Clinical pharmacy, Clinical pharmacology

Clinical pharmacy, Clinical pharmacokinetics

Clinical pharmacy, Analytical Sciences

2021
Shinshu University; Shinshu University Hospital, Pharmacy; Professor, Director

2018 - 2021
Hamamatsu University School of Medicine; Hamamatsu University Hospital, Hospital Pharmacy; Associate Professor, Vice-Director

2018
日本薬学会, Sato Memorial Domestic Award
患者情報の多面的評価に基づく薬物治療の適正化

2013
日本薬物動態学会, 2013年度DMPK賞 DMPK Editors’ Award for the Most Excellent Article in 2012, 3rd Place.
Impact of CYP3A5 and ABCB1 gene polymorphisms on plasma disposition of fentanyl and its clinical responses in cancer patients with opioid switching to fentanyl transdermal system

2012
FIP World Centennial Congress 2012 of Pharmacy and Pharmaceutical Sciences, First Prize（First Author） Outstanding poster presentation, FIP Hospital Pharmacy Section
Netherland

Effect of enoxaparin and daikenchuto coadministration on hepatic disorder markers in gynecological cancer patients after abdominal surgery
Hiroaki Watanabe, Keita Hirai, Yuka Nakazawa, Ayaka Koike, Hiroyuki Tsuchiya, Takafumi Naito
Biological and Pharmaceutical Bulletin, 47(4), 758-763, Jun. 2024, Refereed

Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics
Emi Nakatsugawa, Takafumi Naito, Kaito Shibata, Ryo Kitajima, Junichi Kawakami
Fundamental & Clinical Pharmacology, 38(3), 596-605, Jun. 2024, Refereed
Corresponding

Associations of plasma aprepitant and its N-dealkylated metabolite with cachexia status and clinical responses in head and neck cancer patients
Yusuke Suzuki, Takafumi Naito, Kaito Shibata, Seiji Hosokawa, Junichi Kawakami
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 91(6), 481-490, Apr. 2023, Refereed
Corresponding

Characterization of endogenous markers of hepatic function in patients receiving itraconazole treatment for prophylaxis of deep mycosis
Emi Nakatsugawa, Takafumi Naito, Yumi Imoto, Kaito Shibata, Takaaki Ono, Junichi Kawakami
JOURNAL OF INFECTION AND CHEMOTHERAPY, 29(3), 244-249, Mar. 2023, Refereed
Corresponding

Characterization of plasma daptomycin in patients with serum highly glycated albumin and obesity
Yukari Miyadera, Takahiro Yamada, Yumi Imoto, Tatsuya Yagi, Takafumi Naito, Junichi Kawakami
JOURNAL OF INFECTION AND CHEMOTHERAPY, 29(2), 119-125, Feb. 2023, Refereed
Corresponding

Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration
Hideki Kobayashi, Shugo Tohyama, Hideaki Kanazawa, Hajime Ichimura, Shuji Chino, Yuki Tanaka, Yota Suzuki, Jian Zhao, Naoko Shiba, Shin Kadota, Kazumasa Narita, Takafumi Naito, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba, Keiichi Fukuda
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 174, 77-87, Jan. 2023, Refereed

LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification
Takashi Mochizuki, Kaito Shibata, Takafumi Naito, Kumiko Shimoyama, Noriyoshi Ogawa, Masato Maekawa, Junichi Kawakami
Journal of Pharmaceutical Analysis, 12(6), 852-859, Dec. 2022, Refereed

Investigation of the boxed warnings in package inserts of prescription medicines for medical professionals in Japan
Yasuaki Mino, Takafumi Naito, Junya Ohshiro, TakahiroYamada, Junichi Kawakami
Pharmacy Practice, 20(4), 2733-2733, Oct. 2022, Refereed

Stereoselective interaction of tolvaptan with amiodarone under racemic metabolic impact by CYP3A5 genotypes in heart failure patients
Akutsu, Shunta; Mino, Yasuaki; Naito, Takafumi; Hoshikawa, Kohei; Saotome, Masao; Maekawa, Yuichiro; Kawakami, Junichi;
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 78(2022), 1311-1320, May 2022, Refereed

Maternal plasma and cord blood concentration profiles of duloxetine during the peripartum period and their associations with the modified Finnegan score
Reina Taguchi, Takafumi Naito, Koji Suzuki, Yuko Kurosawa, Hiroaki Itoh, Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 44(2), 351-352, Apr. 2022, Refereed
Corresponding

Impacts of cachexia progression in addition to serum IgG and blood lymphocytes on serum nivolumab in advanced cancer patients
Kazuki Abe,Kaito Shibata,Takafumi Naito,Atsushi Otsuka,Masato Karayama,Masato Maekawa,Hideaki Miyake,Takafumi Suda,Junichi Kawakami
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 78, 77-87, Jan. 2022, Refereed
Corresponding

Simple Liquid Chromatography–Tandem Mass Spectrometry Method for Quantitation of Total and Free Aprepitant and Its Active N-Dealkylated Metabolites in Human Plasma
Takafumi Naito,Yusuke Suzuki,Kaito Shibata,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 43(3), 422-428, Jun. 2021, Refereed
Lead, Corresponding

