医学博士, 北海道大学大学院

Immunology

Tumor diagnostics and therapeutics

Tumor biology

2025 - Present
Shinshu University, Shinshu University Hospital Shinshu Cancer Center, Associate Professor

2019 - 2025
Hokkaido University Graduate School of Medicine, Medical Oncology, Assistant Professor

2017 - 2020
Nagoya University Graduate School of Medicine, Department of Immunology, Visiting staff

2017 - 2019
Shinshu University Hospital, Shinshu Cancer Center, 医員

2012 - 2017
Washington University in St. Louis, Postdoctoral Associate

2010 - 2012
Mamorial Sloan-Kettering Cancer Center, Research Fellow

2007 - 2012, 北海道大学大学院, 医学研究科

1997 - 2003, Hokkaido University, School of Medicine, 医学科

2019
アメリカがん学会, The Best of the AACR Journals 2019
Takuro Noguchi

2016
American Association for Cancer Research, AACR-Aflac, Inc. Scholar-in-Training Award
Takuro Noguchi

2013
Hokkaido Medical Association, Best Articles of the Year
Takuro Noguchi

Multicenter phase II trial of trastuzumab and docetaxel for HER2-positive salivary gland cancer.
Satoshi Kano; Naomi Kiyota; Ichiro Kinoshita; Yuichiro Tada; Kei Ijichi; Tomoko Yamazaki; Yasushi Shimizu; Yutaka Hatanaka; Hitoshi Tsuda; Shojiroh Morinaga; Yoshihiro Matsuno; Yoichi M Ito; Naoki Nishimoto; Keiko Kobayashi; Toshiyuki Isoe; Takuro Noguchi; Akihiro Homma; Hirotoshi Dosaka-Akita
Japanese journal of clinical oncology, 55(10), 1131-1140, Oct. 2025

Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer.
Shotaro Ito; Jun Sakakibara-Konishi; Mineyoshi Sato; Tetsuaki Shoji; Megumi Furuta; Hirofumi Takahashi; Kosuke Tsuji; Daisuke Morinaga; Masahiro Kashima; Hidenori Kitai; Junko Kikuchi; Eiki Kikuchi; Kanako C Hatanaka; Yutaka Hatanaka; Kyoko Hida; Takuro Noguchi; Satoshi Konno
Cancer medicine, 14(13), e71034, Jul. 2025

Actionable Gene Alterations Identified in Patients With Malignant Melanoma by Targeted Sequencing in Japan.
Takuro Noguchi; Shin Ariga; Rika Moku; Junko Kikuchi; Toraji Amano; Takuya Maeda; Kosuke Ishikawa; Taku Maeda; Akihiko Shiiya; Tomohiro Goda; Yoshihito Ohhara; Kanako Hagio; Yusuke Saito; Kanako C Hatanaka; Yutaka Hatanaka; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita
JCO precision oncology, 9, e2400437, Jan. 2025

Successful Response to First-Line Carboplatin, Pemetrexed, and Bevacizumab for Peritoneal Mesothelioma: Two Case Reports.
Tomonobu Koizumi; Shintaro Kanda; Nodoka Sekiguchi; Takuro Noguchi; Sei-Ichiro Eda; Hiroto Kitahara
Case reports in oncology, 18(1), 278-285, 2025

Polymorphisms of the PD-L1 gene 3'-untranslated region are associated with the expression of PD-L1 in non-small cell lung cancer.
Yoshihito Ohhara; Utano Tomaru; Ichiro Kinoshita; Kanako C Hatanaka; Takuro Noguchi; Yutaka Hatanaka; Toraji Amono; Yoshihiro Matsuno; Hirotoshi Dosaka-Akita
Genes, chromosomes & cancer, 63(1), e23216, Jan. 2024

EGFR変異陽性肺癌におけるCD24発現の検討
椎谷 研彦; 野口 卓郎; 外丸 詩野; 有賀 伸; 高島 雄太; 品川 尚文; 木下 一郎; 松野 吉宏; 榊原 純; 秋田 弘俊
日本病理学会会誌, 112(1), 247-247, Mar. 2023

