Okumura Nobuo

School of Medicine Department of Health Sciences 

Professor 

Degree

  • Ph.D., Shinshu University

Research Keyword

    Biomedical Laboratory Sciences, Clinical Laboratory Sciences, Clinical Chemistry, Clinical Immunology, Genetic testing, Thrombosis and Haemostasis

Field Of Study

  • Pathological Examination
  • Pathological Medical Chemistry

Career

  • 1996 - 1997
    長期在外研究員(乙)

Educational Background

  • 1977, School of Allied Medical Sciences, Shinshu University
  • 1982, Science University of Tokyo, Faculty of Science

Paper

  • Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
    Han Y, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S.
    Nature Communications., 14(1), 4960, 2023, Refereed電子ジャーナル
  • A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder
    Osada M, Maruyama K, Kokame K, Denda R, Yamazaki K, Kunieda H, Hirao M, Madoiwa S, Okumura N, Murata M, Ikeda Y, Watanabe K, Tsukada Y, Kikuchi T
    Blood Advance, 5, 3830-3838, 2021
  • A novel variant fibrinogen, AalphaE11del, demonstrating the important of AalphaE11 residue in thrombin binding
    Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi K, Okumura N
    Int J Hematology, 114, 591-598, 2021
  • Novel variant fibrinogen gammap.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
    Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
    Int J Hematology, 114, 325-333, 2021
  • Automated screening procedure for phenotype of congenital fibrinogen disorder using novel parameters, |min1|c and Ac/|min1|c obtained from clot waveform analysis of Clauss method
    Arai S, Kamijo T, Kaido T, Yoda M, Shinohara S, Suzuki T, Arai N, Sugano M, Uehara T, Okumura N.
    CLINICA CHIMICA ACTA, 521, 170-176, 2021
  • 28年間で解析した長野県内のフィブリノゲン異常症18家系28例
    上條途夢,海藤貴大, 依田将宏, 平千明, 樋口由美子,新井慎平, 竹澤由夏,奥村伸生
    長臨技会誌, 10(2), 1-5, 2021
  • Recombinant gammaY278H fibrinogen shows normal secretion from CHO cells,
    KamijoT, Kaido T, Yoda M, Arai S, Yamauchi K, Okumura N.
    Int J Mol Sci, 22, 22:5218; doi:10.3390/ijms22105218, 2021
  • Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy.
    Niwa K, Nagata K, Nakagami T, Shimaoka R, Niwa K, Takenaka M, Tanaka K, Okumura N.
    Case Reports in Clinical Medicine, 10, 108-116, 2021
  • Screening method for congenital dysfibrinogenemia and hypodysfibrinogenemia using clot waveform analysis with the Clauss method
    Arai S, Kamijo T, Hayashi F, Shinohara S, Arai N, Sugano M, Uehara T, Honda T, Okumura N.
    Int J Lab Hematol, 43, 281-289, 2021
  • Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB gene.
    Shinozuka J, Okumura N, Nagasawa M, Nishikado M, Kadowaki S, Katsuda I, Imashuku S.
    Pediatric Reports, 13, 113-117, 2021
  • Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients
    Fujimura S, Higuchi Y, Usami Y, Yamaura M, Higuchi T, Terasawa F, Okumura N.
    Clin Chim Acta, 512, 127-134, 2021
  • A novel amino acid substitution, fibrinogen Bbetap.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion
    Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
    Int. J. Mol. Sci., 21, 9422; doi:10.3390/ijms21249422, 2021
  • Acquired dysfibrinogenemia: monoclonal lamda-type IgA binding to fibrinogen caused lower functional plasma fibrinogen level and abnormal clot formation.
    Arai S, Kamijo T, Takezawa Y, Sugano M, Nakazawa H, Yanagisawa R, Uehara T, Honda T, Okumura N.
    Int J Hematol, 112, 96-104, 2020
  • Comparison of molecular structure and fibrin polymerization between two Bbeta-chain N-terminal region fibrinogen variants, Bbetap.G45C and Bbetap.R74C
    Kaido T, Yoda M, KamijoT, Taira C, Higuchi Y, Okumura N.
    Int J Hematol, 112, 331-340, 2020
  • フィブリノゲン低下の著しい重症線溶亢進型DICに認められた2つのフィブリノゲン遺伝子変異 
