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Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL
Education and Research OrganizationSchool of Medicine Center for Medical Education and TrainingFAX
PositionAssistant ProfessorMail
Address3-1-1 Asahi, Matsumoto, Nagano, 390-8621Web site


Research Field
Metabolism and nutrition
Food ingredients and function
Keywords:Lipid , Nuclear receptor
Current Subject
Studies on physiological roles of sulfated glycolipids
Research on physiological functions of fatty acids
Keywords:SCFA , PUFA
Academic Societies
Academic Societies
Academic Background
Graduate School
Shinshu University , 2009
Shinshu University , 2005

Kindai University , 2003

博士(医学) , 信州大学
修士(農学) , 信州大学
Research Career
Research Career
2010- , 現職
2009-2010 , 日本学術振興会 特別研究員PD
2008-2009 , 日本学術振興会 特別研究員DC2


Books, Articles, etc.
Function and Regulation of the Multifunctional Molecules Sulfated Glycolipids
The Shinshu Medical Journal,71(3):137-147 2023
Author:Takero Nakajima and Naoki Tanaka

Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.
Cancers,15(14):3744-3744 2023
Author:Zheng Q, Kawaguchi M, Mikami H, Diao P, Zhang X, Zhang Z, Nakajima T, Iwadare T, Kimura T, Nakayama J, and Tanaka N.

Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor alpha Modulator (SPPARM alpha), Lowers Serum Triglyceride Levels by Targeting Hepatic PPAR alpha in Mice
BIOMEDICINES,10(7):1667 2022(Jul.)
Author:Zhang, Zhe; Diao, Pan; Zhang, Xuguang; Nakajima, Takero; Kimura, Takefumi; Tanaka, Naoki;
Keywords:beta-oxidation; pemafibrate; PPAR alpha; triglycerides; liver; FGF21;

Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Author:Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
Keywords:serum sulfatides; anti-neutrophil cytoplasmic antibody-associated vasculitis; crescentic glomerulonephritis;

Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
Author:Zhang, Xuguang; Diao, Pan; Yokoyama, Hiroaki; Inoue, Yoshiki; Tanabe, Kazuhiro; Wang, Xiaojing; Hayashi, Chihiro; Yokoyama, Tomoki; Zhang, Zhe; Hu, Xiao; Nakajima, Takero; Kimura, Takefumi; Nakayama, Jun; Nakamuta, Makoto; Tanaka, Naoki;
Keywords:obesity; acidic activated charcoal; insulin resistance; metabolic syndrome; metabolomic analysis; bile acid; intestine; enterohepatic circulation;

Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
ENGINEERING,7(12):1797-1805 2021(Dec.)
Author:Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
Keywords:Steatosis; Hepatocellular carcinoma; Trans fatty acid; Saturated fatty acid; Dietary restriction; HCV core protein;

Pemafibrate protects against fatty acid-induced nephropathy by maintaining renal fatty acid metabolism.
Metabolites,11(6):372-372 2021(Jun.)
Author:1. Aomura D, Harada M, Yamada Y, Nakajima T, Hashimoto K, Tanaka N, Kamijo Y.

Gallbladder cancer with ascites in a child with metachromatic leukodystrophy.
Brain Dev,43(1):140-143 2021(Jan.)
Author:Koshu K, Ikeda T, Tamura D, Muramatsu K, Osaka H, Ono S, Adachi K, Nanba E, Nakajima T, Yamagata T.

Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
FASEB J,34(7):9594-9614 2020(Jul.)
Author:Wang Y, Nakajima T, Diao P, Yamada Y, Nakamura K, Nakayama J, Tanaka N, Aoyama T, Kamijo Y.

A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.
Carcinogenesis,41(2):159-170 2020(Apr.)
Author:Hu X, Wang X, Jia F, Tanaka N, Kimura T, Nakajima T, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T.

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.
Int J Mol Sci.,21:2061 2020(Mar.)
Author:Wang Y, Nakajima T, Gonzalez FJ, Tanaka N.

Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism
HYPERTENSION RESEARCH,42(5):598-609 2019(May)
Author:Guo, Ran; Hu, Xiao; Yamada, Yosuke; Harada, Makoto; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice
GLYCOCONJUGATE JOURNAL,36(1):1-11 2019(Feb.)
Author:Yamada, Yosuke; Harada, Makoto; Hashimoto, Koji; Guo, Ran; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;

Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
ARCHIVES OF TOXICOLOGY,93(1):149-161 2019(Jan.)
Author:Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;

Fermentation-induced changes in the concentrations of organic acids, amino acids, sugars, and minerals and superoxide dismutase-like activity in tomato vinegar.
Int. J. Food Prop.,20(4):888-898 2017(Jun.)
Author:Koyama M, Ogasawara Y, Endou K, Akano H, Nakajima T, Aoyama T, Nakamura K.

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
J Nutr Biochem,39:77-85 2017
Author:Hu X, Tanaka N, Guo R, Lu Y, Nakajima T, Gonzalez FJ, Aoyama T

Decreased fatty acid β-oxidation is the main cause of fatty liver induced by polyunsaturated fatty acid deficiency in mice.
Tohoku J Exp Med,242(3):229-239 2017
Author:Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T.

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs.
J Food Sci Technol,53:581-90 2016
Author:Nakamura K, Koyama M, Ishida R, Kitahara T, Nakajima T, Aoyama T

Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Glycoconj J,33(6):927-936 2016
Author:Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.

Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
Clin Sci,130(21):1969-1981 2016
Author:Harada M, Kamijo Y, Nakajima T, Hashimoto K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T.

Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.
Tohoku J Exp Med,240(2):113-22 2016
Author:Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα.
Biochim Biophys Acta,1852:473-481 2015
Author:Komatsu M, Kimura T, Yazaki M, Tanaka N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S, Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S, Aoyama T.

Serum sulfatide abnormality is associated with increased oxidative stress in hemodialysis patients.
Hemodial Int,19:429-438 2015
Author:Yuzhe H, Kamijo Y, Hashimoto K, Harada M, Kanno T, Sugiyama E, Kyogashima M, Oguchi T, Nakajima T, Kanno Y, Aoyama T.

Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Arch Toxicol,88:367-379 2014
Author:Kanbe H, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Wang L, Fang ZZ, Hara A, Gonzalez FJ, Aoyama T

One-pot esterification and amidation of phenolic acids
Tetrahedron,70:8097-8107 2014
Author:Nakamura K, Nakajima T, Aoyama T, Okitsu S, Koyama M

Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Author:Nakajima, T; Kamijo, Y; Huang, YZ; Kimura, T; Tanaka, N; Sugiyama, E; Nakamura, K; Kyogashima, M; Hara, A; Aoyama, T

Purification and identification of antihypertensive peptides from fermented buckwheat sprouts.
J Agric Food Chem,61:3013-3021 2013
Author:Koyama M, Naramoto K, Nakajima T, Aoyama T, Watanabe M, Nakamura K

Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
Tohoku J Exp Med,227:1-12 2012(May)
Author:Sheng X, Nakajima T, Wang L, Zhang X, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A.

Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels.
Clin Exp Nephrol,in:press 2012(May)
Author:Kamijo Y, Wang L, Matsumoto A, Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A.

Hepatic cerebroside sulfotransferase is induced by PPARalpha activation in mice.
PPAR Res,2012:174932 2012(May)
Author:Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T.

Fatty acid accumulation and resulting PPARalpha activation infibroblasts due to trifunctional protein deficiency.
PPAR Res,2012:371691 2012(May)
Author:Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Yangyang T, Kimura T, Aoyama T.

PPARalpha activation protects against anti-Thy1 nephritis by suppressing glomerular NF-kappaB signaling.
PPAR Res,2012:976089 2012(May)
Author:Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T.

Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARalpha deterioration.
Toxicol Appl Pharmacol,252:237-249 2011
Author:Takahashi K, Kamijo Y, Hora K, Hashimoto K, Higuchi M, Nakajima T, Ehara T, Shigematsu H, Gonzalez FJ, Aoyama T.

Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count.
Glycoconj J,28:125-135 2011
Author:Wang L, Kamijo Y, Matsumoto A, Nakajima T, Higuchi M, Kannagi R, Kyogashima M, Aoyama T, HaraA.

Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
Redox Rep,15:123-130 2010(Jun.)
Author:Nakajima T, Tanaka N, Li G, Hu R, Kamijo Y, Hara A, Aoyama T.

Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
Genes Cells,15(2):91-100 2010
Author:Komatsu M, Tong Y, Li Y, Nakajima T, Li G, Hu R, Sugiyama E, Kamijo Y, Tanaka N, Hara A, Aoyama T.

Sulfatides are associated with neointimal thickening after vascular injury.
Atherosclerosis,211:291-296 2010
Author:Inoue T, Taguchi I, Abe S, Li G, Hu R, Nakajima T, Hara A, Aoyama T, Kannagi R, Kyogashima M, Node K.

Down-regulation of SREBP-1c is associated with the development of burned-out NASH.
J Hepatol,53:724-731 2010
Author:Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Nakayama J, Tanaka E, Aoyama T.

Eicosapentaenoic acid improves hepatic steatosis independent of PPARalpha activation through inhibition of SREBP-1 maturation in mice.
Biochem Pharmacol,80:1601-1612 2010
Author:Tanaka N, Zhang X, Sugiyama E, Kono H, Horiuchi A, Nakajima T, Kanbe H, Tanaka E, Gonzalez FJ, Aoyama T.

Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides.
Biochem Biophys Res Commun,390:1382-1388 2009(Dec.)
Author:Zhang X, Nakajima T, Kamijo Y, Li G, Hu R, Kannagi R, Kyogashima M, Aoyama T, Hara A.

Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism.
Mol Pharmacol,75:782-792 2009(Apr.)
Author:Nakajima T, Tanaka N, Kanbe H, Hara A, Kamijo Y, Zhang X, Gonzalez FJ, Aoyama T.

Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice.
Nephrology,14(7):658-662 2009
Author:Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Ehara T, Shigematsu H, Kannagi R, Kyogashima M, Hara A.

Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.
Biochem Pharmacol,76:108-119 2008(Jul.)
Author:Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Hara A, Hu R, Li G, Li Y, Nakamura K, Gonzalez FJ, Aoyama T.

Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry.
Anal Biochem,362:1-7 2007
Author:Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.

Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.
Glycoconj J,24:565-571 2007
Author:Hu R, Li G, Kamijo Y, Aoyama T, Nakajima T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.

Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation.
Biochem Biophys Res Commun,346:1307-1311 2006
Author:Zhang X, Tanaka N, Nakajima T, Kamijo Y, Gonzalez FJ, Aoyama T.

Base-labile tert-butoxycarbonyl (Boc) group on phenols.
Tetrahedron Lett,45:495-499 2004
Author:Nakamura K, Nakajima T, Kayahara H, Nomura E, Taniguchi H.