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Sato Takashi

Academic OrganizationFaculty of AgricultureTEL81-265-77-1403
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical SciencesFAX81-265-77-1403
PositionSpecially Appointed ProfessorMail Address
Address8304, Minamiminowa-Village, Kamiina-County 399-4598Web site



Academic Societies
Academic Societies
American Thoracic Society

Committee of Academic Societies
2012-2015 , American Thoracic Society , Program Committee Member
2008-2010 , American Thoracic Society , Program Committee Member
Academic Background
Graduate School
Yokohama City University , 2006

Yokohama City University , 2000
Tokyo Institute of Technology , 1994

Ph.D , Yokohama City University (Japan)
2013 , NIH Fellows Award for Research Excellence (FARE) 2014
2007 , The Oak Ridge Institute for Science and Education (ORISE) Research Award
Research Career
Research Career
2019-2019 , Faculty of Agriculture, Shinshu University
2014-2019 , Associate professor, Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
2008-2012 , Assistant professor, Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine

Overseas Education


Books, Articles, etc.
Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
Science Impact Ltd , Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents 2019(Mar.)
Author:SATO Takashi、SHIMOSATO Takeshi

Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
Springer , Respiratory Disease Series: Diagnostic Tools and Disease Managements: Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases? 2018(Jul.)
Author:SATO Takashi

第40章 肺胞を拡散する酸素と二酸化炭素のガス交換の原理、第41章 血液や組織液中の酸素と二酸化炭素の輸送
ガイトン生理学(原著第13版) 2018(Mar.)
Author:佐藤 隆

Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Anim Sci J,89(12):1707-1711 2018(Dec.)
Author:Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T

Silicosis and lung cancer: current perspectives
Lung Cancer (Auckl),9:91-101 2018(Oct.)
Author:Sato T, Shimosato T, Klinman DM

Regulatory role of heme oxygenase-1 in silica-induced lung injury.
Respiratory Research,19(1):144- 2018(Aug.)
Author:Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T

Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components.
Anim Sci J,89(10):1504-1511 2018(Jul.)
Author:Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T

Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells
Current Microbiology,75(1):92-98 2018(Jan.)
Author:Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology,18:44- 2017(Oct.)
Author:Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T

Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
J Dairy Sci,100(9):7007-2015 2017(Sep.)
Author:Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T

Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology,8:1049- 2017(Aug.)
Author:Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T

Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Appl Microbiol Biotechnol,101(1):341-349 2017(Jan.)
Author:Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T

The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdiscip Rev Nanomed Nanobiotechnol,8(4):631-637 2016(Jul.)
Author:Klinman DM, Sato T, Shimosato T

Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Anim Sci J,87(5):710-717 2016(May)
Author:Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T, Shimosato T

The effectiveness of sputum pH analysis in the prediction of response to therapy in patients with pulmonary tuberculosis
PeerJ,3:e1448 2015(Nov.)
Author:Masuda M, Sato T, Sakamaki K, Kudo M, Kaneko T, Ishigatsubo Y

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice.
Microbial Cell Factories,14(1):189 2015(Nov.)
Author:Shigemori S, Watanabe T, Kudo K, Ihara M, Nigar S, Yamamoto Y, Oshiro K, Sato T, Kitazawa H, Shimosato T.

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors.
Mol Cancer Ther,14(10):2198 2015(Oct.)
Author:Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman D

Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice.
Mol Ther,23(2):297 2015(Feb.)
Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T

IKKα negatively regulates ASC-dependent inflammasome activation.
Nat Commun,5:4977 2014(Sep.)
Author:Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, et al.

Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
BioMed Research International,2014:393598 2014(Aug.)
Author:Shigemori S, Oshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y, Shimosato T

Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis.
Appl Microbiol Biotechnol,97(8):3603 2013(Apr.)
Author:Shigemori S, Yonekura S, Sato T, Otani H, Shimosato T.

Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells.
Int J Oncol,42(2):429 2013(Feb.)
Author:Takahashi R, Sato T, Klinman DM, Shimosato T, Kaneko T, Ishigatsubo Y

Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
Int J Tuberc Lung Dis,17(1):54 2013(Jan.)
Author:Horita N, Miyazawa N, Yoshiyama T, Sato T, Yamamoto M, Tomaru K, Masuda M, Tashiro K, Sasaki M, Morita S, Kaneko T, Ishigatsubo Y

Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis.
J Occup Environ Med,54(12):1461 2012(Dec.)
Author:Sato T, Saito Y, Inoue S, Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y

Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.
FEBS Open Bio,3:41 2012(Nov.)
Author:Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H, Shimosato T

Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: a case report
J Med Case Rep,6:266 2012(Aug.)
Author:Sato T, Tomaru K, Koide T, Masuda M, Yamamoto M, Miyazawa N, Inayama Y, Kaneko T, Ishigatsubo Y

Expression of a biologically active GFP-α(S1)-casein fusion protein in Lactococcus lactis.
Curr Microbiol,64(6):569 2012(Jun.)
Author:Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H, Shimosato T.

Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
BMJ Open,1(1):e000105 2011(Jul.)
Author:Inoue S, Watanuki Y, Kaneko T, Sato T, Miyazawa N, Kaneko T, Ishigatsubo Y, Morita S, Natsumeda Y, Mizushima S

The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides.
Biomaterials,32(18):4238 2011(Jun.)
Author:Yamamoto M, Sato T, Beren J, Verthelyi D, Klinman DM

Accelerated wound healing mediated by activation of Toll-like receptor 9
Wound Repair Regen,18(6):586 2010(Nov.)
Author:Sato T, Yamamoto M, Shimosato T, Klinman DM

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Biochem Biophys Res Commun,394(1):81 2010(Mar.)
Author:Shimosato T, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H

High frequency of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
J Infect Chemother,16(1):72 2010(Feb.)
Author:Inoue S, Watanuki Y, Miyazawa N, Kudo M, Sato T, Kobayashi N, Mishina K, Sasaki M, Kaneko T, Ishigatsubo Y

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Anim Sci J,80(5):597 2009(Oct.)
Author:Shimosato T, Tohno M, Sato T, Nishimura J, Kawai Y, Saito T, Kitazawa H

Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
Ann N Y Acad Sci,1175:80 2009(Sep.)
Author:Klinman DM, Tross D, Klaschik S, Shirota H, Sato T

CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
Adv Drug Deliv Rev,61(3):248 2009(Mar.)
Author:Klinman DM, Klaschik S, Sato T, Tross D

Synthetic oligonucleotides as modulators of inflammation
J Leukoc Biol,84(4):958 2008(Oct.)
Author:Klinman D, Shirota H, Tross D, Sato T, Klaschik S

Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
J Immunol,180(11):7648 2008(Jun.)
Author:Sato T, Shimosato T, Alvord WG, Klinman DM

Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Am J Respir Crit Care Med,174(8):906 2006(Oct.)
Author:Sato T, Takeno M, Honma K, Yamauchi H, Saito Y, Sasaki T, Morikubo H, Nagashima Y, Takagi S, Yamanaka K, Kaneko T, Ishigatsubo Y

Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
Inflamm Res,54(5):229 2005(May)
Author:Tagawa A, Kaneko T, Shinohara T, Ueda A, Sato T, Ishigatsubo Y

Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation
Eur J Pharmacol,507(1-3):223 2005(Jan.)
Author:Tagawa A, Kaneko T, Nishiyama H, Shinohara T, Sato T, Geppetti P, Ishigatsubo Y

Innovative therapy for lung cancer ~Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment~
NIH/NCI Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman 2019(Jun. 27)
Author:SATO Takashi

横浜市立大学先端医科学研究センター 第54回市民講座 2018(Oct. 30)
Author:佐藤 隆

Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer
Method of treating pneumoconiosis with oligodeoxynucleotides
Use of CpG oligodeoxynucleotides to induce epithelial cell growth
Research Grants
Grants‐in‐aid for Scientific Research(Research Representative)
2019 - 2022 , 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証 , 国際共同研究加速基金(国際共同研究強化(B))
2018 - 2019 , 吸入療法イノベーションの実現:高分子・抗体医薬の経気道投与による肺癌治療戦略 , 挑戦的研究(萌芽)
2015 - 2017 , ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究 , 基盤C
2011 - 2012 , 微生物由来 DNA を利用した吸入型炎症性肺疾患治療薬の開発 , 若手B
2009 - 2010 , 免疫調節性DNAとナノ・マイクロ粒子キャリアーを用いた吸入型DNA治療薬の開発 , 若手B

Grants‐in‐aid for Scientific Research(Researcher)
2017 - 2020 , 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明 , 基盤B

Other Research Grants
2017 - 2019 , 日本医療研究開発機構(AMED)・創薬基盤推進研究事業・Fine Droplet Dryingテクノロジーによる経気道治療用ナノマイクロ粒子包埋医薬品の創出を目指した研究
2017 - 2019 , ライフイノベーションプラットフォーム横浜推進プロジェクト・圧電素子を用いた経気道投与用パーソナル吸入デバイスの開発研究