
HARADA Makoto
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Shinshu University Hospital Clinical Division of Internal Medicine 2
Assistant Professor
Researcher Information
Research Keyword
- Metabolomics, ANCA-associated vasculitis, Sulfatide, PPARα, kidney
Web site
Career
Research activity information
Award
Paper
- Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals
Aiko Yamada; Makoto Harada; Tadahiko Kikugawa; Takeshi Nakata; Koji Hashimoto; Tsuneo Konta; Yuji Kamijo
Therapeutic Apheresis and Dialysis, Apr. 2026, Refereed
Corresponding

- The Role of Kidney Biopsy as a Tool for Personalized Treatment Decision-Making in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Nephritis
Makoto Harada; Shotaro Aso; Takayuki Nimura; Kosuke Yamaka; Daiki Aomura; Aiko Yamada; Kosuke Sonoda; Akinori Yamaguchi; Yutaka Kamimura; Tohru Ichikawa; Mamoru Kobayashi; Koji Hashimoto; Yuji Kamijo
Journal of Personalized Medicine, 16(3), 153-153, Mar. 2026, Refereed
Lead, Corresponding

- Proximal Tubule‐Specific Genetic Deficiency of
PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting
Daiki Aomura; Takayuki Nimura; Kosuke Yamaka; Yosuke Yamada; Makoto Harada; Takero Nakajima; Takefumi Kimura; Koji Hashimoto; Hiroyuki Kanno; Motoko Yanagita; Frank J. Gonzalez; Naoki Tanaka; Yuji Kamijo
The FASEB Journal, Jan. 2026, Refereed

- Urea cycle modulation by combined SGLT2 inhibitors and metformin
Makoto Harada; Jonathan Adam; Siyu Han; Mengya Shi; Jianhong Ge; Jutta Lintelmann; Alexander Cecil; Sven Zukunft; Cornelia Prehn; Michael Witting; Markus F. Scheerer; Susanne Neschen; Martin Irmler; Johannes Beckers; Jerzy Adamski; Daniel Teupser; Birgit Linkohr; Christian Gieger; Martin Hrabě de Angelis; Annette Peters; Rui Wang-Sattler
BMC Medicine, Jan. 2026, Refereed
Lead

- Effect of Tofogliflozin on Urinary Albumin-to-Creatinine Ratio vs. Metformin in Diabetic Kidney Disease: Rationale and Study Protocol of the TRUTH-DKD Trial
Kazuhiro Kimura; Yoshiko Takagi; Makoto Harada; Shinichiro Ueda; Masatoshi Minamisawa; Kosuke Sonoda; Ako Oiwa; Yoshikazu Yazaki; Shunpei Sakurai; Takeshi Tomita; Kazuaki Kaneko; Kazuya Yamamoto; Noriaki Takama; Shigeki Momose; Yoshito Inobe; Kazutaka Nogi; Megumi Koshikawa; Takuo Misawa; Toshio Kasai; Hiroshi Tsutsui; Noboru Watanabe; Kyohei Yamazaki; Takahide Miyamoto; Takashi Midorikawa; Tatsuya Usui; Tatsuya Saigusa; Hirohiko Motoki; Yoshihiko Saito; Yuji Kamijo; Mitsuhisa Komatsu; Koichiro Kuwahara
Diabetes Therapy, Jan. 2026, Refereed
Corresponding

- Integrative Metabolomics of Targeted and Non-Targeted Analyses in T2D Progression
Jianhong Ge; Siyu Han; Mengya Shi; Makoto Harada; Shixiang Yu; Jiaqi Zheng; Cornelia Prehn; Jerzy Adamski; Gabi Kastenmüller; Sabrina Schlesinger; Wolfgang Koenig; Birgit Linkohr; Barbara Thorand; Karsten Suhre; Christian Gieger; Annette Peters; Rui Wang-Sattler
Diabetes Care, Dec. 2025, Refereed

- LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer
Siyu Han; Shixiang Yu; Mengya Shi; Makoto Harada; Jianhong Ge; Jiesheng Lin; Cornelia Prehn; Agnese Petrera; Ying Li; Flora Sam; Giuseppe Matullo; Jerzy Adamski; Karsten Suhre; Christian Gieger; Stefanie Hauck; Christian Herder; Michael Roden; Francesco Paolo Casale; Na Cai; Annette Peters; Rui Wang-Sattler
Nature Communications, Apr. 2025, Refereed

- Impact of prepared vascular access on mortality and medical expenses in elderly and non-elderly Japanese patients with chronic kidney disease stage G5: a retrospective cohort study
Takayuki Nimura; Makoto Harada; Daiki Aomura; Kosuke Yamaka; Koji Hashimoto; Yuji Kamijo
Clinical and Experimental Nephrology, Mar. 2025, Refereed
Lead

- Role of major cardiovascular surgery-induced metabolic reprogramming in acute kidney injury in critical care.
Velho TR; Pinto F; Ferreira R; Pereira RM; Duarte A; Harada M; Willmann K; Pedroso D; Paixão T; Guerra NC; Neves-Costa A; Santos I; Gouveia E Melo R; Brito D; Almeida AG; Nobre Â; Wang-Sattler R; Köcher T; Pedro LM; Pinto F; Luis Moita
Intensive care medicine, Jan. 2025, Refereed

- Novel Membrane Designed Polyether Sulfone Filter Reduces Filtration Membrane Obstruction Rate in Drop-Type With Adjustable Concentrator Cell-Free and Concentrated Ascites Reinfusion Therapy (DC-CART).
Inui K; Yamada Y; Daiki Aomura; Sonoda K; Harada M; Hashimoto K; Yuji Kamijo
Artificial organs, Dec. 2024, Refereed

- Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
Makoto Harada; Jonathan Adam; Marcela Covic; Jianhong Ge; Stefan Brandmaier; Caroline Muschet; Jialing Huang; Siyu Han; Martina Rommel; Markus Rotter; Margit Heier; Robert P. Mohney; Jan Krumsiek; Gabi Kastenmüller; Wolfgang Rathmann; Zhongmei Zou; Sven Zukunft; Markus F. Scheerer; Susanne Neschen; Jerzy Adamski; Christian Gieger; Annette Peters; Donna P. Ankerst; Thomas Meitinger; Tanya L. Alderete; Martin Hrabe de Angelis; Karsten Suhre; Rui Wang-Sattler
Cardiovascular Diabetology, Jun. 2024, Refereed
Lead

- Prediction of Myocardial Infarction Using a Combined Generative Adversarial Network Model and Feature-Enhanced Loss Function
Shixiang Yu; Siyu Han; Mengya Shi; Makoto Harada; Jianhong Ge; Xuening Li; Xiang Cai; Margit Heier; Gabi Karstenmüller; Karsten Suhre; Christian Gieger; Wolfgang Koenig; Wolfgang Rathmann; Annette Peters; Rui Wang-Sattler
Metabolites, Apr. 2024, Refereed

- Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice
Makoto Harada; Siyu Han; Mengya Shi; Jianhong Ge; Shixiang Yu; Jonathan Adam; Jerzy Adamski; Markus F. Scheerer; Susanne Neschen; Martin Hrabe de Angelis; Rui Wang-Sattler
International Journal of Biological Macromolecules, Apr. 2024, Refereed
Lead

- Investigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research
Takayuki Nimura; Daiki Aomura; Makoto Harada; Akinori Yamaguchi; Kosuke Yamaka; Takero Nakajima; Naoki Tanaka; Takashi Ehara; Koji Hashimoto; Yuji Kamijo
International Journal of Molecular Sciences, Jan. 2024, Refereed
Corresponding

- A Case of an Elderly Woman Who Developed Corneal Perforation in the Clinical Course of Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Shuhei Kobayashi; Makoto Harada; Aiko Yamada; Yasuhiro Iesato; Koji Hashimoto; Yuji Kamijo
Case Reports in Rheumatology, Aug. 2023, Refereed
Corresponding

- Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts.
Shi M; Han S; Klier K; Fobo G; Montrone C; Yu S; Harada M; Henning AK; Friedrich N; Martin Bahls; Dörr M; Nauck M; Völzke H; Homuth G; Grabe HJ; Cornelia Prehn; Adamski J; Suhre K; Rathmann W; Ruepp A; Hertel J; Peters A; Rui Wang-Sattler
Cardiovascular diabetology, Jun. 2023, Refereed

- Anti-SARS-CoV-2 IgG antibody titer after BNT162b2 mRNA COVID-19 vaccination in Japanese patients who underwent renal replacement therapy, hemodialysis, peritoneal dialysis, and kidney transplantation.
Iwabuchi R; Harada M; Yamada A; Aomura D; Yamada Y; Sonoda K; Nakazawa H; Sakai K; Mizukami E; Hashimoto K; Yuji Kamijo
Clinical and experimental nephrology, Apr. 2023, Refereed
Lead

- Predictive Factors of Cytomegalovirus Viremia during the Clinical Course of Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Single Center Observational Study
Makoto Harada; Ryohei Iwabuchi; Akinori Yamaguchi; Daiki Aomura; Yosuke Yamada; Kosuke Sonoda; Yutaka Kamimura; Koji Hashimoto; Yuji Kamijo
Journal of Clinical Medicine, Jan. 2023, Refereed
Lead, Corresponding

- Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Makoto Harada; Takero Nakajima; Yosuke Yamada; Daiki Aomura; Akinori Yamaguchi; Kosuke Sonoda; Naoki Tanaka; Koji Hashimoto; Yuji Kamijo
Journal of Clinical Medicine, Jan. 2022, Refereed
Lead, Corresponding

- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Developing Pancreatic Lesion and Diabetes Mellitus: A Case Report and Review of the Literature
Aiko Yamada; Makoto Harada; Takahiko Nobuoka; Akinori Yamaguchi; Kosuke Sonoda; Koji Hashimoto; Yuji Kamijo
The Tohoku Journal of Experimental Medicine, 256(2), 161-168, 2022, Refereed
Corresponding

- Comparison of the factors associated with the short-term prognosis between elderly and non-elderly patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective observational study
Makoto Harada; Akinori Yamaguchi; Kosuke Sonoda; Yosuke Yamada; Daiki Aomura; Yutaka Kamimura; Koji Hashimoto; Tohru Ichikawa; Mamoru Kobayashi; Yuji Kamijo
Clinical and Experimental Rheumatology, Mar. 2021, Refereed
Lead, Corresponding

- Efficacy of plasma exchange for antineutrophil cytoplasmic antibody-associated systemic vasculitis: a systematic review and meta-analysis
Yosuke Yamada; Makoto Harada; Yuuta Hara; Ryohei Iwabuchi; Koji Hashimoto; Shuhei Yamamoto; Yuji Kamijo
Arthritis Research & Therapy, 23(1), Jan. 2021, Refereed
Lead

- Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study
Koji Hashimoto; Makoto Harada; Yosuke Yamada; Mitsutoshi Sugano; Tomonori Minagawa; Teruyuki Ogawa; Osamu Ishizuka; Yuji Kamijo
Renal Replacement Therapy, 6(1), Jan. 2020, Refereed

- Relationship Between Immunosuppressive Therapy and the Development of Infectious Complications Among Patients with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: A Single-center, Retrospective Observational Study
Makoto Harada; Wataru Ishii; Takeshi Masubuchi; Tohru Ichikawa; Mamoru Kobayashi
Cureus, Sep. 2019, Refereed
Lead, Corresponding

- A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Taketoshi Nonaka; Makoto Harada; Masahiko Sumi; Wataru Ishii; Tohru Ichikawa; Mamoru Kobayashi
Case Reports in Rheumatology, 2019, 1-4, Jul. 2019, Refereed
Corresponding

- Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Yu Lu; Makoto Harada; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Mamoru Kyogashima; Frank J. Gonzalez; Toshifumi Aoyama
Archives of Toxicology, 93(1), 149-161, Oct. 2018, Refereed
Lead

