論文 Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis Nature Communications.,14(1):4960 2023 Author:Han Y, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S.
A novel amino acid substitution, fibrinogen Bbetap.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion Int. J. Mol. Sci.,21:9422; doi:10.3390/ijms21249422 2021 Author:Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients Clin Chim ACTA,512:127-134 2021 Author:Fujimura S, Higuchi Y, Usami Y, Yamaura M, Higuchi T, Terasawa F, Okumura N
Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB gene. Pediatric Reports,13:113-117 2021 Author:Shinozuka J, Okumura N, Nagasawa M, Nishikado M, Kadowaki S, Katsuda I, Imashuku S.
Screening method for congenital dysfibrinogenemia and hypodysfibrinogenemia using clot waveform analysis with the Clauss method Int J Lab Hematol,43:281-289 2021 Author:Arai S, Kamijo T, Hayashi F, Shinohara S, Arai N, Sugano M, Uehara T, Honda T, Okumura N.
Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy. Case Reports in Clinical Medicine,10:108-116 2021 Author:Niwa K, Nagata K, Nakagami T, Shimaoka R, Niwa K, Takenaka M, Tanaka K, Okumura N.
Recombinant gammaY278H fibrinogen shows normal secretion from CHO cells, but a corresponding heterozygous patient showed hypofibrinogenemia Int J Mol Sci,22:22:5218; doi:10.3390/ijms22105218 2021 Author:KamijoT, Kaido T, Yoda M, Arai S, Yamauchi K, Okumura N.
Automated screening procedure for phenotype of congenital fibrinogen disorder using novel parameters, |min1|c and Ac/|min1|c obtained from clot waveform analysis of Clauss method Clinica Chimica ACTA,521:170-176 2021 Author:Arai S, Kamijo T, Kaido T, Yoda M, Shinohara S, Suzuki T, Arai N, Sugano M, Uehara T, Okumura N.
Novel variant fibrinogen gammap.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment Int J Hematology,114:325-333 2021 Author:Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
A novel variant fibrinogen, AalphaE11del, demonstrating the important of AalphaE11 residue in thrombin binding Int J Hematology,114:591-598 2021 Author:Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi K, Okumura N
A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder Blood Advance,5:3830-3838 2021 Author:Osada M, Maruyama K, Kokame K, Denda R, Yamazaki K, Kunieda H, Hirao M, Madoiwa S, Okumura N, Murata M, Ikeda Y, Watanabe K, Tsukada Y, Kikuchi T
Heterozygous variant fibrinogen γA289V (Kanazawa III) was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens Int J Lab Hematol,42:190-197 2020 Author:Takahiro Kaido, Masahiro Yoda, Tomu Kamijo, Chiaki Taira, Yumiko Higuchi, Nobuo Okumura
Acquired dysfibrinogenemia: monoclonal lamda-type IgA binding to fibrinogen caused lower functional plasma fibrinogen level and abnormal clot formation. Int J Hematol,112:96-104 2020 Author:Arai S, Kamijo T, Takezawa Y, Sugano M, Nakazawa H, Yanagisawa R, Uehara T, Honda T, Okumura N.
Comparison of molecular structure and fibrin polymerization between two Bbeta-chain N-terminal region fibrinogen variants, Bbetap.G45C and Bbetap.R74C Int J Hematol,112:331-340 2020 Author:Kaido T, Yoda M, KamijoT, Taira C, Higuchi Y, Okumura N.
γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal Thromb Res,182:150-158 2019 Author:KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.
フィブリノゲン活性の偽低値と異常凝固波形を示したIgA M 蛋白血症の解析 臨床病理,67:449-456 2019 Author:新井慎平，上條途夢，竹澤由夏，菅野光俊，上原剛，本田孝行，奥村伸生．
DVTを発症した先天性フィブリノゲン異常症患者Fibrinogen Matsumoto I のFDP-E分画異常高値の精査 検査血液,19:306-313 2018 Author:新井慎平，中越りつこ，倉田淳一，川崎健治，菅野光俊，上原剛，本田孝行，奥村伸生
Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics. Int. J. Mol. Sci.,19:320; doi:10.3390/ijms19010320 2018 Author:Yazaki M, Yoshinaga T, Sekijima Y, Kametani F, Okumura N.
