理学博士, 九州大学

機能生物化学

2015年
信州大学医学部医学科　講師

2008年
信州大学医学部医学科　助教

2002年 - 2008年
信州大学医学部医学科 助手

2000年 - 2002年
日本学術振興会 特別研究員（PD)

2000年, 九州大学, 理学研究科, 化学専攻

1997年, 九州大学, 理学研究科, 化学専攻

1995年, 九州大学, 理学部, 化学科

2001年
第18回　井上研究奨励賞

MK-6, a novel not-alpha IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance
Kobayashi, Maki; Kojima, Katsuhiko; Murayama, Kazutaka; Amano, Yuji; Koyama, Takashi; Ogama, Naoko; Takeshita, Toshikazu; Fukuhara, Tatsuro; Tanaka, Nobuyuki;
CANCER SCIENCE, 112(11), 4478-4489, 2021年11月

Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics
Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kikuchi, Shiho; Shimada, Yuto; Nakamura, Rikiya; Arikawa, Mikihiko; Miyata, Seiji; Kinoshita, Eiji; Suizu, Futoshi; Matsuoka, Tatsuomi;
ACTA PROTOZOOLOGICA, 59(3-4), 107-120, 2020年

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
Amano, Yuji; Akazawa, Yohei; Yasuda, Jun; Yoshino, Kazuhisa; Kojima, Katsuhiko; Kobayashi, Norimoto; Matsuzaki, Satoshi; Nagasaki, Masao; Kawai, Yosuke; Minegishi, Naoko; Ishida, Noriko; Motoki, Noriko; Hachiya, Akira; Nakazawa, Yozo; Yamamoto, Masayuki; Koike, Kenichi; Takeshita, Toshikazu;
PEDIATRIC RHEUMATOLOGY, 17, 34, 2019年

Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, 2018年

Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
Kashihara, Toshihide; Nakada, Tsutomu; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
JOURNAL OF PHYSIOLOGY-LONDON, 595(13), 4207-4225, 2017年

Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1
Funadani, Ryoji; Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamamoto, Keisuke; Tsujizono, Tomoya; Suizu, Futoshi; Miyata, Seiji; Yagyu, Ken-Ichi; Suzuki, Tomohiko; Arikawa, Mikihiko; Matsuoka, Tatsuomi;
FEMS Microbiology Letters, 363(18), fnw203, 2016年09月

Identification of Differentially Expressed Water-insoluble Proteins in the Encystment Process of Colpoda cucullus by Two-dimensional Electrophoresis and LC-MS/MS Analysis
Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 61(1), 51-60, 2014年01月

ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation
Kojima, Katsuhiko; Amano, Yuji; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
JOURNAL OF BIOLOGICAL CHEMISTRY, 289(48), 33296-33310, 2014年

A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal
Amano, Yuji; Yoshino, Kazuhisa; Kojima, Katsuhiko; Takeshita, Toshikazu;
Biochemical and biophysical research communications, 441(1), 164-168, 2013年

Excystment-Dependent Alteration of Protein Expression in Terrestrial Ciliate Colpoda cucullus
Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Funadani, Ryoji; Matsuoka, Tatsuomi;
Microbes and Environments, 28(3), 388-390, 2013年

Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins
Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Fujiwara, Shigeki; Miyata, Seiji; Kinoshita, Eiji; Matsuoka, Tatsuomi;
FEMS Microbiology Letters, 331(2), 128-135, 2012年06月

EF-1 alpha and Mitochondrial ATP Synthase beta Chain: Alteration of their Expression in Encystment-Induced Colpoda cucullus
Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 59(4), 401-406, 2012年

Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
Amano, Yuji; Yamashita, Yuki; Kojima, Katsuhiko; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
JOURNAL OF BIOLOGICAL CHEMISTRY, 286(17), 15458-15472, 2011年