EGFR inhibition in EGFR-mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment.
Akihiko Shiiya; Takuro Noguchi; Utano Tomaru; Shin Ariga; Yuta Takashima; Yoshihito Ohhara; Jun Taguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Tomonobu Koizumi; Yoshihiro Matsuno; Naofumi Shinagawa; Jun Sakakibara-Konishi; Hirotoshi Dosaka-Akita
Cancer science, Dec. 2022

Notch pathway regulates osimertinib drug-tolerant persistence in EGFR-mutated non-small-cell lung cancer.
Hirofumi Takahashi; Jun Sakakibara-Konishi; Megumi Furuta; Tetsuaki Shoji; Kosuke Tsuji; Daisuke Morinaga; Eiki Kikuchi; Junko Kikuchi; Takuro Noguchi; Kanako C Hatanaka; Yutaka Hatanaka; Naofumi Shinagawa; Satoshi Konno
Cancer science, Nov. 2022

Clinical analysis of extrapulmonary neuroendocrine carcinoma: a retrospective and single institution experience.
Taiki Okumura; Takuro Noguchi; Nodoka Sekiguchi; Takashi Kobayashi; Shintaro Kanda; Koichi Ida; Tomonori Minagawa; Shigeo Tokumaru; Takeji Umemura; Tomonobu Koizumi
Chemotherapy, Nov. 2022

EGFR変異陽性非小細胞肺癌におけるosimertinib耐性とNotch経路の関わり
高橋 宏典; 榊原 純; 古田 恵; 庄司 哲明; 辻 康介; 森永 大亮; 菊地 英毅; 菊地 順子; 野口 卓郎; 畑中 佳奈子; 畑中 豊; 品川 尚文; 今野 哲
肺癌, 62(6), 715-715, Nov. 2022

Expression of karyopherin alfa 2 and karyopherin beta 1 correlate with poor prognosis in gastric cancer.
Yoshihito Ohhara; Ichiro Kinoshita; Akira Suzuki; Makoto Imagawa; Jun Taguchi; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Hideyuki Seki; Junichi Suzuki; Hirotoshi Dosaka-Akita
Oncology, Oct. 2022

Risk Factor Analysis for the Occurrence of Severe Adverse Effects in Eribulin Treatment.
Yoshitaka Saito; Yoh Takekuma; Takashi Takeshita; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Mitsuru Sugawara
Anticancer research, 42(7), 3693-3700, Jul. 2022

Suitability of Oral Rehydration Solution (ORS) for Use in the Cisplatin Short Hydration Method.
Yoshitaka Saito; Yoh Takekuma; Masaki Kobayashi; Naofumi Shinagawa; Takuro Noguchi; Satoshi Takeuchi; Yasushi Shimizu; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Mitsuru Sugawara
Anticancer research, 42(6), 3185-3193, Jun. 2022

Response to lorlatinib on a patient with ALK-rearranged non-small cell lung cancer harboring 1151Tins mutation with uterine metastasis.
Takashi Kobayashi; Shintaro Kanda; Toshirou Fukushima; Takuro Noguchi; Nodoka Sekiguchi; Tomonobu Koizumi
Thoracic cancer, 12(16), 2275-2278, Aug. 2021

Primary mediastinal germ cell tumors - A retrospective analysis of >30 years of experience in a single institution.
Tomonobu Koizumi; Shintaro Kanda; Ryo Nihonmatu; Daisuke Gomi; Nodoka Sekiguchi; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Hiroshi Yamamoto; Tetsu Takeda
Thoracic cancer, 12(6), 807-813, Mar. 2021

CCR4-positive peripheral T-cell lymphoma presenting as eosinophilic pneumonia and developing from prolonged pustular psoriasis.
Nodoka Sekiguchi; Masamichi Komatsu; Takashi Ichiyama; Aya Kobayashi; Daisuke Gomi; Toshirou Fukushima; Takashi Kobayashi; Takuro Noguchi; Hideyuki Nakazawa; Naoko Asano; Fumihiro Ishida; Tomonobu Koizumi
The Journal of international medical research, 49(2), 300060521996165-300060521996165, Feb. 2021