The fibrous form of intracellular inclusion bodies in recombinant variant fibrinogen-producing cells is specific to the hapatic fibrinogen storage disease-inducible variant fibrinogen Int J Hematol,105:758-768 2017(Jun. 30) Author:Arai S, Ogiwara N, Mukai S, Takezawa Y, Sugano M, Honda T, Okumura N
A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia Int. J. Mol. Sci,18:2470(doi:10.3390/ijms18112470) 2017 Author:Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.
Congenital dysfibrinogenemia in a Japanese family with Fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis Blood Coag Fibrinolysis,28:580-584 2017 Author:Yoshida S, Kibe T, Matsubara R, Koizumi S, Nara K, Amono K, Okumura N.
A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia. Thromb Res,159:82-85 2017 Author:Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N,
Hypodysfibrinogenemia with a heterozygous mutation of γCys326Ser by the novel transversion of TGT to TCT in a patient with pulmonary thromboembolism and right ventricular thrombus Cardiology(Karger),137:167-172 2017 Author:Ushijima A, Komai T, Matsukawa A, Oikawa K, Morita N, Asai S, Mukai S, Okumura N, Kobayashi Y, Miyachi H.
Genetic analyses of novel compound heterozygous hypodysfibrinogenemia, Tsukuba I: FGG c.1129+62_65 del AATA and FGG c.1299+4 del A Thromb Res,148:111-117 2016(Dec. 31) Author:Mukai S, Nagata K, Ikeda M, Arai S, Sugano M, Honda T, Okumura N
Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous gamma D320G (Okayama II) and gamma Delta N319-Delta D320 (Otsu I) THROMBOSIS RESEARCH,136(6):1318-1324 2015(Dec.) Author:Mukai, S; Ikeda, M; Takezawa, Y; Sugano, M; Honda, T; Okumura, N
Novel heterozygous dysfibrinogenemia, Sumida (A alpha C472S), showed markedly impaired lateral aggregation of protofibrils and mildly lower functional fibrinogen levels THROMBOSIS RESEARCH,135(4):710-717 2015(Apr.) Author:Ikeda, M; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites THROMBOSIS RESEARCH,134(2):518-525 2014(Aug.) Author:Ikeda, M; Kobayashi, T; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
ヘテロ異常血漿フィブリノゲンKyoto V (γF322S)とリコンビナントフィブリノゲンγ322Sのフィブリン重合障害の比較検討 日本検査血液学会雑誌,15:163-170 2014 Author:池田み奈美，新井慎平，向井早紀，稲葉 亨，奥村伸生
γ375W fibrinogen-synthesizing CHO cells indicate the accumulation of variant fibrinogen within endoplasmic reticulum THROMBOSIS RESEARCH,133(1):101-107 2014 Author:Kobayashi, T; Arai, S; Ogiwara, N; Takezawa, Y; Nanya, M; Terasawa, F; Okumura, N
Successdul living-related kidney transplantation in a boy with inherited dysfibrinogenemia Pediatr Transplant,17:E161- E164 2013 Author:Imamura H, Akioka Y, Asano T, Sugawara N, Ishizuka K, Chikamoto H, Taki M, Terasawa F, Okumura N, Hattori M.
