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江原 孝史  エハラ タカシ

教員組織電話番号
教育組織医学部 医学科 病理組織学FAX番号
職名特任教授メールアドレス
住所ホームページURL

更新日:2023/04/21

プロフィール

兼担研究科・学部
医学部附属病院 臨床検査部
研究分野
人体病理学
実験病理学
キーワード:糸球体腎炎
現在の研究課題
糸球体腎炎
キーワード:IgA 腎症
糸球体腎炎の病理組織診断

糸球体の破壊メカニズムについての研究

慢性腎不全阻止の研究

所属学会
所属学会
日本病理学会
日本腎臓学会
日本癌学会
国際病理アカデミー
International Society of Nephrology
日本臨床細胞学会
日本細胞生物学会
日本小児科学会
学歴
出身大学院
1986 , 信州大学 , 医学部 , 病理

出身学校・専攻等(大学院を除く)
1981 , 信州大学 , 医学部 , 医学科

取得学位
博士(医学) , 信州大学
受賞学術賞
2004 , 信州医学会賞
1994 , 松医会賞
研究職歴等
研究職歴
2003- , 信州大学医学部助教授
1996-2003 , 信州大学医学部講師
1988-1996 , 信州大学医学部助手

留学歴
1991-1992 , University of Alabama at Birmingham

研究活動業績

研究業績(著書・
発表論文等)
論文
Collagenofibrotic Glomerulopathy
Intern Med.,60(6):911-915 2021(Mar.)
Author:Miyake M, Katayama K, Ehara T, Sado Y, Nawa S, Murata T, Mizutani Y, Joh K, Ito M, Dohi K.
Abstract:2021 Mar 15;60(6):911-915. doi:


An autopsy case of amyloid tubulopathy exhibiting characteristic spheroid-type deposition
Virchows Arch.,477(1):157-163 2020(Jul.)
Author:chimata S, Hata Y, Abe R, Yoshinaga T, Katoh N, Kametani F, Yazaki M, Sekijima Y, Ehara T, Nishida N.
Abstract:2020 Jul;477(1):157-163.


AL-Kappa primary amyloidosis with apolipoprotein A-IV deposition
Intern Med.,61:871-876 2020


Fibrillary glomerulopqathy with a high level of myeloperoxidase-ANCA: A case report
Case reports in Nephrology 2020
Author:Asakawa T,Asou M, Hara S, Ehara T, Araki M


Trypsin digestion on paraffin sections is a useful tool for diagnosis of Alport syndrome
Ultrastructural Pathology,34(4):199-206 2010
Author:Jiang YS, Ehara T
Keywords:Alport syndrome, trypsin antigen unmasking


Tranilast modulates fibrosis,epithelial-mesenchymal transition and peritubular capillary injuries in unilateral ureteral obstruction rats
Pathology,42(6):564-573 2010
Author:Kaneyama T, Kobayashi S, Aoyagi D, Ehara T
Keywords:vascular endothelial cadherin, renal fibrosis


Comparison of the histological and immunohistochemical features of the thymus in young- and elderly-onset myasthenia gravis without thymoma
JOURNAL OF CLINICAL NEUROSCIENCE,14(2):110-115 2007
Author:Ishii, W; Matsuda, M; Hanyuda, M; Momose, M; Nakayama, J; Ehara, T; Ikeda, S


Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS
GLYCOBIOLOGY,16(8):719-728 2006
Author:Kyogashima, M; Tamiya-Koizumi, K; Ehara, T; Li, G; Hu, R; Hara, A; Aoyama, T; Kannagi, R


Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: A cybrid study
DIABETES RESEARCH AND CLINICAL PRACTICE,74(2):148-153 2006
Author:Chen, J; Hattori, Y; Nakajima, K; Eizawa, T; Ehara, T; Koyama, M; Hirai, T; Fukuda, Y; Kinoshita, M; Sugiyama, A; Hayashi, JI; Onaya, T; Kobayashi, T; Tawata, M


最近の腎臓病学の進歩とあゆみ : Slit diaphragmと糸球体腎炎を中心に
信州医学雑誌,53(6):365-379 2005
Author:江原孝史
Keywords:slit diaphragm, glomerulus, glomerulonephritis, proteinuria, スリットダイアフラグム, 糸球体, 糸球体腎炎, 蛋白尿


直腸原発malignant rhabdoid tumor の1例
日本消化器外科学会雑誌,38:1630-1635 2005
Author:中山 中,辻本和雄,伊藤憲雄,竹内信道,松下昌充,江原孝史


最近の腎臓病学の進歩とあゆみ
信州医学雑誌,53:365-379 2005
Author:江原孝史


Ethnicity affects the diagnostic validity of alpha-fetoprotein in hepatocellular carcinoma
Asia-Pacific Journal of clinical oncology,1:64-70 2005
Author:Gad A, Tanaka E, Matsumoto A, Serwah Ael-H , Attia F , Hassan A, Ali K , Abbas A, el-Deeb Ael- , Sun X, Umemura T, Ichijyo T, Ehara T, Yoshizawa K, Kiyosawa K


