
NOGUCHI Takuro
Shinshu University Hospital Shinshu Cancer Center
Senior Assistant Professor
Researcher Information
Research Keyword
- Tumor immunology
Career
- 2025 - Present
Shinshu University, Shinshu University Hospital Shinshu Cancer Center, Associate Professor - 2019 - 2025
Hokkaido University Graduate School of Medicine, Medical Oncology, Assistant Professor - 2017 - 2020
Nagoya University Graduate School of Medicine, Department of Immunology, Visiting staff - 2017 - 2019
Shinshu University Hospital, Shinshu Cancer Center, 医員 - 2012 - 2017
Washington University in St. Louis, Postdoctoral Associate - 2010 - 2012
Mamorial Sloan-Kettering Cancer Center, Research Fellow
Research activity information
Award
Paper
- Actionable Gene Alterations Identified in Patients With Malignant Melanoma by Targeted Sequencing in Japan.
Takuro Noguchi; Shin Ariga; Rika Moku; Junko Kikuchi; Toraji Amano; Takuya Maeda; Kosuke Ishikawa; Taku Maeda; Akihiko Shiiya; Tomohiro Goda; Yoshihito Ohhara; Kanako Hagio; Yusuke Saito; Kanako C Hatanaka; Yutaka Hatanaka; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita
JCO precision oncology, 9, e2400437, Jan. 2025 - Polymorphisms of the PD-L1 gene 3'-untranslated region are associated with the expression of PD-L1 in non-small cell lung cancer.
Yoshihito Ohhara; Utano Tomaru; Ichiro Kinoshita; Kanako C Hatanaka; Takuro Noguchi; Yutaka Hatanaka; Toraji Amono; Yoshihiro Matsuno; Hirotoshi Dosaka-Akita
Genes, chromosomes & cancer, 63(1), e23216, Jan. 2024 - EGFR inhibition in EGFR-mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment.
Akihiko Shiiya; Takuro Noguchi; Utano Tomaru; Shin Ariga; Yuta Takashima; Yoshihito Ohhara; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Tomonobu Koizumi; Yoshihiro Matsuno; Naofumi Shinagawa; Jun Sakakibara-Konishi; Hirotoshi Dosaka-Akita
Cancer science, Dec. 2022 - Notch pathway regulates osimertinib drug-tolerant persistence in EGFR-mutated non-small-cell lung cancer.
Hirofumi Takahashi; Jun Sakakibara-Konishi; Megumi Furuta; Tetsuaki Shoji; Kosuke Tsuji; Daisuke Morinaga; Eiki Kikuchi; Junko Kikuchi; Takuro Noguchi; Kanako C Hatanaka; Yutaka Hatanaka; Naofumi Shinagawa; Satoshi Konno
Cancer science, Nov. 2022 - Expression of karyopherin alfa 2 and karyopherin beta 1 correlate with poor prognosis in gastric cancer.
Yoshihito Ohhara; Ichiro Kinoshita; Akira Suzuki; Makoto Imagawa; Jun Taguchi; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Hideyuki Seki; Junichi Suzuki; Hirotoshi Dosaka-Akita
Oncology, Oct. 2022 - Suitability of Oral Rehydration Solution (ORS) for Use in the Cisplatin Short Hydration Method.
Yoshitaka Saito; Yoh Takekuma; Masaki Kobayashi; Naofumi Shinagawa; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Mitsuru Sugawara
Anticancer research, 42(6), 3185-3193, Jun. 2022 - Primary mediastinal germ cell tumors - A retrospective analysis of >30 years of experience in a single institution.
Tomonobu Koizumi; Shintaro Kanda; Ryo Nihonmatu; Daisuke Gomi; Nodoka Sekiguchi; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Hiroshi Yamamoto; Tetsu Takeda
Thoracic cancer, 12(6), 807-813, Mar. 2021 - CCR4-positive peripheral T-cell lymphoma presenting as eosinophilic pneumonia and developing from prolonged pustular psoriasis.