Nonsense-mediated mRNA decay was demonstrated in two hypofibrinogenemias caused by heterozygous nonsense mutations of FGG, Shizuoka III and Kanazawa II Thromb Res,132:465-470 2013 Author:Soya K, Takezawa Y, Okumura N, Terasawa F
siRNA down-regulation of FGA mRNA in HepG2 cells demonstratedthat heterozygous abnormality of the Aalfa-chain gene does not affect the plasma fibrinogen level Thrombosis Research,131:342-348 2013 Author:Takezawa Y, Matsuda K, Terasawa F, Sugano M, Honda T, Okumura N
Fibrinopeptide A release is necessary for effective B:b interactions in polymerization of variant fibrinogens with impaired A:a interactions Thrombosis and Haemostasis,109:221-228 2013 Author:Soya K, Terasawa F, Okumura N
Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bpdeletion and novel FGA c.54+3A>C substitution INTERNATIONAL JOURNAL OF HEMATOLOGY,96(1):39-46 2012(Jul.) Author:Takezawa, Y; Terasawa, F; Matsuda, K; Sugano, M; Tanaka, A; Fujiwara, M; Kainuma, K; Okumura, N
Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia Brain and Development,34:857-860 2012 Author:Kibe T, Ikeya M. Yokochi K, Okumura N
Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: Comparison of mutant levels with autologousDNA percentage by short tandem repeat-PCR. Clinica Chimica Acta,413:516-519 2012 Author:Taira C, Matsuda K, Saito S, Sakashita K, Sugano M, Okumura N, Honda T.
Heterozygous Bβ C-terminal 12 amino acid-elongation variant,BβX462W (Kyoto VI), showed dysfibrinogenemia. Blood Coagulation and Fibrinolysis,23(1):87-90 2012 Author:Okumura N , Terasawa F, Takezawa Y, Hirota-Kawadobora M, Inaba T, Fujita N, Saito M, Sugano M, Honda T.
Quantitative monitoring of single nucleotide mutation by allele-specific quantitative PCR can be used for assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course. Clinica Chimica Acta,412:53-58 2011 Author:Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T.
Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency. Thrombosis and Haemostasis,104:1284-1285 2010 Author:Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A.
A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia. Thrombosis and Haemostasis,104(2):213-223 2010 Author:Fujihara N, Haneishi A, Yamauchi K, Terasawa F, Ito T, Ishida F, Okumura N.
In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing Clinica Chimica Acta,411(17-18):1325-1329 2010 Author:Fumiko Terasawa, Yuka Kamijyo, Noriko Fujihara, Kazuyoshi Yamauchi, Toshiko Kumagai, Takayuki Honda, Satoshi Shigematsud and Nobuo Okumura
Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, betaGly15Cys (Hamamatsu II). Blood Coagulation and Fibrinolysis,20(8):726-732 2009 Author:Kamijyo Y, Hirota-Kawadobora M, Yamauchi K, Terasawa F, Honda T, Ikeya M, Okumura N.
Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and “A:a” interactions. Biochemistry,48:8656-8663 2009 Author:Bowley SR, Okumura N, Lord ST.
Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen. Thrombosis Research,124:368-372 2009 Author:HaneishiA, Terasawa F, Fujihara N, Yamauchi K, Okumura N, Katsuyama T.
Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin. Clinica Chimica Acta,401:119-123 2009 Author:Okumura N, Haneishi A, Terasawa F.
Sialic acid moiety of apolipoprotein E3 at Thr194affects its ｉｎｔｅｒａｃｔｉｏｎ ｗｉｔｈ ?-ａｍｙｌｏｉｄ1-42 peptides Clinica Chimica Acta,388:123-129 2008 Author:Sugano M, Yamauchi K, Kawasaki K, Tozuka M, Fujita K, Okumura N, Ota H
B:b interactions are essential for polymerization of variant fibrinogens with impaired holes ‘a’ Journal of Thrombosis and Haemostasis,5:2352-2359 2007 Author:Okumura N, Terasawa F, Haneishi A，Fujihara N，Hirota-Kawadobora M, Yamauchi K, Ota H, Lord ST
In vitro expression of a-thalassaemia gene (IVS1-1G>C) reveals complete inactivation of the normal 5’splice site and alternative aberrant RNA splicing. Annals of Clinical Biochemistry,44:573-578 2007 Author:Fujihara N, Yamauchi K, Hirota-Kawadobora M, Ishikawa S, Tozuka M, Ishii E, Katsuyama T, Okumura N, Taniguchi S
Co-localization of TFF2 with gland mucouscell mucin in gastric mucous cellsand in extracellular mucous gel adherent to normal and damaged gastric mucosa HISTOCHEMISTRY AND CELL BIOLOGY,126:617-625 2006 Author:Ota, H; Hayama, M; Momose, M; El-Zimaity, HMT; Matsuda, K; Sano, K; Maruta, F; Okumura, N; Katsuyama, T
An immunoglobulin A1 that inhibits lactate dehydrogenaseactivity, with reversal of inhibition by addition of NADH Annals of Clinical and Laboratory Science,36:461-468 2006 Author:Fujita K, Sato H, Kameko F, Terasawa F, Okumura N, Sugano M, Yamauchi K, Maekawa M, Sakurabayashi I.
Invitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gAsn319,Asp320 deletion dysfibrinogen, Otsu I. Thrombosis Research,118:651-661 2006 Author:Terasawa F, Kani S, Hongo M, Okumura N.
Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation BLOOD,108:1887-1894 2006 Author:Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N
Mechanism of IgA-albumin complex formation that affectsthe fructosamine assay Journal of Electrophoresis,50:19-23 2006 Author:Fijita K, Kameko F, Kato Y, Fukushima M, Okumura N, Terasawa F, Sugano M, YamauchiK, Sato H, Kameko M, Sakurabayashi I.
A novel variant fibrinogen, deletion of B beta 111Ser in coiled-coil region, affecting fibrin lateral aggregation CLINICA CHIMICA ACTA,365:160-167 2006 Author:Okumura, N; Terasawa, F; Hirota-Kawadobora, M; Yamauchi, K; Nakanishi, K; Shiga, S; Ichiyama, S; Saito, M; Kawai, M; Nakahata, T
遺伝子疾患の遺伝子検査 医学検査,54:1477-1484 2005 Author:奥村伸生
In vitro expression demonstrates impaired secretion of the gammaAsn 319, Asp320 deletion variant fibrinogen Thromb Haemost,94:53-59 2005 Author:Kani S, Terasawa F, Lord ST, Tozuka M, Ota H, Okumura N, Katsuyama T
Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils Journal of Thrombosis and Haemostasis,3:983-990 2005 Author:M.Hirota-Kawadobora, S.Kani, F.Terasawa, N.Fujihara, K.Yamauchi, M.Tozuka, N.Okumura
Residue gamma153Cys is essential for the formationof the complexes Aalpha-gamma and Bbeta-gamma, assembly intermediates for the Aalpha-Bbeta-gamma complex and intact fibrinogen Clinica Chimica Acta,353:157-164 2005 Author:Fumiko Terasawa, Kiyotaka Fujita, Nobuo Okumura
フィブリノゲン欠損症とフィブリノゲンの機能 Medical Technology,32:122-123 2004 Author:奥村伸生
Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency Annals of Clinical and Laboratory Science,34:218-225 2004 Author:Noriko Fijihara, Minoru Tozuka, Kazuyoshi Yamauchi, Ichiro Ueno, Nobuyuki Urasawa, Shinsuke Ishikawa, Masako Hirota-Kawadobora, Nobuo Okumura, Hiroya Hidaka, Tsutomu Katsuyama
Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma275C, gamma275H, and gamam275A Journal of Thrombosis and Haemostasis,2:1359-1367 2004 Author:M.Hirota-Kawadobora, F.Terasawa, T.Suzuki, M.Tozuka, K.Sano, N.Okumura
Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking Blood,103:4157-4163 2004 Author:Nobuo Okumura, Oleg V. Gorkun, Fumiko Terasawa, Susan T. Lord
Recombinant fibrinogen, gamma275Arg->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions Journal of Thrombosis and Haemostasis,2:468-475 2004 Author:S.Ishikawa, M.Hirota-Kawadobora, M.Tozuka, K.Ishii, F.Terasawa, N.Okumura
The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese Thrombosis Research,112:257-259 2003 Author:Fumiko Terasawa, Masako Hirota-Kawadobora, Hikaru Kobayashi, Hiroshi Saito, Minoru Tozuka, Nobuo Okumura
Sequence gamam377-395(P2), but not gamma190-202(P1),is the binding site for the alphaMI-domain of integrin alphaMbeta2 inthe gammaC-domain of fibrinogen Biochemistry,42:9365-9373 2003 Author:Tatiana P. Ugarova, Valeryi K. Lishko, Nataly P. Podolnikova, Nobuo Okumura, et al (5)
