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小嶋 克彦  コジマ カツヒコ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 免疫・微生物学FAX番号
職名講師メールアドレス
住所ホームページURL

更新日:2022/12/14

プロフィール

研究分野
機能生物化学
現在の研究課題
膜輸送を介したサイトカインシグナルの制御機構の解析
キーワード:小胞輸送 サイトカイン シグナル伝達
学歴
出身大学院
2000 , 九州大学 , 理学研究科 , 化学専攻
1997 , 九州大学 , 理学研究科 , 化学専攻

出身学校・専攻等(大学院を除く)
1995 , 九州大学 , 理学部 , 化学科

取得学位
理学博士 , 九州大学
受賞学術賞
2001 , 第18回 井上研究奨励賞
研究職歴等
研究職歴
2015- , 信州大学医学部医学科 講師
2008- , 信州大学医学部医学科 助教
2002-2008 , 信州大学医学部医学科 助手
2000-2002 , 日本学術振興会 特別研究員(PD)

研究活動業績

研究業績(著書・
発表論文等)
論文
MK-6, a novel not-alpha IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance
CANCER SCIENCE,112(11):4478-4489 2021(Nov.)
Author:Kobayashi, Maki; Kojima, Katsuhiko; Murayama, Kazutaka; Amano, Yuji; Koyama, Takashi; Ogama, Naoko; Takeshita, Toshikazu; Fukuhara, Tatsuro; Tanaka, Nobuyuki;
Keywords:cancer immunotherapy; cytokines; IL-2 Mutein; regulatory T cells; tumor-infiltrating lymphocytes;


Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics
ACTA PROTOZOOLOGICA,59(3-4):107-120 2020
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kikuchi, Shiho; Shimada, Yuto; Nakamura, Rikiya; Arikawa, Mikihiko; Miyata, Seiji; Kinoshita, Eiji; Suizu, Futoshi; Matsuoka, Tatsuomi;
Keywords:resting cyst formation; microtubules; actin; lepidosomes; resorption of cilia;


A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
PEDIATRIC RHEUMATOLOGY,17:34 2019
Author:Amano, Yuji; Akazawa, Yohei; Yasuda, Jun; Yoshino, Kazuhisa; Kojima, Katsuhiko; Kobayashi, Norimoto; Matsuzaki, Satoshi; Nagasaki, Masao; Kawai, Yosuke; Minegishi, Naoko; Ishida, Noriko; Motoki, Noriko; Hachiya, Akira; Nakazawa, Yozo; Yamamoto, Masayuki; Koike, Kenichi; Takeshita, Toshikazu;
Keywords:Kawasaki disease; Interleukin-4 receptor; IVIG-resistance; Single nucleotide variant;


Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(17):4507-4512 2018
Author:Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Keywords:skeletal muscle; dihydropyridine receptor; junctophilin; triad; ryanodine receptor;


Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
JOURNAL OF PHYSIOLOGY-LONDON,595(13):4207-4225 2017
Author:Kashihara, Toshihide; Nakada, Tsutomu; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Keywords:angiotensin II; Ca(V)1.2 Ca2+ channels; cardiomyocytes;


Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1
FEMS MICROBIOLOGY LETTERS,363(18):fnw203 2016(Sep.)
Author:Funadani, Ryoji; Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamamoto, Keisuke; Tsujizono, Tomoya; Suizu, Futoshi; Miyata, Seiji; Yagyu, Ken-Ichi; Suzuki, Tomohiko; Arikawa, Mikihiko; Matsuoka, Tatsuomi;
Keywords:Colpoda cucullus Nag-1; 18S rRNA; encystment; cyst wall proteins; lepidosome;


Identification of Differentially Expressed Water-insoluble Proteins in the Encystment Process of Colpoda cucullus by Two-dimensional Electrophoresis and LC-MS/MS Analysis
JOURNAL OF EUKARYOTIC MICROBIOLOGY,61(1):51-60 2014(Jan.)
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
Keywords:Actin; ATP synthase; cellular differentiation; cryptobiosis; cyst formation; heat shock protein; tubulin;


ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation
JOURNAL OF BIOLOGICAL CHEMISTRY,289(48):33296-33310 2014
Author:Kojima, Katsuhiko; Amano, Yuji; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;


Excystment-Dependent Alteration of Protein Expression in Terrestrial Ciliate Colpoda cucullus
MICROBES AND ENVIRONMENTS,28(3):388-390 2013
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Funadani, Ryoji; Matsuoka, Tatsuomi;
Keywords:Colpoda; excystment; DEAD-box RNA helicase;


A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,441(1):164-168 2013
Author:Amano, Yuji; Yoshino, Kazuhisa; Kojima, Katsuhiko; Takeshita, Toshikazu;
Keywords:Ubiquitin-independent; Endosomal sorting; Sorting signal; IL-2 receptor; IL-4 receptor; Hrs;


Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins
FEMS MICROBIOLOGY LETTERS,331(2):128-135 2012(Jun.)
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Fujiwara, Shigeki; Miyata, Seiji; Kinoshita, Eiji; Matsuoka, Tatsuomi;
Keywords:Colpoda; encystment; phosphorylation; Phos-tag; ribosomal P0 protein; ribosomal S5 protein;


EF-1 alpha and Mitochondrial ATP Synthase beta Chain: Alteration of their Expression in Encystment-Induced Colpoda cucullus
JOURNAL OF EUKARYOTIC MICROBIOLOGY,59(4):401-406 2012
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
Keywords:LC-MS; MS analysis; cellular morphogenesis; cyst formation;


Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
JOURNAL OF BIOLOGICAL CHEMISTRY,286(17):15458-15472 2011
Author:Amano, Yuji; Yamashita, Yuki; Kojima, Katsuhiko; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;


A HIGH INCIDENCE REGION FOR RETROVIRAL VECTOR INTEGRATION NEAR EXON 1 OF THE LMO2 LOCUS
JOURNAL OF GENE MEDICINE,12(12):1038-1038 2010(Dec.)
Author:Tsukahara, Tomonori; Yamada, Koichiro; Yoshino, Kazuhisa; Kojima, Katsuhiko; Yamashita, Yuki; Ozawa, Keiya; Takeshita, Toshikazu;


Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
RETROVIROLOGY,6:79 2009
Author:Yamada, Koichiro; Tsukahara, Tomonori; Yoshino, Kazuhisa; Kojima, Katsuhiko; Agawa, Hideyuki; Yamashita, Yuki; Amano, Yuji; Hatta, Mariko; Matsuzaki, Yasunori; Kurotori, Naoki; Wakui, Keiko; Fukushima, Yoshimitsu; Osada, Ryosuke; Shiozawa, Tanri; Sakashita, Kazuo; Koike, Kenichi; Kumaki, Satoru; Tanaka, Nobuyuki; Takeshita, Toshikazu;


Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain
JOURNAL OF CELL SCIENCE,121(10):1727-1738 2008
Author:Yamashita, Yuki; Kojima, Katsuhiko; Tsukahara, Tomonori; Agawa, Hideyuki; Yamada, Koichiro; Amano, Yuji; Kurotori, Naoki; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
Keywords:IL-2R beta; Hrs; Ubiquitin-dependent sorting;


AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes
CELL STRUCTURE AND FUNCTION,31(2):159-172 2006
Author:Kyuuma, Masanao; Kikuchi, Kazu; Kojima, Katsuhiko; Sugawara, Yuriko; Sato, Mariko; Mano, Nariyasu; Goto, Junichi; Takeshita, Toshikazu; Yamamoto, Akitsugu; Sugamura, Kazuo; Tanaka, Nobuyuki;
Keywords:deubiquitination; endosome; ESCRT-III; MVB; ubiquitin;


Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(3):1099-1107 2006
Author:Tsukahara, Tomonori; Agawa, Hideyuki; Matsumoto, Sayori; Matsuda, Mizuho; Ueno, Shuichi; Yamashita, Yuki; Yamada, Koichiro; Tanaka, Nobuyuki; Kojima, Katsuhiko; Takeshita, Toshikazu;
Keywords:MLV vector; T-cells; insertional mutagenesis; oncogenes; X-SCID; leukemia; gene therapy;


Recognitionof mitochondrial protein precursor lacking arginine at position -2 by mitochondrial processing peptidase
Journal of Biochemistry,130:497-502 2001(Oct.)
Author:Katsuhiko Kojima, Eiki Yamasaki, Sakae Kitada, Tadashi Ogishima and Akio Ito.


A proposed common structure of substrates bound to mitochondrial processing peptidase
The Journal of Biological Chemistry,276:2115-2121 2001(Jan.)
Author:Katsuhiko Kojima, Sakae Kitada, Tadashi Ogishima and Akio Ito


Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase
The Journal of Biological Chemistry,273:32542-32546 1998(Dec.)
Author:Katsuhiko Kojima, Sakae Kitada, Kunitoshi Shimokata, Tadashi Ogishima and Akio Ito.

研究費
科学研究費補助金(研究代表者)
2021 - 2023 , 胆管癌の浸潤転移能獲得におけるS100A10の機能解明と治療戦略への展開 , 基盤研究(C)
2018 - 2020 , 胆管癌幹細胞に高発現するS100分子群の癌悪性形質維持機構の解明 , 基盤研究(C)
2004 - 2005 , 脱ユビキチン化酵素AMSHによる細胞内小胞輸送の制御機構の解析 , 若手研究(B)

教育活動実績

授業等
2002 , 細菌学・ウィルス学実習