- Protein Concentration of Refractory Ascites in Cancer Patients is Reflected by the Presence and Severity of Peritoneal and Liver Metastasis
Yosuke Yamada; Akinori Yamaguchi; Makoto Harada; Yukifumi Kurasawa; Yuuta Hara; Daiki Yamazaki; Satoshi Fujita; Kosuke Sonoda; Tomoe Masuda; Aiko Yamada; Yohei Ogawa; Koji Hashimoto; Yuji Kamijo
Therapeutic Apheresis and Dialysis, 21(3), 263-269, Jun. 2017, Refereed

- Technical Performance and Clinical Effectiveness of Drop Type With Adjustable Concentrator‐Cell Free and Concentrated Ascites Reinfusion Therapy
Yosuke Yamada; Makoto Harada; Akinori Yamaguchi; Yasuko Kobayashi; Takashi Chino; Takashi Minowa; Takashi Kosuge; Wataru Tsukada; Koji Hashimoto; Yuji Kamijo
Artificial Organs, 41(12), 1135-1144, Jun. 2017, Refereed

- Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function
Aoi Ogawara; Makoto Harada; Tohru Ichikawa; Kazuaki Fujii; Takashi Ehara; Mamoru Kobayashi
The Tohoku Journal of Experimental Medicine, 243(4), 335-341, 2017, Refereed
Corresponding

- The Optimal Cut-off Value of Ankle Brachial Index for Screening Cardiovascular Disease Risk in Hemodialysis Patients
M HARADA; W TSUKADA; O TSUKADA; K HASHIMOTO; Y KAMIJO
THE SHINSHU MEDICAL JOURNAL 64 (3), 135-146, 2016, 2016, Refereed
Lead - Acute Phosphate Nephropathy with Diffuse Tubular Injury Despite Limited Calcium Phosphate Deposition
Yosuke Yamada; Makoto Harada; Akinori Yamaguchi; Mai Sugiyama; Taro Kanno; Koji Hashimoto; Takashi Ehara; Hisashi Shimojo; Hidekazu Shigematsu; Yuji Kamijo
Internal Medicine, 55(16), 2229-2235, 2016, Refereed

- Serum sulfatide abnormality is associated with increased oxidative stress in hemodialysis patients
Huang Yuzhe; Yuji Kamijo; Koji Hashimoto; Makoto Harada; Taro Kanno; Eiko Sugiyama; Mamoru Kyogashima; Tomomasa Oguchi; Takero Nakajima; Yutaka Kanno; Toshifumi Aoyama
Hemodialysis International, 19(3), 429-438, Feb. 2015, Refereed

MISC
- Impact of Prepared Vascular Access on Mortality and Medical Expenses in Elderly and Nonelderly Japanese Patients with CKD Stage G5: A Retrospective Cohort Study
Yuji Kamijo; Takayuki Nimura; Yuki Nakayama; Daiki Aomura; Kosuke Yamaka; Koji Hashimoto; Makoto Harada
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 35(10), Oct. 2024