Novel beta-thalassemia trait (IVS I-1 G->C) in a Japanese family American Journal of Hematology,72:64-66 2003 Author:Noriko Fijihara, Minoru Tozuka, Ichiro Ueno, Kazuyoshi Yamauchi, Ritsuko Nakagoshi, Shinsuke Ishikawa, Masako Hirota, Nobuo Okumura, Eizaburo Ishii, Tsutomu Katsuyama
Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats Cardiovascular Research,60:692-699 2003 Author:Hironaka E, Hongo M, Sakai A, Mawatari E, Ushiyama Y, Terasawa F, Okumura N,Yamazaki A, Yazaki Y, Kinoshita O, Kubo
Identification and properties of glycated monoclonal IgA that Affect the fructosamine assay. Clinical Chemistry,49:805-808 2003 Author:Fujita K, Curtiss LK, Sakurabayashi I, Kameko F, Okumura N, Terasawa F, Tozuka M, Katsuyama
Fibrinogen Otsu I: A γAsn319, Asp320 deletiondysfibrinogen identified in an asymotomatic pregnant woman. Thrombosis and Haemostasis,90:757-758 2003 Author:Terasawa F, Hogan KA, Kani S, Hirose M, Eguchi Y, Noda Y, Hongo M, Okumura N
Immunohistochemical lacalization of sodium-potassium ATPase in human normal stomach and gastric adenocarcinomas. Histochem Cell Biol,119:317-322 2003 Author:Kobayashi C, Hayama M, Harada O, Terasawa F, Okumura N, Sugiyama A, Ota H
Fibrinogens Kosai and Ogasa: Bβ15Gly-Cys(GGT-TGT) substitution associated with impairment of fibrinopeptide B release and lateral aggregation. J Thrombosis and Haemostasis,1:275-283 2003 Author:Hirota-Kawadobora M, Terasawa F, Yonekawa O, Sahara N, Shimizu E, Okumura N, Katsuyama T, Shigematsu
Evidence that heterodimers exist in the fibrinogenMatsumoto II (γ308N-K) proband and participate infibrin fiber formation. Thrombosis Reseach,107:157-162 2002 Author:Okumura N, Terasawa F, Kiyotaka Fujita, Noriko Fujiwara, Minoru Tozuka, Chang-Sung Koh
Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of g-chain Clinica Chimica Acta,319:67-73 2002 Author:Hirota-Kawadobora M, Tozuka M, Yamauchi K,Hidaka E, Ueno I, Sugano M, Terasawa F, Okumura N,Katuyama T, Shigematsu H
Analysisof fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein Blood,99:3654-3660 2002 Author:Okumura N, Terasawa F, Tanaka H, Hirota M, Ota H, Kitano K, Kiyosawa K, Lord ST
Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid Ann Clin Lab Sci,32:369-376 2002 Author:Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K
Hypofibrinogenemia associated with a heterozygous C->T nucleotide substitution at position -1138 bp of the 5'-flanking region of the fibrinogen Aα-chain. Annals of New York Academy of Science,936:526-530 2001 Author:Okumura N, Terasawa F, Yonekawa O, Hamada E, Kaneko H
The formation of β fibrin requires a functional a site. Annals of New York Academy of Science,936:219-222 2001 Author:Hogan KA, Bolliger B, Okumura N, Lord ST
Polymerization site a function dependence on structural integrity of its nearby calcium binding site. Annals of New York Academy of Science,936:205-209 2001 Author:Lounes KC, Okumura N, Hogan KA, Ping L, Lord ST