    依田 将宏, 海藤 貴大, 上條 途夢, 新井 慎平, 平 千明, 樋口 由美子, 長田 眞, 塚田 唯子, 奥村 伸生. 依田 将宏, 海藤 貴大, 上條 途夢, 新井 慎平, 平 千明, 樋口 由美子, 長田 眞, 塚田 唯子, 奥村 伸生.
    臨床病理, 68, 390-397, 2020
  • Heterozygous variant fibrinogen γA289V (Kanazawa III) was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens
    Takahiro Kaido, Masahiro Yoda, Tomu Kamijo, Chiaki Taira, Yumiko Higuchi, Nobuo Okumura
    Int J Lab Hematol, 42, 190-197, 2020WebofScienceリポジトリ電子ジャーナル
  • γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal
    KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.
    Thromb Res, 182, 150-158, 2019
  • Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics.
    Yazaki M, Yoshinaga T, Sekijima Y, Kametani F, Okumura N.
    Int. J. Mol. Sci., 19, 320; doi:10.3390/ijms19010320, 2018WebofScienceリポジトリ電子ジャーナル
  • Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization
    Kamijo T, Nagata K, Taira C, Higuchi Y, Arai S, Okumura N
    Thromb Res, 172, 1-3, 2018WebofScienceリポジトリ電子ジャーナル
  • The fibrous form of intracellular inclusion bodies in recombinant variant fibrinogen-producing cells is specific to the hapatic fibrinogen storage disease-inducible variant fibrinogen
    Arai S, Ogiwara N, Mukai S, Takezawa Y, Sugano M, Honda T, Okumura N
    Int J Hematol, 105, 758-768, 30 Jun. 2017電子ジャーナル
  • Hypodysfibrinogenemia with a heterozygous mutation of γCys326Ser by the novel transversion of TGT to TCT in a patient with pulmonary thromboembolism and right ventricular thrombus
    Ushijima A, Komai T, Matsukawa A, Oikawa K, Morita N, Asai S, Mukai S, Okumura N, Kobayashi Y, Miyachi H.
    Cardiology(Karger), 137, 167-172, 2017
  • A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia.
    Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N,
    Thromb Res, 159, 82-85, 2017
  • Congenital dysfibrinogenemia in a Japanese family with Fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis
    Yoshida S, Kibe T, Matsubara R, Koizumi S, Nara K, Amono K, Okumura N.
    Blood Coag Fibrinolysis, 28, 580-584, 2017
  • A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia
    Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.
    Int. J. Mol. Sci, 18, 2470(doi:10.3390/ijms18112470), 2017
  • Genetic analyses of novel compound heterozygous hypodysfibrinogenemia, Tsukuba I: FGG c.1129+62_65 del AATA and FGG c.1299+4 del A
    Mukai S, Nagata K, Ikeda M, Arai S, Sugano M, Honda T, Okumura N
    Thromb Res, 148, 111-117, 31 Dec. 2016WebofScienceリポジトリ電子ジャーナル
  • Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous gamma D320G (Okayama II) and gamma Delta N319-Delta D320 (Otsu I)
    Mukai, S; Ikeda, M; Takezawa, Y; Sugano, M; Honda, T; Okumura, N
    THROMBOSIS RESEARCH, 136(6), 1318-1324, Dec. 2015WebofScienceリポジトリ電子ジャーナル
  • Novel heterozygous dysfibrinogenemia, Sumida (A alpha C472S), showed markedly impaired lateral aggregation of protofibrils and mildly lower functional fibrinogen levels
    Ikeda, M; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
    THROMBOSIS RESEARCH, 135(4), 710-717, Apr. 2015WebofScienceリポジトリ電子ジャーナル
  • Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites
    Ikeda, M; Kobayashi, T; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
    THROMBOSIS RESEARCH, 134(2), 518-525, Aug. 2014WebofScienceリポジトリ電子ジャーナル
  • γ375W fibrinogen-synthesizing CHO cells indicate the accumulation of variant fibrinogen within endoplasmic reticulum
    Kobayashi, T; Arai, S; Ogiwara, N; Takezawa, Y; Nanya, M; Terasawa, F; Okumura, N
    THROMBOSIS RESEARCH, 133(1), 101-107, 2014WebofScienceリポジトリ電子ジャーナル
  • Successdul living-related kidney transplantation in a boy with inherited dysfibrinogenemia
    Imamura H, Akioka Y, Asano T, Sugawara N, Ishizuka K, Chikamoto H, Taki M, Terasawa F, Okumura N, Hattori M.
