Ph.D, Yokohama City University (Japan)

Respiratory medicine

2022
富士電機株式会社 半導体事業本部, 松本工場, 専属産業医

2020 - 2022
Head of Medical Oncology Department／Director of Research Center, Tokyo Shinagawa Hospital

2020
Department of Pulmonology, School of Medicine, Yokohama City University

2019
Interdisciplinary Cluster for Cutting Edge Research, Shinshu University

2019 - 2019
Faculty of Agriculture, Shinshu University

2012 - 2014, 米国国立衛生研究所（NIH）国立がん研究所（NCI）

2007 - 2008, 米国国立衛生研究所（NIH）国立がん研究所（NCI）

2005 - 2006, 米国食品医薬品局（FDA）生物製剤評価研究センター（CBER）

2002 - 2006, Yokohama City University, 医学研究科, 病態免疫制御内科学

1994 - 2000, Yokohama City University, 医学部, 医学科

1990 - 1994, Tokyo Institute of Technology, 工学部, 機械宇宙学科

2012 - 2015
Program Committee Member, American Thoracic Society

2008 - 2010
Program Committee Member, American Thoracic Society

2013
NIH Fellows Award for Research Excellence (FARE) 2014

2013
米国国立衛生研究所（NIH）Appreciation Award

2009
横浜市立大学第一内科同門会賞

2008
神奈川難病財団研究奨励賞

2007
The Oak Ridge Institute for Science and Education (ORISE) Research Award

2007
横浜総合医学振興財団呼吸器疾患研究賞

Analysis of antigen specificity of Treg cell clonotypes expanded upon SARS-CoV-2 infection
Yukiko Takeuchi; Eri Ishikawa; Takashi Sato; Masaharu Shinkai; Yoshimasa Takahashi; Xiuyuan Lu; Sho Yamasaki
International Immunology, Dec. 2024, Refereed

Oral administration of Limosilactobacillus ingluviei C37 inhibits Campylobacter jejuni colonization in chicks
Aito Murakami; Ayako Watanabe-Yanai; Taketoshi Iwata; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Sutisa Khempaka; Takeshi Shimosato
Frontiers in Microbiology, 15, Nov. 2024, Refereed

Development of engineered IL-36γ-hypersecreting Lactococcus lactis to improve the intestinal environment
Masahiro Yoda; Shogo Takase; Kaho Suzuki; Aito Murakami; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato*
World Journal of Microbiology and Biotechnology, in press, Oct. 2024, Refereed

Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice.
Aito Murakami; Haruka Yamaguchi; Fu Namai; Takashi Sato; Maki Yamazaki; Hiroshi Uehara; Tadashi Fujii; Takumi Tochio; Kunihiro Shiomi; Takeshi Shimosato
Frontiers in cellular and infection microbiology, 14, 1383774-1383774, 2024

Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
Animal Science Journal, 94(1), Dec. 2023, Refereed

CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes
Taishi Onodera; Nicolas Sax; Takashi Sato; Yu Adachi; Ryutaro Kotaki; Takeshi Inoue; Ryo Shinnakasu; Takayuki Nakagawa; Shuetsu Fukushi; Tommy Terooatea; Mai Yoshikawa; Keisuke Tonouchi; Takaki Nagakura; Saya Moriyama; Takayuki Matsumura; Masanori Isogawa; Kazutaka Terahara; Tomohiro Takano; Lin Sun; Ayae Nishiyama; Shinnya Omoto; Masaharu Shinkai; Tomohiro Kurosaki; Kazuo Yamashita; Yoshimasa Takahashi
Science Advances, 9(24), Jun. 2023, Refereed

High Fever, Wide Distribution of Viral Pneumonia, and Pleural Effusion are More Critical Findings at the First Visit in Predicting the Prognosis of COVID-19: A Single Center, retrospective, Propensity Score-Matched Case–Control Study
Masahiro Shinoda; Shinichiro Ota; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Naoki Ishii; Masaharu Shinkai
International Journal of General Medicine, Volume 16, 2337-2348, Jun. 2023, Refereed

Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria
Suzuka Oshima; Fu Namai; Takashi Sato; Takeshi Shimosato
Molecular Biotechnology, Apr. 2023, Refereed
Corresponding

Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain.
Tomohiro Takano; Takashi Sato; Ryutaro Kotaki; Saya Moriyama; Shuetsu Fukushi; Masahiro Shinoda; Kiyomi Kabasawa; Nagashige Shimada; Mio Kousaka; Yu Adachi; Taishi Onodera; Kazutaka Terahara; Masanori Isogawa; Takayuki Matsumura; Masaharu Shinkai; Yoshimasa Takahashi
Nature communications, 14(1), 1451-1451, Mar. 2023, Refereed
Lead

Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
AMB Express, 13(1), Jan. 2023, Refereed
Corresponding

SARS-CoV-2 specific CD4+ T cell longevity correlates with Th17-like phenotype
Kazutaka Terahara; Takashi Sato; Yu Adachi; Keisuke Tonouchi; Taishi Onodera; Saya Moriyama; Lin Sun; Tomohiro Takano; Ayae Nishiyama; Ai Kawana-Tachikawa; Tetsuro Matano; Takayuki Matsumura; Masaharu Shinkai; Masanori Isogawa; Yoshimasa Takahashi
iScience, 104959-104959, Aug. 2022, Refereed

Immunogenicity and safety of booster dose of S-268019-b or BNT162b2 in Japanese participants: An interim report of phase 2/3, randomized, observer-blinded, noninferiority study
Masaharu Shinkai; Takuhiro Sonoyama; Akari Kamitani; Risa Yokokawa Shibata; Naomi M. Seki; Shinya Omoto; Masahiro Shinoda; Takashi Sato; Naoki Ishii; Kenji Igarashi; Mari Ariyasu
Vaccine, Jun. 2022, Refereed

Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir
Kanako Shinada; Takashi Sato; Saya Moriyama; Yu Adachi; Masahiro Shinoda; Shinichiro Ota; Miwa Morikawa; Masamichi Mineshita; Takayuki Matsumura; Yoshimasa Takahashi; Masaharu Shinkai
Viruses, 14(4), 670-670, Mar. 2022, Refereed
Corresponding

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients
Xiuyuan Lu; Yuki Hosono; Masamichi Nagae; Shigenari Ishizuka; Eri Ishikawa; Daisuke Motooka; Yuki Ozaki; Nicolas Sax; Yuichi Maeda; Yasuhiro Kato; Takayoshi Morita; Ryo Shinnakasu; Takeshi Inoue; Taishi Onodera; Takayuki Matsumura; Masaharu Shinkai; Takashi Sato; Shota Nakamura; Shunsuke Mori; Teru Kanda; Emi E. Nakayama; Tatsuo Shioda; Tomohiro Kurosaki; Kiyoshi Takeda; Atsushi Kumanogoh; Hisashi Arase; Hironori Nakagami; Kazuo Yamashita; Yoshimasa Takahashi; Sho Yamasaki
Journal of Experimental Medicine, 218(12), Dec. 2021, Refereed

Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses
Ryo Shinnakasu; Shuhei Sakakibara; Hiromi Yamamoto; Po-hung Wang; Saya Moriyama; Nicolas Sax; Chikako Ono; Atsushi Yamanaka; Yu Adachi; Taishi Onodera; Takashi Sato; Masaharu Shinkai; Ryosuke Suzuki; Yoshiharu Matsuura; Noritaka Hashii; Yoshimasa Takahashi; Takeshi Inoue; Kazuo Yamashita; Tomohiro Kurosaki
Journal of Experimental Medicine, 218(12), Dec. 2021, Refereed

Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
Takuma Okajima, Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato and Takeshi Shimosato
Frontiers in Immunology, Nov. 2021, Refereed

Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
Saya Moriyama; Yu Adachi; Takashi Sato; Keisuke Tonouchi; Lin Sun; Shuetsu Fukushi; Souichi Yamada; Hitomi Kinoshita; Kiyoko Nojima; Takayuki Kanno; Minoru Tobiume; Keita Ishijima; Yudai Kuroda; Eun-Sil Park; Taishi Onodera; Takayuki Matsumura; Tomohiro Takano; Kazutaka Terahara; Masanori Isogawa; Ayae Nishiyama; Ai Kawana-Tachikawa; Masaharu Shinkai; Natsuo Tachikawa; Shigeki Nakamura; Takahiro Okai; Kazu Okuma; Tetsuro Matano; Tsuguto Fujimoto; Ken Maeda; Makoto Ohnishi; Takaji Wakita; Tadaki Suzuki; Yoshimasa Takahashi
Immunity, 54(8), 1841-1852.e4, Aug. 2021, Refereed

Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Frontiers in Nutrition, 7, Feb. 2021, Refereed

A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
Takatomo Hirouchi; Shinichiro Ota; Dai Mashima; Ryuichi Boku; Yuto Yoshida; Koki Iwata; Kanako Shinada; Takashi Matsumoto; Miwa Morikawa; Takashi Sato; Masahiro Shinoda; Kenichi Kamachi; Masaharu Shinkai
Journal of Infection and Chemotherapy, 27(2), 379-383, Feb. 2021

Two cases of severe covid-19 pneumonia effectively treated with extracorporeal membrane oxygenation in addition to favipiravir and corticosteroid
Masahiro Shinoda; Kenichi Kamachi; Shinichiro Ota; Lynn Yoshimatsu; Ryuichi Boku; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Koki Iwata; Takashi Matsumoto; Masaharu Shinkai
Internal Medicine, 60(1), 123-130, Jan. 2021

Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
Fu Namai; Aito Murakami; Asami Ueda; Masami Tsukagoshi; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Molecular Biotechnology, 62(11-12), 572-579, Dec. 2020, Refereed

Clinical Features of 154 COVID-19 Patients and the Parameters for the Effective Detection of Pneumonia at the Time of the Initial Diagnosis in Japan
Miwa Morikawa; Masahiro Shinoda; Shinichiro Ohta; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Osamu Sasaki; Takashi Sato; Kenichi Kamachi; Masaharu Shinkai
Internal Medicine, Nov. 2020, Refereed
Corresponding

Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Kentaro Yumoto; Takashi Sato; Kentaro Nakashima; Fu Namai; Suguru Shigemori; Takeshi Shimosato; Takeshi Kaneko
Antioxidants, 9(11), 1049-1049, Oct. 2020, Refereed
Corresponding

Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Molecular Biology Reports, 47(9), 7039-7047, Sep. 2020, Refereed

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Experimental & Molecular Medicine, 52(9), 1627-1636, Sep. 2020, Refereed

Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Molecular Biology Reports, 47(9), 6717-6725, Sep. 2020, Refereed, Not invited

Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Applied and Environmental Microbiology, 86(20), Aug. 2020, Refereed, Not invited

The clinical significance of CXCL16 in the treatment of advanced non‐small cell lung cancer
Yuji Shibata; Nobuaki Kobayashi; Takashi Sato; Kentaro Nakashima; Takeshi Kaneko
Thoracic Cancer, 11(5), 1258-1264, May 2020, Refereed
Corresponding

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
Tasuku Ogita; Yoshinari Yamamoto; Ayane Mikami; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Frontiers in Immunology, 11, Feb. 2020, Refereed, Not invited

Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
Suguru Shigemori; Fu Namai; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Animal Science Journal, 91(1), Jan. 2020, Refereed

Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
Masami Tsukagoshi; Merisa Sirisopapong; Fu Namai; Minori Ishida; Supattra Okrathok; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Sutisa Khempaka; Takeshi Shimosato
Animal Science Journal, 91(1), Jan. 2020, Refereed, Not invited

Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture-negative.
Ken Tashiro; Masaki Yamamoto; Ryota Ushio; Nobuaki Kobayashi; Takashi Sato; Makoto Kudo; Takeshi Kaneko
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 86, 47-54, Sep. 2019, Refereed, Not invited

Clinical significance of Charlson comorbidity index as a prognostic parameter for patients with acute or subacute idiopathic interstitial pneumonias and acute exacerbation of collagen vascular diseases-related interstitial pneumonia.
Kota Murohashi; Yu Hara; Yusuke Saigusa; Nobuaki Kobayashi; Takashi Sato; Masaki Yamamoto; Makoto Kudo; Takeshi Kaneko
Journal of thoracic disease, 11(6), 2448-2457, Jun. 2019, Refereed, Not invited

Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages.
Fu Namai; Yoshinari Yamamoto; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Animal science journal = Nihon chikusan Gakkaiho, 89(12), 1707-1711, Dec. 2018, Refereed, Not invited

Silicosis and lung cancer: current perspectives
Sato T; Shimosato T; Klinman DM
Lung Cancer (Auckl), 9, 91-101, Oct. 2018, Refereed, Invited

Regulatory role of heme oxygenase-1 in silica-induced lung injury
Kentaro Nakashima; Takashi Sato; Suguru Shigemori; Takeshi Shimosato; Masaharu Shinkai; Takeshi Kaneko
Respiratory Research, 19(1), Aug. 2018, Refereed
Corresponding

Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components.
Nigar S; Yamamoto Y; Okajima T; Sato T; Ogita T; Shimosato T
Anim Sci J, 89(10), 1504-1511, Jul. 2018, Refereed, Not invited

Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells.
Fu Namai; Suguru Shigemori; Koichi Sudo; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
Current microbiology, 75(1), 92-98, Jan. 2018, Refereed, Not invited

The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
Internal Medicine, 57(10), 1391-1397, 2018, Refereed, Not invited

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
BMC IMMUNOLOGY, 18, 44, Oct. 2017, Refereed, Not invited

Genetically modified Lactococcus lactis producing a green fluorescent protein bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
S. Shigemori; F. Namai; Y. Yamamoto; S. Nigar; T. Sato; T. Ogita; T. Shimosato
JOURNAL OF DAIRY SCIENCE, 100(9), 7007-7015, Sep. 2017, Refereed, Not invited

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
Yoshinari Yamamoto; Ryu Sugimura; Takafumi Watanabe; Suguru Shigemori; Takuma Okajima; Shireen Nigar; Fu Namai; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
FRONTIERS IN IMMUNOLOGY, 8, 1049, Aug. 2017, Refereed, Not invited

HbA1c level cannot predict the treatment outcome of smearpositive non-multi-drug-resistant HIV-negative pulmonary tuberculosis inpatients
Ken Tashiro; Nobuyuki Horita; Kenjiro Nagai; Misako Ikeda; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Atsuya Narita; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 7, 46488, Apr. 2017, Refereed, Not invited

Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Suguru Shigemori; Masaki Ihara; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101(1), 341-349, Jan. 2017, Refereed, Not invited

Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
INTERNAL MEDICINE, 56(24), 3277-3282, 2017, Refereed, Not invited

Diagnostic test accuracy of loop-mediated isothermal amplification assay for Mycobacterium tuberculosis: systematic review and meta-analysis
Kenjiro Nagai; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, 39090, Dec. 2016, Refereed, Not invited

Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells
Akimichi Nagashima; Masaharu Shinkai; Masahiro Shinoda; Tadasuke Shimokawaji; Yasuhiro Kimura; Kei Mishina; Takashi Sato; Mariko Toda; Yoshiaki Inayama; Bruce K. Rubin; Takeshi Kaneko
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(11), 6585-6590, Nov. 2016, Refereed, Not invited

Diagnostic test accuracy of anti-glycopeptidolipid-core IgA antibodies for Mycobacterium avium complex pulmonary disease: systematic review and meta-analysis
Yuji Shibata; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, 29325, Jul. 2016, Refereed, Not invited

Digital PCR assay detection of circulating Mycobacterium tuberculosis DNA in pulmonary tuberculosis patient plasma
Ryota Ushio; Masaki Yamamoto; Kentaro Nakashima; Hiroki Watanabe; Kenjiro Nagai; Yuji Shibata; Ken Tashiro; Toshinori Tsukahara; Hideyuki Nagakura; Nobuyuki Horita; Takashi Sato; Masaharu Shinkai; Makoto Kudo; Atsuhisa Ueda; Takeshi Kaneko
TUBERCULOSIS, 99, 47-53, Jul. 2016, Refereed, Not invited