Phase II trial of combination treatment with S-1/cetuximab in patients with platinum-ineligible recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Jun Taguchi; Yasushi Shimizu; Shin Ariga; Tomohiro Goda; Yoshihito Ohhara; Rio Honma; Takuro Noguchi; Satoshi Takeuchi; Ichiro Kinoshita; Toraji Amano; Takatsugu Mizumachi; Satoshi Kano; Miki Takahara; Takahisa Abe; Akihiro Homma; Hirotoshi Dosaka-Akita
International journal of clinical oncology, 26(1), 51-58, Jan. 2021

Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T-cell-dependent manner.
Tomoaki Muramatsu; Takuro Noguchi; Daisuke Sugiyama; Yoshie Kanada; Kaori Fujimaki; Sachiko Ito; Momokazu Gotoh; Hiroyoshi Nishikawa
International immunology, 33(1), 39-48, Jan. 2021, Refereed

Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget's disease: Four cases and a review.
Nodoka Sekiguchi; Sae Kubota; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Shintaro Kanda; Tomonobu Koizumi; Tomomi Miyake; Takushi Shirai; Ryuhei Okuyama
The Journal of dermatology, Jul. 2020, Refereed

Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature.
Takuro Noguchi; Toshirou Fukushima; Hiroaki Hara; Nodoka Sekiguchi; Takashi Kobayashi; Takesumi Ozawa; Daisuke Gomi; Tomonobu Koizumi
Journal of medical case reports, 14(1), 86-86, Jul. 2020, Refereed

A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva
Fumihiro Nishimaki; Takahiko Gibo; Keita Tsukada; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Nodoka Sekiguchi; Takesumi Ozawa; Tomonobu Koizumi
Case Reports in Oncology, 13(2), 683-688, Jun. 2020

National incidence and initial therapy for thymic carcinoma in Japan: based on analysis of hospital-based cancer registry data, 2009-2015.
Tomonobu Koizumi; Kengo Otsuki; Yuriko Tanaka; Takuro Noguchi; Toshirou Fukushuima; Takashi Kobayashi; Takesumi Ozawa; Nodoka Sekiguchi; Kazutoshi Hamanaka
Japanese journal of clinical oncology, 50(4), 434-439, Apr. 2020, Refereed

Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review.
Nodoka Sekiguchi; Takuro Noguchi; Toshirou Fukushima; Takashi Kobayashi; Takesumi Ozawa; Yoshinori Sato; Tetsu Takeda; Kazuo Yoshida; Tomonobu Koizumi
Thoracic cancer, 11(2), 451-455, Feb. 2020, Refereed

Intra-oesophageal invasion of thymoma.
Ozawa M; Fukushima T; Noguchi T; Kobayashi T; Sekiguchi N; Koizumi T
Respirology case reports, 7(8), e00485, Nov. 2019, Refereed

Targeted therapy with trastuzumab for epidermal growth factor receptor 2 (HER2)-positive advanced salivary duct carcinoma: A case report.
Gibo T; Sekiguchi N; Gomi D; Noguchi T; Fukushima T; Kobayashi T; Ozawa T; Yamada SI; Koizumi T
Molecular and clinical oncology, 11(2), 111-115, Aug. 2019, Refereed

[What Are Patients' Expectations from Palliative Chemotherapy ?]
Takeuchi N; Koike K; Yoshida S; Sekiguchi N; Noguchi T
Gan to kagaku ryoho. Cancer & chemotherapy, 46(8), 1275-1279, Aug. 2019, Refereed

ACTH-producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review.
Okumura T; Takayama S; Nishio SI; Miyakoshi T; Noguchi T; Kobayashi T; Fukushima T; Sekiguchi N; Otsuki T; Komatsu M; Koizumi T
Thoracic cancer, 10(7), 1648-1653, Jul. 2019, Refereed

