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米倉 真一  ヨネクラ シンイチ

教員組織学術研究院(農学系)電話番号0265-77-1443
教育組織先鋭領域融合研究群 バイオメディカル研究所FAX番号
職名教授メールアドレスyonekura@shinshu-u.ac.jp
住所〒399-4598 長野県上伊那郡南箕輪村8304ホームページURLhttp://www.shinshu-u.ac.jp/faculty/agriculture/lab/yonekura/top/top.html

プロフィール

研究分野
動物生理学(神経科学、細胞生理学)
現在の研究課題
ストレス応答機構と中枢・末梢組織の機能障害

成長ホルモン遺伝子の転写調節機構の解明

筋形成の分子メカニズムの解明

所属学会
所属学会
日本神経科学学会
日本分子生物学会
日本畜産学会
北米神経科学学会
学歴
出身大学院
2002 , 東北大学大学院 , 農学研究科
1999 , 東北大学大学院 , 農学研究科

出身学校・専攻等(大学院を除く)
1997 , 東北大学 , 農学部

取得学位
博士(農学) , 東北大学
受賞学術賞
2006 , Fellows Award for Research Excellence in NIH
2004 , 日本畜産学会奨励賞
研究職歴等
研究職歴
2010- , 信州大学 農学部 助教
2010- , 東京都医学研究機構 東京都神経科学総合研究所 客員研究員
2006-2009 , 東京都医学研究機構 東京都神経科学総合研究所 主任研究員
2004-2006 , 米国国立衛生研究所(NIH) 日本学術振興会 海外特別研究員
2002-2006 , 米国国立衛生研究所(NIH) 博士研究員
2000-2002 , 東北大学大学院農学研究科 日本学術振興会 特別研究員(DC2)

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
新編 家畜生理学
養賢堂 2015
Author:加藤和雄・古瀬充宏・盧尚建・山崎淳・佐野宏明・麻生久・野地智法・米倉真一・萩野顕彦・林英明


論文
IGF-1 induces IRE1/XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE 2021(Oct.)
Author:Sharmin, S. Hayashi, M. Miyaji, H. Ishizaki, H. Matsuyama, S. Haga, S. Yonekura*


Effects of starvation-induced negative energy balance on ER stress in the liver of cows
ANIMAL BIOSCIENCE 2021(Sep.)
Author:Md Aminul Islam, Shuya Adachi, Yuichiroh Shiiba, Ken-ichi Takeda, Satoshi Haga, Shinichi Yonekura*


Protective effects of 5-aminolevulinic acid on heat stress in bovine mammary epithelial cells
ANIMAL BIOSCIENCE,34(6):1006-1013 2021(Jun.)
Author:Islam, Md Aminul; Noguchi, Yoko; Taniguchi, Shin; Yonekura, Shinichi*;


Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
Frontiers in Physiology,12:679152 2021(May 24)
Author:Nakamura, Shunichi; Yonekura, Shinichi; Shimosato, Takeshi; Takaya, Tomohide


5-ALA Attenuates the Palmitic Acid-Induced ER Stress and Apoptosis in Bovine Mammary Epithelial Cells
MOLECULES,26(4) 2021(Feb.)
Author:Sharmin, Mst Mamuna; Islam, Md Aminul; Yamamoto, Itsuki; Taniguchi, Shin; Yonekura, Shinichi*;


Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,103(9):8643-8654 2020(Sep.)
Author:Sharmin, Mst Mamuna; Mizusawa, Moeko; Hayashi, Satoko; Arai, Wataru; Sakata, Shotaro; Yonekura, Shinichi*;


TRPV4 Increases the Expression of Tight Junction Protein-Encoding Genes via XBP1 in Mammary Epithelial Cells
ANIMALS,10(7) 2020(Jul.)
Author:Islam, Md Aminul; Mizusawa, Moeko; Sharmin, Mst Mamuna; Hayashi, Satoko; Yonekura, Shinichi*;


IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(1) 2020
Author:Tokutake, Yukako; Yamada, Keita; Hayashi, Satoko; Arai, Wataru; Watanabe, Takafumi; Yonekura, Shinichi*;