Nodoka Sekiguchi; Masamichi Komatsu; Takashi Ichiyama; Aya Kobayashi; Daisuke Gomi; Toshirou Fukushima; Takashi Kobayashi; Takuro Noguchi; Hideyuki Nakazawa; Naoko Asano; Fumihiro Ishida; Tomonobu Koizumi
The Journal of international medical research, 49(2), 300060521996165-300060521996165, Feb. 2021 - Phase II trial of combination treatment with S-1/cetuximab in patients with platinum-ineligible recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Jun Taguchi; Yasushi Shimizu; Shin Ariga; Tomohiro Goda; Yoshihito Ohhara; Rio Honma; Takuro Noguchi; Satoshi Takeuchi; Ichiro Kinoshita; Toraji Amano; Takatsugu Mizumachi; Satoshi Kano; Miki Takahara; Takahisa Abe; Akihiro Homma; Hirotoshi Dosaka-Akita
International journal of clinical oncology, 26(1), 51-58, Jan. 2021 - Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T-cell-dependent manner.
Tomoaki Muramatsu; Takuro Noguchi; Daisuke Sugiyama; Yoshie Kanada; Kaori Fujimaki; Sachiko Ito; Momokazu Gotoh; Hiroyoshi Nishikawa
International immunology, 33(1), 39-48, Jan. 2021, Refereed, Not invited - Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget's disease: Four cases and a review.
Nodoka Sekiguchi; Sae Kubota; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Shintaro Kanda; Tomonobu Koizumi; Tomomi Miyake; Takushi Shirai; Ryuhei Okuyama
The Journal of dermatology, Jul. 2020, Refereed, Not invited - Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature.
Takuro Noguchi; Toshirou Fukushima; Hiroaki Hara; Nodoka Sekiguchi; Takashi Kobayashi; Takesumi Ozawa; Daisuke Gomi; Tomonobu Koizumi
Journal of medical case reports, 14(1), 86-86, Jul. 2020, Refereed, Not invited - National incidence and initial therapy for thymic carcinoma in Japan: based on analysis of hospital-based cancer registry data, 2009-2015.
Tomonobu Koizumi; Kengo Otsuki; Yuriko Tanaka; Takuro Noguchi; Toshirou Fukushuima; Takashi Kobayashi; Takesumi Ozawa; Nodoka Sekiguchi; Kazutoshi Hamanaka
Japanese journal of clinical oncology, 50(4), 434-439, Apr. 2020, Refereed, Not invited - Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review.
Nodoka Sekiguchi; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Takesumi Ozawa; Yoshinori Sato; Tetsu Takeda; Kazuo Yoshida; Tomonobu Koizumi
Thoracic cancer, 11(2), 451-455, Feb. 2020, Refereed, Not invited - Targeted therapy with trastuzumab for epidermal growth factor receptor 2 (HER2)-positive advanced salivary duct carcinoma: A case report.
Gibo T; Sekiguchi N; Gomi D; Noguchi T; Fukushima T; Kobayashi T; Ozawa T; Yamada SI; Koizumi T
Molecular and clinical oncology, 11(2), 111-115, Aug. 2019, Refereed, Not invited - ACTH-producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review.
Okumura T; Takayama S; Nishio SI; Miyakoshi T; Noguchi T; Kobayashi T; Fukushima T; Sekiguchi N; Otsuki T; Komatsu M; Koizumi T
Thoracic cancer, 10(7), 1648-1653, Jul. 2019, Refereed, Not invited - [Desensitization Therapy for Osimertinib in Patients Who Developed Toxic Erythema - Two Case Reports].