    Pediatr Transplant, 17, E161- E164, 2013WebofScience電子ジャーナル
  • Fibrinopeptide A release is necessary for effective B:b interactions in polymerization of variant fibrinogens with impaired A:a interactions
    Soya K, Terasawa F, Okumura N
    THROMBOSIS AND HAEMOSTASIS, 109, 221-228, 2013WebofScienceリポジトリ電子ジャーナル
  • siRNA down-regulation of FGA mRNA in HepG2 cells demonstratedthat heterozygous abnormality of the Aalfa-chain gene does not affect the plasma fibrinogen level
    Takezawa Y, Matsuda K, Terasawa F, Sugano M, Honda T, Okumura N
    THROMBOSIS RESEARCH, 131, 342-348, 2013WebofScienceリポジトリ電子ジャーナル
  • Nonsense-mediated mRNA decay was demonstrated in two hypofibrinogenemias caused by heterozygous nonsense mutations of FGG, Shizuoka III and Kanazawa II
    Soya K, Takezawa Y, Okumura N, Terasawa F
    Thromb Res, 132, 465-470, 2013WebofScienceリポジトリ電子ジャーナル
  • Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bpdeletion and novel FGA c.54+3A>C substitution
    Takezawa, Y; Terasawa, F; Matsuda, K; Sugano, M; Tanaka, A; Fujiwara, M; Kainuma, K; Okumura, N
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 96(1), 39-46, Jul. 2012WebofScienceリポジトリ電子ジャーナル
  • Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: Comparison of mutant levels with autologousDNA percentage by short tandem repeat-PCR.
    Taira C, Matsuda K, Saito S, Sakashita K, Sugano M, Okumura N, Honda T.
    CLINICA CHIMICA ACTA, 413, 516-519, 2012WebofScience電子ジャーナル
  • Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia
    Kibe T, Ikeya M. Yokochi K, Okumura N
    Brain and Development, 34, 857-860, 2012WebofScience電子ジャーナル
  • Heterozygous Bβ C-terminal 12 amino acid-elongation variant,BβX462W (Kyoto VI), showed dysfibrinogenemia.
    Okumura N , Terasawa F, Takezawa Y, Hirota-Kawadobora M, Inaba T, Fujita N, Saito M, Sugano M, Honda T.
    Blood Coagulation and Fibrinolysis, 23(1), 87-90, 2012WebofScienceリポジトリ電子ジャーナル
  • フィブリノゲンの細胞内生成・分泌におけるBβ鎖D領域454-458残基の重要性
    寺澤文子, 竹澤由夏, 廣田(川戸洞)雅子, 奥村伸生
    臨床病理, 59, 741-748, 2011
  • Quantitative monitoring of single nucleotide mutation by allele-specific quantitative PCR can be used for assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course.
    Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T.
    CLINICA CHIMICA ACTA, 412, 53-58, 2011WebofScience電子ジャーナル
  • Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency.
    Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A.
    THROMBOSIS AND HAEMOSTASIS, 104, 1284-1285, 2010
  • In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing
    Fumiko Terasawa, Yuka Kamijyo, Noriko Fujihara, Kazuyoshi Yamauchi, Toshiko Kumagai, Takayuki Honda, Satoshi Shigematsud and Nobuo Okumura
    CLINICA CHIMICA ACTA, 411(17-18), 1325-1329, 2010WebofScienceリポジトリ電子ジャーナル
  • A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia.
    Fujihara N, Haneishi A, Yamauchi K, Terasawa F, Ito T, Ishida F, Okumura N.
    THROMBOSIS AND HAEMOSTASIS, 104(2), 213-223, 2010WebofScienceリポジトリ電子ジャーナル
  • Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and “A:a” interactions.
    Bowley SR, Okumura N, Lord ST.
    Biochemistry, 48, 8656-8663, 2009WebofScience電子ジャーナル
  • Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin.
    Okumura N, Haneishi A, Terasawa F.
    CLINICA CHIMICA ACTA, 401, 119-123, 2009, RefereedWebofScienceリポジトリ電子ジャーナル
  • Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.
    HaneishiA, Terasawa F, Fujihara N, Yamauchi K, Okumura N, Katsuyama T.
    THROMBOSIS RESEARCH, 124, 368-372, 2009WebofScienceリポジトリ電子ジャーナル
  • Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, betaGly15Cys (Hamamatsu II).