[Desensitization Therapy for Osimertinib in Patients Who Developed Toxic Erythema - Two Case Reports].
Hiroaki Watanabe; Akira Mimura; Toshiro Fukushima; Takuro Noguchi; Takesumi Ozawa; Takashi Kobayashi; Nodoka Sekiguchi; Shigeru Ohmori; Tomonobu Koizumi
Gan to kagaku ryoho. Cancer & chemotherapy, 46(5), 961-963, May 2019, Refereed

Late and Rapid Relapse in Mediastinum from Testicular Germ Cell Tumor Stage I Over 13 Years after Surgery.
Fukushima T; Noguchi T; Kobayashi T; Sekiguchi N; Ozawa T; Koizumi T; Tamada H
Case reports in oncology, 12(2), 500-505, May 2019, Refereed

A Case of Unresectable Pulmonary Artery Intimal Sarcoma with Prolonged Survival by Chemotherapy
Noguchi Takuro; Gomi Daisuke; Fukushima Toshirou; Ozawa Takesumi; Kobayashi Takashi; Sekiguchi Nodoka; Mamiya Keiko; Koizumi Tomonobu
CASE REPORTS IN ONCOLOGY, 12(1), 192-198, 2019, Refereed

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(5), 1443-1443, Nov. 2018

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin; Ekaterina Esaulova; Jeffrey P Ward; Olga N Malkova; Daniele Runci; Pamela Wong; Takuro Noguchi; Cora D Arthur; Wei Meng; Elise Alspach; Ruan F V Medrano; Catrina Fronick; Michael Fehlings; Evan W Newell; Robert S Fulton; Kathleen C F Sheehan; Stephen T Oh; Robert D Schreiber; Maxim N Artyomov
Cell, 175(4), 1014-1030, Nov. 2018, Refereed

Chemotherapy for advanced and metastatic thymic carcinoma
Noguchi T; Koizumi T
Mediastinum, 2(52), Aug. 2018, Refereed, Invited

Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.
Takuro Noguchi; Jeffrey P Ward; Matthew M Gubin; Cora D Arthur; Sang Hun Lee; Jasreet Hundal; Mark J Selby; Robert F Graziano; Elaine R Mardis; Alan J Korman; Robert D Schreiber
Cancer immunology research, 5(2), 106-117, Feb. 2017, Refereed

Tumor-specific mutant antigens in cancer immunotherapy
Gubin Matthew M; Ward Jeffrey P; Noguchi Takuro; Zhang Xiuli; Arthur Cora; Krebber Willem-Jan; Mulder Gwenn E; Melief Cornelis J. M; Gillanders William E; Artyomov Maxim; Mardis Elaine R; Schreiber Robert D
CANCER IMMUNOLOGY RESEARCH, 4(11), Nov. 2016, Refereed

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D. Buck; Takuro Noguchi; Jonathan D. Curtis; Qiongyu Chen; Mariel Gindin; Matthew M. Gubin; Gerritje J. W. van der Windt; Elena Tonc; Robert D. Schreiber; Edward J. Pearce; Erika L. Pearce
CELL, 162(6), 1229-1241, Sep. 2015, Refereed

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Matthew M. Gubin; Xiuli Zhang; Heiko Schuster; Etienne Caron; Jeffrey P. Ward; Takuro Noguchi; Yulia Ivanova; Jasreet Hundal; Cora D. Arthur; Willem-Jan Krebber; Gwenn E. Mulder; Mireille Toebes; Matthew D. Vesely; Samuel S. K. Lam; Alan J. Korman; James P. Allison; Gordon J. Freeman; Arlene H. Sharpe; Erika L. Pearce; Ton N. Schumacher; Ruedi Aebersold; Hans-Georg Rammensee; Cornelis J. M. Melief; Elaine R. Mardis; William E. Gillanders; Maxim N. Artyomov; Robert D. Schreiber
NATURE, 515(7528), 577-+, Nov. 2014, Refereed

