TOCHIO Takumi
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Professor
Researcher Information
Research activity information
Award
- 2023
公益財団法人 発明協会, 発明奨励賞
International academic award - 2023
日本マーケティング学会, ベストポスター賞
腸内環境を良くする餡子「腸ええ餡」の開発, International academic award - 2021
公益社団法人 発明協会, 発明奨励賞
International academic award - 2019
一般社団法人 ウエルネスフーズ, ウエルネスフーズアワード2019 食品原料部門銅賞
International academic award - 2019
公益社団法人 日本栄養・食糧学会, 研究技術賞
International academic award - 2018
公益財団法人 食品科学振興財団, 飯島藤十郎食品技術賞
International academic award - 2017
一般社団法人 日本プロバイオティクス学会, 日本プロバイオティクス学会 学会賞
International academic award
Paper
- Development of engineered IL-36γ-hypersecreting Lactococcus lactis to improve the intestinal environment
Masahiro Yoda; Shogo Takase; Kaho Suzuki; Aito Murakami; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato*
World Journal of Microbiology and Biotechnology, in press, Oct. 2024, Refereed
Lead - Alterations in the Gut Microbiota in Patients with Long-Term Follow-Up after Pancreaticoduodenectomy and Their Association with Postoperative Fatty Liver: A Pilot Study.
Yuichiro Uchida; Tadashi Fujii; Hideaki Takahashi; Kazunori Nakaoka; Kohei Funasaka; Eizaburo Ohno; Yoshiki Hirooka; Takeshi Takahara; Koichi Suda; Takumi Tochio
Pancreatology, Oct. 2024, Refereed, Not invited
Last - Altered intestinal Streptococcus anginosus and 5α-reductase gene levels in patients with hepatocellular carcinoma and elevated Bacteroides stercoris in atezolizumab/bevacizumab non-responders.
Tadashi Fujii; Teiji Kuzuya; Nobuhiro Kondo; Kohei Funasaka; Eizaburo Ohno; Yoshiki Hirooka; Takumi Tochio
Journal of medical microbiology, 73(9), Sep. 2024, Refereed, Not invited
Last - Efficacy of 1-Kestose Supplementation in Patients with Pancreatic Ductal Adenocarcinoma: A Randomized Controlled Pilot Study
Kazunori Nakaoka; Eizaburo Ohno; Kento Kuramitsu; Teiji Kuzuya; Kohei Funasaka; Takumi Tochio; Tadashi Fujii; Hideaki Takahashi; Nobuhiro Kondo; Ryoji Miyahara; Senju Hashimoto; Yoshiki Hirooka
Nutrients, 16(17), 2889-2889, Aug. 2024, Refereed, Not invited
Last - Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides
Koki Nishida; Shinji Ueno; Yusuke Seino; Shihomi Hidaka; Naoya Murao; Yuki Asano; Haruki Fujisawa; Megumi Shibata; Takeshi Takayanagi; Kento Ohbayashi; Yusaku Iwasaki; Katsumi Iizuka; Shoei Okuda; Mamoru Tanaka; Tadashi Fujii; Takumi Tochio; Daisuke Yabe; Yuuichiro Yamada; Yoshihisa Sugimura; Yoshiki Hirooka; Yoshitaka Hayashi; Atsushi Suzuki
Nutrients, 16(14), 2270-2270, Jul. 2024, Refereed
Lead - Erythritol alters phosphotransferase gene expression and inhibits the in vitro growth of Staphylococcus coagulans isolated from canines with pyoderma
Saki Onishi-Sakamoto; Tadashi Fujii; Keito Watanabe; Reina Makida; Keita Iyori; Yoichi Toyoda; Takumi Tochio; Koji Nishifuji
Frontiers in Veterinary Science, 10, Jan. 2024, Refereed, Not invited
Lead - Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice.