    Kamijyo Y, Hirota-Kawadobora M, Yamauchi K, Terasawa F, Honda T, Ikeya M, Okumura N.
    Blood Coagulation and Fibrinolysis, 20(8), 726-732, 2009WebofScienceリポジトリ電子ジャーナル
  • Sialic acid moiety of apolipoprotein E3 at Thr194affects its interaction with ?-amyloid1-42 peptides
    Sugano M, Yamauchi K, Kawasaki K, Tozuka M, Fujita K, Okumura N, Ota H
    CLINICA CHIMICA ACTA, 388, 123-129, 2008
  • Polymerization-defective fibrinogen variant gammaD364A binds knob “A” peptide mimic
    Bowley SR, Merenbloom BK, Okumura N, Betts L, Heroux A, Gorkun OV, Lord ST
    Biochemistry, 37, 8607-8613, 2008
  • In vitro expression of a-thalassaemia gene (IVS1-1G>C) reveals complete inactivation of the normal 5’splice site and alternative aberrant RNA splicing.
    Fujihara N, Yamauchi K, Hirota-Kawadobora M, Ishikawa S, Tozuka M, Ishii E, Katsuyama T, Okumura N, Taniguchi S
    ANNALS OF CLINICAL BIOCHEMISTRY, 44, 573-578, 2007
  • B:b interactions are essential for polymerization of variant fibrinogens with impaired holes ‘a’
    Okumura N, Terasawa F, Haneishi A,Fujihara N,Hirota-Kawadobora M, Yamauchi K, Ota H, Lord ST
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 5, 2352-2359, 2007WebofScienceリポジトリ電子ジャーナル
  • Mechanism of IgA-albumin complex formation that affectsthe fructosamine assay
    Fijita K, Kameko F, Kato Y, Fukushima M, Okumura N, Terasawa F, Sugano M, YamauchiK, Sato H, Kameko M, Sakurabayashi I.
    Journal of Electrophoresis, 50, 19-23, 2006
  • An immunoglobulin A1 that inhibits lactate dehydrogenaseactivity, with reversal of inhibition by addition of NADH
    Fujita K, Sato H, Kameko F, Terasawa F, Okumura N, Sugano M, Yamauchi K, Maekawa M, Sakurabayashi I.
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 36, 461-468, 2006
  • Co-localization of TFF2 with gland mucouscell mucin in gastric mucous cellsand in extracellular mucous gel adherent to normal and damaged gastric mucosa
    Ota, H; Hayama, M; Momose, M; El-Zimaity, HMT; Matsuda, K; Sano, K; Maruta, F; Okumura, N; Katsuyama, T
    HISTOCHEMISTRY AND CELL BIOLOGY, 126, 617-625, 2006WebofScience
  • A novel variant fibrinogen, deletion of B beta 111Ser in coiled-coil region, affecting fibrin lateral aggregation
    Okumura, N; Terasawa, F; Hirota-Kawadobora, M; Yamauchi, K; Nakanishi, K; Shiga, S; Ichiyama, S; Saito, M; Kawai, M; Nakahata, T
    CLINICA CHIMICA ACTA, 365, 160-167, 2006WebofScienceリポジトリ電子ジャーナル
  • Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation
    Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N
    BLOOD, 108, 1887-1894, 2006WebofScienceリポジトリ電子ジャーナル
  • Invitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gAsn319,Asp320 deletion dysfibrinogen, Otsu I.
    Terasawa F, Kani S, Hongo M, Okumura N.
    THROMBOSIS RESEARCH, 118, 651-661, 2006WebofScienceリポジトリ電子ジャーナル
  • Residue gamma153Cys is essential for the formationof the complexes Aalpha-gamma and Bbeta-gamma, assembly intermediates for the Aalpha-Bbeta-gamma complex and intact fibrinogen
    Fumiko Terasawa, Kiyotaka Fujita, Nobuo Okumura
    CLINICA CHIMICA ACTA, 353, 157-164, 2005WebofScienceリポジトリ電子ジャーナル
  • Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils
    M.Hirota-Kawadobora, S.Kani, F.Terasawa, N.Fujihara, K.Yamauchi, M.Tozuka, N.Okumura
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 3, 983-990, 2005WebofScienceリポジトリ電子ジャーナル
  • In vitro expression demonstrates impaired secretion of the gammaAsn 319, Asp320 deletion variant fibrinogen
    Kani S, Terasawa F, Lord ST, Tozuka M, Ota H, Okumura N, Katsuyama T
    Thromb Haemost, 94, 53-59, 2005WebofScienceリポジトリ電子ジャーナル
  • Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency
    Noriko Fijihara, Minoru Tozuka, Kazuyoshi Yamauchi, Ichiro Ueno, Nobuyuki Urasawa, Shinsuke Ishikawa, Masako Hirota-Kawadobora, Nobuo Okumura, Hiroya Hidaka, Tsutomu Katsuyama