A HIGH INCIDENCE REGION FOR RETROVIRAL VECTOR INTEGRATION NEAR EXON 1 OF THE LMO2 LOCUS
Tsukahara, Tomonori; Yamada, Koichiro; Yoshino, Kazuhisa; Kojima, Katsuhiko; Yamashita, Yuki; Ozawa, Keiya; Takeshita, Toshikazu;
JOURNAL OF GENE MEDICINE, 12(12), 1038-1038, 2010年12月

Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
Yamada, Koichiro; Tsukahara, Tomonori; Yoshino, Kazuhisa; Kojima, Katsuhiko; Agawa, Hideyuki; Yamashita, Yuki; Amano, Yuji; Hatta, Mariko; Matsuzaki, Yasunori; Kurotori, Naoki; Wakui, Keiko; Fukushima, Yoshimitsu; Osada, Ryosuke; Shiozawa, Tanri; Sakashita, Kazuo; Koike, Kenichi; Kumaki, Satoru; Tanaka, Nobuyuki; Takeshita, Toshikazu;
RETROVIROLOGY, 6, 79, 2009年

Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain
Yamashita, Yuki; Kojima, Katsuhiko; Tsukahara, Tomonori; Agawa, Hideyuki; Yamada, Koichiro; Amano, Yuji; Kurotori, Naoki; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
JOURNAL OF CELL SCIENCE, 121(10), 1727-1738, 2008年

Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line
Tsukahara, Tomonori; Agawa, Hideyuki; Matsumoto, Sayori; Matsuda, Mizuho; Ueno, Shuichi; Yamashita, Yuki; Yamada, Koichiro; Tanaka, Nobuyuki; Kojima, Katsuhiko; Takeshita, Toshikazu;
Biochemical and biophysical research communications, 345(3), 1099-1107, 2006年

AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes
Kyuuma, Masanao; Kikuchi, Kazu; Kojima, Katsuhiko; Sugawara, Yuriko; Sato, Mariko; Mano, Nariyasu; Goto, Junichi; Takeshita, Toshikazu; Yamamoto, Akitsugu; Sugamura, Kazuo; Tanaka, Nobuyuki;
CELL STRUCTURE AND FUNCTION, 31(2), 159-172, 2006年

Recognitionof mitochondrial protein precursor lacking arginine at position -2 by mitochondrial processing peptidase
Katsuhiko Kojima, Eiki Yamasaki, Sakae Kitada, Tadashi Ogishima and Akio Ito.
JOURNAL OF BIOCHEMISTRY, 130, 497-502, 2001年10月

A proposed common structure of substrates bound to mitochondrial processing peptidase
Katsuhiko Kojima, Sakae Kitada, Tadashi Ogishima and Akio Ito
The Journal of biological chemistry, 276, 2115-2121, 2001年01月

Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase
Katsuhiko Kojima, Sakae Kitada, Kunitoshi Shimokata, Tadashi Ogishima and Akio Ito.
The Journal of biological chemistry, 273, 32542-32546, 1998年12月

細菌学・ウィルス学実習
信州大学

進行がんを制圧する分子進化型人工サイトカイン医薬の開発
受託事業, 日本医療研究開発機構(AMED)橋渡し研究プログラムpreF
2023年 - 2024年

胆管癌の浸潤転移能獲得におけるS100A10の機能解明と治療戦略への展開
科学研究費補助金, 基盤研究（C)
2021年 - 2023年

改変型サイトカイン分子設計による抗腫瘍免疫療法の開発
受託事業, 日本医療研究開発機構(AMED)次世代がん医療創生研究事業(P-CREATE)
2021年 - 2022年

胆管癌幹細胞に高発現するS100分子群の癌悪性形質維持機構の解明
科学研究費補助金, 基盤研究（C）
2018年 - 2020年

脱ユビキチン化酵素ＡＭＳＨによる細胞内小胞輸送の制御機構の解析
科学研究費補助金, 若手研究（Ｂ）
2004年 - 2005年

膜輸送を介したサイトカインシグナルの制御機構の解析