【第Ⅱ編 機能性評価】第2章 血圧降下作用、1 in vitro ACE 阻害活性試験、2 ex vivo ACE 阻害活性試験、3 in vivo ACE 阻害活性試験、4 ラット血圧測定試験, 機能性食品開発のための初期評価試験プロトコール集（監修： 山本(前田)万里） , 53-75 シーエムシー出版 2017(Jun.) Author:山本(前田)万里他57名
ACE Inhibitory Peptide Accumulated and Produced ACE Inhibitory Fragments in Rat Aorta Tissue to Suppress Vasoconstriction, Peptide Science 2015 , 49-52 2016(Mar.) Author:Masahiro Koyama, Sho Okitsu, Daisuke Hayasaki, Kozo Nakamura*
Difference between In Vitro, Ex Vivo, and In Vivo Angiotensin I Converting Enzyme Inhibition by Antihypertensive Peptides from Fermented Buckwheat Sprout, Peptide Science 2014 , 43-46 2015(Mar.) Author:Masahiro Koyama1, Sho Okitsu, Akira Watanabe and Kozo Nakamura*
Antihypertensive Peptides Isolated from Fermented Buckwheat Sprout, Peptide Science 2012 , 27-30 2013(Mar.) Author:Masahiro Koyama, Seiji Hattori, Mai Kato, Kyoko Naramoto, and Kozo Nakamura*
Antihypertensive Actions of the Gly-His-Gly Isolated from Fermented Buckwheat Sprout, Peptide Science 2011 , 115-118 2012 Author:Masahiro Koyama, Yukimi Hashiguchi and Kozo Nakamura*
Blood-pressure-lowering Effect of Fermented Buckwheat Sprout and the Peptides Contained Therein, Peptide Science 2007 , 13-16 2008(Jan.) Author:Kozo Nakamura, Kyoko Naramoto, and Mari Fujita
Using Computer Modeling to Study Lactam Ring Formation during Monatin and the Analogue Synthesis, Peptide Science 2005 , 191-194 2006(Mar.) Author:Kana Kogiso, Kazumasa Furuta, Hiroshi Kayahara, and Kozo Nakamura*
Isolation of Hydrophilic ACE Inhibitory Peptides from Fermented Buckwheat Sprout, Peptide Science 2005 , 155-158 2006(Mar.) Author:KozoNakamura, Yasunori Maejima, Shigeyoshi Maejima, and Emi Niimura
Functionality Enhancement in Germinated Brown Rice, Food Flavor and Chemistry, Explorations into the 21st Century , 356-371 The Royal Society of Chemistry 2005(Jun.) Author:Kozo Nakamura，Su Tian, and Hiroshi Kayahara
The Functionality of Backwheat Sour Juice, Food Flavor and Chemistry, Explorations into the 21st Century , 350-355 The Royal Society of Chemistry 2005(Jun.) Author:Kozo Nakamura，Chiho Nakamura，Shigeyoshi Maejima，Masataka Maejima，Michiaki Watanabe， Mayumi Shiro，and Hiroshi Kayahara
Synthesis of Taurine Peptides and Taste., Peptide Science 2003 , 199-202 2004(Jan.) Author:Takuro Koyama, Hiroshi Kayahara and Kozo Nakamura
Control of Lactamization in the Synthesis of Monatin Analogue., Peptide Science 2003 , 195-198 2004(Jan.) Author:Kana Kogiso, Kozo Nakamura and Hiroshi Kayahara
Total Synthesis of Monatin and the Taste Expression., Peptide Science 2003 , 61-64 2004(Jan.) Author:Kozo Nakamura, Kana Kogiso, Takero Nakajima and Hiroshi Kayahara
Taste and ACE Inhibitory Activity of g-Aminobutyric Acid Containing Peptides, Peptide Science 2002 , 179-182 2003(Mar.) Author:Kozo Nakamura, Eri Kato, Kana Ando and Hiroshi Kayahara
Chemical properties of acyl groups on phenolic hydroxy group of tyrosine., Peptide Science 2001 , 43-46 2002(Mar.) Author:Kozo Nakamura, Eisaku Nomura and Hisaji Taniguchi
What is the Meaning of the Structural Similarities between Sweet and Bitter Compounds?, Chemistry of Novel Foods , 66-79 Allured Pub. Corp. 1997(Jan.) Author:Kozo Nakamura, Takao Fukuma, Toshinori Shimizu, and Hideo Okai
Convenient Synthesis of Flavor Peptides Using DSP, HOBMCl, and Their Derivatives, Chemistry of Novel Foods , 33-43 Allured Pub. Corp. 1997(Jan.) Author:Jirou Okai, Takashi Nakata, Kozo Nakamura, Masahiro Tamura, and Hideo Okai
Role of "Ionic Tastes” in Food Materials, Chemistry of Novel Foods, , 19-31 Allured Pub. Corp 1997(Jan.) Author:Rie Kuramitu, Kozo Nakamura, and Hideo Oka
