 2020年04月, 査読有り

- [Desensitization Therapy for Osimertinib in Patients Who Developed Toxic Erythema - Two Case Reports].
Hiroaki Watanabe; Akira Mimura; Toshiro Fukushima; Takuro Noguchi; Takesumi Ozawa; Takashi Kobayashi; Nodoka Sekiguchi; Shigeru Ohmori; Tomonobu Koizumi
Gan to kagaku ryoho. Cancer & chemotherapy, 46(5), 961-963, 2019年05月, 査読有り
- High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(5), 1443-1443, 2018年11月

- High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(4), 1014-1030, 2018年11月, 査読有り

- Chemotherapy for advanced and metastatic thymic carcinoma
Noguchi T; Koizumi T
Mediastinum, 2(52), 2018年08月, 査読有り, 招待有り - Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.
Takuro Noguchi; Jeffrey P Ward; Matthew M Gubin; Cora D Arthur; Sang Hun Lee; Jasreet Hundal; Mark J Selby; Robert F Graziano; Elaine R Mardis; Alan J Korman; Robert D Schreiber
Cancer immunology research, 5(2), 106-117, 2017年02月, 査読有り


- Tumor-specific mutant antigens in cancer immunotherapy
Gubin Matthew M; Ward Jeffrey P; Noguchi Takuro; Zhang Xiuli; Arthur Cora; Krebber Willem-Jan; Mulder Gwenn E; Melief Cornelis J. M; Gillanders William E; Artyomov Maxim; Mardis Elaine R; Schreiber Robert D
CANCER IMMUNOLOGY RESEARCH, 4(11), 2016年11月, 査読有り


- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D. Buck; Takuro Noguchi; Jonathan D. Curtis; Qiongyu Chen; Mariel Gindin; Matthew M. Gubin; Gerritje J. W. van der Windt; Elena Tonc; Robert D. Schreiber; Edward J. Pearce; Erika L. Pearce
CELL, 162(6), 1229-1241, 2015年09月, 査読有り


- Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Matthew M. Gubin; Xiuli Zhang; Heiko Schuster; Etienne Caron; Jeffrey P. Ward; Takuro Noguchi; Yulia Ivanova; Jasreet Hundal; Cora D. Arthur; Willem-Jan Krebber; Gwenn E. Mulder; Mireille Toebes; Matthew D. Vesely; Samuel S. K. Lam; Alan J. Korman; James P. Allison; Gordon J. Freeman; Arlene H. Sharpe; Erika L. Pearce; Ton N. Schumacher; Ruedi Aebersold; Hans-Georg Rammensee; Cornelis J. M. Melief; Elaine R. Mardis; William E. Gillanders; Maxim N. Artyomov; Robert D. Schreiber
NATURE, 515(7528), 577-+, 2014年11月, 査読有り


- A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy
Anurag Gupta; Natko Nuber; Christoph Esslinger; Mareike Wittenbrink; Martin Treder; Alexandro Landshammer; Takuro Noguchi; Marcus Kelly; Sacha Gnjatic; Erika Ritter; Lotta von Boehmer; Hiroyoshi Nishikawa; Hiroshi Shiku; Lloyd Old; Gerd Ritter; Alexander Knuth; Maries van den Broek
Cancer Immunity, 13(1), 3, 2013年, 査読有り
- Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy
Takuro Noguchi; Takuma Kato; Linan Wang; Yuka Maeda; Hiroaki Ikeda; Eiichi Sato; Alexander Knuth; Sacha Gnjatic; Gerd Ritter; Shimon Sakaguchi; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
CANCER RESEARCH, 72(7), 1672-1682, 2012年04月, 査読有り


- Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8(+) T Cells
Daisuke Muraoka; Takuma Kato; Linan Wang; Yuka Maeda; Takuro Noguchi; Naozumi Harada; Kazuyoshi Takeda; Hideo Yagita; Philippe Guillaume; Immanuel Luescher; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
JOURNAL OF IMMUNOLOGY, 185(6), 3768-3776, 2010年09月, 査読有り


- Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals
Jun Mitsui; Hiroyoshi Nishikawa; Daisuke Muraoka; Linan Wang; Takuro Noguchi; Eiichi Sato; Satoshi Kondo; James P. Allison; Shimon Sakaguchi; Lloyd J. Old; Takuma Kato; Hiroshi Shiku
CLINICAL CANCER RESEARCH, 16(10), 2781-2791, 2010年05月, 査読有り


MISC
講演・口頭発表等
- 手術可能トリプルネガティブ乳癌に対する新規RNA-seqアルゴリズムを用いた化学療法効果予測
野口 卓郎,押野 智博, 富岡 伸元, 畑中 佳奈子, Evdokimova Anastasiya, Turova Polina, Kushnarev Vladimir, Kotlov Nikita, Chernyshov Konstantin, Polyakova Zlata, Kryukov Kirill, Makarova Anastasiya, 細田 充主, 有賀 伸, 杢 里花, 塩津 行正, 畑中 豊, 髙橋 將人, 木下 一郎
第23回日本臨床腫瘍学会学術集会, 2026年03月27日 - Novel RNA-seq profiling algorithms predict chemotherapy response in operable triple-negative breast cancer
Takuro Noguchi; Tomohiro Oshino; Nobumoto Tomioka; Kanako.C Hatanaka; Anastasiya Evdokimova; Polina Turova; Vladimir Kushnarev; Nikita Kotlov; Konstantin Chernyshov; Zlata Polyakova; Kirill Kryukov; Anastasiya Makarova; Mitsuchika Hosoda; Shin Ariga; Rika Moku; Yukimasa Shiotsu; Yutaka Hatanaka; Masato Takahashi; lchiro Kinoshita
第23回日本臨床腫瘍学会学術集会, 2026年03月 - Real-world anti-cancer therapy sequences and timing of CGP in 237 patients with advanced melanoma in Japan
野口 卓郎; 杢 里花; 有賀 伸; 椎谷 研彦; 合田 智宏; 田口 純; 竹内 啓; 萩尾 加奈子; 齋藤 祐介; 清水 康; 木下一郎
第22回日本臨床腫瘍学会学術集会, 2025年03月 - Actionable Oncogenic Gene Alterations in Japanese Malignant Melanoma: Insights from Real-world C-CAT Data
TAKURO NOGUCHI, , Shin Ariga , Toraji Amano , Ichiro Kinoshita
第21回日本臨床腫瘍学会学術集会, 2024年02月 - Establishment of a Novel Preclinical Model for Evaluating Immune Checkpoint Blockade-induced Antitumor Immunological Memory in Lung Cancer
Noguchi, T., Arisato, H., Shiiya, A., Kinoshita, I., Akita, H.
SITC's 38th Annual Meeting & Pre-Conference Programs, 2023年11月 - A Novel Murine Tumor System for Optimizing Combined RAS-Targeted Therapy and Immune Checkpoint Blockade in NSCLC
Arisato, H., Noguchi, T., Shiiya, A., Kinoshita, I., Akita, H., Konno, S.
The 82nd Annual Meeting of the Japanese Cancer Association, 2023年09月 - 悪性黒色腫がん免疫療法治療効果予測におけるSWI/SNF複合体遺伝子変異解析有用性の検討
野口卓郎、菊地順子、有賀伸、木下一郎
第27回日本がん免疫学会総会, 2023年07月 - EGFR変異陽性肺癌のEGFR阻害薬に対する免疫学的耐性因子の検討
野口卓郎、木下一郎、秋田弘俊
第27回日本がん分子標的治療学会学術集会, 2023年06月 - EGFR inhibition in EGFR-mutant lung cancer triggers the innate immune response associated with tumor immune escape
Shiiya, A., Noguchi, T., Tomaru, U., Ariga, S., Takashima, U., Ohhara, Y., Taguchi, J., Takeuchi, S., Shimizu, Y., Kinoshita, I., Koizumi, T., Matsuno, Y., Shinagawa, N., Sakakibara-Konishi, J., Dosaka-Akita, H.