Aito Murakami; Haruka Yamaguchi; Fu Namai; Takashi Sato; Maki Yamazaki; Hiroshi Uehara; Tadashi Fujii; Takumi Tochio; Kunihiro Shiomi; Takeshi Shimosato
Frontiers in cellular and infection microbiology, 14, 1383774-1383774, 2024, Refereed, Not invited
Lead - Co-administration of the prebiotic 1-kestose and the paraprobiotic <i>Lactiplantibacillus plantarum</i> FM8 in magellanic penguins promotes the activity of intestinal Lactobacillaceae and reduces the <i>plc</i> gene levels encoding <i>Clostridium perfringens</i> toxin
Tadashi FUJII; Chiho KEZUKA; Yuichiro KAWAGUCHI; Saki YAMAKAWA; Nobuhiro KONDO; Kohei FUNASAKA; Yoshiki HIROOKA; Takumi TOCHIO
Journal of Veterinary Medical Science, 86(2), 193-201, 2024, Refereed, Not invited
Last - Effects of 1‐kestose on microbiome changes caused by vonoprazan: a randomized, double‐blind, placebo‐controlled pilot study
Satoshi Furune; Takahiro Suzuki; Takashi Honda; Kenta Yamamoto; Kazuhiro Furukawa; Masanao Nakamura; Masatoshi Ishigami; Fumie Kinoshita; Yoshihiro Kadota; Takumi Tochio; Yoshiharu Shimomura; Yoshiki Hirooka; Mitsuhiro Fujishiro; Hiroki Kawashima
Journal of Gastroenterology and Hepatology, Dec. 2023, Refereed, Not invited
Lead - Topical erythritol combined with L-ascorbyl-2-phosphate inhibits staphylococcal growth and alleviates staphylococcal overgrowth in skin lesions of canine superficial pyoderma
T. Tochio, K. Kawano, K. Iyori, R. Makida, Y. Kadota, T. Fujii, H. Ishikawa, T. Yasutake, A. Watanabe, K. Funasaka, Y. Hirooka, K. Nishifuji
Polish Journal of Veterinary Sciences, Dec. 2023, Refereed, Not invited
Lead, Corresponding - Synbiotic administration in Japanese eels with prebiotic 1-kestose and probiotic Lactiplantibacillus plantarum FM8 improved feed efficiency and significantly reduced the levels of Edwardsiella
Tadashi Fujii; Masayuki Yoshikawa; Nobuhiro Kondo; Saki Yamakawa; Kohei Funasaka; Yoshiki Hirooka; Takumi Tochio
Fisheries Science, Dec. 2023, Refereed, Not invited
Last - Combined oral intake of short and long fructans alters the gut microbiota in food allergy model mice and contributes to food allergy prevention.
Hideaki Takahashi; Tadashi Fujii; Saki Yamakawa; Chikako Yamada; Kotoyo Fujiki; Nobuhiro Kondo; Kohei Funasaka; Yoshiki Hirooka; Takumi Tochio
BMC microbiology, 23(1), 266-266, Sep. 2023, Refereed, Not invited
Last - Incidence and clinical relevance of postoperative diarrhea after minimally invasive gastrectomy for gastric cancer: a single institution retrospective study of 1476 patients.
Masahiro Fujita; Masaya Nakauchi; Kazumitsu Suzuki; Akiko Serizawa; Shingo Akimoto; Tsuyoshi Tanaka; Susumu Shibasaki; Kazuki Inaba; Takumi Tochio; Yoshiki Hirooka; Ichiro Uyama; Koichi Suda
Langenbeck's archives of surgery, 408(1), 364-364, Sep. 2023, Refereed, Not invited
Lead - Kestose Increases the Relative Abundance of Faecalibacterium spp. and Nominally Increases Cow Milk Tolerant Dose in Children with Cow's Milk Allergy - Preliminary Results.
Shohei Kubota; Shiro Sugiura; Mayuko Takahashi; Yoshihiro Kadota; Yoshihiro Takasato; Teruaki Matsui; Katsumasa Kitamura; Takumi Tochio; Komei Ito
Polish journal of microbiology, 72(3), 299-306, Sep. 2023, Refereed, Not invited
Lead - Characterization and alteration of product specificity of Beijerinckia indica subsp. indica β-fructosyltransferase
Ding Li; Yuki Miyasaka; Arisa Kubota; Takuma Kozono; Yoshikazu Kitano; Nobumitsu Sasaki; Tadashi Fujii; Takumi Tochio; Yoshihiro Kadota; Atsushi Nishikawa; Takashi Tonozuka
Bioscience, Biotechnology, and Biochemistry, Jun. 2023, Refereed, Not invited
Lead - Consumption of 1-Kestose Upregulates MicroRNA-200 and -192/215 Families in Lamina Propria Leukocytes of the Murine Large Intestine
Fumina OHSAKA; Daiki HONMA; Yoshihiro KADOTA; Takumi TOCHIO; Kei SONOYAMA
Journal of Nutritional Science and Vitaminology, 69(2), 150-154, Apr. 2023, Refereed, Not invited
Lead - Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study.