Can We Obtained Strong Sweetness According to Sweet Peptide Model?, Peptide Chemistry 1994 , 57-60 1995(Mar.) Author:Masatoshi Takahashii, Kozo Nakamura and Hideo Okai
Conversion of Bitterness of C-Terminal Octapeptide of Bovine b-Casein (Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val) into Sweetness, Peptide Chemistry 1994 , 281-284 1995(Mar.) Author:Masatoshi Takahashi, Takashi Nakata, Masaru Nakatani, Shirou Kataoka, Kozo Nakamura, and Hideo Okai
Molecular Recognition of Sweet Compounds and Bitter Compounds, Peptide Chemistry 1993 , 329-332 1994(Mar.) Author:Kozo Nakamura and Hideo Okai
Synthesis of Saccharoide (Complex Containing Saccharide and Peptide), Peptide Chemistry 1992 , 427-430 1993(Jul.) Author:Kozo Nakamura, Daisuke Segawa, Keisuke Kinomura, Masahiro Tamura and Hideo Okai
Do We Recognize Sweetness and Bitterness at the Same Receptor?, Food Flavor and Safety, Molecular Analysis and Design , 28-35 American Chemical Society 1993(Feb.) Author:Kozo Nakamura, and Hideo Okai*
論文 Antihypertensive Mechanism of Orally Administered Acetylcholine in Spontaneously Hypertensive Rats Nutrients,14(4):905 2022(Feb. 21) Author:Yamaguchi, Shohei, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, and Kozo Nakamura*
Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats Foods,10(9):2107 2021(Sep. 06) Author:Yamaguchi Shohei,Matsumoto Kento,Wang Wenhao, Nakamura Kozo*
Investigation of the Distribution and Content of Acetylcholine, a Novel Functional Compound in Eggplant Foods,10(1):81 2021(Jan. 04) Author:Wenhao Wang, Shohei Yamaguchi, Ayako Suzuki, Naomi Wagu, Masahiro Koyama, Akihiko Takahashi, Risa Takada, Koji Miyatake, Kozo Nakamura*
LC–MS/MS Analysis of Choline Compounds in Japanese-Cultivated Vegetables and Fruits Foods,9(8):1029 2020(Jul. 31) Author:Wenhao Wang, Shohei Yamaguchi, Masahiro Koyama, Su Tian, Aya Ino, Koji Miyatake, Kozo Nakamura *
Polyunsaturated Fatty Acid Deficiency Affects Sulfatides and Other Sulfated Glycans in Lysosomes Through Autophagy-Mediated Degradation FASEB Journal,34(7):9594-9614 2020(Jun. 30) Author:Yaping Wang, Takero Nakajima, Pan Diao, Yosuke Yamada, Kozo Nakamura, Jun Nakayama, Naoki Tanaka, Toshifumi Aoyama, Yuji Kamijo *
Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study Nutrients,11:2797 2019(Nov. 16) Author:Mie Nishimura, Miho Suzuki, Ryuto Takahashi, Shohei Yamaguchi, Kazufumi Tsubaki, Tomoyuki Fujita, Jun Nishihira *, Kozo Nakamura *
Antihypertensive effects of orally administered eggplant (Solanum melongena) rich in acetylcholine on spontaneously hypertensive rats Food Chem.,276:376-382 2019(Mar. 15) Author:Shohei Yamaguchi, Kento Matsumoto, Masahiro Koyama, Su Tian, Masanori Watanabe, Akihiko Takahashi, Koji Miyatake and Kozo Nakamura*
Evaluating of quality of rice bran protein concentrate prepared by a combination of isoelectronic precipitation and electrolyzed water treatment LWT-Food Sci. Technol.,99:262-267 2018(Oct. 05) Author:Masanori Watanabe*, Chikako Yamada, Isamu Maeda, Charin Techapun, Ampin Kuntiya, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Shinji Takenaka, Tadahiko Shiono, Kozo Nakamura, Shujiro Endo
Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice Tohoku J. Exp. Med.,242:229-239 2017(Jul.) Author:Takero Nakajima, Yang Yang, Yu Lu, Yuji Kamijo, Yosuke Yamada, Kozo Nakamura, Masahiro Koyama, Shohei Yamaguchi, Eiko Sugiyama, Naoki Tanaka, Toshifumi