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 34, 218-225, 2004
  • Recombinant fibrinogen, gamma275Arg->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions
    S.Ishikawa, M.Hirota-Kawadobora, M.Tozuka, K.Ishii, F.Terasawa, N.Okumura
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2, 468-475, 2004WebofScienceリポジトリ電子ジャーナル
  • Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking
    Nobuo Okumura, Oleg V. Gorkun, Fumiko Terasawa, Susan T. Lord
    BLOOD, 103, 4157-4163, 2004WebofScienceリポジトリ電子ジャーナル
  • Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma275C, gamma275H, and gamam275A
    M.Hirota-Kawadobora, F.Terasawa, T.Suzuki, M.Tozuka, K.Sano, N.Okumura
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2, 1359-1367, 2004WebofScienceリポジトリ電子ジャーナル
  • Fibrinogens Kosai and Ogasa: Bβ15Gly-Cys(GGT-TGT) substitution associated with impairment of fibrinopeptide B release and lateral aggregation.
    Hirota-Kawadobora M, Terasawa F, Yonekawa O, Sahara N, Shimizu E, Okumura N, Katsuyama T, Shigematsu
    J Thrombosis and Haemostasis, 1, 275-283, 2003
  • Immunohistochemical lacalization of sodium-potassium ATPase in human normal stomach and gastric adenocarcinomas.
    Kobayashi C, Hayama M, Harada O, Terasawa F, Okumura N, Sugiyama A, Ota H
    Histochem Cell Biol, 119, 317-322, 2003
  • Fibrinogen Otsu I: A γAsn319, Asp320 deletiondysfibrinogen identified in an asymotomatic pregnant woman.
    Terasawa F, Hogan KA, Kani S, Hirose M, Eguchi Y, Noda Y, Hongo M, Okumura N
    THROMBOSIS AND HAEMOSTASIS, 90, 757-758, 2003
  • Identification and properties of glycated monoclonal IgA that Affect the fructosamine assay.
    Fujita K, Curtiss LK, Sakurabayashi I, Kameko F, Okumura N, Terasawa F, Tozuka M, Katsuyama
    CLINICAL CHEMISTRY, 49, 805-808, 2003
  • Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats
    Hironaka E, Hongo M, Sakai A, Mawatari E, Ushiyama Y, Terasawa F, Okumura N,Yamazaki A, Yazaki Y, Kinoshita O, Kubo
    Cardiovascular Research, 60, 692-699, 2003
  • Novel beta-thalassemia trait (IVS I-1 G->C) in a Japanese family
    Noriko Fijihara, Minoru Tozuka, Ichiro Ueno, Kazuyoshi Yamauchi, Ritsuko Nakagoshi, Shinsuke Ishikawa, Masako Hirota, Nobuo Okumura, Eizaburo Ishii, Tsutomu Katsuyama
    American Journal of Hematology, 72, 64-66, 2003
  • Sequence gamam377-395(P2), but not gamma190-202(P1),is the binding site for the alphaMI-domain of integrin alphaMbeta2 inthe gammaC-domain of fibrinogen
    Tatiana P. Ugarova, Valeryi K. Lishko, Nataly P. Podolnikova, Nobuo Okumura, et al (5)
    Biochemistry, 42, 9365-9373, 2003
  • The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese
    Fumiko Terasawa, Masako Hirota-Kawadobora, Hikaru Kobayashi, Hiroshi Saito, Minoru Tozuka, Nobuo Okumura
    THROMBOSIS RESEARCH, 112, 257-259, 2003
  • Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid
    Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K
    Ann Clin Lab Sci, 32, 369-376, 2002
  • Analysisof fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein
    Okumura N, Terasawa F, Tanaka H, Hirota M, Ota H, Kitano K, Kiyosawa K, Lord ST
    BLOOD, 99, 3654-3660, 2002
  • Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of g-chain
    Hirota-Kawadobora M, Tozuka M, Yamauchi K,Hidaka E, Ueno I, Sugano M, Terasawa F, Okumura N,Katuyama T, Shigematsu H
    CLINICA CHIMICA ACTA, 319, 67-73, 2002
  • Evidence that heterodimers exist in the fibrinogenMatsumoto II (γ308N-K) proband and participate infibrin fiber formation.
    Okumura N, Terasawa F, Kiyotaka Fujita, Noriko Fujiwara, Minoru Tozuka, Chang-Sung Koh
    Thrombosis Reseach, 107, 157-162, 2002