Shuji Ikegami; Masanao Nakamura; Takashi Honda; Takeshi Yamamura; Keiko Maeda; Tsunaki Sawada; Eri Ishikawa; Kenta Yamamoto; Satoshi Furune; Takuya Ishikawa; Kazuhiro Furukawa; Eizaburo Ohno; Masatoshi Ishigami; Fumie Kinoshita; Yoshihiro Kadota; Takumi Tochio; Yoshiharu Shimomura; Yoshiki Hirooka; Hiroki Kawashima
Alimentary pharmacology & therapeutics, 57(11), 1249-1257, Jan. 2023, Refereed
Lead - Current Status of the Diagnosis of Early-Stage Pancreatic Ductal Adenocarcinoma.
Kazunori Nakaoka; Eizaburo Ohno; Naoto Kawabe; Teiji Kuzuya; Kohei Funasaka; Yoshihito Nakagawa; Mitsuo Nagasaka; Takuya Ishikawa; Ayako Watanabe; Takumi Tochio; Ryoji Miyahara; Tomoyuki Shibata; Hiroki Kawashima; Senju Hashimoto; Yoshiki Hirooka
Diagnostics (Basel, Switzerland), 13(2), Jan. 2023, Refereed
Lead - Oral administration of
Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
Animal Science Journal, 94(1), Jan. 2023, Refereed, Not invited
Lead - Changes in intestinal bacteria and imbalances of metabolites induced in the intestines of pancreatic ductal adenocarcinoma patients in a Japanese population: a preliminary result.
Senju Hashimoto; Takumi Tochio; Kohei Funasaka; Kazuki Funahashi; Tenagy Hartanto; Yuka Togashi; Misa Saito; Yuichiro Nishimoto; Mizuguchi Yoshinori; Kazunori Nakaoka; Ayako Watanabe; Mitsuo Nagasaka; Yoshihito Nakagawa; Ryoji Miyahara; Tomoyuki Shibata; Yoshiki Hirooka
Scandinavian journal of gastroenterology, 1-6, Aug. 2022, Refereed
Corresponding - Prediction and control of glass transition temperature for hydrogenated starch hydrolysates and its impact on the texture modification of gummy
Yuichi Kashiwakura; Tomochika Sogabe; Yuri Hiyama; Natsuki Arakawa; Tadashi Fujii; Takumi Tochio; Kiyoshi Kawai
Food Hydrocolloids, 126, May 2022, Refereed
Lead - Enzymatic and structural characterization of β-fructofuranosidase from the honeybee gut bacterium Frischella perrara.
Arisa Kubota; Reika Kawai; Ding Li; Takuma Kozono; Nobumitsu Sasaki; Atsushi Nishikawa; Tadashi Fujii; Takumi Tochio; Takashi Tonozuka
Applied microbiology and biotechnology, 106(7), 2455-2470, Apr. 2022, Refereed
Lead - Consumption of indigestible saccharides and administration of Bifidobacterium pseudolongum reduce mucosal serotonin in murine colonic mucosa.
Misa Tatsuoka; Yosuke Osaki; Fumina Ohsaka; Takeshi Tsuruta; Yoshihiro Kadota; Takumi Tochio; Shingo Hino; Tatsuya Morita; Kei Sonoyama
The British journal of nutrition, 127(4), 513-525, Feb. 2022, Refereed
Lead - The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State.
Hiroshi Matsuoka; Takumi Tochio; Ayako Watanabe; Kohei Funasaka; Yoshiki Hirooka; Tenagy Hartanto; Yuka Togashi; Misa Saito; Yuichiro Nishimoto; Yoshinori Mizuguchi; Masanobu Kumon; Chieko Sakuragi; Kouichi Suda; Yuichi Hirose; Isao Morita
Foods (Basel, Switzerland), 11(4), Feb. 2022, Refereed
Corresponding - Subjective Evaluation Using Patient-Oriented Eczema Measure of the Clinical Effects of 1-Kestose on Atopic Dermatitis in Children: A Pilot Study
Yoshihiro Kadota; Yasuhiro Koga; Takumi Tochio; Rumiko Shibata
International Journal of Probiotics and Prebiotics, 17(1), 47-52, 2022, Refereed, Not invited
Lead - 1-Kestose Supplementation Increases Levels of a 5α-Reductase Gene, a Key Isoallolithocholic Acid Biosynthetic Gene, in the Intestinal Microbiota.
Tadashi Fujii; Masahiro Nakano; Hiroe Shinohara; Hirohito Ishikawa; Takanori Yasutake; Ayako Watanabe; Kohei Funasaka; Yoshiki Hirooka; Takumi Tochio
Journal of nutritional science and vitaminology, 68(5), 446-451, 2022, Refereed
Last - Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts.
