中嶌 岳郎 (ナカジマ タケロウ)   

学術研究院(医学系)

医学部 医学教育研修センター 

助教 

学位

  • 博士(医学), 信州大学
  • 修士(農学), 信州大学

研究キーワード

    脂質, 核内受容体

研究分野

  • 医化学, 生化学
  • 医化学, 代謝栄養
  • 食品科学, 食品成分機能

メールアドレス

    nakat★shinshu-u.ac.jp

経歴

  • 2010年
    現職
  • 2009年 - 2010年
    日本学術振興会 特別研究員PD
  • 2008年 - 2009年
    日本学術振興会 特別研究員DC2

学歴

  • 2009年, 信州大学
  • 2005年, 信州大学
  • 2003年, 近畿大学

論文

  • Establishment of novel mouse model of dietary NASH rapidly progressing into liver cirrhosis and tumors.
    Zheng Q, Kawaguchi M, Mikami H, Diao P, Zhang X, Zhang Z, Nakajima T, Iwadare T, Kimura T, Nakayama J, and Tanaka N.
    CANCERS, 15(14), 3744-3744, 2023年, 査読有り電子ジャーナル
  • 多機能性分子・硫酸化糖脂質の機能と制御
    中嶌岳郎、田中直樹
    信州医学雑誌, 71(3), 137-147, 2023年, 査読有り
    筆頭著者, 責任著者リポジトリ電子ジャーナル
  • Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor alpha Modulator (SPPARM alpha), Lowers Serum Triglyceride Levels by Targeting Hepatic PPAR alpha in Mice
    Zhang, Zhe; Diao, Pan; Zhang, Xuguang; Nakajima, Takero; Kimura, Takefumi; Tanaka, Naoki;
    BIOMEDICINES, 10(7), 1667, 2022年07月WebofScience電子ジャーナル
  • Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
    Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
    JOURNAL OF CLINICAL MEDICINE, 11(3), 762, 2022年02月WebofScience電子ジャーナル
  • Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice
    Zhang, Xuguang; Diao, Pan; Yokoyama, Hiroaki; Inoue, Yoshiki; Tanabe, Kazuhiro; Wang, Xiaojing; Hayashi, Chihiro; Yokoyama, Tomoki; Zhang, Zhe; Hu, Xiao; Nakajima, Takero; Kimura, Takefumi; Nakayama, Jun; Nakamuta, Makoto; Tanaka, Naoki;
    Frontiers in Nutrition, 9, 852767, 2022年WebofScience電子ジャーナル
  • Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
    Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
    ENGINEERING, 7(12), 1797-1805, 2021年12月WebofScience電子ジャーナル
  • Pemafibrate protects against fatty acid-induced nephropathy by maintaining renal fatty acid metabolism.
    1. Aomura D, Harada M, Yamada Y, Nakajima T, Hashimoto K, Tanaka N, Kamijo Y.
    METABOLITES, 11(6), 372-372, 2021年06月電子ジャーナル
  • Gallbladder cancer with ascites in a child with metachromatic leukodystrophy.
    Koshu K, Ikeda T, Tamura D, Muramatsu K, Osaka H, Ono S, Adachi K, Nanba E, Nakajima T, Yamagata T.
    Brain Dev, 43(1), 140-143, 2021年01月電子ジャーナル
  • Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
    Wang Y, Nakajima T, Diao P, Yamada Y, Nakamura K, Nakayama J, Tanaka N, Aoyama T, Kamijo Y.
    FASEB J, 34(7), 9594-9614, 2020年07月電子ジャーナル
  • A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.
    Hu X, Wang X, Jia F, Tanaka N, Kimura T, Nakajima T, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T.
    CARCINOGENESIS, 41(2), 159-170, 2020年04月電子ジャーナル
  • PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.
    Wang Y, Nakajima T, Gonzalez FJ, Tanaka N.
    Int J Mol Sci., 21, 2061, 2020年03月電子ジャーナル
  • Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism
    Guo, Ran; Hu, Xiao; Yamada, Yosuke; Harada, Makoto; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;
    Hypertension Research, 42(5), 598-609, 2019年05月WebofScience電子ジャーナル
  • Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice
    Yamada, Yosuke; Harada, Makoto; Hashimoto, Koji; Guo, Ran; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;
    GLYCOCONJUGATE JOURNAL, 36(1), 1-11, 2019年02月WebofScience電子ジャーナル
  • Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
    Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;
    ARCHIVES OF TOXICOLOGY, 93(1), 149-161, 2019年01月WebofScience電子ジャーナル