  • Fibrinogen Matsumoto V: a variant with Aα19 Arg->Gly(AGG->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization.
    Tanaka H, Terasawa F, Ito T,Tokunaga S, Ishida F, Kitano K, Kiyosawa K, Okumura N
    THROMBOSIS AND HAEMOSTASIS, 85, 108-113, 2001
  • Polymerization site a function dependence on structural integrity of its nearby calcium binding site.
    Lounes KC, Okumura N, Hogan KA, Ping L, Lord ST
    Annals of New York Academy of Science, 936, 205-209, 2001
  • The formation of β fibrin requires a functional a site.
    Hogan KA, Bolliger B, Okumura N, Lord ST
    Annals of New York Academy of Science, 936, 219-222, 2001
  • Hypofibrinogenemia associated with a heterozygous C->T nucleotide substitution at position -1138 bp of the 5'-flanking region of the fibrinogen Aα-chain.
    Okumura N, Terasawa F, Yonekawa O, Hamada E, Kaneko H
    Annals of New York Academy of Science, 936, 526-530, 2001
  • Difference in electrophoretic mobility and plasmic digestion profile between four recombinant fibrinogens, gamma 308K, gamma 308I, gamma 308A, and wild type (gamma 308N)
    Okumura, N; Terasawa, F; Fujita, K; Tozuka, M; Ota, H; Katsuyama, T
    Electrophoresis, 21(12), 2309-2315, 2000WebofScience
  • A functional assay suggests that heterodimers exist in two C-terminal γ-chaindysfibrinogens; Matsumoto I and Vlissingen/Frankfurt IV.
    Hogan KA, Lord ST, Okumura N, Terasawa F, Galanakis DK, Scharrer I, Gorkun OV
    THROMBOSIS AND HAEMOSTASIS, 83(4), 592-597, 2000WebofScience
  • Identification of a dysfibrinogen, the substitution of γ308Asn(AAT) to Lys(AAG), using coagulation tests, immunoblot analysis, and allele-specific polymerase chain reaction.
    Terasawa F, Fujita K, Tozuka M, Ota H, Katsuyama T, Okumura N
    CLINICA CHIMICA ACTA, 295(1-2), 77-85, 2000WebofScience
  • Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method.
    Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T
    Electrophoresis, 21(14), 3016-3019, 2000WebofScience
  • Comparison of functions between recombinant variant fibrinogens, r308K, r308I and r308A
    Okumura, N; Terasawa, F; Lord, ST
    THROMBOSIS AND HAEMOSTASIS, 321-321, 1999WebofScience
  • Fibrinogen Matsumoto IV: A heterozygous fibrinogen deficiency caused by a missense mutation ofr153Cys toArg
    Terasawa, F; Okumura, N; Lord, ST
    THROMBOSIS AND HAEMOSTASIS, 42-42, 1999WebofScience
  • Hypofibrinogenemia associated with a heterozygous missense mutation γ153Cys to Arg (Matsumoto IV): In vitro expression demonstrates defective secretion of the variant fibrinogen.
    Terasawa F, Okumura N, Kitano K, Hayashida N, Shimosaka M, Okazaki M, Lord ST
    BLOOD, 94(12), 4122-4131, 1999WebofScience
  • Fibrinogen Matsumoto III: a variant with γ275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (γ364Asp→His) and Matsumoto II (γ308Asn→Lys).
    Terasawa F, Okumura N,Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T
    THROMBOSIS AND HAEMOSTASIS, 81(5), 763-766, 1999WebofScience
  • Genetic analyses in homozygous and heterozygous variant of lactate dehydrogenese-B(H) subunit-LD-B Matsumoto I and II (LD-B W323R)-.
    Okumura N, Terasawa F, Ueno I, Oki K, Yamauchi K, Hidaka H, Tozuka M, Okura M, Katsuyama T
    Clinica Chimica Acta, 287(1-2), 163-171, 1999WebofScience
  • Flow Cytometryを用いた血小板活性化能測定の基礎的検討とその評価法
    石川伸介, 戸塚 実, 廣田雅子, 佐々木由美子, 奥村伸生, 降旗謙一, 勝山 努
    臨床病理, 46, 605-610, 1998
  • PlasminogenKanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R
    Higuchi Yumiko, Furihata Kenichi, Ueno Ichiro, Ishikawa Shinshuke, Okumura Nobuo, Tozuka Minoru, Sakurai Noriko
    British J of Haematology, 103(3), 867-870, 1998WebofScience電子ジャーナル
  • Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