Renal cholesterol embolism: Analysis of two spontaneous autopsy cases
Nephrology,10(1):90-96 2005
Author:Ehara T, Yazawa M, Konishi K, Hora K, Shigematsu H


Immunohistochemical detection of immunoglobulins and complements in formaldehyde-fixed and paraffin-embedded renal biopsy tissues: an adjunct for diagnosis of glomerulonephritis
Nephrology,10(3):298-304 2005
Author:Chowdhury AKM, Ehara T, Higuchi M, Hora K, Shigematsu H


A heteroplasmic mitochondrial DNA 3310 mutation in the ND1 gene in a patient with type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation
Exp Clin Endocr Diab,113(6):318-323 2005
Author:Hattori Y, Takeoka M, Nakajima K, Ehara T, Koyama M


Decreased distribution of nitric oxide synthase and vasoactive intestinal polypeptide positive nerve cells in the sphincter of Oddi in humans with pancreatobiliary diseases
Arch Histol Cytol,68(2):121-131 2005
Author:Zhang M, Shimojo H, Ehara T, Shigematsu H


MPO-ANCA, PR3-ANCA, 抗GBM抗体陽性の肺腎症候群の1剖検例
腎と透析,57:130-133 2004
Author:村木真紀子,出浦 正,徳永真一,渡辺正秀,江原孝史,重松秀一,洞 和彦,清沢研道


肥満細胞と腎障害
腎と透析,57:410-418 2004
Author:江原孝史,重松秀一


穿刺吸引細胞診で推測しえた甲状腺硝子化索状腺腫の1例
日本臨床細胞学会雑誌,43:281-285 2004
Author:半田幸雄,中村ひさ子,小嶋紀子,草間 律,江原孝史


Loss of calponin h1 in renal angiomyolipoma correlates with aggressive clinical behavior
Urology,64(3):468-473 2004
Author:Islam AH, Ehara T, Kato H, Hayama M, Nishizawa O


Angiomyolipoma of kidney involving the inferior vena cava
Int J Urol,11(10):897-902 2004
Author:Islam AH, Ehara T, Kato H, Hayama M, Kashiwabara T, Nishizawa O


Calponin h1 expression in renal tumor vessels: correlations with multiple pathological factors of renal cell carcinoma
J Urol,171(3):1319-1323 2004
Author:Islam AH, Ehara T, Kato H, Hayama M, Kobayashi S, Igawa Y, Nishizawa O


Structural and phenotypic changes of podocyte in puromycin aminonucleosisde and protamine sulfate intermittent treated rat model.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,14:155A-155A 2003
Author:Ichikawa, T; Shimojo, H; Kaneko, Y; Kamijo, Y; Higuchi, M; Hora, K; Kiyosawa, K; Otani, M; Ehara, T; Shigematsu, H


尿細管間質性病変を呈した腎生検例の検討-1990年から2002年までの53例について
信州医学雑誌,51:411-418 2003
Author:江原孝史,小口智雄,下条久志,重松秀一


尿細管間質病変の病理
腎と透析,55:429-437 2003
Author:江原孝史,重松秀一


Mast cells in the kidney
Nephrology,8(3):130-138 2003
Author:Ehara T, Shigematsu H


Heteroplasmic mitochondrial DNA 3310 mutation in NADH dehydrogenase subunit 1 associated with type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation in a single patient
Diabetes Care,26(3):952-953 2003
Author:Hattori Y, Nakajima K, Eizawa T, Ehara T, Koyama M, Hirai T, Fukuda Y, Kinoshita M


Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma
British J Dermatology,148(5):971-980 2003
Author:Koganehira Y, Takeoka M, Ehara T, Sasaki K, Murata H, Saida T, Taniguchi S


Younger onset myeloperoxidase-specific antineutrophil cytoplasmic antibody-(MPO-ANCA) related glomerulonephritis accompanied with nephrotic syndrome
Clin Nephrol,60(4):275-278 2003
Author:Kaneko Y, Kamijo Y, Kobayashi N, Higuchi M, Ehara T, Hora K, Shigematsu S, Kiyosawa K


Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter
J Clin Endoclinol Metab,88(8):3531-3538 2003
Author:Takeda T, Inaba H, Yamazaki M, Kyo S, Miyamoto T, Suzuki S, Ehara T,Kakizawa T, Hara M, DeGroot LJ, Hashizume K


腎生検で診断し得たコレステロール塞栓症の2例-腎組織に出現した炎症細胞についての検討-
信州医学雑誌,50:361-369 2002
Author:江原孝史,上條祐司,金子洋子,中沢功,重松秀一


Calponin H1 induced a flattened morphology and suppressed the growth of human fibrosasrcoma HT1080 cells
Eur J Cancer,38(3):436-442 2002
Author:Takeoka M, Ehara T, Hashimoto S, Taniguchi S