Hiroaki Watanabe; Akira Mimura; Toshiro Fukushima; Takuro Noguchi; Takesumi Ozawa; Takashi Kobayashi; Nodoka Sekiguchi; Shigeru Ohmori; Tomonobu Koizumi
Gan to kagaku ryoho. Cancer & chemotherapy, 46(5), 961-963, May 2019, Refereed, Not invited - High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(5), 1443-1443, Nov. 2018 - High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(4), 1014-1030, Nov. 2018, Refereed, Not invited - Chemotherapy for advanced and metastatic thymic carcinoma
Noguchi T; Koizumi T
Mediastinum, 2(52), Aug. 2018, Refereed, Invited - Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.
Takuro Noguchi; Jeffrey P Ward; Matthew M Gubin; Cora D Arthur; Sang Hun Lee; Jasreet Hundal; Mark J Selby; Robert F Graziano; Elaine R Mardis; Alan J Korman; Robert D Schreiber
Cancer immunology research, 5(2), 106-117, Feb. 2017, Refereed, Not invited - Tumor-specific mutant antigens in cancer immunotherapy
Gubin Matthew M; Ward Jeffrey P; Noguchi Takuro; Zhang Xiuli; Arthur Cora; Krebber Willem-Jan; Mulder Gwenn E; Melief Cornelis J. M; Gillanders William E; Artyomov Maxim; Mardis Elaine R; Schreiber Robert D
CANCER IMMUNOLOGY RESEARCH, 4(11), Nov. 2016, Refereed, Not invited - Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D. Buck; Takuro Noguchi; Jonathan D. Curtis; Qiongyu Chen; Mariel Gindin; Matthew M. Gubin; Gerritje J. W. van der Windt; Elena Tonc; Robert D. Schreiber; Edward J. Pearce; Erika L. Pearce
CELL, 162(6), 1229-1241, Sep. 2015, Refereed, Not invited - Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Matthew M. Gubin; Xiuli Zhang; Heiko Schuster; Etienne Caron; Jeffrey P. Ward; Takuro Noguchi; Yulia Ivanova; Jasreet Hundal; Cora D. Arthur; Willem-Jan Krebber; Gwenn E. Mulder; Mireille Toebes; Matthew D. Vesely; Samuel S. K. Lam; Alan J. Korman; James P. Allison; Gordon J. Freeman; Arlene H. Sharpe; Erika L. Pearce; Ton N. Schumacher; Ruedi Aebersold; Hans-Georg Rammensee; Cornelis J. M. Melief; Elaine R. Mardis; William E. Gillanders; Maxim N. Artyomov; Robert D. Schreiber
NATURE, 515(7528), 577-+, Nov. 2014, Refereed, Not invited - Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells
Daisuke Muraoka; Hiroyoshi Nishikawa; Takuro Noguchi; Linan Wang; Naozumi Harada; Eiichi Sato; Immanuel Luescher; Eiichi Nakayama; Takuma Kato; Hiroshi Shiku
VACCINE, 31(17), 2110-2118, Apr. 2013, Refereed, Not invited - A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy
Anurag Gupta; Natko Nuber; Christoph Esslinger; Mareike Wittenbrink; Martin Treder; Alexandro Landshammer; Takuro Noguchi; Marcus Kelly; Sacha Gnjatic; Erika Ritter; Lotta von Boehmer; Hiroyoshi Nishikawa; Hiroshi Shiku; Lloyd Old; Gerd Ritter; Alexander Knuth; Maries van den Broek
Cancer Immunity, 13(1), 3, 2013, Refereed, Not invited - Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy
Takuro Noguchi; Takuma Kato; Linan Wang; Yuka Maeda; Hiroaki Ikeda; Eiichi Sato; Alexander Knuth; Sacha Gnjatic; Gerd Ritter; Shimon Sakaguchi; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