    Higuchi, T; Koike, K; Sawai, N; Mwamtemi, HH; Takeuchi, K; Shiohara, M; Kikuchi, T; Yasui, K; Ito, S; Yamagami, O; Sasaki, Y; Okumura, N; Kato, T; Miyazaki, H; Ikeda, M; Yamada, M; Komiyama, A
    BRITISH JOURNAL OF HAEMATOLOGY, 99(3), 509-516, 1997WebofScience
  • Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma
    Tozuka, M; Yamauchi, K; Hidaka, H; Nakabayashi, T; Okumura, NS; Katsuyama, T
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 27(5), 351-357, 1997WebofScience
  • Fibrinogen Matsumoto II: gamma(308)Asn->Lys(AAT->AAG) mutation associated with bleeding tendency
    Okumura, N; Furihata, K; Terasawa, F; Ishikawa, S; Ueno, I; Katsuyama, T
    BRITISH JOURNAL OF HAEMATOLOGY, 94(3), 526-528, 1996WebofScience
  • A case of immunoglobulin A-lambda conjugated with lactate dehydrogenase-5 isoenzyme, causing an extremely high enzyme activity in serum
    Tozuka, M; Hidaka, H; Okumura, N; Ichikawa, T; Furibata, K; Katsuyama, T
    CLINICAL CHEMISTRY, 42(8), 1288-1290, 1996WebofScience
  • Fibrinogen Matsumoto I: A gamma 364 Asp->His (GAT->CAT) substitution associated with defective fibrin polymerization
    Okumura, N; Furihata, K; Terasawa, F; Nakagoshi, R; Ueno, I; Katsuyama, T
    THROMBOSIS AND HAEMOSTASIS, 75(6), 887-891, 1996WebofScience
  • Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells
    Okumura, N; Tsuji, K; Ebihara, Y; Tanaka, I; Sawai, N; Koike, K; Komiyama, A; Nakahata, T
    BLOOD, 87(10), 4100-4108, 1996WebofScience
  • Influence of apolipoprotein E phenotypes on total serum cholesterol in Japanese children
    Tozuka, M; Ohta, H; Hidaka, H; Okumura, N; Furihata, K; Katsuyama, T
    CLINICA CHIMICA ACTA, 247(1-2), 175-180, 1996WebofScience
  • Aberrant growth of granulocyte-macrophage progenitors in juvenile chronic myelogenous leukemia in serum-free culture
    Sawai, N; Koike, K; Ito, S; Okumura, N; Kamijo, T; Shiohara, M; Amano, Y; Tsuji, K; Nakahata, T; Oda, M; Okamura, J; Kobayashi, M; Komiyama, A
    EXPERIMENTAL HEMATOLOGY, 24(2), 116-122, 1996WebofScience
  • Fibrinogen Matsumoto II: A gamma 308ASN->Lys(AAT->AAG) mutation associated with defective fibrin polymerization.
    Okumura, N; Terasawa, F; Ueno, I; Kaysuyama, T; Furihata, K
    BLOOD, 86(10), 3520-3520, 1995WebofScience
  • PREVENTION OF HEPATIC-ARTERY THROMBOSIS IN PEDIATRIC LIVER-TRANSPLANTATION
    HASHIKURA, Y; KAWASAKI, S; OKUMURA, N; ISHIKAWA, S; MATSUNAMI, H; IKEGAMI, T; NAKAZAWA, Y; MAKUUCHI, M
    TRANSPLANTATION, 60(10), 1109-1112, 1995WebofScience
  • GENETIC-ANALYSIS OF FIBRINOGEN MATSUMOTO - A POINT MUTATION IN EXON-9 OF GAMMA-CHAIN RESPONSIBLE FOR DEFECTIVE FIBRIN POLYMERIZATION
    TERASAWA, F; OKUMURA, N; UENO, I; HIDAKA, E; FURUWATARI, C; YAN, J; KATSUYAMA, T; FURIHATA, K
    BLOOD, 84(10), A60-A60, 1994WebofScience
  • CELL-SURFACE ANTIGEN EXPRESSION IN HUMAN ERYTHROID PROGENITORS - ERYTHROID AND MEGAKARYOCYTIC MARKERS
    NAKAHATA, T; OKUMURA, N
    LEUKEMIA&LYMPHOMA, 13(5-6), 401-409, 1994WebofScience
  • CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
    OKUMURA, N; TSUJI, K; NAKAHATA, T
    BLOOD, 80(3), 642-650, 1992WebofScience
  • CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
    OKUMURA, N; NAKAHATA, T
    EXPERIMENTAL HEMATOLOGY, 20(6), 793-793, 1992WebofScience
  • INTERLEUKIN-6 SUPPORTS HUMAN MEGAKARYOCYTIC PROLIFERATION AND DIFFERENTIATION INVITRO
    IMAI, T; KOIKE, K; KUBO, T; KIKUCHI, T; AMANO, Y; TAKAGI, M; OKUMURA, N; NAKAHATA, T
    BLOOD, 78(8), 1969-1974, 1991WebofScience
  • COAGULATION ABNORMALITIES FOLLOWED ORTHOTOPIC LIVING RELATED LIVER-TRANSPLANTATION
    SAITO, H; OKUMURA, N; HARADA, H; KUDO, M; MAKUUCHI, M; FURUTA, S
    THROMBOSIS AND HAEMOSTASIS, 65(6), 1090-1090, 1991WebofScience