Combined Impact of Inflammation and Pharmacogenomic Variants on Voriconazole Trough Concentrations: A Meta-Analysis of Individual Data
Léa Bolcato,Charles Khouri,Anette Veringa,Jan Willem C. Alffenaar,Takahiro Yamada,Takafumi Naito,Fabien Lamoureux,Xavier Fonrose,Françoise Stanke-Labesque,Elodie Gautier-Veyret
JOURNAL OF CLINICAL MEDICINE, 10(10), 2089-2089, 13 May 2021, Refereed

Correlations between serum cetuximab and EGFR-related markers, and skin disorders in head and neck cancer patients
Kaito Shibata,Takafumi Naito,Satoshi Hirakawa,Koji Suzuki,Seiji Hosokawa,Hiroyuki Mineta,Junichi Kawakami
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 87(4), 555-565, Apr. 2021, Refereed
Corresponding

Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head and neck cancer patients
Koji Suzuki,Takafumi Naito,Hironari Tanaka,Kaito Shibata,Yasuhide Yamada,Kunihiko Itoh,Junichi Kawakami
Basic & Clinical Pharmacology & Toxicology, 128(3), 472-481, Mar. 2021, Refereed
Corresponding

Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder
Yumi Imoto,Takafumi Naito,Yukari Miyadera,Takaaki Ono,Junichi Kawakami
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 77(3), 369-379, Mar. 2021, Refereed
Corresponding

Association Between the Prothrombin Time–International Normalized Ratio and Concomitant Use of Antibiotics in Warfarin Users: Focus on Type of Antibiotic and Susceptibility of Bacteroides fragilis to Antibiotics
Tatsuya Yagi,Takafumi Naito,Ayami Kato,Kensho Hirao,Junichi Kawakami
Annals of Pharmacotherapy, 55(2), 157-164, Feb. 2021, Refereed

Simultaneous determination of itraconazole and its CYP3A4-mediated metabolites including N-desalkyl itraconazole in human plasma using liquid chromatography-tandem mass spectrometry and its clinical application
Yumi Imoto,Yasuaki Mino,Takafumi Naito,Takaaki Ono,Junichi Kawakami
Journal of Pharmaceutical Health Care and Sciences, 6(11), Dec. 2020, Refereed
Corresponding

Simple LC-MS/MS method using core-shell ODS microparticles for the simultaneous quantitation of edoxaban and its major metabolites in human plasma
Saki Ariizumi,Takafumi Naito,Kohei Hoshikawa,Shunta Akutsu,Masao Saotome,Yuichiro Maekawa,Junichi Kawakami
Journal of Chromatography B, 1146, 122121-122121, Jun. 2020, Refereed
Corresponding

A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation
Koji Suzuki,Takafumi Naito,Hironari Tanaka,Yasuhide Yamada,Kunihiko Itoh,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 42(3), 503-511, Jun. 2020, Refereed
Corresponding

Construction of Quantitative Analysis Workflow for Determination of Serum Concentrations of Monoclonal Antibody Drugs Aiming to Promote Therapeutic Drug Monitoring in Clinical Practice
Takafumi NAITO,Kaito SHIBATA,Hiroaki SHIDA,Kazuki ABE,Junichi KAWAKAMI
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 51(3), 161-166, 31 May 2020, Refereed, Invited
Lead, Corresponding

Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients
Kohei Hoshikawa,Takafumi Naito,Shunta Akutsu,Masao Saotome,Yuichiro Maekawa,Junichi Kawakami
Basic & Clinical Pharmacology & Toxicology, 126(4), 353-363, Apr. 2020, Refereed
Corresponding

An enantiomeric quantitative LC-MS/MS method for tolvaptan and its monohydroxylates in human plasma using a reversed-phase separation procedure
Shunta Akutsu,Takafumi Naito,Kohei Hoshikawa,Masao Saotome,Yuichiro Maekawa,Junichi Kawakami
Journal of Pharmaceutical and Biomedical Analysis, 180, 113061-113061, Feb. 2020, Refereed
Corresponding

Quantitative LC-MS/MS method for nivolumab in human serum using IgG purification and immobilized tryptic digestion
Kazuki Abe,Kaito Shibata,Takafumi Naito,Masato Karayama,Etsuko Hamada,Masato Maekawa,Yasuhide Yamada,Takafumi Suda,Junichi Kawakami
Analytical Methods, 12(1), 54-62, 2020, Refereed
Corresponding

Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process
Masaki Tashiro,Takafumi Naito,Chikoto Yamamoto,Shin-Ya Katoh,Junichi Kawakami
Biological and Pharmaceutical Bulletin, 42(12), 2062-2068, 01 Dec. 2019, Refereed
Corresponding

Impact of flavin-containing monooxygenase 3 and CYP2C19 genotypes on plasma disposition and adverse effects of voriconazole administered orally in immunocompromised patients
Takahiro Yamada,Yasuaki Mino,Takafumi Naito,Junichi Kawakami
JOURNAL OF INFECTION AND CHEMOTHERAPY, 25(12), 1019-1025, Dec. 2019, Refereed
Corresponding

Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients
Nozomi Yoshikawa,Takafumi Naito,Tatsuya Yagi,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 41(5), 591-597, Oct. 2019, Refereed
Corresponding

Is Dose Adjustment of Prednisolone Required in Patients With IgA Nephropathy During Rifampicin Treatment for Mycobacterium avium Complex Lung Disease?
Nozomi Yoshikawa,Naro Ohashi,Takayuki Tsuji,Soichiro Nagata,Takafumi Naito,Hideo Yasuda,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 41(4), 546-547, Aug. 2019, Refereed