Antibody-based therapy in colorectal cancer
Takuro Noguchi; Gerd Ritter; Hiroyoshi Nishikawa
IMMUNOTHERAPY, 5(5), 533-545, May 2013, Refereed

Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells
Daisuke Muraoka; Hiroyoshi Nishikawa; Takuro Noguchi; Linan Wang; Naozumi Harada; Eiichi Sato; Immanuel Luescher; Eiichi Nakayama; Takuma Kato; Hiroshi Shiku
VACCINE, 31(17), 2110-2118, Apr. 2013, Refereed

A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy
Anurag Gupta; Natko Nuber; Christoph Esslinger; Mareike Wittenbrink; Martin Treder; Alexandro Landshammer; Takuro Noguchi; Marcus Kelly; Sacha Gnjatic; Erika Ritter; Lotta von Boehmer; Hiroyoshi Nishikawa; Hiroshi Shiku; Lloyd Old; Gerd Ritter; Alexander Knuth; Maries van den Broek
Cancer Immunity, 13(1), 3, 2013, Refereed

Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy
Takuro Noguchi; Takuma Kato; Linan Wang; Yuka Maeda; Hiroaki Ikeda; Eiichi Sato; Alexander Knuth; Sacha Gnjatic; Gerd Ritter; Shimon Sakaguchi; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
CANCER RESEARCH, 72(7), 1672-1682, Apr. 2012, Refereed

Extrapleural hematoma as a complication following thoracotomy for pulmonary lobectomy.
Takuro Noguchi; Yasuhiro Hida; Kichizo Kaga; Masaya Kawada; Hiroto Niizeki; Satoshi Kondo
General thoracic and cardiovascular surgery, 59(1), 57-60, Jan. 2011, Refereed

Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8(+) T Cells
Daisuke Muraoka; Takuma Kato; Linan Wang; Yuka Maeda; Takuro Noguchi; Naozumi Harada; Kazuyoshi Takeda; Hideo Yagita; Philippe Guillaume; Immanuel Luescher; Lloyd J. Old; Hiroshi Shiku; Hiroyoshi Nishikawa
JOURNAL OF IMMUNOLOGY, 185(6), 3768-3776, Sep. 2010, Refereed

Minimally Invasive Esophagectomy for Cancer Patients with Low Pulmonary Function
Takuro Noguchi; Toshiaki Shichinohe; Satoshi Hirano; Satoshi Kondo
HEPATO-GASTROENTEROLOGY, 57(101), 768-771, Jul. 2010, Refereed

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals
Jun Mitsui; Hiroyoshi Nishikawa; Daisuke Muraoka; Linan Wang; Takuro Noguchi; Eiichi Sato; Satoshi Kondo; James P. Allison; Shimon Sakaguchi; Lloyd J. Old; Takuma Kato; Hiroshi Shiku
CLINICAL CANCER RESEARCH, 16(10), 2781-2791, May 2010, Refereed

A case report of peripheral pulmonary nodule due to pulmonary infarction with polycythemia diagnosed by video assisted thoracoscopic surgery
NOGUCHI Takuro; SUZUKI Takayuki; ASADA Masakatsu; ITOH Kiyotaka; HASHIMOTO Masato
The Journal of the Japanese Association for Chest Surgery, 20(7), 28-32, Nov. 2006

Osimertinibの早期中毒性皮疹出現症例に減感作再投与療法を試みた2例
渡辺 宏晃; 三村 享; 福嶋 敏郎; 野口 卓郎; 小沢 岳澄; 小林 孝至; 関口 和; 大森 栄; 小泉 知展
癌と化学療法, 46(5), 961 - 963, May 2019
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00296&link_issn=&doc_id=20190604480028&doc_link_id=%2Fab8gtkrc%2F2019%2F004605%2F029%2F0961-0963%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2019%2F004605%2F029%2F0961-0963%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