Affiliated academic society

  • Japanese Society of LaboratoryMedicine
  • Japanese Societ of Clinical Chemistry
  • Japanese Society of Thrombosis and Hematostasis
  • Japanese Society of Laboratory Hematology
  • Japanese Society of Laboratory Automation
  • International Fibrinogen Research Society
  • International Society for Thrombosis and Haemostasis

Research Themes

  • 血清中シトルリン化フィブリノーゲン測定による好中球細胞外トラップ検出の検討
    科学研究費補助金, 基盤研究(C)
    2020 - 2022
  • フィブリノゲン機能異常症例の解析からフィブリン重合機序の詳細を解明する研究
    科学研究費補助金, 基盤研究(C)
    2017 - 2019
  • 肝硬変を引き起こすフィブリノゲン低下症の鑑別法の開発と分子生物学的発生機序解明
    科学研究費補助金, 基盤研究C
    2014 - 2016
  • 血漿および関節液中のシトルリン化フィブリノゲンとその抗体定量法の確立.
    科学研究費補助金, 科学研究費 基盤研究C
    2013 - 2015
  • シトルリン化フィブリノゲン・フィブリンの溶解性に関する研究
    科学研究費補助金, 基盤(C)
    01 Apr. 2010 - 31 Mar. 2012
  • シトルリン化フィブリノゲンの凝固・線溶機能異常とその病因との関係
    科学研究費補助金, 基盤研究(C)
    01 Apr. 2007 - 31 Mar. 2009
  • リコンビナントフィブリノゲンを用いたフィブリノゲン-フィブリン転換の分子メカニズムの解析とその正常機能を抑制する合成ペプチドの検索
    01 Jan. 2007 - 31 Mar. 2008
  • Functional analysis for citrullinated fibrinogen and fibrin
    2007
  • フィブリノゲンの組み立て・分泌におけるBβ鎖・γ鎖の機能の相違に関する研究
    科学研究費補助金, 基盤研究(C)
    01 Apr. 2004 - 31 Mar. 2006
  • リコンビナントヒト正常・異常フィブリノゲンを用いたフィブリン繊維形成機序の解析と合成ペプチドによるその抑制
    01 Apr. 2002 - 31 Mar. 2003
  • 異常フィブリノゲンMataumotoIVの遺伝子導入による原因の研究
    01 Aug. 1998 - 31 Jul. 1999
  • リコンビナント異常フィブリノゲンを用いたフィブリン凝集能の解析
    01 Apr. 1997 - 31 Mar. 1998
  • Molecular biological research for causes of fibrinogen deficiency
    1997
  • Functional analysis for dysfibrinogenemia
    1993

Academic Contribution Activities

  • Others
    臨床病理(編集委員), 01 Jan. 2008 - 31 Dec. 2011
  • Others
    Clinica Chimica Acta (Editorial Board), 01 Jan. 2003

Inviting researchers

  • 20 Oct. 2003 - 02 Nov. 2003
    日本学術振興会外国人招へい研究者(短期), Susan Trimble Lord, 日本学術振興会外国人招へい研究者(短期), Professor of The University of North Carolina