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小嶋 克彦  コジマ カツヒコ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 免疫・微生物学FAX番号
職名講師メールアドレス
住所ホームページURL

更新日:2021/07/19

プロフィール

研究分野
機能生物化学
現在の研究課題
膜輸送を介したサイトカインシグナルの制御機構の解析
キーワード:小胞輸送 サイトカイン シグナル伝達
学歴
出身大学院
2000 , 九州大学 , 理学研究科 , 化学専攻
1997 , 九州大学 , 理学研究科 , 化学専攻

出身学校・専攻等(大学院を除く)
1995 , 九州大学 , 理学部 , 化学科

取得学位
理学博士 , 九州大学
受賞学術賞
2001 , 第18回 井上研究奨励賞
研究職歴等
研究職歴
2015- , 信州大学医学部医学科 講師
2008- , 信州大学医学部医学科 助教
2002-2008 , 信州大学医学部医学科 助手
2000-2002 , 日本学術振興会 特別研究員(PD)

研究活動業績

研究業績(著書・
発表論文等)
論文
A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
PEDIATRIC RHEUMATOLOGY,17 2019
Author:Amano, Yuji; Akazawa, Yohei; Yasuda, Jun; Yoshino, Kazuhisa; Kojima, Katsuhiko; Kobayashi, Norimoto; Matsuzaki, Satoshi; Nagasaki, Masao; Kawai, Yosuke; Minegishi, Naoko; Ishida, Noriko; Motoki, Noriko; Hachiya, Akira; Nakazawa, Yozo; Yamamoto, Masayuki; Koike, Kenichi; Takeshita, Toshikazu;


Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(17):4507-4512 2018
Author:Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;


Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
JOURNAL OF PHYSIOLOGY-LONDON,595(13):4207-4225 2017
Author:Kashihara, Toshihide; Nakada, Tsutomu; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;


Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1
FEMS microbiology letters,363(18):fnw203 2016
Author:Funadani R, Sogame Y, Kojima K, Takeshita T, Yamamoto K, Tsujizono T, Suizu F, Miyata S, Yagyu KI, Suzuki T, Arikawa M, Matsuoka T.


Identification of Differentially Expressed Water-insoluble Proteins in the Encystment Process of Colpoda cucullus by Two-dimensional Electrophoresis and LC-MS/MS Analysis
JOURNAL OF EUKARYOTIC MICROBIOLOGY,61(1):51-60 2014(Jan.)
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi


ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation
JOURNAL OF BIOLOGICAL CHEMISTRY,289(48):33296-33310 2014
Author:Kojima, Katsuhiko; Amano, Yuji; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;


A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,441(1):164-168 2013(Nov. 08)
Author:Amano, Yuji; Yoshino, Kazuhisa; Kojima, Katsuhiko; Takeshita, Toshikazu


Excystment-Dependent Alteration of Protein Expression in Terrestrial Ciliate Colpoda cucullus
MICROBES AND ENVIRONMENTS,28(3):388-390 2013(Sep. 21)
Author:Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Funadani, Ryoji; Matsuoka, Tatsuomi


Protein phosphorylation in encystment-induced Colpoda cucullus: Localization and identification of phosphoproteins
FEMS Microbiology Letters,331:128-135 2012
Author:Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Shigeki Fujiwara, Seiji Miyata, Eiji Kinoshita and Tatsuomi Matsuoka


EF-1α and Mitochondrial ATP Synthase β Chain: Alteration of Their Expression in Encystment-Induced Colpoda cucullus
The Journal of Eukaryotic Microbiology,59:401-406 2012
Author:Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Eiji Kinoshita and Tatsuomi Matsuoka


Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting
The Journal of Biological Chemistry,286(17):15458-15472 2011
Author:Yuji Amano, Yuki Yamashita, Katsuhiko Kojima, Kazuhisa Yoshino, Nobuyuki Tanaka, Kazuo Sugamura and Toshikazu Takeshita


Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
RETROVIROLOGY,6:79 2009
Author:Koichiro Yamada, Tomonori Tsukahara, Kazuhisa Yoshino, Katsuhiko Kojima, Hideyuki Agawa, Yuki Yamashita, Yuji Amano, Mariko Hatta, Yasunori Matsuzaki, Naoki Kurotori, Keiko Wakui, Yoshimitsu Fukushima, Ryosuke Osada, Tanri Shiozawa, Kazuo Sakashita, Kenichi Koike, Satoru Kumaki, Nobuyuki Tanaka and Toshikazu Takeshita


Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta chain
Journal of Cell Science,121:1727-1738 2008
Author:Yuki Yamashita, Katsuhiko Kojima, Tomonori Tsukahara, Hideyuki Agawa, Koichiro Yamada, Yuji Amano, Naoki Kurotori, Nobuyuki Tanaka, Kazuo Sugamura and Toshikazu Takeshita


AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes
Cell structure and function,31:159-172 2007
Author:Masanao Kyuuma, Kazu Kikuchi, Katsuhiko Kojima, Yuriko Sugawara, Mariko Sato, Nariyasu Mano, Junichi Goto, Toshikazu Takeshita, Akitsugu Yamamoto, Kazuo Sugamura and Nobuyuki Tanaka


Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line
Biochem Biophys Res Commun.,345:1099-1107 2006
Author:Tsukahara T., Agawa H., Matsumoto S., Matsuda M., Ueno S., YamashitaY., Yamada K., Tanaka N., Kojima K., Takeshita T


Recognitionof mitochondrial protein precursor lacking arginine at position -2 by mitochondrial processing peptidase
Journal of Biochemistry,130:497-502 2001(Oct.)
Author:Katsuhiko Kojima, Eiki Yamasaki, Sakae Kitada, Tadashi Ogishima and Akio Ito.


A proposed common structure of substrates bound to mitochondrial processing peptidase
The Journal of Biological Chemistry,276:2115-2121 2001(Jan.)
Author:Katsuhiko Kojima, Sakae Kitada, Tadashi Ogishima and Akio Ito


Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase
The Journal of Biological Chemistry,273:32542-32546 1998(Dec.)
Author:Katsuhiko Kojima, Sakae Kitada, Kunitoshi Shimokata, Tadashi Ogishima and Akio Ito.

教育活動実績

授業等
2002 , 細菌学・ウィルス学実習