抗体について教えてください
野口 卓郎
Immuno-Oncology Frontier, 1(1), 34 - 35, Jan. 2015

細胞内腫瘍抗原に対する新規抗体療法の開発
野口 卓郎; 加藤 琢磨; 王 立楠; 池田 裕明; 佐藤 永一; KNUTH Alexander; GNJATIC Sacha; RITTER Gerd; 坂口 志文; OLD Lloyd; 宮本 正樹; 平野 聡; 珠玖 洋; 西川 博嘉
北海道醫學雜誌 = Acta medica Hokkaidonensia, 88(1), 29 - 29, 01 Jan. 2013

RS-308 肝切除を伴う胆嚢癌手術術式の検討(要望演題20 胆嚢癌に必要な肝切除とは,第63回日本消化器外科学会総会)
野口 卓郎; 平野 聡; 田中 栄一; 七戸 俊明; 鈴木 温; 佐川 憲明; 橋田 秀明; 近藤 哲
日本消化器外科学会雑誌, 41(7), 1135 - 1135, 01 Jul. 2008

RS-332 肝切除術における自動縫合器の応用 : グリソン処理に用いた場合の有用性と問題点(要望演題21-3 自動縫合器の使用法 肝・胆・膵,第63回日本消化器外科学会総会)
新垣 雅人; 田中 栄一; 野口 卓郎; 加藤 健太郎; 橋田 秀明; 佐川 憲明; 鈴木 温; 七戸 俊明; 平野 聡; 近藤 哲
日本消化器外科学会雑誌, 41(7), 1138 - 1138, 01 Jul. 2008

DP-001-6 IPMNに対する周囲臓器を温存した膵実質のみの切除 : Parenchymal Pancreatectomy(第108回日本外科学会定期学術集会)
田中 栄一; 平野 聡; 鈴木 温; 佐川 憲明; 市村 龍之助; 橋田 秀明; 鈴置 真人; 野口 卓郎; 近藤 哲
日本外科学会雑誌, 109(2), 347 - 347, 25 Apr. 2008

DP-099-6 StageIII・IV胆嚢癌に対する外科的治療戦略(第108回日本外科学会定期学術集会)
橋田 秀明; 野口 卓郎; 市村 龍之助; 鈴置 真人; 佐川 憲明; 鈴木 温; 七戸 俊明; 田中 栄一; 平野 聡; 近藤 哲
日本外科学会雑誌, 109(2), 543 - 543, 25 Apr. 2008

24年間の経過をたどり巨大嚢胞を形成した甲状腺乳頭癌の1例
野口 卓郎; 高橋 弘昌; 高橋 将人; 細田 充主; 佐々木 彩実; 藤堂 省
日本臨床外科学会雑誌, 68(1), 27 - 30, Jan. 2007
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J03156&link_issn=&doc_id=20070130060006&doc_link_id=10.3919%2Fjjsa.68.27&url=https%3A%2F%2Fdoi.org%2F10.3919%2Fjjsa.68.27&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

多血症を伴う末梢型肺腫瘤影を呈した肺梗塞の1切除例
野口 卓郎; 鈴木 雅行; 朝田 政克; 伊藤 清高; 橋本 正人
日本呼吸器外科学会雑誌, 20(7), 914 - 918, Nov. 2006
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J02256&link_issn=&doc_id=20061213250006&doc_link_id=10.2995%2Fjacsurg.20.914&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.20.914&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

硝子化した虫垂壁を表在性に進展した早期虫垂粘液嚢胞腺癌の1例 早期虫垂癌の治療方針の検討
野口 卓郎; 鈴木 康弘; 高橋 基夫; 近藤 哲
日本外科系連合学会誌, 31(2), 209 - 213, Apr. 2006

画像上肉腫様変化も疑った大腸脂肪腫の1例
野口 卓郎; 鈴木 康弘; 高橋 基夫; 近藤 哲
日本外科系連合学会誌, 30(5), 771 - 774, Oct. 2005