Thermal stimulation at 39 degrees C facilitates the fusion and elongation of C2C12 myoblasts
ANIMAL SCIENCE JOURNAL,90(8):1008-1017 2019(Aug.)
Author:Hayashi, Satoko; Yonekura, Shinichi*;


Mild heat stress induces transcription of the beta-casein gene via unfolded protein response-activated XBP1 signaling in undifferentiated mammary epithelial cells
ANIMAL SCIENCE JOURNAL,90(8):1026-1032 2019(Aug.)
Author:Mizusawa, Moeko; Sharmin, Mamuna; Yonekura, Shinichi*;


Adzuki bean (Vigna angularis) extract reduces amyloid- beta aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease
NUTRITION RESEARCH AND PRACTICE,13(1):64-69 2019(Feb.)
Author:Miyazaki, Honami; Okamoto, Yoko; Motoi, Aya; Watanabe, Takafumi; Katayama, Shigeru; Kawahara, Sei-ichi; Makabe, Hidefumi; Fujii, Hiroshi; Yonekura, Shinichi*;


Peg1/Mest, an imprinted gene, is involved in mammary gland maturation
JOURNAL OF CELLULAR PHYSIOLOGY,234(2):1080-1087 2019(Feb.)
Author:Yonekura, Shinichi*; Ohata, Masaki; Tsuchiya, Megumi; Tokita, Hitomi; Mizusawa, Moeko; Tokutake, Yukako;


骨格筋分化の制御に寄与するIRE1-XBP1の機能解明
栄養生理研究会報 = Reviews on Animal Nutrition and Metabolism,63(1):15-22 2019
Author:徳武 優佳子;山田 啓太;林 聡子;坂田 章太郎;米倉 真一


The unfolded protein response is involved in both differentiation and apoptosis of bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,101(4):3568-3578 2018(Apr.)
Author:Yonekura, Shinichi*; Tsuchiya, Megumi; Tokutake, Yukako; Mizusawa, Moeko; Nakano, Miwa; Miyaji, Makoto; Ishizaki, Hiroshi; Haga, Satoshi;


The role of unfolded protein response in differentiation of mammary epithelial cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,484(4):903-908 2017
Author:Tsuchiya, Megumi; Koizumi, Yumiko; Hayashi, Satoko; Hanaoka, Miyuki; Tokutake, Yukako; Yonekura, Shinichi*


Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes
ANIMAL BIOTECHNOLOGY,27(2):96-103 2016
Author:Yonekura, Shinichi*; Hirota, Shohei; Miyazaki, Honami; Tokutake, Yukako;


ALS-Linked P56S-VAPB Mutation Impairs the Formation of Multinuclear Myotube in C2C12 Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(8):18628-18641 2015(Aug.)
Author:Tokutake, Yukako; Yamada, Keita; Ohata, Masaki; Obayashi, Yoshihito; Tsuchiya, Megumi; Yonekura, Shinichi*


Soluble extract of soybean fermented with Aspergillus oryzae GB 107 inhibits fat accumulation in cultured 3T3-L1 adipocytes
NUTRITION RESEARCH AND PRACTICE,9(4):439-444 2015(Aug.)
Author:So, Kyoung-Ha; Suzuki, Yasuki; Yonekura, Shinichi; Suzuki, Yutaka; Lee, Chan Ho; Kim, Sung Woo; Katoh, Kazuo; Roh, Sang-Gun;


Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
MOLECULAR THERAPY,23(2):297-309 2015(Feb.)
Author:Wang, Yeqin; Yamamoto, Yoshinari; Shigemori, Suguru; Watanabe, Takafumi; Oshiro, Kazushi; Wang, Xinyu; Wang, Pengfei; Sato, Takashi; Yonekura, Shinichi; Tanaka, Sachi; Kitazawa, Haruki; Shimosato, Takeshi;


ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(3):831-837 2015
Author:Tokutake, Yukako; Gushima, Kazunari; Miyazaki, Honami; Shimosato, Takeshi; Yonekura, Shinichi*


Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
CELL AND TISSUE RESEARCH,357(1):55-61 2014(Jul.)
Author:Watanabe, Takafumi; Nishimura, Kei; Hosaka, Yoshinao Z.; Shimosato, Takeshi; Yonekura, Shinichi; Suzuki, Daisuke; Takemoto, Chihiro; Monir, Mohammad Moniruzzaman; Hiramatsu, Kohzy;


Effect of single nucleotide polymorphisms in GH gene promoter region on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle
LIVESTOCK SCIENCE,165:15-21 2014(Jul.)
Author:Sugita, Haruna; Ardiyanti, Astrid; Yokota, Shoko; Yonekura, Shinichi; Hirayama, Takuji; Shoji, Noriaki; Yamauchi, Eri; Suzuki, Keiichi; Katoh, Kazuo; Roh, Sang-Gun;


Influences of protein ingestion on glucagon-like peptide (GLP)-1-immunoreactive endocrine cells in the chicken ileum
ANIMAL SCIENCE JOURNAL,85(5):581-587 2014(May)
Author:Monir, Mohammad M.; Hiramatsu, Kohzy; Matsumoto, Sachiko; Nishimura, Kei; Takemoto, Chihiro; Shioji, Tomomi; Watanabe, Takafumi; Kita, Kazumi; Yonekura, Shinichi; Roh, Sang Gun


Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES,27(4):567-573 2014(Apr.)
Author:Yonekura, Shinichi*; Hirota, Shohei; Tokutake, Yukako; Rose, Michael T.; Katoh, Kazuo; Aso, Hisashi


Proliferating bovine intramuscular preadipocyte cells synthesize leptin
DOMESTIC ANIMAL ENDOCRINOLOGY,45(1):33-37 2013(Jul.)
Author:Yonekura, S*.; Tokutake, Y.; Hirota, S.; Rose, M. T.; Katoh, K.; Aso, H.


Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(8):3603-3611 2013(Apr.)
Author:Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Otani, Hajime; Shimosato, Takeshi


Expression of a Biologically Active GFP-alpha(S1)-Casein Fusion Protein in Lactococcus lactis
CURRENT MICROBIOLOGY,64(6):569-575 2012(Jun.)
Author:Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Nakanishi, Maya; Otani, Hajime; Shimosato, Takeshi


細胞分化における小胞体ストレス応答の役割
栄養生理研究会報,56(1):25-34 2012(May 01)
Author:米倉 真一; 具島 一成; 徳武 優佳子;


特異的シナプス形成の分子メカニズム
信州大学農学部紀要,48(1):1-7 2012(Mar.)
Author:米倉 真一;
Keywords:シナプス形成; ショウジョウバエ; 視覚中枢; Nカドヘリン; 遺伝学; neuronal connectivity; Drosophila; visual system; N-cadherin; genetics;


AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
JOURNAL OF CELL SCIENCE,125(3):634-648 2012(Feb. 01)
Author:Kametaka, Satoshi; Kametaka, Ai; Yonekura, Shinichi; Haruta, Mineyuki; Takenoshita, Seiichi; Goto, Satoshi; Waguri, Satoshi


長野県北部地震における産業動物、伴侶動物および飼育施設の被災状況とその支援方策の検討
長野県北部地震災害調査研究報告書,:61-71 2012(Jan. 27)
Author:竹田 謙一; 米倉 真一; 渡辺 敬文; 濵野 光市;


反芻動物の脂肪以外の組織におけるレプチン発現の生理学的意義
北信越畜産学会報,(102):1-9 2011(May)
Author:米倉 真一; 佐々木 晋一;
Keywords:レプチン; 反芻動物; VFA; leptin; ruminants;


Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin
PLOS GENETICS,5(4) 2009(Apr.)
Author:Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Iwai, Youichi; Uemura, Tadashi; Lee, Chi-Hon; Chiba, Akira


Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion
NEURON,56(5):793-806 2007(Dec. 06)
Author:Ting, Chun-Yuan; Herman, Tory; Yonekura, Shinichi; Gao, Shuying; Wang, Jian; Serpe, Mihaela; O'Connor, Michael B.; Zipursky, S. Lawrence; Lee, Chi-Hon