Ayako Watanabe; Takumi Tochio; Yoshihiro Kadota; Motoki Takahashi; Yasuyuki Kitaura; Hirohito Ishikawa; Takanori Yasutake; Masahiro Nakano; Hiroe Shinohara; Toru Kudo; Yuichiro Nishimoto; Yoshinori Mizuguchi; Akihito Endo; Yoshiharu Shimomura
Nutrients, 13(9), Aug. 2021, Refereed
Lead - エリスリトールはニキビや蚊誘引の原因となる皮膚常在菌の増殖を抑制する
藤井 匡; 栃尾 巧; 遠藤 明仁
応用糖質科学, 11(3), 35-35, Aug. 2021, Refereed
Lead - Oligosaccharide Metabolism and Lipoteichoic Acid Production in Lactobacillus gasseri and Lactobacillus paragasseri.
Tsukasa Shiraishi; Shintaro Maeno; Sayoko Kishi; Tadashi Fujii; Hiroki Tanno; Katsuaki Hirano; Takumi Tochio; Yasuhiro Tanizawa; Masanori Arita; Shin-Ichi Yokota; Akihito Endo
Microorganisms, 9(8), Jul. 2021, Refereed
Lead - Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Fumina Ohsaka; Yugo Karatsu; Yoshihiro Kadota; Takumi Tochio; Naoki Takemura; Kei Sonoyama
Biochemical and biophysical research communications, 534, 808-814, Jan. 2021, Refereed
Lead - Characterization of fructooligosaccharide metabolism and fructooligosaccharide-degrading enzymes in human commensal butyrate producers
Hiroki Tanno; Tadashi Fujii; Katsuaki Hirano; Shintaro Maeno; Takashi Tonozuka; Mitsuo Sakamoto; Moriya Ohkuma; Takumi Tochio; Akihito Endo
Gut Microbes, 13(1), 1-20, 2021, Refereed
Lead - Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.
Kentaro Tominaga; Atsunori Tsuchiya; Oki Nakano; Yasutoshi Kuroki; Kentaro Oka; Ayaka Minemura; Asami Matsumoto; Motomichi Takahashi; Yoshihiro Kadota; Takumi Tochio; Yusuke Niwa; Tomoaki Yoshida; Masatoshi Sato; Takeshi Yokoo; Satoru Hashimoto; Junji Yokoyama; Jun Matsuzawa; Katsuya Fujimori; Shuji Terai
Bioscience of microbiota, food and health, 40(3), 150-155, 2021, Refereed
Lead - Crystal structure of a glycoside hydrolase family 68 β-fructosyltransferase from Beijerinckia indica subsp. indica in complex with fructose.
Takashi Tonozuka; Junichi Kitamura; Mika Nagaya; Reika Kawai; Atsushi Nishikawa; Katsuaki Hirano; Keisuke Tamura; Tadashi Fujii; Takumi Tochio
Bioscience, biotechnology, and biochemistry, 84(12), 2508-2520, Dec. 2020, Refereed
Last - Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.
Teranart Udomsopagit; Akiho Miwa; Manami Seki; Emiko Shimbori; Yoshihiro Kadota; Takumi Tochio; Kei Sonoyama
Biochemical and biophysical research communications, 529(1), 64-69, Aug. 2020, Refereed
Lead - Activation of butyrate-producing bacteria as well as bifidobacteria in the cat intestinal microbiota by the administration of 1-kestose, the smallest component of fructo-oligosaccharide.
Mikako Shinohara; Masaharu Kiyosue; Takumi Tochio; Seiji Kimura; Yasuhiro Koga
The Journal of veterinary medical science, 82(7), 866-874, Jul. 2020, Refereed
Lead - Reply to Comment on Watanabe, A.; Kadota, Y.; Yokoyama, H.; Tsuruda, S.; Kamio, R.; Tochio, T.; Shimomura, Y.; Kitaura, Y. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4.
Ayako Watanabe; Yoshihiro Kadota; Takumi Tochio; Yoshiharu Shimomura; Yasuyuki Kitaura
Foods (Basel, Switzerland), 9(4), Apr. 2020, Refereed
Lead - In Vitro Evaluation of Different Prebiotics on the Modulation of Gut Microbiota Composition and Function in Morbid Obese and Normal-Weight Subjects.