早期胃癌に対する完全腹腔鏡下幽門側胃切除,再建と左副腎同時切除の経験
野口 卓郎; 奥芝 俊一
手術, 59(9), 1363 - 1366, Aug. 2005

漿膜浸潤を疑う胃印環細胞癌に対し,開腹術に先行した腹腔鏡検査で腹膜播種を評価した1例
野口 卓郎; 奥芝 俊一; 北城 秀司; 森川 利昭; 近藤 哲; 加藤 紘之
北海道外科雑誌, 50(1), 19 - 22, Jun. 2005
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2005&ichushi_jid=J01375&link_issn=&doc_id=20050711420004&doc_link_id=%2Fdc7hksrg%2F2005%2F005001%2F005%2F0019-0022%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdc7hksrg%2F2005%2F005001%2F005%2F0019-0022%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Novel RNA-seq profiling algorithms predict chemotherapy response in operable triple-negative breast cancer
Takuro Noguchi; Tomohiro Oshino; Nobumoto Tomioka; Kanako.C Hatanaka; Anastasiya Evdokimova; Polina Turova; Vladimir Kushnarev; Nikita Kotlov; Konstantin Chernyshov; Zlata Polyakova; Kirill Kryukov; Anastasiya Makarova; Mitsuchika Hosoda; Shin Ariga; Rika Moku; Yukimasa Shiotsu; Yutaka Hatanaka; Masato Takahashi; lchiro Kinoshita
第23回日本臨床腫瘍学会学術集会, Mar. 2026

Real-world anti-cancer therapy sequences and timing of CGP in 237 patients with advanced melanoma in Japan
野口 卓郎; 杢 里花; 有賀 伸; 椎谷 研彦; 合田 智宏; 田口 純; 竹内 啓; 萩尾 加奈子; 齋藤 祐介; 清水 康; 木下一郎
第22回日本臨床腫瘍学会学術集会, Mar. 2025

Actionable Oncogenic Gene Alterations in Japanese Malignant Melanoma: Insights from Real-world C-CAT Data
TAKURO NOGUCHI, , Shin Ariga , Toraji Amano , Ichiro Kinoshita
第21回日本臨床腫瘍学会学術集会, Feb. 2024

Establishment of a Novel Preclinical Model for Evaluating Immune Checkpoint Blockade-induced Antitumor Immunological Memory in Lung Cancer
Noguchi, T., Arisato, H., Shiiya, A., Kinoshita, I., Akita, H.
SITC's 38th Annual Meeting & Pre-Conference Programs, Nov. 2023

A Novel Murine Tumor System for Optimizing Combined RAS-Targeted Therapy and Immune Checkpoint Blockade in NSCLC
Arisato, H., Noguchi, T., Shiiya, A., Kinoshita, I., Akita, H., Konno, S.
The 82nd Annual Meeting of the Japanese Cancer Association, Sep. 2023

悪性黒色腫がん免疫療法治療効果予測におけるSWI/SNF複合体遺伝子変異解析有用性の検討
野口卓郎、菊地順子、有賀伸、木下一郎
第27回日本がん免疫学会総会, Jul. 2023

EGFR変異陽性肺癌のEGFR阻害薬に対する免疫学的耐性因子の検討
野口卓郎、木下一郎、秋田弘俊
第27回日本がん分子標的治療学会学術集会, Jun. 2023

EGFR inhibition in EGFR-mutant lung cancer triggers the innate immune response associated with tumor immune escape
Shiiya, A., Noguchi, T., Tomaru, U., Ariga, S., Takashima, U., Ohhara, Y., Taguchi, J., Takeuchi, S., Shimizu, Y., Kinoshita, I., Koizumi, T., Matsuno, Y., Shinagawa, N., Sakakibara-Konishi, J., Dosaka-Akita, H.
Proceedings of the American Association for Cancer Research Annual Meeting 2023, Apr. 2023