  • Fermentation-induced changes in the concentrations of organic acids, amino acids, sugars, and minerals and superoxide dismutase-like activity in tomato vinegar.
    Koyama M, Ogasawara Y, Endou K, Akano H, Nakajima T, Aoyama T, Nakamura K.
    Int. J. Food Prop., 20(4), 888-898, 2017年06月, 査読有り
  • Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice.
    Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T.
    Tohoku J Exp Med, 242(3), 229-239, 2017年
  • PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
    Hu X, Tanaka N, Guo R, Lu Y, Nakajima T, Gonzalez FJ, Aoyama T
    J Nutr Biochem, 39, 77-85, 2017年
  • Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.
    Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.
    Tohoku J Exp Med, 240(2), 113-22, 2016年
  • Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
    Harada M, Kamijo Y, Nakajima T, Hashimoto K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T.
    Clin Sci, 130(21), 1969-1981, 2016年
  • Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
    Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.
    Glycoconj J, 33(6), 927-936, 2016年
  • Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs.
    Nakamura K, Koyama M, Ishida R, Kitahara T, Nakajima T, Aoyama T
    J Food Sci Technol, 53, 581-90, 2016年
  • Serum sulfatide abnormality is associated with increased oxidative stress in hemodialysis patients.
    Yuzhe H, Kamijo Y, Hashimoto K, Harada M, Kanno T, Sugiyama E, Kyogashima M, Oguchi T, Nakajima T, Kanno Y, Aoyama T.
    Hemodial Int, 19, 429-438, 2015年
  • Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα.
    Komatsu M, Kimura T, Yazaki M, Tanaka N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S, Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S, Aoyama T.
    Biochim Biophys Acta, 1852, 473-481, 2015年
  • One-pot esterification and amidation of phenolic acids
    Nakamura K, Nakajima T, Aoyama T, Okitsu S, Koyama M
    Tetrahedron, 70, 8097-8107, 2014年
  • Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
    Kanbe H, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Wang L, Fang ZZ, Hara A, Gonzalez FJ, Aoyama T
    Arch Toxicol, 88, 367-379, 2014年
  • Purification and identification of antihypertensive peptides from fermented buckwheat sprouts.
    Koyama M, Naramoto K, Nakajima T, Aoyama T, Watanabe M, Nakamura K
    J Agric Food Chem, 61, 3013-3021, 2013年
  • Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
    Nakajima, T; Kamijo, Y; Huang, YZ; Kimura, T; Tanaka, N; Sugiyama, E; Nakamura, K; Kyogashima, M; Hara, A; Aoyama, T
    GLYCOCONJUGATE JOURNAL, 30(6), 553-560, 2013年WebofScienceリポジトリ電子ジャーナル
  • PPARalpha activation protects against anti-Thy1 nephritis by suppressing glomerular NF-kappaB signaling.
    Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T.
    PPAR Res, 2012, 976089, 2012年05月
  • Fatty acid accumulation and resulting PPARalpha activation infibroblasts due to trifunctional protein deficiency.
    Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Yangyang T, Kimura T, Aoyama T.
    PPAR Res, 2012, 371691, 2012年05月
  • Hepatic cerebroside sulfotransferase is induced by PPARalpha activation in mice.
    Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T.
    PPAR Res, 2012, 174932, 2012年05月
  • Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels.
    Kamijo Y, Wang L, Matsumoto A, Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A.
    Clin Exp Nephrol, in, press, 2012年05月
  • Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