Relationships between concomitant biologic DMARDs and prednisolone administration and blood tacrolimus exposure or serum CYP3A4/5-related markers in rheumatoid arthritis patients
Takafumi Naito,Junya Ohshiro,Hikaru Sato,Eiji Torikai,Motohiro Suzuki,Noriyoshi Ogawa,Junichi Kawakami
CLINICAL BIOCHEMISTRY, 69, 8-14, Jul. 2019, Refereed
Lead, Corresponding

Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension
Reina Taguchi,Takafumi Naito,Naoko Kubono,Noriyoshi Ogawa,Hiroaki Itoh,Junichi Kawakami
Pregnancy Hypertension, 17, 209-215, Jul. 2019, Refereed
Corresponding

Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma
Kohei Hoshikawa,Takafumi Naito,Masao Saotome,Yuichiro Maekawa,Junichi Kawakami
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 56(3), 387-396, May 2019, Refereed
Corresponding

Optimization of Individual Pharmacotherapy Based on Multiple Evaluations of Patient Data
Takafumi Naito
Biological and Pharmaceutical Bulletin, 42(2), 149-157, 01 Feb. 2019, Refereed, Invited
Lead, Corresponding

Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation
Shigeki Ikeya,Jun-ichi Sakabe,Takahiro Yamada,Takafumi Naito,Yoshiki Tokura
SCIENTIFIC REPORTS, 8(1), Dec. 2018, Refereed

Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients
Hironari Tanaka,Takafumi Naito,Hikaru Sato,Takanori Hiraide,Yasuhide Yamada,Junichi Kawakami
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 74(11), 1461-1469, Nov. 2018, Refereed
Corresponding

Simple LC-MS/MS Methods Using Core–Shell Octadecylsilyl Microparticulate for the Quantitation of Total and Free Daptomycin in Human Plasma
Yukari Miyadera,Takafumi Naito,Takahiro Yamada,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 40(5), 589-595, Oct. 2018, Refereed
Corresponding

LC–MS/MS method for denosumab quantitation in human serum with rapid protein digestion using immobilized trypsin
Hiroaki Shida,Takafumi Naito,Kaito Shibata,Yasuhide Yamada,Junichi Kawakami
Bioanalysis, 10(18), 1501-1510, Sep. 2018, Refereed
Corresponding

Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients
Masaki Tashiro,Takafumi Naito,Yoshiyuki Kagawa,Junichi Kawakami
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 55(3), 385-393, May 2018, Refereed
Corresponding

Validated LC–MS/MS Method for Simultaneous Determination of Aripiprazole and its Three Metabolites in Human Plasma
Yusuke Suzuki,Takafumi Naito,Junichi Kawakami
Chromatographia, 80(12), 1805-1812, Dec. 2017, Refereed
Corresponding

Validated LC-MS/MS Method for the Simultaneous Determination of Amlodipine and Its Major Metabolites in Human Plasma of Hypertensive Patients
Reina Taguchi,Takafumi Naito,Hikaru Sato,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 39(6), 625-631, Dec. 2017, Refereed
Corresponding

Simple and rapid LC-MS/MS method for the absolute determination of cetuximab in human serum using an immobilized trypsin
Kaito Shibata,Takafumi Naito,Jun Okamura,Seiji Hosokawa,Hiroyuki Mineta,Junichi Kawakami
Journal of Pharmaceutical and Biomedical Analysis, 146, 266-272, Nov. 2017, Refereed
Corresponding

Mycophenolic acid exposure and complement fraction C3 influence inosine 5′-monophosphate dehydrogenase activity in systemic lupus erythematosus
Yasuaki Mino,Takafumi Naito,Kumiko Shimoyama,Noriyoshi Ogawa,Junichi Kawakami
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 54(4), 490-494, Jul. 2017, Refereed
Corresponding

Transfer of vaginal chloramphenicol to circulating blood in pregnant women and its relationship with their maternal background and neonatal health
Satoe Harauchi,Takashi Osawa,Naoko Kubono,Hiroaki Itoh,Takafumi Naito,Junichi Kawakami
JOURNAL OF INFECTION AND CHEMOTHERAPY, 23(7), 446-451, Jul. 2017, Refereed
Corresponding

Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain
Hironari Tanaka,Takafumi Naito,Yasuaki Mino,Junichi Kawakami
Journal of Pharmaceutical Health Care and Sciences, 2(1), Dec. 2016, Refereed
Corresponding

Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients
Hikaru Sato,Takafumi Naito,Takuya Ishida,Junichi Kawakami
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 72(12), 1463-1470, Dec. 2016, Refereed
Corresponding

A Validated Fluorometric Method for the Rapid Determination of Pregabalin in Human Plasma Applied to Patients With Pain
Nozomi Yoshikawa,Takafumi Naito,Tatsuya Yagi,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 38(5), 628-633, Oct. 2016, Refereed
Corresponding

Trends in Non-prescription Drug Recalls in Japan
Chikoto Yamamoto,Takuya Ishida,Takashi Osawa,Takafumi Naito,Junichi Kawakami
YAKUGAKU ZASSHI, 136(9), 1307-1312, 01 Sep. 2016, Refereed
Corresponding

Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain
Takuya Ishida,Takafumi Naito,Hikaru Sato,Junichi Kawakami
DRUG METABOLISM AND PHARMACOKINETICS, 31(3), 242-248, Jun. 2016, Refereed
Corresponding