A case of an ABO-incompatible renal transplant with abundant intratubular basement membrane immune deposits
Clin Transplant,16:68-71 2002
Author:Shiozawa S, Ichikawa T, Nakazawa K, Ehara T, Shigematsu H


A study of IgA nephropathy cases with minor glomerular abnormalities and nephrotic syndrome
Nephrology,7:A102 2002
Author:Ehara T,Shigematsu H


A case of mixed membranous nephropathy and purpura nephritis
Clin Nephrol,57(6):480-483 2002
Author:Ehara T, Muramatsu T, Shigematsu H


Calponin h1 suppresses tumor growth of src-induced transformed 3Y1 cells in association with a decrease in angiogenesis
Jpn J Cancer Res,93(8):935-943 2002
Author:Kaneko M, Takeoka M, Oguchi M, Koganehira Y, Murata H, Ehara T, Tozuka M, Saida T, Taniguchi S


Close relation of reduced expression of actin-binding proteins, calponin-h1 and h-caldesmon, in the vascular smooth muscle inside human malignant melanoma with the poor prognosis
JOURNAL OF INVESTIGATIVE DERMATOLOGY,117(2):393-393 2001
Author:Koganehira, Y; Takeoka, T; Ehara, T; Hashimoto, S; Murata, H; Saida, T; Taniguchi, S


Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells
CANCER RESEARCH,61(20):7627-7634 2001
Author:Taniguchi, S; Takeoka, M; Ehara, T; Hashimoto, S; Shibuki, H; Yoshimura, N; Shigematsu, H; Takahashi, K; Katsuki, M


CyA-mediated renal interstitial and vascular lesions in the rat under low-sodium diet
TOXICOLOGIC PATHOLOGY,28(4):518-528 2000
Author:Nagasawa, T; Ehara, T


Promoted dermal fibrosis during wound healing in calponin h 1 (CNhl)-deleted mice
JOURNAL OF INVESTIGATIVE DERMATOLOGY,112(4):583-583 1999
Author:Takeoka, M; Ehara, T; Murata, H; Saida, T; Katsuki, M; Takahashi, K; Taniguchi, S


Reduced expression of an actin binding protein, calponin h 1 (CNh1), in blood vessels of human malignant skin tumors
JOURNAL OF INVESTIGATIVE DERMATOLOGY,112(4):569-569 1999
Author:Koganehira, Y; Ehara, T; Takeoka, M; Saida, T; Taniguchi, S


Nodular lung disease with five year survival and unilateral pleural effusion in AL amyloidosis
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION,6(4):292-296 1999
Author:Ikeda, S; Takabayashi, Y; Maejima, Y; Tachibana, N; Ehara, T; Nezu, A; Hoshii, Y


Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis
KIDNEY INTERNATIONAL,54(5):1675-1683 1998
Author:Ehara, T; Shigematsu, H


BASEMENT-MEMBRANE CHONDROITIN SULFATE PROTEOGLYCAN ALTERATIONS IN A RAT MODEL OF POLYCYSTIC KIDNEY-DISEASE
AMERICAN JOURNAL OF PATHOLOGY,144(3):612-621 1994
Author:EHARA, T; CARONE, FA; MCCARTHY, KJ; COUCHMAN, JR


CHARACTERIZATION OF GLYCOCONJUGATES FOUND IN GRANULAR-CELL TUMORS, WITH SPECIAL REFERENCE TO KERATAN SULFATE
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY,58(3):221-227 1990
Author:EHARA, T; KATSUYAMA, T


HIGH-RESOLUTION ULTRASOUND OF THE CHEST-WALL
FORTSCHRITTE AUF DEM GEBIETE DER RONTGENSTRAHLEN UND DER NEUEN BILDGEBENDEN VERFAHREN,153(4):390-394 1990
Author:SAKAI, F; SONE, S; KIYONO, K; IMAI, S; IZUNO, I; OGUCHI, M; OKAZAKI, Y; KASUGA, T; EHARA, T

研究費
科学研究費補助金(研究代表者)
2005 - 2006 , 病気の教育方法についての研究(バーチャル病気博物館の作成) , 基盤研究(C)

科学研究費補助金(研究分担者)
2009 - 2010 , IL. 1beta, IL. 18を活性化するASCを標的とした関節リウマチ治療実験 , 基盤研究(C)
2002 - 2004 , ヒト肉腫細胞におけるカルポニンh1の増殖抑制部位の特定及びシグナル伝達系の解明 , 基盤研究(C)

その他公的資金
2008 - 2010 , 進行性腎障害に関する調査研究
2008 - 2008 , 長野県におけるANCA関連腎炎について

社会活動実績

社会活動等
出前講座
20070301 - , 目で見る病気の話と人間の体の働きについて

メディア・報道
199802 , オリンピックボランティア

その他社会活動
20060818 - 2010 , 夏休み体験学習 , 体の構造を知る
20040817 - 2005 , 子供見学デー , 体の構造を知る