Alternative splicing expands spatiotemporal expression complexity of arthropod N-Cadherin
DEVELOPMENTAL BIOLOGY,306(1):376-376 2007(Jun. 01)
Author:Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Lee, Chi-Hon; Chiba, Akira


Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents
DEVELOPMENTAL BIOLOGY,304(2):759-770 2007(Apr. 15)
Author:Yonekura, Shinichi; Xu, Lei; Ting, Chun-Yuan; Lee, Chi-Hon


The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity
MOLECULAR AND CELLULAR BIOLOGY,26(17):6598-6608 2006(Sep.)
Author:Yonekura, Shinichi; Ting, Chun-Yuan; Neves, Guilherme; Hung, Kimberly; Hsu, Shu-ning; Chiba, Akira; Chess, Andrew; Lee, Chi-Hon


Growth hormone and lactogenic hormones can reduce the leptin mRNA expression in bovine mammary epithelial cells
DOMESTIC ANIMAL ENDOCRINOLOGY,31(1):88-96 2006(Jul.)
Author:Yonekura, S; Sakamoto, K; Komatsu, T; Hagino, A; Katoh, K; Obara, Y


乳腺上皮細胞における脂肪酸添加による細胞内TAG蓄積及び脂肪酸受容体に関する研究
栄養生理研究会報,50(1):66-67 2006(Mar. 16)
Author:米沢 朋; 米倉 真一; 芳賀 聡; 小林 洋介; 加藤 和雄; 小原 嘉昭;


Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents
DEVELOPMENT,132(5):953-963 2005(Mar.)
Author:Ting, CY*; Yonekura, S*; Chung, P; Hsu, SN; Robertson, HM; Chiba, A; Lee, CH. *contributed equally to this work.


Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits Acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells
JOURNAL OF DAIRY RESEARCH,71(4):398-404 2004(Nov.)
Author:Yonezawa, T; Yonekura, S; Sanosaka, M; Hagino, A; Katoh, K; Obara, Y


Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,87(8):2527-2534 2004(Aug.)
Author:Yonezawa, T; Yonekura, S; Kobayashi, Y; Hagino, A; Katoh, K; Obara, Y


Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells
CELL BIOLOGY INTERNATIONAL,28(6):463-469 2004
Author:Katoh, K; Matsuda, A; Ishigami, A; Yonekura, S; Ishiwata, H; Chen, C; Obara, Y


Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells
GENERAL AND COMPARATIVE ENDOCRINOLOGY,133(2):165-172 2003(Sep.)
Author:Yonekura, S; Senoo, T; Kobayashi, Y; Yonezawa, T; Katoh, K; Obara, Y


In vitro differentiation of a cloned bovine mammary epithelial cell
JOURNAL OF DAIRY RESEARCH,69(3):345-355 2002(Aug.)
Author:Rose, MT; Aso, H; Yonekura, S; Komatsu, T; Hagino, A; Ozutsumi, K; Obara, Y


Effects of nutritional conditions around weaning on carbonic anhydrase activity in the parotid gland and ruminal and abomasal epithelia of Holstein calves
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY,172(5):379-385 2002(Jul.)
Author:Kitade, K; Takahashi, K; Yonekura, S; Katsumata, N; Furukawa, G; Ohsuga, S; Nishita, T; Katoh, K; Obara, Y


Effects of aging and weaning on mRNA expression of leptinand CCK receptors in the calf rumen and abomasum
DOMESTIC ANIMAL ENDOCRINOLOGY,22(1):25-35 2002(Mar.)
Author:Yonekura, S; Kitade, K; Furukawa, G; Takahashi, K; Katsumata, N; Katoh, K; Obara, Y


反芻動物の下垂体ソマトトロフ(成長ホルモン分泌細胞)の分泌機能に及ぼす加齢および栄養素の影響
畜産の研究,56(1):65-72 2002(Jan.)
Author:加藤 和雄; 米倉 真一; 小原 嘉昭;


Relationship between serum leptin concentrations and the marbling scores in Japanese Black Cattle.
Anim Sci J,22:25-35 2002
Author:Yonekura S, Kitade K, Furukawa G, Takahashi K, Katsumata N, Katoh K, Obara Y.