Preventive Effect of Eucommia Leaf Extract on Aortic Media Hypertrophy in Wistar Kyoto Rats Fed a High-fat Diet Hypertension Research,40(6):546-551 2017(Jul.) Author:Shingo Hosoo, Masahiro Koyama, Akira Watanabe, Ryuya Ishida, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Keiji Wada, Yukihito Higashi and Kozo Nakamura*
Fermentation-induced changes in the concentrations of organic acids, amino acids, sugars, and minerals and superoxide dismutase-like activity in tomato vinegar Int. J. Food Prop.,20(4):888–898 2017(Mar.) Author:Masahiro Koyama, Yasushi Ogasawara, Kiyoshi Endou, Hirofumi Akano, Takero Nakajima, Toshifumi Aoyama, Kozo Nakamura*
Extracellular protease derived from lactic acid bacteria stimulates the fermentative lactic acid production from the by-products of rice as a biomass refinery function J. Biosci. Bioeng.,123(2):245-251 2017(Jan.) Author:Masanori Watanabe*, Charin Techapun, Ampin Kuntiya, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Shinji Takenaka, Isamu Maeda, Masahiro Koyama, Kozo Nakamura
Identification of natural lactoylcholine in lactic acid bacteria-fermented food Food Chem.,201:188-191 2016(Jun. 15) Author:Kozo Nakamura*, Sho Okitsu, Ryuya Ishida, Su Tian, Naoki Igari, Yoshihiko Amano
The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats Molecules,20:21971-81 2015(Dec. 09) Author:Shingo Hosoo, Masahiro Koyama, Mai Kato, Tetsuya Hirata*, Yasuyo Yamaguchi, Hiroo Yamasaki, Atsunori Wada, Keiji Wada, Sansei Nishibe and Kozo Nakamura*
Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs J. Food Sci. Tech.,published online (DOI 10.1007/s13197-015-2048-0) 2015(Oct. 01) Author:Kozo Nakamura*, Masahiro Koyama, Ryuya Ishida, Takashi Kitahara, Takero Nakajima, Toshifumi Aoyama
Simultaneous recovery and purification of rice protein and phosphorus compounds from full-fat and defatted rice bran with organic solvent-free process J. Biosci. Bioeng.,119(2):206-2011 2015(Feb.) Author:Masanori Watanabe, Isamu Maeda, Kozo Nakamura, Masahiro Koyama, Kazuo Sasano
One-pot esterification and amidation of phenolic acids TETRAHEDRON,70(43):8097-8107 2014(Oct. 28) Author:Nakamura, K; Nakajima, T; Aoyama, T; Okitsu, S; Koyama, M
Blood Pressure-Lowering Peptides from Neo-Fermented Buckwheat Sprouts: a New Approach to Estimating ACE-Inhibitory Activity PLoS ONE,9(9):e105802 2014(Aug.) Author:Masahiro Koyama, Seiji Hattori, Yoshihiko Amano, Masanori Watanabe, Kozo Nakamura*
Vasoactivities in Normotensive and Hypertensive Rats of Neo-Fermented Buckwheat Sprout and an Antihypertensive Peptides Therein th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013,:401-404 2014(Mar.) Author:Masahiro Koyama, Seiji Hattori, Mai Kato, Kyoko Naramoto, and Kozo Nakamura*
An Ex Vivo Assay to Measure ACE Inhibitory Activities using Thoracic Aorta Ring th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013,:397-400 2014(Mar.) Author:Masahiro Koyama, Ryuya Ishida, Seiji Hattori, and Kozo Nakamura*
Identification of Trypsin Inhibitors from Potato Extract th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013,:393-396 2014(Mar.) Author:Keisuke Yataka, Hiroshi Tomozawa, Masahito Tsubata, Kazuya Yamaguchi, and Kozo Nakamura*
Purification and identification of anti-hypertensive peptides from fermented buckwheat sprouts J. Agric. Food Chem.,61(12):3013-21 2013(Feb.) Author:Masahiro Koyama, Kyoko Naramoto, Takero Nakajima, Toshifumi Aoyama, Masanori Watanabe, Kozo Nakamura*
Blood-pressure-lowering Effect of Fermented Buckwheat Sprout in Spontaneously Hypertensive Rats J. Funct. Food.,5(1):406-415 2013(Jan.) Author:Kozo Nakamura*, Kyoko Naramoto, and Masahiro Koyama