Alicja M Nogacka; Nuria Salazar; Silvia Arboleya; Patricia Ruas-Madiedo; Leonardo Mancabelli; Adolfo Suarez; Ceferino Martinez-Faedo; Marco Ventura; Takumi Tochio; Katsuaki Hirano; Akihito Endo; Clara G de Los Reyes-Gavilán; Miguel Gueimonde
International journal of molecular sciences, 21(3), Jan. 2020, Refereed
Lead - Changes in the intestinal microbiota and systemic immune responses by dietary 1-kestose supplementation in healthy dogs
Y. Kadota; Y. Asami; R. Azuma; R. Oishi; K. Torihama; A. Tanaka; A. Kumagai; K. Masuda; Takumi Tochio
International Journal of Probiotics and Prebiotics, 16(1), 7-15, 2020, Refereed
Last, Corresponding - Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae.
Hiroki Tanno; Tadashi Fujii; Riichi Ose; Katsuaki Hirano; Takumi Tochio; Akihito Endo
Biochemical and biophysical research communications, 518(2), 294-298, Oct. 2019, Refereed
Lead - Rapid evaluation of 1-kestose producing β-fructofuranosidases from Aspergillus species and enhancement of 1-kestose production using a PgsA surface-display system.
Tadashi Fujii; Takumi Tochio; Katsuaki Hirano; Keisuke Tamura; Takashi Tonozuka
Bioscience, biotechnology, and biochemistry, 82(9), 1599-1605, Sep. 2018, Refereed
Lead - Crystal structure of a β-fructofuranosidase with high transfructosylation activity from Aspergillus kawachii.
Mika Nagaya; Miyoko Kimura; Yoshifumi Gozu; Shona Sato; Katsuaki Hirano; Takumi Tochio; Atsushi Nishikawa; Takashi Tonozuka
Bioscience, biotechnology, and biochemistry, 81(9), 1786-1795, Sep. 2017, Refereed
Lead - Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.
Yasuhiro Koga; Shouji Tokunaga; Jun Nagano; Fuyuhiko Sato; Kenta Konishi; Takumi Tochio; Youko Murakami; Natsuko Masumoto; Jun-Ichirou Tezuka; Nobuyuki Sudo; Chiharu Kubo; Rumiko Shibata
Pediatric research, 80(6), 844-851, Dec. 2016, Refereed
Lead - An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats.
Takumi Tochio; Yasuyuki Kitaura; Saki Nakamura; Chie Sugawa; Motoki Takahashi; Akihito Endo; Yoshiharu Shimomura
PloS one, 11(11), e0166850, 2016, Refereed
Lead, Corresponding - Embryonic dermal condensation and adult dermal papilla induce hair follicles in adult glabrous epidermis through different mechanisms.
Mutsumi Inamatsu; Takumi Tochio; Aya Makabe; Tetsuya Endo; Souichi Oomizu; Eiji Kobayashi; Katsutoshi Yoshizato
Development, growth & differentiation, 48(2), 73-86, Feb. 2006, Refereed
Lead - Characterization and alteration of product specificity of Beijerinckia indica subsp. indica β-fructosyltransferase