Population pharmacokinetics analysis of generic teicoplanin with MRSA or GPC infection by multicenter study
Tsuji Y, Ota Y, Kasai H, Hiraki Y, Yamada T, Matsunaga N, Ohishi H, Yaguchi T, Kitahara T, Naito T, To H
The Japanese Journal of Therapeutic Drug Monitoring, 32(4), 188-197, Dec. 2015, Refereed, Not invited

CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine
Takafumi Naito,Naoko Kubono,Takuya Ishida,Shuhei Deguchi,Masahisa Sugihara,Hiroaki Itoh,Naohiro Kanayama,Junichi Kawakami
DRUG METABOLISM AND PHARMACOKINETICS, 30(6), 419-424, Dec. 2015, Refereed
Lead, Corresponding

Interindividual Variation of Pharmacokinetic Disposition of and Clinical Responses to Opioid Analgesics in Cancer Pain Patients
Takafumi Naito,Junichi Kawakami
YAKUGAKU ZASSHI, 135(5), 709-715, 01 May 2015, Refereed, Invited
Lead, Corresponding

Amlodipine Passage into Breast Milk in Lactating Women with Pregnancy-Induced Hypertension and Its Estimation of Infant Risk for Breastfeeding
Takafumi Naito,Naoko Kubono,Shuhei Deguchi,Masahisa Sugihara,Hiroaki Itoh,Naohiro Kanayama,Junichi Kawakami
Journal of Human Lactation, 31(2), 301-306, May 2015, Refereed
Lead, Corresponding

Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application
Takuya Ishida,Takafumi Naito,Junichi Kawakami
Biomedical Chromatography, 29(5), 643-646, May 2015, Refereed
Corresponding

ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis
Takafumi Naito,Yasuaki Mino,Yuki Aoki,Kumi Hirano,Kumiko Shimoyama,Noriyoshi Ogawa,Yoshiyuki Kagawa,Junichi Kawakami
CLINICA CHIMICA ACTA, 445, 79-84, May 2015, Refereed
Lead, Corresponding

Impact of inflammation and concomitant glucocorticoid administration on plasma concentration of triazole antifungals in immunocompromised patients
Takafumi Naito,Takahiro Yamada,Yasuaki Mino,Junichi Kawakami
CLINICA CHIMICA ACTA, 441, 127-132, Feb. 2015, Refereed
Lead, Corresponding

Saturated Metabolism of Voriconazole N-Oxidation Resulting in Nonlinearity of Pharmacokinetics of Voriconazole at Clinical Doses
Takahiro Yamada,Yasuaki Mino,Tatsuya Yagi,Takafumi Naito,Junichi Kawakami
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(10), 1496-1503, 2015, Refereed
Corresponding

Blood distribution of bortezomib and its kinetics in multiple myeloma patients
Takashi Osawa,Takafumi Naito,Takanori Kaneko,Yasuaki Mino,Kazunori Ohnishi,Hiroshi Yamada,Junichi Kawakami
CLINICAL BIOCHEMISTRY, 47(15), 54-59, Oct. 2014, Refereed

Impact of CYP3A5*3 on Plasma Exposure and Urinary Excretion of Fentanyl and Norfentanyl in the Early Postsurgical Period
Noriaki Tanaka,Takafumi Naito,Tatsuya Yagi,Matsuyuki Doi,Shigehito Sato,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 36(3), 345-352, Jun. 2014, Refereed

Simple and validated UHPLC method coupled to UV detection for determination of daptomycin in human plasma and urine
Takafumi Naito,Takahiro Yamada,Tatsuya Yagi,Junichi Kawakami
Biomedical Chromatography, 28(3), 317-319, Mar. 2014, Refereed

Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients
Masaki Tashiro,Takafumi Naito,Kazunori Ohnishi,Yoshiyuki Kagawa,Junichi Kawakami
CLINICA CHIMICA ACTA, 429, 175-180, Feb. 2014, Refereed

Medication Incidents Related to the Process of Prescribing, Dispensing, and Administration of Medicines to Pediatric Patients
Yasuaki Mino,Takafumi Naito,Kazuka Kasahara,Junichi Kawakami
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 40(8), 449-453, 2014, Refereed
Corresponding

Optimization of Individualized Analgesic Therapy in Patients with Cancer Pain
Junichi KAWAKAMI,Takafumi NAITO
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 45(4), 169-175, 2014, Refereed, Invited

Plasma exposure of free linezolid and its ratio to minimum inhibitory concentration varies in critically ill patients
Tatsuya Yagi,Takafumi Naito,Matsuyuki Doi,Osanori Nagura,Takahiro Yamada,Masato Maekawa,Shigehito Sato,Junichi Kawakami
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 42(4), 329-334, Oct. 2013, Refereed

Cancer Cachexia Raises the Plasma Concentration of Oxymorphone Through the Reduction of CYP3A But Not CYP2D6 in Oxycodone-Treated Patients
Takafumi Naito,Masaki Tashiro,Takuya Ishida,Kazunori Ohnishi,Junichi Kawakami
The Journal of Clinical Pharmacology, 53(8), 812-818, Aug. 2013, Refereed
Lead