Fermentative L-(+)-lactic acid production from non-sterilized rice washing drainage containing rice bran by a newly isolated lactic acid bacteria without any additions of nutrients J. Biosci. Bioeng.,115(4):449-52 2012(Nov.) Author:Masanori Watanabe*, Masahiro Makino, Nobuo Kaku, Masahiro Koyama, Kozo Nakamura, and Kazuo Sasano
Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs Glycoconjugate J.,30(6):553-60 2012(Oct.) Author:Takero Nakajima1, Yuji Kamijo, Huang Yuzhe, Takefumi Kimura, Naoki Tanaka, Eiko Sugiyama, Kozo Nakamura, Mamoru Kyogashima, Atsushi Hara, Toshifumi Aoyama
A Selective Preparation of Highly Deuterated Hydroxybenzoic Acids Lett. Org. Chem.,8(5):332-336 2011(Jun.) Author:Kozo Nakamura*, Kazuki Morozumi, Daisuke Amano
Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy Biochim. Biophys. Acta,1808(6):1654-1660 2011(Jun.) Author:Yoshinori Uekusa, Miya Kamihira-Ishijima, Osamu Sugimoto, Takeshi Ishii, Shigenori Kumazawa, Kozo Nakamura, Ken-ichi Tanji, Akira Naito, and Tsutomu Nakayama*
Peptides in an Antihypertensive Food Made from Buckwheat Proceeding Book for 5th International Peptide Symposium/Peptide Science 2010,:280 2011(Apr.) Author:Masahiro Koyama, Kyoko Naramoto, and Kozo Nakamura
Changes in phenols contents from buckwheat sprouts during growth stage J. Food Sci. Tech.,50(1):86-93 2011(Feb.) Author:Masahiro Koyama, Chiho Nakamura and Kozo Nakamura*
Phenolic Compounds Responsible for the Superoxide Dismutase-like Activity in High-Brix Apple Vinegar. J. Agric. Food Chem,58(18):10124-10132 2010(Sep.) Author:Kozo Nakamura*, Yasushi Ogasawara, Kiyoshi Endou, Seiji Fujimori, Masahiro Koyama, and Hirofumi Akano
Correlation of Polyphenolics Content to Antioxidant Activity of Forsythia Suspensa Leaves Program&Proceedings of Shinshu University International Symposium 2010,:79-84 2010(Feb.) Author:Su Tian, Yan Wang, and Kozo Nakamura
Differences of Sesquiterpene Lactones Content in Different Leaf Parts and Head Formation Stages in Lettuce Hort. Res.,8(1):13-17 2009(Aug.) Author:Kojiro Arakawa, Mineo Minami*, Kozo Nakamura, Ken-ichi Matsushima and Kazuhiro Nemoto
Loss of Sweetness of Monatin with Lactamization Proceedings of 7th Australian Peptide Conferences/ 4th International Peptide Symposium/ 2nd Asia-Pacific Peptide Symposium,:1-4 2008(Sep.) Author:Reito Ikeda, Kana Kogiso, Yasunori Maejima, and Kozo Nakamura
Variation of Sesquiterpene Lactones Content in Lactuca and Cichorium Species Hort. Res.,7(4):499–504 2008(Aug.) Author:Kojiro Arakawa, Mineo Minami*, Kozo Nakamura, Ken-ichi Matsushima and Kazuhiro Nemoto
Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice. Biochem Pharmacol,76:108-119 2008(Apr.) Author:Tekero Nakajima, Tanaka N, Sugiyama E, Kamijo Y, Hara A, Hu R, Li G, Li Y, Kozo Nakamura, Gonzalez FJ and Toshifumi Aoyama*
Development of Taste Evaluation System of Monatin Related Compounds Using Computer Modeling Method Proceeding of the International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting/Peptide Science 2006,:133-134 2007(Nov.) Author:Kozo Nakamura, Kana Kogiso, Reito Ikeda, and Kazumasa Furuta
Polyphenolic content and physiological activities of Chinese hawthorn extracts Biosci. Biotech. Biochem.,70(12):2948-2956 2006(Dec.) Author:Tong Cui, Kozo Nakamura*, Su Tian, Hiroshi Kayahara, Yi-Ling Tian
Quantification of the polyphenols and triterpene acids in Chinese hawthorn fruit by high-performance liquid chromatography J. Agric. Food Chem.,54(13):4574-4581 2006(Jun.) Author:Tong Cui, Jian-Zhong Li, Hiroshi Kayahara, Liang Ma, Li-Xia Wu, and Kozo Nakamura*