Human macrophages exert antibody-dependent cellular phagocytosis of EGFR-mutant lung cancer cells via EGFR-TKI-induced CD24
Noguchi, T.; Shiiya, A.; Ariga, S.; Goda, T.; Ohhara, Y.; Taguchi, J.; Takeuchi, S.; Shimizu, Y.; Akita, H.; Kinoshita, I.
2023 The Japanese Society of Medical Oncology Annual Meeting, Mar. 2023

EGFR-mutated lung cancer cells upregulate an inhibitory immune checkpoint of CD24 upon EGFR-TKI treatment
Noguchi, T., Tomaru, U., Takashima, U., Shiiya, A., Ariga, S., Goda, T., Taguchi, J., Ohhara, Y., Takeuchi, S., Shimizu, Y., Sakakibara, J., Shinagawa, N., Kinoshita, I., Akita, H.
2022 The Japanese Society of Medical Oncology Annual Meeting

Cell-free DNA from EGFR-mutated lung cancer cells treated with EGFR-TKIs engages in innate immune signaling pathways
Shiiya, A., Noguchi, T., Ariga, S., Ohhara, Y., Shimizu, Y., Kinoshita, I., Akita, H.
The 80th Annual Meeting of the Japanese Cancer Association

CD24, an immunosuppressive immune checkpoint, is up-regulated in EGFR-mutated non-small lung cancer cell lines upon EGFR-TKI treatment
Noguchi, T., Shiiya, A., Ariga, S., Ohhara, Y., Shimizu, Y., Kinoshita, I., Akita, H.
The 39th Sapporo International Cancer Symposium

A single institute analysis of cell-free DNA concentrations in plasma of patients with various cancer types
Noguchi T, Miyagawa M, Sekiguchi N, Gomi D, Fukushima T, Ozawa T, Kobayashi T, Taniguchi S, Koizumi T
Mini-Oral Abstract Session 3-6 (MO3-6-6), The 17th Annual Meeting of JSMO

肝切除を伴う胆嚢癌手術術式の検討（要望演題「胆嚢癌に必要な肝切除とは」）
野口卓郎、近藤哲、平野聡、田中栄一、七戸俊明、鈴木温、佐川憲明、市村龍之助、加藤健太郎、鈴置真人、橋田秀明、土川貴裕、新垣雅人
第63回日本消化器外科学会

肝胆膵外科医育成への当科の取り組みと提言（シンポジウム「肝胆膵外科志望者の減少を止めるには-若手外科医からの提言」）
野口卓郎、近藤哲、平野聡、田中栄一、七戸俊明、鈴木温、佐川憲明、市村龍之助、加藤健太郎、鈴置真人、橋田秀明、土川貴裕、新垣雅人
第20回日本肝胆膵外科学会

がんと免疫
信州大学医学部附属病院

American Association for Cancer Research

JAPANESE SOCIETY OF GASTROENTEROLOGY

Japanese Breast Cancer Society

Japanese Society of Medical Oncology

JAPAN SURGICAL SOCIETY

免疫関連因子CD73のトリプルネガティブ乳癌周術期治療効果・有害事象との関連性の検討
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
北海道大学
01 Apr. 2024 - 31 Mar. 2027

切除不能進行肺癌に対する免疫抑制経路Ｘの標的検証
創薬ブースター, 日本医療研究開発機構(AMED)
2024 - 2024

肺癌免疫療法におけるメモリー型T細胞・樹状細胞クロストークの解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
北海道大学
01 Apr. 2023 - 31 Mar. 2026

宿主免疫抑制性分子を標的とした新規肺癌免疫療法の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
Apr. 2023 - Mar. 2024

肺癌に対するメモリー型抗腫瘍T細胞誘導治療薬の開発
橋渡し研究プログラム・研究開発シーズA, 日本医療研究開発機構(AMED)
Apr. 2021 - Mar. 2022

非小細胞肺癌に対するシアロ糖タンパク質を標的とした新規がん免疫治療の開発
公益財団法人 秋山記念生命科学振興財団
2020 - 2020

The role of blood cell-free DNA in cancer patients in systemic inflammation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists
Hokkaido University
01 Apr. 2019 - 31 Mar. 2022