Interindividual Variations in Aprepitant Plasma Pharmacokinetics in Cancer Patients Receiving Cisplatin-Based Chemotherapy for the First Time
Shinya Motohashi,Yasuaki Mino,Katsuhito Hori,Takafumi Naito,Seiji Hosokawa,Hiroshi Furuse,Seiichiro Ozono,Hiroyuki Mineta,Junichi Kawakami
Biological and Pharmaceutical Bulletin, 36(4), 676-681, Apr. 2013, Refereed

Investigation of voluntary recall of drug product by pharmaceutical manufacturers in Japan
Ishida T, Naito T, Osawa T, Yamakawa K, Kawakami J
Journal of Japanese Society of Hospital Pharmacists, 49(3), 283-286, Mar. 2013, Refereed, Not invited

Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole
Yasuaki Mino,Takafumi Naito,Takayuki Watanabe,Takahiro Yamada,Tatsuya Yagi,Hiroshi Yamada,Junichi Kawakami
CLINICA CHIMICA ACTA, 415, 128-132, Jan. 2013, Refereed

Impact of CYP3A5 genetic polymorphism on cross-reactivity in tacrolimus chemiluminescent immunoassay in kidney transplant recipients
Kumi Hirano,Takafumi Naito,Yasuaki Mino,Tatsuya Takayama,Seiichiro Ozono,Junichi Kawakami
CLINICA CHIMICA ACTA, 414, 120-124, Dec. 2012, Refereed

Comparison of Contamination Levels on the Exterior Surfaces of Vials Containing Platinum Anticancer Drugs in Japan
Takafumi Naito,Takashi Osawa,Naoya Suzuki,Toshiya Goto,Akira Takada,Hidenori Nakamichi,Yoshiko Onuki,Kimie Imai,Kunio Nakanishi,Junichi Kawakami
Biological and Pharmaceutical Bulletin, 35(11), 2043-2049, Nov. 2012, Refereed
Lead

Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients
Takafumi Naito,Masaki Tashiro,Keisuke Yamamoto,Kazunori Ohnishi,Yoshiyuki Kagawa,Junichi Kawakami
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 68(10), 1411-1418, Oct. 2012, Refereed
Lead

Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry
Masaki Tashiro,Takafumi Naito,Yoshiyuki Kagawa,Junichi Kawakami
Biomedical Chromatography, 26(6), 754-760, Jun. 2012, Refereed

Impact of CYP3A5 and ABCB1 Gene Polymorphisms on Fentanyl Pharmacokinetics and Clinical Responses in Cancer Patients Undergoing Conversion to a Transdermal System
Yoshiaki Takashina,Takafumi Naito,Yasuaki Mino,Tatsuya Yagi,Kazunori Ohnishi,Junichi Kawakami
DRUG METABOLISM AND PHARMACOKINETICS, 27(4), 414-421, Apr. 2012, Refereed

Effective plasma concentrations of mycophenolic acid and its glucuronide in systemic lupus erythematosus patients in the remission-maintenance phase
Yasuaki Mino,Takafumi Naito,Kumiko Shimoyama,Noriyoshi Ogawa,Junichi Kawakami
Journal of Clinical Pharmacy and Therapeutics, 37(2), 217-220, Apr. 2012, Refereed

Impact of Concomitant Antacid Administration on Gabapentin Plasma Exposure and Oral Bioavailability in Healthy Adult Subjects
Tatsuya Yagi,Takafumi Naito,Yasuaki Mino,Kazuo Umemura,Junichi Kawakami
DRUG METABOLISM AND PHARMACOKINETICS, 27(2), 248-254, Feb. 2012, Refereed

Rapid and validated fluorometric HPLC method for determination of gabapentin in human plasma and urine for clinical application
Tatsuya Yagi,Takafumi Naito,Yasuaki Mino,Yoshiyuki Takashina,Kazuo Umemura,Junichi Kawakami
Journal of Clinical Pharmacy and Therapeutics, 37(1), 89-94, Feb. 2012, Refereed

Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application
Takafumi Naito,Yoshiaki Takashina,Tatsuya Yagi,Junichi Kawakami
Chemical and Pharmaceutical Bulletin, 60(1), 56-61, Jan. 2012, Refereed
Lead

Rapid simultaneous determination of voriconazole and its N-oxide in human plasma using an isocratic high-performance liquid chromatography method and its clinical application
Takahiro Yamada,Yasuaki Mino,Tatsuya Yagi,Takafumi Naito,Junichi Kawakami
CLINICAL BIOCHEMISTRY, 45(1-2), 134-138, Jan. 2012, Refereed

CYP3A5*3 Affects Plasma Disposition of Noroxycodone and Dose Escalation in Cancer Patients Receiving Oxycodone
Takafumi Naito,Yoshiaki Takashina,Keisuke Yamamoto,Masaki Tashiro,Kazunori Ohnishi,Yoshiyuki Kagawa,Junichi Kawakami
The Journal of Clinical Pharmacology, 51(11), 1529-1538, Nov. 2011, Refereed
Lead

Validated method using liquid chromatography-electrospray ionization tandem mass spectrometry for the determination of contamination of the exterior surface of vials containing platinum anticancer drugs
Takashi Osawa,Takafumi Naito,Naoya Suzuki,Kimie Imai,Kunio Nakanishi,Junichi Kawakami
Talanta, 85(3), 1614-1620, Sep. 2011, Refereed