Analyses of Arbutin and Chlorogenic Acid, the Major Phenolic Constituents in Oriental Pear J. Agric. Food Chem.,53(10):3882-3887 2005(Jun.) Author:Tong Cui, Kozo Nakamura*, Liang Ma, Jian-Zhong Li, and Hiroshi Kayahara
Sweetness Production of Taurine Di-peptides Based on Their Crystal Structures and Characterized Conformations The Proceedings of the Joint Meeting of 1st Asia-Pacific International Peptide Symposium&40st Japanese Peptide Symposium, Peptide Science 2004,:165-168 2005(Apr.) Author:Kozo Nakamura, Takuro Koyama, Takero Nakajima, Kana Kogiso, and Hiroshi Kayahara
The C-C bond formation with Alkyl Halide in Monatin Analogue Synthesis and Their Tastes Expression The Proceedings of the Joint Meeting of 1st Asia-Pacific International Peptide Symposium&40st Japanese Peptide Symposium, Peptide Science 2004,:553-556 2005(Apr.) Author:Kana Kogiso, Kozo Nakamura, and Hiroshi Kayahara
High-Performance Liquid Chromatographic Determination of Phenolic Compounds inRice Journal of Chromatography A,1063(1-2):121-128 2005(Jan.) Author:Su Tian, Kozo Nakamura*, and Hiroshi Kayahara
Analysis of Phenolic Compounds in White Rice, Brown Rice, and Germinated Brown Rice J. Agric. Food Chem.,52(15):4808-4813 2004(Aug.) Author:Su Tian, Kozo Nakamura*, and Hiroshi Kayahara
Base-labile tert-Butoxycarbonyl (Boc) Group on Phenols Tetrahedron Lett.,45(3):495-499 2004(Jan.) Author:Kozo Nakamura*, Takero Nakajima, Hiroshi Kayahara, Eisaku Nomura and Hisaji Taniguchi
Synthesis of Amide Compounds of Ferulic Acid, and Their Stimulatory Effect on Insulin Secretion In Vitro Bioorg. Med. Chem.,11:3807-3813 2003(Mar.) Author:Eisuke Nomura, Ayumi Kashiwada, Asao Hosoda, Kozo Nakamura, Hideko Morishita, Takuo Tsuno and Hisaji Taniguchi*
Design of Functional Foods using Synthetic Conjugates Journal of Faculty of Agriculture SHINSHU UNICERSITY,39(1-2):1-11 2003(Mar.) Author:Kozo Nakamura Keywords:functional food,conjugate,synthesis,food design
Total Synthesis of Monatin Org. Lett.,2(19):2967-2970 2000(Aug.) Author:Kozo Nakamura, Tracy J. Baker, and Murray Goodman*
Further studies on the preparation of low sodium chloride-containing soy sauce by using ornithyltaurine hydrochloride and its related compounds Biosci. Biotech. Biochem.,61(7):1163-1167 1997(Jul.) Author:Rie Kuramitu, Daisuke Segawa, Kozo Nakamura, Syunsuke Muramatsu and Hideo Okai*
Tastes Produced by Peptides Containing Ionic Groups and by Related Compounds Biosci. Biotech. Biochem.,60(10):1637-1642 1996(Oct.) Author:Rie Kuramitu, Masatoshi Takahashi, Kouji Tahara, Daisuke Segawa, Kozo Nakamura, and Hideo Okai*
A Convenient Synthesis of L-Ornithyltaurine･HCl and the Effect on Saltiness in a Food Material J. Agric. Food. Chem.,44(9):2481-2485 1996(Sep.) Author:Kozo Nakamura, Rie Kuramitu, Shiro Kataoka, Daisuke Segawa, Kouji Tahara, Masahiro Tamura, and Hideo Okai*
Preparation of Low Sodium Chloride Containing Soy Sauce Using Amino Acid Based Saltiness Enhancers Biosci. Biotech. Biochem.,59(1):35-39 1995(Jan.) Author:Daisuke Segawa, Kozo Nakamura, Rie Kuramitu, Syunsuke Muramatu, Yoshio Sano, Yasuyuki Uzuka, Masahiro Tamura, and Hideo Okai*
Relationship between Taste and Structure of O-Aminoacyl Sugars Containing Basic Amino Acid. Biosci. Biotech. Biochem.,57(1):20-23 1993(Jan.) Author:Masahiro Tamura, Kozo Nakamura, Keisuke Kinomura and Hideo Okai*
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