Books and other publications
- Clinical Significance of Sulfatide Abnormality and its Developmental Mechanism Associated with Kidney Disease
Makoto Harada; Yuji Kamijo, Joint work
Shinshu Medical Journal, Oct. 2025ANCA関連血管炎における血清スルファチド異常の臨床的重要性
信州大学医学部附属病院腎臓内科 原田 真; 上條祐司, Clinical Academic Topics
アレルギーの臨床 2023年10月号 ANCA関連血管炎の病態と治療, Oct. 2023免疫チェックポイント阻害薬によるirAEとその管理 8) irAEの治療 腎障害
信州大学医学部附属病院 腎臓内科 原田真, 上條祐司, 免疫チェックポイント阻害薬によるirAEとその管理 8) irAEの治療 腎障害
日本臨牀 79 (増刊号2) 461-464, 2021., 2021Lectures, oral presentations, etc.
- ループス腎炎の病型・活動性予測マーカーとしての血清スルファチドの有用性
山家 公輔; 青村 大輝; 二村 駿行; 原田 真; 橋本 幸始; 上條 祐司
第68回日本腎臓学会学術集会, Jun. 2025慢性腎臓病G4期におけるSGLT2阻害薬新規処方の効果の検証
松井 大介; 青村 大輝; 山家 公輔; 原田 真; 橋本 幸始; 上條 祐司
第68回日本腎臓学会学術集会, Jun. 2025Multi-omics analysis of global longitudinal strain in left and right ventricles
Makoto Harada, Rui Wang-Sattler
EU IMI2 CARDIATEAM project (Paris, France), Sep. 2024Metabolic effects of metformin and its combination of SGLT 2 inhibitor
Makoto Harada; Rui Wang-Sattler
12th Grainau Workshop of Genetic Epidemiology (Grainau, Germany), Jul. 2024全身性血管炎症候群の腎重症度を予測するバイオマーカーとしての血清Sulfatides値の可能性
上條 祐司; 青村 大輝; 原田 真; 二村 駿行; 山家 公輔; 山田 洋輔; 山口 晃典; 園田 光佑; 橋本 幸始
第67回日本腎臓学会学術集会, Jun. 2024虚血性急性腎障害の重症化阻止に腎臓のPPARαは重要な役割を果たす
二村 駿行; 青村 大輝; 山家 公輔; 山田 洋輔; 原田 真; 橋本 幸始; 柳田 素子; 上條 祐司
第66回日本腎臓学会学術集会, Jun. 2023Systemic metabolomic effects of combination therapy of SGLT2i with metformin
Makoto Harada; Rui Wang-Sattler
11th Grainau Workshop of Genetic Epidemiology (Grainau, Germany), May 2023現場評価による腎生検検体の糸球体数と光顕標本の糸球体数の関連
園田 光佑; 原田 真; 青村 大輝; 原 悠太; 山田 洋輔; 山口 晃典; 橋本 幸始; 上條 祐司
第65回日本腎臓学会学術集会, Jun. 2022ANCA関連血管炎患者における血清Sulfatides値の意義の検討
原田 真; 中嶌 岳郎; 山田 洋輔; 山口 晃典; 園田 光佑; 山田 愛子; 岩渕 良平; 橋本 幸始; 上條 祐司
第65回日本腎臓学会学術集会, Jun. 2022腎不全患者における腎代替療法とBNT162b2 mRNA Covid-19 Vaccine接種後の抗体獲得率の検討
岩渕 良平; 原田 真; 橋本 幸始; 上條 祐司
第65回日本腎臓学会学術集会, Jun. 2022新しいCKD-EPI式に基づく推算GFR値の日本人における正確性の検討
橋本 幸始; 山田 洋輔; 園田 光佑; 山口 晃典; 原田 真; 上條 祐司
第65回日本腎臓学会学術集会, Jun. 2022Serum sulfatides, the glycosphingolipids as a biomarker of kidney diseases
Makoto Harada
10th Grainau Workshop of Genetic Epidemiology (Grainau, Germany), May 2022Close relationship between vascular endothelial function and serum uric acid level in hemodialysis patients
Makoto Harada; Wataru Tsukada; Koji Hashimoto; Yuji Kamijo
American Society of Nephrology (annual congress) 2015, at San Diego, Nov. 2015The Different Cut-Off Value of Ankle Brachial Index of Hemodialysis Patients, which Predict Cardiovascular Diseases, by Presence of Diabetes Mellitus
Makoto Harada; Wataru Tsukada; Koji Hashimoto; Yuji Kamijo
American Society of Nephrology (annual congress) 2014, at Philadelphia, Nov. 2014A cross-sectional study investigating relationship between cardiovascular events and several atherosclerotic markers in Japanese hemodialysis patients
Makoto Harada; Wataru Tsukada; Koji Hashimoto; Yuji Kamijo
World Congress of Nephrology 2013, at Hongkong, May 2013Research Themes
- Systemic metabolomic effects of combination therapy of SGLT2i with metformin
DZD NEXT (Deutsches Zentrum für Diabetesforschung) Conference Travel Grant
2023 - 腎臓・近位尿細管特異的PPARα (peroxisome-proliferator-activated receptor α)欠損マウスを用いた慢性腎臓病進展過程におけるPPARαの機能解明
バイエル薬品アカデミックサポート2021
2021 - SGLT2阻害薬による全身性代謝性変化と臓器効果のメカニズムの解明
上原記念生命科学財団海外留学助成リサーチフェローシップ
2021