Pharmacokinetic Variability of Mycophenolic Acid and Its Glucuronide in Systemic Lupus Erythematosus Patients in Remission Maintenance Phase
Yasuaki Mino,Takafumi Naito,Kumiko Shimoyama,Noriyoshi Ogawa,Junichi Kawakami
Biological and Pharmaceutical Bulletin, 34(5), 755-759, May 2011, Refereed

Suitability of chemiluminescent enzyme immunoassay for the measurement of blood tacrolimus concentrations in rheumatoid arthritis
Kumi Hirano,Shuji Maruyama,Yasuaki Mino,Takafumi Naito,Junichi Kawakami
CLINICAL BIOCHEMISTRY, 44(5-6), 397-402, Apr. 2011, Refereed

Cyclosporine alters correlation between free and total mycophenolic acid in kidney transplant recipients in the initial phase
Yasuaki Mino,Takafumi Naito,Atsushi Otsuka,Tatsuya Takayama,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
Journal of Clinical Pharmacy and Therapeutics, 36(2), 217-224, Apr. 2011, Refereed

Evidence-based pharmaceutical care using therapeutic drug monitoring of immunosuppressants in clinical practice
Takafumi Naito
Journal of Pharmaceutical Health Care and Sciences, 37(5), 277-287, 2011, Refereed, Invited
Lead, Corresponding

Optimal Immunosuppressive Therapy Based on Pharmacokinetics and Pharmacodynamics of Antimetabolites in Clinical Practice
Takafumi Naito
YAKUGAKU ZASSHI, 130(12), 1695-1700, 01 Dec. 2010, Refereed, Invited
Lead, Corresponding

Surveillance of workplace contamination and occupational exposure to antineoplastic agents in a hospital setting: establishment of a monitoring method using Doxorubicin
Matsumoto Keiji,Naito Takafumi,Hori Katsuhito,Suzuki Naoya,Miyamoto Yasunori,Takashina Yoshiaki,Ohnishi Kazunori,Kawakami Junichi
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130(3), 431-9, Mar. 2010, Refereed, Not invited

Effects of histamine H2-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide
Hiroki Itoh,Takafumi Naito,Masaharu Takeyama
JOURNAL OF PHARMACY AND PHARMACOLOGY, 54(11), 1559-1563, Feb. 2010, Refereed

Impact of Concentrative Nucleoside Transporter 1 Gene Polymorphism on Oral Bioavailability of Mizoribine in Stable Kidney Transplant Recipients
Takafumi Naito,Shunsuke Tokashiki,Yasuaki Mino,Atsushi Otsuka,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
Basic & Clinical Pharmacology & Toxicology, 106(4), 310-316, Nov. 2009, Refereed
Lead

Inosine monophosphate dehydrogenase activity depends on plasma concentrations of mycophenolic acid and its glucuronides in kidney transplant recipients
Yasuaki Mino,Takafumi Naito,Atsushi Otsuka,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
CLINICA CHIMICA ACTA, 409(1-2), 56-61, Nov. 2009, Refereed

Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure
Yoshiaki Takashina,Takafumi Naito,Yasuaki Mino,Yoshiyuki Kagawa,Junichi Kawakami
Journal of Clinical Pharmacy and Therapeutics, 34(5), 523-529, Oct. 2009, Refereed

Impact of Calcineurin Inhibitors on Urinary Excretion of Mycophenolic Acid and Its Glucuronide in Kidney Transplant Recipients
Takafumi Naito,Yasuaki Mino,Atsushi Otsuka,Tomomi Ushiyama,Toshiki Ito,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
The Journal of Clinical Pharmacology, 49(6), 710-718, Jun. 2009, Refereed
Lead

Cyclosporine concentration-dependent increase in concentration ratio of mycophenolic acid acyl and phenol glucuronides to mycophenolic acid in stable kidney transplant recipients
Yasuaki Mino,Takafumi Naito,Atsushi Otsuka,Tomomi Ushiyama,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
CLINICAL BIOCHEMISTRY, 42(7-8), 595-601, May 2009, Refereed

Comparison of Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Between Patients With Lupus Nephritis and With Kidney Transplantation
Yasuaki Mino,Takafumi Naito,Tomomi Matsushita,Atsushi Otsuka,Tomomi Ushiyama,Seiichiro Ozono,Akira Hishida,Yoshiyuki Kagawa,Junichi Kawakami
THERAPEUTIC DRUG MONITORING, 30(6), 656-661, Dec. 2008, Refereed

Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients
Takafumi Naito,Yasuaki Mino,Atsushi Otsuka,Tomomi Ushiyama,Seiichiro Ozono,Yoshiyuki Kagawa,Junichi Kawakami
Biological and Pharmaceutical Bulletin, 31(6), 1292-1296, Jun. 2008, Refereed
Lead

Simultaneous determination of mycophenolic acid and its glucuronides in human plasma using isocratic ion pair high-performance liquid chromatography
Yasuaki Mino,Takafumi Naito,Tomomi Matsushita,Yoshiyuki Kagawa,Junichi Kawakami
Journal of Pharmaceutical and Biomedical Analysis, 46(3), 603-608, Feb. 2008, Refereed

Effects of Calcineurin Inhibitors on Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Metabolite during the Maintenance Period Following Renal Transplantation
Takafumi Naito,Kazuko Shinno,Toshio Maeda,Yoshiyuki Kagawa,Hisakuni Hashimoto,Atsushi Otsuka,Tatsuya Takayama,Tomomi Ushiyama,Kazuo Suzuki,Seiichiro Ozono
Biological and Pharmaceutical Bulletin, 29(2), 275-280, Feb. 2006, Refereed
Lead, Corresponding