CANCER RESEARCH, 72(7), 1672-1682, Apr. 2012, Refereed, Not invited - Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8(+) T Cells
Daisuke Muraoka; Takuma Kato; Linan Wang; Yuka Maeda; Takuro Noguchi; Naozumi Harada; Kazuyoshi Takeda; Hideo Yagita; Philippe Guillaume; Immanuel Luescher; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
JOURNAL OF IMMUNOLOGY, 185(6), 3768-3776, Sep. 2010, Refereed, Not invited - Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals
Jun Mitsui; Hiroyoshi Nishikawa; Daisuke Muraoka; Linan Wang; Takuro Noguchi; Eiichi Sato; Satoshi Kondo; James P. Allison; Shimon Sakaguchi; Lloyd J. Old; Takuma Kato; Hiroshi Shiku
CLINICAL CANCER RESEARCH, 16(10), 2781-2791, May 2010, Refereed, Not invited
MISC
- Osimertinibの早期中毒性皮疹出現症例に減感作再投与療法を試みた2例
渡辺 宏晃; 三村 享; 福嶋 敏郎; 野口 卓郎; 小沢 岳澄; 小林 孝至; 関口 和; 大森 栄; 小泉 知展
癌と化学療法, 46(5), 961 - 963, May 2019
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00296&link_issn=&doc_id=20190604480028&doc_link_id=%2Fab8gtkrc%2F2019%2F004605%2F029%2F0961-0963%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2019%2F004605%2F029%2F0961-0963%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif - 抗体について教えてください
野口 卓郎
Immuno-Oncology Frontier, 1(1), 34 - 35, Jan. 2015 - 24年間の経過をたどり巨大嚢胞を形成した甲状腺乳頭癌の1例
野口 卓郎; 高橋 弘昌; 高橋 将人; 細田 充主; 佐々木 彩実; 藤堂 省
日本臨床外科学会雑誌, 68(1), 27 - 30, Jan. 2007
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J03156&link_issn=&doc_id=20070130060006&doc_link_id=10.3919%2Fjjsa.68.27&url=https%3A%2F%2Fdoi.org%2F10.3919%2Fjjsa.68.27&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif - 多血症を伴う末梢型肺腫瘤影を呈した肺梗塞の1切除例
野口 卓郎; 鈴木 雅行; 朝田 政克; 伊藤 清高; 橋本 正人
日本呼吸器外科学会雑誌, 20(7), 914 - 918, Nov. 2006
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J02256&link_issn=&doc_id=20061213250006&doc_link_id=10.2995%2Fjacsurg.20.914&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.20.914&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif - 漿膜浸潤を疑う胃印環細胞癌に対し,開腹術に先行した腹腔鏡検査で腹膜播種を評価した1例
野口 卓郎; 奥芝 俊一; 北城 秀司; 森川 利昭; 近藤 哲; 加藤 紘之
北海道外科雑誌, 50(1), 19 - 22, Jun. 2005
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2005&ichushi_jid=J01375&link_issn=&doc_id=20050711420004&doc_link_id=%2Fdc7hksrg%2F2005%2F005001%2F005%2F0019-0022%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdc7hksrg%2F2005%2F005001%2F005%2F0019-0022%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Affiliated academic society
Research Themes
- 切除不能進行肺癌に対する免疫抑制経路Xの標的検証
創薬ブースター, 日本医療研究開発機構(AMED)
2024 - 2024 - 肺癌免疫療法におけるメモリー型T細胞・樹状細胞クロストークの解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
北海道大学
01 Apr. 2023 - 31 Mar. 2026 - 宿主免疫抑制性分子を標的とした新規肺癌免疫療法の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
Apr. 2023 - Mar. 2024 - 肺癌に対するメモリー型抗腫瘍T細胞誘導治療薬の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
Apr. 2021 - Mar. 2022 - 非小細胞肺癌に対するシアロ糖タンパク質を標的とした新規がん免疫治療の開発
公益財団法人 秋山記念生命科学振興財団
2020 - 2020 - The role of blood cell-free DNA in cancer patients in systemic inflammation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists
Hokkaido University
01 Apr. 2019 - 31 Mar. 2022