Ding Li; Yuki Miyasaka; Arisa Kubota; Takuma Kozono; Yoshikazu Kitano; Nobumitsu Sasaki; Tadashi Fujii; Takumi Tochio; Yoshihiro Kadota; Atsushi Nishikawa; Takashi Tonozuka - Oral administration of
Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato - Effects of 1‐kestose on microbiome changes caused by vonoprazan: a randomized, double‐blind, placebo‐controlled pilot study
Satoshi Furune; Takahiro Suzuki; Takashi Honda; Kenta Yamamoto; Kazuhiro Furukawa; Masanao Nakamura; Masatoshi Ishigami; Fumie Kinoshita; Yoshihiro Kadota; Takumi Tochio; Yoshiharu Shimomura; Yoshiki Hirooka; Mitsuhiro Fujishiro; Hiroki Kawashima
MISC
- 最新研究の今!犬と猫の"腸活"の実際(第3回) 犬の皮膚科領域への応用(1)
伊從 慶太; 高橋 秀明; 倉満 健人; 藤井 匡; 栃尾 巧
CLINIC NOTE, 20(6), 84 - 91, Jun. 2024
Lead - 消化器がんと細菌叢の研究はネクストステージへ 腸内細菌を「調べ」「改善する」ためには
栃尾 巧; 藤井 匡; 舩坂 好平; 廣岡 芳樹
日本消化器がん検診学会雑誌, 62(Suppl総会), 319 - 319, May 2024
Lead - 先進的手法を用いた消化器がん検診の可能性 腸内環境の検査を日常的に 腸内細菌検査はエンテロタイプからジェノタイプへ
栃尾 巧; 藤井 匡; 舩坂 好平; 廣岡 芳樹
日本消化器がん検診学会雑誌, 62(Suppl総会), 332 - 332, May 2024
Lead - 犬の慢性下痢に対するケストースとアガロオリゴ糖の併用効果について
高橋 秀明; 茂木 千恵; 川野 浩志; 伊從 慶太; 唐澤 幸司; 近藤 修啓; 倉満 健人; 藤井 匡; 舩坂 好平; 廣岡 芳樹; 栃尾 巧
CAP: Companion Animal Practice, 39(5), 83 - 86, May 2024
Lead - 最新研究の今!犬と猫の"腸活"の実際(第2回) 皮膚・口腔内細菌叢に対するプロ・プレバイオティクスの有効性
伊從 慶太; 高橋 秀明; 倉満 健人; 藤井 匡; 栃尾 巧
CLINIC NOTE, 20(4), 98 - 103, Apr. 2024
Lead - 短鎖および長鎖フルクタンの混合摂取は、OVAアレルギーの予防・改善それぞれに特異的な腸内細菌叢を誘導して症状を軽減させる
高橋 秀明; 栃尾 巧; 藤井 匡; 廣岡 芳樹; 藤木 理代; 山田 千佳子
日本栄養・食糧学会大会講演要旨集, 78回, 293 - 293, Apr. 2024
Lead - マゼランペンギンにおける腸内環境改善
栃尾 巧; 毛塚 千穂; 水野 友香; 河口 祐一郎; 藤井 匡; 廣岡 芳樹
日本野生動物医学会誌, 28(Suppl.), 151 - 152, Dec. 2023
Lead - プレバイオティクスの摂取が褥瘡に及ぼす影響とその分子メカニズムの解明
後藤 花梨; 栃尾 巧; 木村 愛実; 河合 文佳; 大石 祐一; 山根 拓実
日本創傷治癒学会プログラム・抄録集, 53回, 87 - 87, Nov. 2023
Lead - 腸内細菌より見た経腸栄養の諸問題~理想的な経腸栄養とは~ 意識障害患者のQOL改善におけるプレバイオティクス・プロバイオティクスの意義
栃尾 巧
Journal of Japan Coma Society: JJCS, 31(1), 46 - 46, Aug. 2023
Lead - 「意識障害患者への口腔健康管理~医科歯科連携・多職種連携」 遷延性意識障害患者の口腔ケアの妥当性の検証
松橋 文; 野中 橘花; 沓名 優惟子; 林 和弥; 中川 葉子; 松岡 宏; 栃尾 巧; 森田 功
Journal of Japan Coma Society: JJCS, 31(1), 48 - 48, Aug. 2023
Lead - 「意識障害患者への口腔健康管理~医科歯科連携・多職種連携」 集中治療室(ICU)での口腔健康管理
坂井 鮎; 金森 大輔; 栃尾 巧; 伊東 里紗; 吉田 光由
Journal of Japan Coma Society: JJCS, 31(1), 48 - 48, Aug. 2023
Lead - プレバイオティクス投与における遷延性意識障害患者の排便コントロールの検討
伊藤 瑞希; 山口 佳穂; 林 和弥; 中川 葉子; 松岡 宏; 栃尾 巧; 森田 功
Journal of Japan Coma Society: JJCS, 31(1), 71 - 71, Aug. 2023
Lead - アレルギー疾患は消化器病!? 腸とアレルギー疾患の関係
栃尾 巧
日本消化器病学会東海支部例会プログラム抄録集, 138回, 28 - 28, Jun. 2023