Monitoring Plasma Neuropeptide-Like Immunoreactivity Levels in a Patient Given Hange-koboku-to for a Week for Swallowing Reflex Disorder
Takafumi Naito,Hiroki Itoh,Fumihiko Katagiri,Hisakuni Hashimoto,Masaharu Takeyama
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 31(7), 585-590, Jul. 2005, Refereed
Lead, Corresponding

Effects of Hange-koboku-to (Banxia-houpo-tang) on Neuropeptide Levels in Human Plasma and Saliva
Takafumi Naito,Hiroki Itoh,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 26(11), 1609-1613, Nov. 2003, Refereed
Lead, Corresponding

Comparison of the Effects of Hange-shashin-to and Rikkunshi-to on Human Plasma Calcitonin Gene-Related Peptide and Substance P Levels
Takafumi Naito,Hiroki Itoh,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 26(8), 1104-1107, Aug. 2003, Refereed
Lead, Corresponding

Application of an Enzyme Immunoassay for Nociceptin (Orphanin FQ)-like Immunoreactive Substances to Determination of the Human Plasma Levels
Takafumi Naito,Hiroki Itoh,Masaharu Takeyama
Journal of health science, 49(5), 353-358, May 2003, Refereed, Not invited
Lead, Corresponding

Some Gastrointestinal Function Regulatory Kampo Medicines Have Modulatory Effects on Human Plasma Adrenocorticotropic Hormone and Cortisol Levels with Continual Stress Exposure.
Takafumi Naito,Hiroki Itoh,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 26(1), 101-104, Jan. 2003, Refereed
Lead, Corresponding

Hange-shashin-to Raises Levels of Somatostatin, Motilin, and Gastrin in the Plasma of Healthy Subjects.
Takafumi Naito,Hiroki Itoh,Fumitaka Yasunaga,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 25(3), 327-331, Mar. 2002, Refereed
Lead, Corresponding

Lafutidine Changes Levels of Somatostatin, Calcitonin Gene-Related Peptide, and Secretin in Human Plasma
Hiroki Itoh,Takafumi Naito,Masaharu Takeyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 25(3), 379-382, Mar. 2002, Refereed

Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma.
Takafumi Naito,Hiroki Itoh,Fumitaka Yasunaga,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 24(7), 841-843, Jul. 2001, Refereed
Lead, Corresponding

Effects of Ninjin-to on Levels of Brain-Gut Peptides (Motilin, Vasoactive Intestinal Peptide, Gastrin, and Somatostatin) in Human Plasma.
Takafumi Naito,Hiroki Itoh,Toshiaki Nagano,Masaharu Takeyama
Biological and Pharmaceutical Bulletin, 24(2), 194-196, Feb. 2001, Refereed
Lead, Corresponding

Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier
Deguchi Y, Yokoyama Y, Sakamoto T, Hayashi H,Naito T, Yamada S, Kimura R
Life Sciences, 66(7), 649-662, Jul. 2000, Refereed, Not invited

Increase in receptor binding affinity for nimodipine in the rat brain with permanent occlusion of bilateral carotid arteries
Shizuo Yamada,Shinya Uchida,Takafumi Naito,Akihiko Urayama,Ryohei Kimura,Yukihisa Murakami,Kinzo Matsumoto,Hiroshi Watanabe
Life Sciences, 66(14), 1351-1357, Feb. 2000, Refereed

Improved Brain Delivery of a Nonsteroidal Anti-Inflammatory Drug with a Synthetic Glyceride Ester: a Preliminary Attempt at a CNS Drug Delivery System for the Therapy of Alzheimer's Disease
Yoshiharu Deguchi,Hideki Hayashi,Shinobu Fujii,Takafumi Naito,Yoshinari Yokoyama,Shizuo Yamada,Ryohei Kimura
Journal of Drug Targeting, 8(6), 371-381, Jan. 2000, Refereed

Blood-Brain Barrier Transport of 125I-Labeled Basic Fibroblast Growth Factor
Yoshiharu Deguchi,Takafumi Naito,Takuro Yuge,Akihiko Furukawa,Shizuo Yamada,William M. Pardridge,Ryohei Kimura
Pharmaceutical Research, 17(1), 63-69, Jan. 2000, Refereed

臨床現場における液体クロマトグラフ質量分析計を用いた生体試料中薬物分析
内藤隆文
第40回日本TDM学会・学術大会, Jul. 2024

人材育成や情報発信を通じて社会に貢献する
内藤隆文
信州大学医学部新教授セミナー, May 2024

信州大学医学部附属病院における入院前休薬の指示漏れ状況に関する薬効毎の比較
松尾純, 小澤秀介, 上松祐貴, 岩本有紀, 岩下わかな, 本木絵梨奈, 松澤菜津子, 小原美保, 小松春香, 土屋広行, 内藤隆文
第144回日本薬学会年会, Mar. 2024

大学病院薬剤部における業務改革および研究活動への取り組み
内藤隆文
茨城県病院薬剤師セミナー, Jan. 2024

術後患者におけるデクスメデトミジンの睡眠の質改善効果の個体間変動要因の検証
八木達也, 見野靖晃, 三浦基靖, 加藤 弘美, 内藤隆文, 土井松幸, 御室総一郎, 中島芳樹, 川上純一
第44回日本臨床薬理学会学術総会, Dec. 2023