Effects of adenosine 5'-triphosphate and growth hormone on cellular H+ transport and calcium ion concentrations in cloned bovine mammary epithelial cells
JOURNAL OF ENDOCRINOLOGY,169(2):381-388 2001(May)
Author:Katoh, K; Komatsu, T; Yonekura, S; Ishiwata, H; Hagino, A; Obara, Y


最近の反芻動物生理学研究動向--第9回国際反芻動物生理学シンポジュウム報告
畜産の研究,54(4):491-496 2000(Apr.)
Author:加藤 和雄; 米倉 真一;


講演・口頭発表等
乳腺の機能的発達と小胞体ストレス応答の関連性について
2015(Mar. 29)
Presenter:土屋萌、大畑真輝、徳武優佳子、米倉真一


骨格筋分化過程における小胞体ストレス応答分子XBP1 の関与
2015(Mar. 29)
Presenter:徳武優佳子、山田啓太、米倉真一


インプリンティング遺伝子が乳腺組織発達に及ぼす影響
2015(Mar. 29)
Presenter:米倉真一、大畑真輝、大林佳人、土屋萌、徳武優佳子、中島恵一


ウシFABP4多型が不飽和脂肪酸含有量の違いを生みだすメカニズムについて
2014(Nov. 27)
Presenter:廣田翔平、徳武優佳子、藤森祐紀、米倉真一


軸索輸送異常によって生じる軸索変性の分子メカニズムの解明
2014(Nov. 26)
Presenter:宮崎穂菜実、Shuying Gao、米倉真一


UPR関連分子XBP-1が骨格筋分化に及ぼす影響
2014(Nov. 26)
Presenter:山田啓太、徳武優佳子、米倉真一


脂肪細胞分化における筋委縮性側索硬化症(ALS)原因因子VAPBの影響
2014(Nov. 25)
Presenter:徳武優佳子、具島一成、米倉真一


Peg1 isoformが乳腺組織発達に及ぼす影響の検討
2014(Nov. 25)
Presenter:大畑真輝、大林佳人、土屋萌、徳武優佳子、米倉真一


乳腺の機能発達・維持とUPRとの関係性について
2014(Nov. 25)
Presenter:土屋萌、大畑真輝、徳武優佳子、米倉真一


Screening System for Alzheimer's Prevention Factors from the Extract of Dietary Foods.
2014(Nov. 21)
Presenter:Yonekura S, Miyazaki H


軸索輸送異常によって生じる軸索変性の分子メカニズムの解明
2014(Aug. 25)
Presenter:宮崎穂菜実、米倉真一


Abnormal mitochondria cause age-dependent axonal degeneration in Drosophila.
The38th annual meeting of the Society for Neuroscience 2008
Presenter:Yonekura S, Gao S, Nagasao J and Watabe K.


A Genome wide screening for novel cell death related gene.
Cold Spring Harbor Laboratory meeting 2007
Presenter:Yonekura S, Gao S, Takazawa T and Watabe K.


N-cadherin regulatesR7 target selection in Drosophila Visual system.
Drosophila Research Conference 2004
Presenter:Yonekura S, Ting CY, Hung K, Hsu SN, Chiba A and Lee CH.


N-cadherin regulates R7 targetselection in Drosophila Visual system.
Cold Spring Harbor Laboratory meeting 2003
Presenter:Yonekura S, Ting CY, Hung K, Hsu SN, Chiba A and Lee CH.

研究費
科学研究費補助金(研究代表者)
2009 - 2010 , 軸索の形態維持におけるmilton遺伝子の分子多様性について , 若手(B)
2007 - 2008 , ゲノムワイドスクリーニングによる遅発性神経変性関連遺伝子の同定と解析 , 若手(B)

奨学寄附金
2014 , 旗影会研究助成金
2013 , 伊藤記念財団研究助成金
2011 , ホクト生物科学振興財団

教育活動実績

授業等
2012 , 前期 , 家畜生理学