Lead - 抗生剤およびビフィズス菌の投与がマウス大腸粘膜固有層白血球におけるmiR-200ファミリーの発現におよぼす影響
本間 大貴; 逢坂 文那; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 77回, 185 - 185, Mar. 2023
Lead - プレバイオティクスが腸内細菌叢と食物アレルギーに与える影響
高橋 秀明; 栃尾 巧; 藤木 理代; 山田 千佳子
日本栄養・食糧学会大会講演要旨集, 77回, 247 - 247, Mar. 2023
Lead - 【機能性糖質と健康 いま大きな注目を浴びる糖質の新たな機能】プレバイオティクスによる糖尿病予防・改善の可能性
栃尾 巧
食と医療, 23, 034 - 042, Nov. 2022
Lead - Bifidobacterium longum subsp.longumにおける1-Kestose代謝メカニズムの解明
難波 有希; 倉持 碧海; 山口 颯人; 吉田 佳鼓; 後藤 恭宏; 門田 吉弘; 栃尾 巧; 小椋 義俊; 林 哲也; 前田 智也; 横田 篤; 吹谷 智
日本乳酸菌学会誌, 33(2), 120 - 120, Jun. 2022
Lead - Bifidobacterium longum subsp.longumにおける1-Kestose代謝メカニズムの解明
難波 有希; 山口 颯人; 吉田 佳鼓; 後藤 恭宏; 門田 吉弘; 栃尾 巧; 小椋 義俊; 林 哲也; 横田 篤; 吹谷 智
日本生物工学会大会講演要旨集, 2021年, 230 - 230, Oct. 2021
Lead - 食物アレルギーの管理 牛乳アナフィラキシー児の負荷試験における乳摂取量増加へのオリゴ糖ケストースの補助効果と腸内細菌叢
柴田 瑠美子; 高橋 真裕子; 栃尾 巧; 村上 洋子
アレルギー, 70(6-7), 797 - 797, Aug. 2021
https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00009&link_issn=&doc_id=20210913480367&doc_link_id=%2Fcw4aller%2F2021%2Ft07006%2F014%2F0797-0797%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw4aller%2F2021%2Ft07006%2F014%2F0797-0797%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 犬アトピー性皮膚炎における新たな臨床的アプローチの提言
川野 浩志; 伊從 慶太; 渡辺 彩子; 栃尾 巧
MVM, 30(4), 79 - 84, May 2021
Lead - 犬アトピー性皮膚炎の新規治療方法に関する提言 医学的視点導入の重要性
川野 浩志; 栃尾 巧
アレルギーの臨床, 41(2), 131 - 137, Feb. 2021
Lead - 犬アトピー性皮膚炎改善に適したシンバイオティクス治療の提唱
川野 浩志; 栃尾 巧
アレルギーの臨床, 41(1), 61 - 65, Jan. 2021
Lead - 犬アトピー性皮膚炎に対するケストースの効果
牧田 玲奈; 高橋 真裕子; 藤井 匡; 栃尾 巧; 川野 浩志
CAP: Companion Animal Practice, 36(1), 93 - 96, Jan. 2021
Lead - 酪酸産生菌の糖加水分解酵素の解析
丹野 広貴; 藤井 匡; 前野 慎太朗; 平野 勝紹; 栃尾 巧; 遠藤 明仁
日本乳酸菌学会誌, 31(3), 158 - 158, Nov. 2020
Lead - アレルギー抑制に向けた妊婦・乳幼児の腸内環境改善
栃尾 巧; 福田 真嗣
アレルギーの臨床, 40(8), 647 - 652, Jul. 2020
Lead - 腸内細菌移植後の腸内細菌叢は1-ケストース摂取による小腸RegIII β発現を増加させる
Teranart Udomsopagit; 新堀 絵美子; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 74回, 202 - 202, Apr. 2020
Lead - 大腸粘膜固有層単核球のmicroRNAの発現に影響を与える腸内細菌因子の探索
逢坂 文那; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 74回, 285 - 285, Apr. 2020
Lead - 投薬コンプライアンスの向上を図る DHCペット用パクッとおくすりの活用
隅田 浩至; 秋元 佐紀; 篠原 実可子; 井手 香織; 西藤 公司; 栃尾 巧
CAP: Companion Animal Practice, 35(3), 113 - 116, Mar. 2020
Lead - 酪酸産生菌のフルクトオリゴ糖代謝
丹野 広貴; 平野 勝紹; 藤井 匡; 大熊 盛也; 坂本 光央; 栃尾 巧; 遠藤 明仁
日本乳酸菌学会誌, 30(2), 101 - 101, Jul. 2019
Lead - 1-ケストースを含むIn vitro糞便培養による糞便微生物叢への影響
平野 勝紹; 小瀬 理市; 前野 慎太郎; 栃尾 巧; 遠藤 明仁
日本乳酸菌学会誌, 30(2), 102 - 102, Jul. 2019
Lead - ケストースの多様な生理機能の解明と実用化
栃尾 巧; 門田 吉弘; 北浦 靖之; 遠藤 明仁
日本栄養・食糧学会大会講演要旨集, 73回, 119 - 119, Apr. 2019
Lead - 1-ケストース摂取により変化した大腸粘膜固有層単核球のmicroRNAの標的mRNAの解析