医師の働き方改革に伴う当直体制変更に併せた病棟配置薬運用の標準化
三村享, 土屋広行, 寺澤美穂, 清水郁夫, 大屋大, 江津篤, 牧田ゆかり, 増田雄一, 内藤隆文, 関島良樹
第18回医療の質・安全学会学術集会, Nov. 2023

イトラコナゾール併用により血中エベロリムス濃度が著明に上昇した肝移植患者の1例
堀口香織, 成田一理, 三田篤義, 副島雄二, 内藤隆文
第25回松本薬剤師会学術交流会, Nov. 2023

複数医療機関で行った保険薬局への研修会
鬼窪利英, 中村久美, 渡辺宏晃, 岩本大紀, 石曽根好雅, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

抗菌薬適正使用支援チームリンク薬剤師制度導入による菌血症患者におけるアウトカム評価
吉川結美, 橋本麻衣子, 松本剛, 平井啓太, 土屋広行, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

婦人科がん術後患者に対する大建中湯およびエノキサパリンの使用が肝障害に与える影響
渡辺宏晃, 平井啓太, 中澤佑香, 小池彩花, 土屋広行, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

周術期薬剤管理加算に係る専任薬剤師の業務時間に及ぼす手術部への非薬剤師配置の効果
本木絵梨奈, 岩間創, 岩下わかな, 坂上進, 堀口香織, 中内佳奈, 松澤菜津子, 太田早紀, 竹澤崇, 土屋広行, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

てんかんを合併した日本人妊婦におけるレベチラセタムの胎盤移行性を評価した1例
松澤菜津子, 小澤秀介, 田中泰裕, 布施谷千穂, 菊地範彦, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

免疫チェックポイント阻害薬投与患者における血栓塞栓症の発症頻度およびリスク因子の評価
井出貴之, 荒木太亮, 内藤隆文, 小泉知展
第33回日本医療薬学会年会, Nov. 2023

胸腺癌に対しレンバチニブ服用後にANCA関連血管炎を発症した1症例：レンバチニブとIL-6の血中濃度からの考察
朝倉充俊, 岩間創, 見野靖晃, 中津川瑛美, 小泉知展, 内藤隆文
第33回日本医療薬学会年会, Nov. 2023

がん病態時における血中ナルデメジン濃度と排便効果に及ぼす遺伝子多型と悪液質進行の影響
中津川瑛美, 内藤隆文, 柴田海斗, 前川真人, 川上純一
第33回日本医療薬学会年会, Nov. 2023

Patient Flow Management を通じた薬物治療管理とその先にあるもの
内藤隆文
静薬学友会長野県同窓会総会, Oct. 2023

薬剤師が行う医療薬科学研究とその先に見えるもの
内藤隆文
第17回次世代を担う若手のための医療薬科学シンポジウム, Sep. 2023

Combined impact of inflammation and pharmacogenomic variants on voriconazole trough concentrations: a meta-analysis of individual data.
Bolcato L, Khouri C, Veringa A, Alffenaar JWC, Yamada T, Naito T, Lamoureux F, Fonrose X, Stanke-Labesque F, Gautier-Veyret E
The 19th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT2021), Sep. 2021

Impact of CYP2D6 activity on enantiomeric pharmacokinetics of tramadol and its demethylated metabolites in patients with head and neck cancer
Suzuki K,Naito T,Tanaka H,Yamada Y,Itoh K,Kawakami J
The 7th Pharmaceutical Sciences World Congress (PSWC2020), Sep. 2020

Relationships between serum nivolumab and peripheral blood lymphocyte, serum IgG, or cachexia stage in cancer patients
Abe K,Shibata K,Naito T,Karayama M,Otsuka A,Maekawa M,Yamada Y,Miyake H,Suda T,Kawakami J
The 7th Pharmaceutical Sciences World Congress (PSWC2020), Sep. 2020

A rapid analytical method using an LC-MS/MS for quantitation of serum tocilizumab and its clinical application
Mochizuki T,Shibata K,Naito T,Shimoyama K,Ogawa N,Kawakami J
The 18th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT2020), Sep. 2020

Relationship between plasma free aprepitant metabolite and chemotherapy-induced nausea in head and neck cancer patients
Suzuki Y, Naito T, Shibata K, Hosokawa S, Mineta H, Kawakami J
The 121st Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT2020), Mar. 2020, American Society for Clinical Pharmacology and Therapeutics

Rapid quantitative LC-MS/MS method of tocilizumab in human serum using immobilized tryptic digestion
Mochizuki T,Shibata K,Naito T,Shimoyama K,Ogawa N,Kawakami J
The 121st Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT2020), Mar. 2020, American Society for Clinical Pharmacology and Therapeutics

Impact of endogenous serum immunoglobulin G on serum level of denosumab in cancer patients
Shida H, Naito T, Shibata K, Yamada Y, Kawakami J
The 14th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2019), Jun. 2019, European Association for Clinical Pharmacology and Therapeutics

A validated lc-ms/ms method for simultaneous quantitation of tolvaptan and its monohydroxylate enantiomers in human plasma using a reversed-phase separation mode
Hoshikawa K, Naito T, Saotome M, Maekawa Y, Kawakami J
The 14th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2019), Jun. 2019, European Association for Clinical Pharmacology and Therapeutics