    Sheng X, Nakajima T, Wang L, Zhang X, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A.
    Tohoku J Exp Med, 227, 1-12, 2012年05月
  • Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARalpha deterioration.
    Takahashi K, Kamijo Y, Hora K, Hashimoto K, Higuchi M, Nakajima T, Ehara T, Shigematsu H, Gonzalez FJ, Aoyama T.
    Toxicol Appl Pharmacol, 252, 237-249, 2011年
  • Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count.
    Wang L, Kamijo Y, Matsumoto A, Nakajima T, Higuchi M, Kannagi R, Kyogashima M, Aoyama T, HaraA.
    Glycoconj J, 28, 125-135, 2011年WebofScienceリポジトリ電子ジャーナル
  • Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
    Nakajima T, Tanaka N, Li G, Hu R, Kamijo Y, Hara A, Aoyama T.
    Redox Rep, 15, 123-130, 2010年06月
  • Eicosapentaenoic acid improves hepatic steatosis independent of PPARalpha activation through inhibition of SREBP-1 maturation in mice.
    Tanaka N, Zhang X, Sugiyama E, Kono H, Horiuchi A, Nakajima T, Kanbe H, Tanaka E, Gonzalez FJ, Aoyama T.
    Biochem Pharmacol, 80, 1601-1612, 2010年
  • Down-regulation of SREBP-1c is associated with the development of burned-out NASH.
    Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Nakayama J, Tanaka E, Aoyama T.
    J Hepatol, 53, 724-731, 2010年
  • Sulfatides are associated with neointimal thickening after vascular injury.
    Inoue T, Taguchi I, Abe S, Li G, Hu R, Nakajima T, Hara A, Aoyama T, Kannagi R, Kyogashima M, Node K.
    Atherosclerosis, 211, 291-296, 2010年
  • Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
    Komatsu M, Tong Y, Li Y, Nakajima T, Li G, Hu R, Sugiyama E, Kamijo Y, Tanaka N, Hara A, Aoyama T.
    Genes Cells, 15(2), 91-100, 2010年WebofScienceリポジトリ電子ジャーナル
  • Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides.
    Zhang X, Nakajima T, Kamijo Y, Li G, Hu R, Kannagi R, Kyogashima M, Aoyama T, Hara A.
    Biochem Biophys Res Commun, 390, 1382-1388, 2009年12月WebofScienceリポジトリ電子ジャーナル
  • Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism.
    Nakajima T, Tanaka N, Kanbe H, Hara A, Kamijo Y, Zhang X, Gonzalez FJ, Aoyama T.
    Mol Pharmacol, 75, 782-792, 2009年04月
  • Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice.
    Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Ehara T, Shigematsu H, Kannagi R, Kyogashima M, Hara A.
    Nephrology, 14(7), 658-662, 2009年WebofScienceリポジトリ電子ジャーナル
  • Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.
    Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Hara A, Hu R, Li G, Li Y, Nakamura K, Gonzalez FJ, Aoyama T.
    Biochem Pharmacol, 76, 108-119, 2008年07月
  • Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.
    Hu R, Li G, Kamijo Y, Aoyama T, Nakajima T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.
    Glycoconj J, 24, 565-571, 2007年
  • Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry.
    Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.
    Anal Biochem, 362, 1-7, 2007年
  • Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation.
    Zhang X, Tanaka N, Nakajima T, Kamijo Y, Gonzalez FJ, Aoyama T.
    Biochem Biophys Res Commun, 346, 1307-1311, 2006年
  • Base-labile tert-butoxycarbonyl (Boc) group on phenols.
    Nakamura K, Nakajima T, Kayahara H, Nomura E, Taniguchi H.
    Tetrahedron Lett, 45, 495-499, 2004年

書籍等出版物

  • 疾患モデルの作製と利用-脂質代謝異常と関連疾患<上巻>,第1章転写因子,第5節PPARα
    中嶌岳郎,上條祐司,田中直樹,青山俊文, 共著
    株式会社エル・アイ・シー, 72-81 2015年01月31日

所属学協会

  • 日本生化学会
  • 日本農芸化学会
  • 日本脂質生化学会
  • 老化促進モデルマウス(SAM)学会

共同研究・競争的資金等の研究課題

  • 硫酸化糖脂質の生理機能探索
  • 脂肪酸類の生理機能探索