Fibrinogen Matsumoto V: a variant with Aα19 Arg->Gly(AGG->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization. Thrombosis and Haemostasis,85:108-113 2001 Author:Tanaka H, Terasawa F, Ito T，Tokunaga S, Ishida F, Kitano K, Kiyosawa K, Okumura N
Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method. Electrophoresis,21(14):3016-3019 2000 Author:Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T
Identification of a dysfibrinogen, the substitution of γ308Asn(AAT) to Lys(AAG), using coagulation tests, immunoblot analysis, and allele-specific polymerase chain reaction. Clinica Chimica Acta,295(1-2):77-85 2000 Author:Terasawa F, Fujita K, Tozuka M, Ota H, Katsuyama T, Okumura N
A functional assay suggests that heterodimers exist in two C-terminal γ-chaindysfibrinogens; Matsumoto I and Vlissingen/Frankfurt IV. Thrombosis and Haemostasis,83(4):592-597 2000 Author:Hogan KA, Lord ST, Okumura N, Terasawa F, Galanakis DK, Scharrer I, Gorkun OV
Difference in electrophoretic mobility and plasmic digestion profile between four recombinant fibrinogens, gamma 308K, gamma 308I, gamma 308A, and wild type (gamma 308N) ELECTROPHORESIS,21(12):2309-2315 2000 Author:Okumura, N; Terasawa, F; Fujita, K; Tozuka, M; Ota, H; Katsuyama, T
Genetic analyses in homozygous and heterozygous variant of lactate dehydrogenese-B(H) subunit-LD-B Matsumoto I and II (LD-B W323R)-. Clinica Chimica Acta,287(1-2):163-171 1999 Author:Okumura N, Terasawa F, Ueno I, Oki K, Yamauchi K, Hidaka H, Tozuka M, Okura M, Katsuyama T
Fibrinogen Matsumoto III: a variant with γ275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (γ364Asp→His) and Matsumoto II (γ308Asn→Lys). Thrombosis and Haemostasis,81(5):763-766 1999 Author:Terasawa F, Okumura N,Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T
Hypofibrinogenemia associated with a heterozygous missense mutation γ153Cys to Arg (Matsumoto IV): In vitro expression demonstrates defective secretion of the variant fibrinogen. Blood,94(12):4122-4131 1999 Author:Terasawa F, Okumura N, Kitano K, Hayashida N, Shimosaka M, Okazaki M, Lord ST
Fibrinogen Matsumoto IV: A heterozygous fibrinogen deficiency caused by a missense mutation ofr153Cys toArg THROMBOSIS AND HAEMOSTASIS,:42-42 1999 Author:Terasawa, F; Okumura, N; Lord, ST
Comparison of functions between recombinant variant fibrinogens, r308K, r308I and r308A THROMBOSIS AND HAEMOSTASIS,:321-321 1999 Author:Okumura, N; Terasawa, F; Lord, ST
PlasminogenKanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R British J of Haematology,103(3):867-870 1998 Author:Higuchi Yumiko, Furihata Kenichi, Ueno Ichiro, Ishikawa Shinshuke, Okumura Nobuo, Tozuka Minoru, Sakurai Noriko
Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma ANNALS OF CLINICAL AND LABORATORY SCIENCE,27(5):351-357 1997 Author:Tozuka, M; Yamauchi, K; Hidaka, H; Nakabayashi, T; Okumura, NS; Katsuyama, T
Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8 BRITISH JOURNAL OF HAEMATOLOGY,99(3):509-516 1997 Author:Higuchi, T; Koike, K; Sawai, N; Mwamtemi, HH; Takeuchi, K; Shiohara, M; Kikuchi, T; Yasui, K; Ito, S; Yamagami, O; Sasaki, Y; Okumura, N; Kato, T; Miyazaki, H; Ikeda, M; Yamada, M; Komiyama, A