Proceedings of the American Association for Cancer Research Annual Meeting 2023, 2023年04月 - Human macrophages exert antibody-dependent cellular phagocytosis of EGFR-mutant lung cancer cells via EGFR-TKI-induced CD24
Noguchi, T.; Shiiya, A.; Ariga, S.; Goda, T.; Ohhara, Y.; Taguchi, J.; Takeuchi, S.; Shimizu, Y.; Akita, H.; Kinoshita, I.
2023 The Japanese Society of Medical Oncology Annual Meeting, 2023年03月 - EGFR-mutated lung cancer cells upregulate an inhibitory immune checkpoint of CD24 upon EGFR-TKI treatment
Noguchi, T., Tomaru, U., Takashima, U., Shiiya, A., Ariga, S., Goda, T., Taguchi, J., Ohhara, Y., Takeuchi, S., Shimizu, Y., Sakakibara, J., Shinagawa, N., Kinoshita, I., Akita, H.
2022 The Japanese Society of Medical Oncology Annual Meeting - Cell-free DNA from EGFR-mutated lung cancer cells treated with EGFR-TKIs engages in innate immune signaling pathways
Shiiya, A., Noguchi, T., Ariga, S., Ohhara, Y., Shimizu, Y., Kinoshita, I., Akita, H.
The 80th Annual Meeting of the Japanese Cancer Association - CD24, an immunosuppressive immune checkpoint, is up-regulated in EGFR-mutated non-small lung cancer cell lines upon EGFR-TKI treatment
Noguchi, T., Shiiya, A., Ariga, S., Ohhara, Y., Shimizu, Y., Kinoshita, I., Akita, H.
The 39th Sapporo International Cancer Symposium - A single institute analysis of cell-free DNA concentrations in plasma of patients with various cancer types
Noguchi T, Miyagawa M, Sekiguchi N, Gomi D, Fukushima T, Ozawa T, Kobayashi T, Taniguchi S, Koizumi T
Mini-Oral Abstract Session 3-6 (MO3-6-6), The 17th Annual Meeting of JSMO - 肝切除を伴う胆嚢癌手術術式の検討(要望演題「胆嚢癌に必要な肝切除とは」)
野口卓郎、近藤哲、平野聡、田中栄一、七戸俊明、鈴木温、佐川憲明、市村龍之助、加藤健太郎、鈴置真人、橋田秀明、土川貴裕、新垣雅人
第63回日本消化器外科学会 - 肝胆膵外科医育成への当科の取り組みと提言(シンポジウム「肝胆膵外科志望者の減少を止めるには-若手外科医からの提言」)
野口卓郎、近藤哲、平野聡、田中栄一、七戸俊明、鈴木温、佐川憲明、市村龍之助、加藤健太郎、鈴置真人、橋田秀明、土川貴裕、新垣雅人
第20回日本肝胆膵外科学会
共同研究・競争的資金等の研究課題
- 免疫関連因子CD73のトリプルネガティブ乳癌周術期治療効果・有害事象との関連性の検討
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
北海道大学
2024年04月01日 - 2027年03月31日 - 切除不能進行肺癌に対する免疫抑制経路Xの標的検証
創薬ブースター, 日本医療研究開発機構(AMED)
2024年 - 2024年 - 肺癌免疫療法におけるメモリー型T細胞・樹状細胞クロストークの解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
北海道大学
2023年04月01日 - 2026年03月31日 - 宿主免疫抑制性分子を標的とした新規肺癌免疫療法の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
2023年04月 - 2024年03月 - 肺癌に対するメモリー型抗腫瘍T細胞誘導治療薬の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
2021年04月 - 2022年03月 - 非小細胞肺癌に対するシアロ糖タンパク質を標的とした新規がん免疫治療の開発
公益財団法人 秋山記念生命科学振興財団
2020年 - 2020年 - がん患者末梢血浮遊DNAの全身性炎症反応への役割の解明
科学研究費助成事業 若手研究, 日本学術振興会, 若手研究
北海道大学
2019年04月01日 - 2022年03月31日