KOJIMA KATSUHIKO

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

School of Medicine Department of Microbiology 

Senior Assistant Professor 

Researcher Information

Degree

  • Ph.D, Kyushu University

Field Of Study

  • Functional biochemistry

Career

  • 2015
    信州大学医学部医学科 講師
  • 2008
    信州大学医学部医学科 助教
  • 2002 - 2008
    Shinshu university school of medicine Rearch associate
  • 2000 - 2002
    Japan society for the promotion of science Postdoctral fellow

Educational Background

  • 1995, Kyushu University, Faculty of Science, 化学科
  • 2000, Kyushu University, Graduate School, Division of Natural Science, Chemistry
  • 1997, Kyushu University, Graduate School, Division of Natural Science, Chemistry
Research activity information

Paper

  • MK-6, a novel not-alpha IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance
    Kobayashi, Maki; Kojima, Katsuhiko; Murayama, Kazutaka; Amano, Yuji; Koyama, Takashi; Ogama, Naoko; Takeshita, Toshikazu; Fukuhara, Tatsuro; Tanaka, Nobuyuki;
    CANCER SCIENCE, 112(11), 4478-4489, Nov. 2021WebofScience電子ジャーナル
  • Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics
    Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kikuchi, Shiho; Shimada, Yuto; Nakamura, Rikiya; Arikawa, Mikihiko; Miyata, Seiji; Kinoshita, Eiji; Suizu, Futoshi; Matsuoka, Tatsuomi;
    ACTA PROTOZOOLOGICA, 59(3-4), 107-120, 2020WebofScience電子ジャーナル
  • A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
    Amano, Yuji; Akazawa, Yohei; Yasuda, Jun; Yoshino, Kazuhisa; Kojima, Katsuhiko; Kobayashi, Norimoto; Matsuzaki, Satoshi; Nagasaki, Masao; Kawai, Yosuke; Minegishi, Naoko; Ishida, Noriko; Motoki, Noriko; Hachiya, Akira; Nakazawa, Yozo; Yamamoto, Masayuki; Koike, Kenichi; Takeshita, Toshikazu;
    PEDIATRIC RHEUMATOLOGY, 17, 34, 2019WebofScience電子ジャーナル
  • Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
    Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
    Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, 2018WebofScience電子ジャーナル
  • Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
    Kashihara, Toshihide; Nakada, Tsutomu; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
    JOURNAL OF PHYSIOLOGY-LONDON, 595(13), 4207-4225, 2017WebofScience電子ジャーナル
  • Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1
    Funadani, Ryoji; Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamamoto, Keisuke; Tsujizono, Tomoya; Suizu, Futoshi; Miyata, Seiji; Yagyu, Ken-Ichi; Suzuki, Tomohiko; Arikawa, Mikihiko; Matsuoka, Tatsuomi;
    FEMS Microbiology Letters, 363(18), fnw203, Sep. 2016WebofScience電子ジャーナル
  • Identification of Differentially Expressed Water-insoluble Proteins in the Encystment Process of Colpoda cucullus by Two-dimensional Electrophoresis and LC-MS/MS Analysis
    Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
    JOURNAL OF EUKARYOTIC MICROBIOLOGY, 61(1), 51-60, Jan. 2014WebofScience電子ジャーナル
  • ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation
    Kojima, Katsuhiko; Amano, Yuji; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 289(48), 33296-33310, 2014WebofScience電子ジャーナル
  • A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal
    Amano, Yuji; Yoshino, Kazuhisa; Kojima, Katsuhiko; Takeshita, Toshikazu;
    Biochemical and biophysical research communications, 441(1), 164-168, 2013WebofScience電子ジャーナル
  • Excystment-Dependent Alteration of Protein Expression in Terrestrial Ciliate Colpoda cucullus
    Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Funadani, Ryoji; Matsuoka, Tatsuomi;
    Microbes and Environments, 28(3), 388-390, 2013WebofScience電子ジャーナル
  • Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins
    Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Fujiwara, Shigeki; Miyata, Seiji; Kinoshita, Eiji; Matsuoka, Tatsuomi;
    FEMS Microbiology Letters, 331(2), 128-135, Jun. 2012WebofScience電子ジャーナル
  • EF-1 alpha and Mitochondrial ATP Synthase beta Chain: Alteration of their Expression in Encystment-Induced Colpoda cucullus
    Sogame, Yoichiro; Kojima, Katsuhiko; Takeshita, Toshikazu; Kinoshita, Eiji; Matsuoka, Tatsuomi;
    JOURNAL OF EUKARYOTIC MICROBIOLOGY, 59(4), 401-406, 2012WebofScience電子ジャーナル
  • Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
    Amano, Yuji; Yamashita, Yuki; Kojima, Katsuhiko; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 286(17), 15458-15472, 2011WebofScience電子ジャーナル
  • A HIGH INCIDENCE REGION FOR RETROVIRAL VECTOR INTEGRATION NEAR EXON 1 OF THE LMO2 LOCUS
    Tsukahara, Tomonori; Yamada, Koichiro; Yoshino, Kazuhisa; Kojima, Katsuhiko; Yamashita, Yuki; Ozawa, Keiya; Takeshita, Toshikazu;
    JOURNAL OF GENE MEDICINE, 12(12), 1038-1038, Dec. 2010WebofScience
  • Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
    Yamada, Koichiro; Tsukahara, Tomonori; Yoshino, Kazuhisa; Kojima, Katsuhiko; Agawa, Hideyuki; Yamashita, Yuki; Amano, Yuji; Hatta, Mariko; Matsuzaki, Yasunori; Kurotori, Naoki; Wakui, Keiko; Fukushima, Yoshimitsu; Osada, Ryosuke; Shiozawa, Tanri; Sakashita, Kazuo; Koike, Kenichi; Kumaki, Satoru; Tanaka, Nobuyuki; Takeshita, Toshikazu;
    RETROVIROLOGY, 6, 79, 2009WebofScience電子ジャーナル
  • Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain
    Yamashita, Yuki; Kojima, Katsuhiko; Tsukahara, Tomonori; Agawa, Hideyuki; Yamada, Koichiro; Amano, Yuji; Kurotori, Naoki; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
    JOURNAL OF CELL SCIENCE, 121(10), 1727-1738, 2008WebofScience電子ジャーナル
  • Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line
    Tsukahara, Tomonori; Agawa, Hideyuki; Matsumoto, Sayori; Matsuda, Mizuho; Ueno, Shuichi; Yamashita, Yuki; Yamada, Koichiro; Tanaka, Nobuyuki; Kojima, Katsuhiko; Takeshita, Toshikazu;
    Biochemical and biophysical research communications, 345(3), 1099-1107, 2006WebofScience電子ジャーナル
  • AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes
    Kyuuma, Masanao; Kikuchi, Kazu; Kojima, Katsuhiko; Sugawara, Yuriko; Sato, Mariko; Mano, Nariyasu; Goto, Junichi; Takeshita, Toshikazu; Yamamoto, Akitsugu; Sugamura, Kazuo; Tanaka, Nobuyuki;
    CELL STRUCTURE AND FUNCTION, 31(2), 159-172, 2006WebofScience
  • Recognitionof mitochondrial protein precursor lacking arginine at position -2 by mitochondrial processing peptidase
    Katsuhiko Kojima, Eiki Yamasaki, Sakae Kitada, Tadashi Ogishima and Akio Ito.
    JOURNAL OF BIOCHEMISTRY, 130, 497-502, Oct. 2001
  • A proposed common structure of substrates bound to mitochondrial processing peptidase
    Katsuhiko Kojima, Sakae Kitada, Tadashi Ogishima and Akio Ito
    The Journal of biological chemistry, 276, 2115-2121, Jan. 2001
  • Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase
    Katsuhiko Kojima, Sakae Kitada, Kunitoshi Shimokata, Tadashi Ogishima and Akio Ito.
    The Journal of biological chemistry, 273, 32542-32546, Dec. 1998

Courses

  • 感染症(2年)
    2023
    信州大学

Research Themes

  • S100A10を標的とした抗腫瘍VHH抗体による胆管癌治療法の開発
    科学研究費補助金, 基盤研究(C)
    2024 - 2026
  • 胆管癌の浸潤転移能獲得におけるS100A10の機能解明と治療戦略への展開
    科学研究費補助金, 基盤研究(C)
    2021 - 2023
  • 胆管癌幹細胞に高発現するS100分子群の癌悪性形質維持機構の解明
    科学研究費補助金, 基盤研究(C)
    2018 - 2020
  • 脱ユビキチン化酵素AMSHによる細胞内小胞輸送の制御機構の解析
    科学研究費補助金, 若手研究(B)
    2004 - 2005