逢坂 文那; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 73回, 214 - 214, Apr. 2019
Lead - Close Up! 犬の腸活始めませんか? ケストース配合製品「犬用5種の国産野菜ふりかけ」という選択
阿部 有希子; 秋元 佐紀; 隅田 浩至; 栃尾 巧; 篠原 実可子; 井手 香織; 西藤 公司
CAP: Companion Animal Practice, 34(3), 97 - 100, Mar. 2019
Lead - フラクトオリゴ糖代謝がビフィズス菌の生育および腸管常在性へ与える影響
岸 沙代子; 小瀬 理市; 平野 勝紹; 栃尾 巧; 遠藤 明仁
日本乳酸菌学会誌, 29(2), 109 - 109, Jul. 2018
Lead - 1-ケストースを摂取させたマウス結腸におけるセロトニン含量とBifidobacteriaとの関係
立岡 三沙; 逢坂 文那; Teranart Udomsopagit; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 72回, 272 - 272, Apr. 2018
Lead - 1-ケストースの摂取はマウス大腸粘膜固有層単核球のmiRNAプロファイルを変化させる
逢坂 文那; 門田 吉弘; 栃尾 巧; 園山 慶
日本栄養・食糧学会大会講演要旨集, 72回, 272 - 272, Apr. 2018
Lead - ラットの高脂肪食誘発インスリン抵抗性に対する1-ケストース摂取の影響
神尾 里奈; 高橋 基毅; 門田 吉弘; 篠原 実可子; 栃尾 巧; 遠藤 明仁; 北浦 靖之; 下村 吉治
日本栄養・食糧学会大会講演要旨集, 72回, 273 - 273, Apr. 2018
Lead - 「細菌とアレルギーの新しい考え方(ブドウ球菌、腸内細菌叢を含む)」に寄せる ケストースのアレルギー疾患改善効果
門田 吉弘; 栃尾 巧; 柴田 瑠美子; 内薗 明裕; 古賀 泰裕
アレルギーの臨床, 37(12), 1184 - 1189, Nov. 2017
Lead - ケストースの犬腸内細菌叢に対する影響
井手 香織; 篠原 実可子; 栃尾 巧; 山岸 翔平; 遠藤 明仁; 西藤 公司
日本獣医学会学術集会講演要旨集, 160回, 478 - 478, Aug. 2017
Lead - 1-ケストースによる腸内環境への影響
門田 吉弘; 高橋 基毅; 神尾 里奈; 栃尾 巧; 遠藤 明仁; 北浦 靖之; 下村 吉治
日本栄養・食糧学会大会講演要旨集, 71回, 249 - 249, Apr. 2017
Lead - マウス食物抗原感作モデルにおける難消化性オリゴ糖摂取による抗体応答への影響 ラフィノースとケストースの比較解析
平野 可奈; 櫻井 那央; 門田 吉弘; 栃尾 巧; 松田 幹
日本栄養・食糧学会大会講演要旨集, 71回, 301 - 301, Apr. 2017
Lead - 「アレルギー性鼻炎の免疫療法-最新知見-」に寄せる 1-ケストースの通年性アレルギー性鼻炎改善効果
門田 吉弘; 栃尾 巧; 古賀 泰裕; 柴田 瑠美子; 内薗 明裕
アレルギーの臨床, 37(2), 154 - 159, Feb. 2017
Lead - 「アトピー性皮膚炎の治療戦略」に寄せる アトピー性皮膚炎治療におけるプレバイオティクスの応用の可能性 1-ケストースの乳幼児アトピー性皮膚炎に対する効果
栃尾 巧; 柴田 瑠美子; 古賀 泰裕
アレルギーの臨床, 36(12), 1162 - 1167, Nov. 2016
Lead - 「特集/アレルギー疾患の新しい治療」に寄せる 1-ケストースの幼児アトピー性皮膚炎に対する効果と1-ケストース配合製品「ベビーオリゴ」の紹介
栃尾 巧; 柴田 瑠美子; 古賀 泰裕
アレルギーの臨床, 36(11), 1050 - 1055, Oct. 2016
Lead - アトピー性皮膚炎とケストース 臨床症状の改善に関する既知のデータと今後の課題
大隅 尊史; 栃尾 巧; 小西 健太; 西藤 公司
CAP: Companion Animal Practice, 31(4), 68 - 70, Apr. 2016
Lead - Canarium albumは過酸化脂質により誘導されたIL-1αを制御することで角栓形成を抑制する
栃尾 巧; 田中 浩; 石井 泉; 中田 悟
日本香粧品学会誌, 32(3), 242 - 243, Sep. 2008
Lead - Inhibitory effect of canarium album leaves extract on cornified plug development.
栃尾巧
Fragrance Journal, 36(8), 28 - 32, Aug. 2008
https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J04020&link_issn=&doc_id=20080820090002&doc_link_id=1521417754736816256&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1521417754736816256&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif
Lead - Possibility in using cellulase for Ann manufacture
Kuge Takaki; Hirano Katsuaki; Tochio Takumi