Aberrant growth of granulocyte-macrophage progenitors in juvenile chronic myelogenous leukemia in serum-free culture EXPERIMENTAL HEMATOLOGY,24(2):116-122 1996 Author:Sawai, N; Koike, K; Ito, S; Okumura, N; Kamijo, T; Shiohara, M; Amano, Y; Tsuji, K; Nakahata, T; Oda, M; Okamura, J; Kobayashi, M; Komiyama, A
Influence of apolipoprotein E phenotypes on total serum cholesterol in Japanese children CLINICA CHIMICA ACTA,247(1-2):175-180 1996 Author:Tozuka, M; Ohta, H; Hidaka, H; Okumura, N; Furihata, K; Katsuyama, T
Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells BLOOD,87(10):4100-4108 1996 Author:Okumura, N; Tsuji, K; Ebihara, Y; Tanaka, I; Sawai, N; Koike, K; Komiyama, A; Nakahata, T
Fibrinogen Matsumoto I: A gamma 364 Asp->His (GAT->CAT) substitution associated with defective fibrin polymerization THROMBOSIS AND HAEMOSTASIS,75(6):887-891 1996 Author:Okumura, N; Furihata, K; Terasawa, F; Nakagoshi, R; Ueno, I; Katsuyama, T
A case of immunoglobulin A-lambda conjugated with lactate dehydrogenase-5 isoenzyme, causing an extremely high enzyme activity in serum CLINICAL CHEMISTRY,42(8):1288-1290 1996 Author:Tozuka, M; Hidaka, H; Okumura, N; Ichikawa, T; Furibata, K; Katsuyama, T
Fibrinogen Matsumoto II: gamma(308)Asn->Lys(AAT->AAG) mutation associated with bleeding tendency BRITISH JOURNAL OF HAEMATOLOGY,94(3):526-528 1996 Author:Okumura, N; Furihata, K; Terasawa, F; Ishikawa, S; Ueno, I; Katsuyama, T
PREVENTION OF HEPATIC-ARTERY THROMBOSIS IN PEDIATRIC LIVER-TRANSPLANTATION TRANSPLANTATION,60(10):1109-1112 1995 Author:HASHIKURA, Y; KAWASAKI, S; OKUMURA, N; ISHIKAWA, S; MATSUNAMI, H; IKEGAMI, T; NAKAZAWA, Y; MAKUUCHI, M
Fibrinogen Matsumoto II: A gamma 308ASN->Lys(AAT->AAG) mutation associated with defective fibrin polymerization. BLOOD,86(10):3520-3520 1995 Author:Okumura, N; Terasawa, F; Ueno, I; Kaysuyama, T; Furihata, K
CELL-SURFACE ANTIGEN EXPRESSION IN HUMAN ERYTHROID PROGENITORS - ERYTHROID AND MEGAKARYOCYTIC MARKERS LEUKEMIA&LYMPHOMA,13(5-6):401-409 1994 Author:NAKAHATA, T; OKUMURA, N
GENETIC-ANALYSIS OF FIBRINOGEN MATSUMOTO - A POINT MUTATION IN EXON-9 OF GAMMA-CHAIN RESPONSIBLE FOR DEFECTIVE FIBRIN POLYMERIZATION BLOOD,84(10):A60-A60 1994 Author:TERASAWA, F; OKUMURA, N; UENO, I; HIDAKA, E; FURUWATARI, C; YAN, J; KATSUYAMA, T; FURIHATA, K
CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS EXPERIMENTAL HEMATOLOGY,20(6):793-793 1992 Author:OKUMURA, N; NAKAHATA, T
CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS BLOOD,80(3):642-650 1992 Author:OKUMURA, N; TSUJI, K; NAKAHATA, T
COAGULATION ABNORMALITIES FOLLOWED ORTHOTOPIC LIVING RELATED LIVER-TRANSPLANTATION THROMBOSIS AND HAEMOSTASIS,65(6):1090-1090 1991 Author:SAITO, H; OKUMURA, N; HARADA, H; KUDO, M; MAKUUCHI, M; FURUTA, S
INTERLEUKIN-6 SUPPORTS HUMAN MEGAKARYOCYTIC PROLIFERATION AND DIFFERENTIATION INVITRO BLOOD,78(8):1969-1974 1991 Author:IMAI, T; KOIKE, K; KUBO, T; KIKUCHI, T; AMANO, Y; TAKAGI, M; OKUMURA, N; NAKAHATA, T
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