Use of nanoparticles to deliver immunomodulatory oligonucleotides
Dennis M. Klinman; Takashi Sato; Takeshi Shimosato
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 8(4), 631-637, Jul. 2016, Refereed, Invited

Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Yoshinari Yamamoto; Suguru Shigemori; Shireen Nigar; Kazushi Oshiro; Yeqin Wang; Takashi Sato; Takeshi Shimosato
ANIMAL SCIENCE JOURNAL, 87(5), 710-717, May 2016, Refereed, Not invited

Multiple nodular pulmonary metastases of lung adenocarcinoma with epidermal growth factor receptor mutation
Natsuki Kawata; Miyo Inoue; Nobuyuki Horita; Koji Tomaru; Masaki Yamamoto; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko
Respiratory Investigation, 54(2), 133-135, Mar. 2016, Refereed, Not invited

Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko
Scientific Reports, 6, 21610, Feb. 2016, Refereed, Not invited

Amrubicin for relapsed small-cell lung cancer: a systematic review and meta-analysis of 803 patients
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Nobuaki Kobayashi; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, Jan. 2016, Refereed, Not invited

Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis of 26999 specimens from 17 Studies.
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Kentaro Sakamaki; Takashi Yoshiyama; Takeshi Kaneko
Scientific reports, 5, 18113-18113, Dec. 2015, Refereed, Not invited

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato
MICROBIAL CELL FACTORIES, 14(1), 189, Nov. 2015, Refereed, Not invited

Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Miyo Inoue; Kentaro Nakashima; Ryota Ushio; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 5, 15437, Oct. 2015, Refereed, Not invited

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Takashi Sato; Takeshi Shimosato; Atsuhisa Ueda; Yoshiaki Ishigatsubo; Dennis M. Klinman
MOLECULAR CANCER THERAPEUTICS, 14(10), 2198-2205, Oct. 2015, Refereed, Not invited

Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
Yeqin Wang; Yoshinari Yamamoto; Suguru Shigemori; Takafumi Watanabe; Kazushi Oshiro; Xinyu Wang; Pengfei Wang; Takashi Sato; Shinichi Yonekura; Sachi Tanaka; Haruki Kitazawa; Takeshi Shimosato
MOLECULAR THERAPY, 23(2), 297-309, Feb. 2015, Refereed, Not invited

An Autopsy Case Report of Malignant Pleural Mesothelioma with Deciduoid Features
Ryota Ushio; Masaki Yamamoto; Yuji Shibata; Hiroshi Ishii; Keisuke Watanabe; Ryohei Takahashi; Takashi Sato; Makoto Kudo; Akio Miyake; Takeshi Kaneko; Yoshiaki Ishigatsubo
INTERNAL MEDICINE, 54(22), 2915-2917, 2015, Refereed, Not invited

The effectiveness of sputum pH analysis in the prediction of response to therapy in patients with pulmonary tuberculosis.
Makoto Masuda; Takashi Sato; Kentaro Sakamaki; Makoto Kudo; Takeshi Kaneko; Yoshiaki Ishigatsubo
PeerJ, 3, e1448, 2015, Refereed, Not invited

IKK alpha negatively regulates ASC-dependent inflammasome activation
Bradley N. Martin; Chenhui Wang; Jami Willette-Brown; Tomasz Herjan; Muhammet F. Gulen; Hao Zhou; Katarzyna Bulek; Luigi Franchi; Takashi Sato; Emad S. Alnemri; Goutham Narla; Xiao-Ping Zhong; James Thomas; Dennis Klinman; Katherine A. Fitzgerald; Michael Karin; Gabriel Nunez; George Dubyak; Yinling Hu; Xiaoxia Li
NATURE COMMUNICATIONS, 5, 4977, Sep. 2014, Refereed, Not invited

Five cases of pulmonary tuberclosis in pregnancy
Ryohei Takahashi; Ryota Ushio; Yusuke Moriyama; Yuji Shibata; Hiroshi Ishii; Keisuke Watanabe; Masaki Yamamoto; Takashi Sato; Makoto Kudo; Takeshi Kaneko; Yoshiaki Ishigatsubo
Yokohama Medical Journal, 65(4), 559-563, 2014

Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from beta-Lactoglobulin Secreted by Lactococcus lactis
Suguru Shigemori; Kazushi Oshiro; Pengfei Wang; Yoshinari Yamamoto; Yeqin Wang; Takashi Sato; Yutaka Uyeno; Takeshi Shimosato
BIOMED RESEARCH INTERNATIONAL, 2014, 393598, 2014, Refereed, Not invited

Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Suguru Shigemori; Shinichi Yonekura; Takashi Sato; Hajime Otani; Takeshi Shimosato
Applied Microbiology and Biotechnology, 97(8), 3603-3611, Apr. 2013, Refereed, Not invited

Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo
International Journal of Oncology, 42(2), 429-436, Feb. 2013, Refereed, Not invited

Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 17(1), 54-60, Jan. 2013, Refereed, Not invited

Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
Yusuke Ito; Suguru Shigemori; Takashi Sato; Tomoyuki Shimazu; Konomi Hatano; Hajime Otani; Haruki Kitazawa; Takeshi Shimosato
FEBS OPEN BIO, 3, 41-45, 2013, Refereed, Not invited

Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis
Takashi Sato; Yoshiaki Saito; Satoshi Inoue; Takeshi Shimosato; Shigeto Takagi; Takeshi Kaneko; Yoshiaki Ishigatsubo
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 54(12), 1461-1466, Dec. 2012, Refereed, Not invited

Expression of a Biologically Active GFP-alpha(S1)-Casein Fusion Protein in Lactococcus lactis
Suguru Shigemori; Shinichi Yonekura; Takashi Sato; Maya Nakanishi; Hajime Otani; Takeshi Shimosato
CURRENT MICROBIOLOGY, 64(6), 569-575, Jun. 2012, Refereed, Not invited

Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo
Journal of Medical Case Reports, 6, 266, 2012, Refereed, Not invited

The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides
Masaki Yamamoto; Takashi Sato; Joel Beren; Daniela Verthelyi; Dennis M. Klinman
BIOMATERIALS, 32(18), 4238-4242, Jun. 2011, Refereed, Not invited

Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima
BMJ OPEN, 1(1), e000105, 2011, Refereed, Not invited

Serum Heme Oxygenase-1 As Marker Of Lung Function Decline In Patients With Chronic Silicosis
T. Sato; N. Miyazawa; Y. Saito; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(12), 1461, 2011, Refereed, Not invited

Accelerated wound healing mediated by activation of Toll-like receptor 9
Takashi Sato; Masaki Yamamoto; Takeshi Shimosato; Dennis M. Klinman
WOUND REPAIR AND REGENERATION, 18(6), 586-593, Nov. 2010, Refereed, Not invited

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Takeshi Shimosato; Megumi Fujimoto; Masanori Tohno; Takashi Sato; Mariko Tateo; Hajime Otani; Haruki Kitazawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(1), 81-86, Mar. 2010, Refereed, Not invited

High frequency of beta-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
Satoshi Inoue; Yuji Watanuki; Naoki Miyazawa; Makoto Kudo; Takashi Sato; Nobuaki Kobayashi; Kei Mishina; Masahiro Sasaki; Takeshi Kaneko; Yoshiaki Ishigatsubo
JOURNAL OF INFECTION AND CHEMOTHERAPY, 16(1), 72-75, Feb. 2010, Refereed, Not invited

Esophagomediastinal and esophagobronchial fistulas associated with invasive aspergillosis.
Kato S; Inoue S; Inamori M; Miyazawa N; Sato T; Kobayashi N; Mishina K; Sasaki M; Ishigatsubo Y; Nakajima A
Endoscopy, 42 Suppl 2, E48-9, 2010, Refereed, Not invited

[The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease].
Kobayashi N; Watanuki Y; Miyazawa N; Kudo M; Inoue S; Sato T; Mishina K; Takahashi H; Kaneko T; Ishigatsubo Y
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(12), 1063-1069, Dec. 2009, Refereed, Not invited

CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
Dennis M. Klinman; Sven Klaschik; Takashi Sato; Debbie Tross
ADVANCED DRUG DELIVERY REVIEWS, 61(3), 248-255, Mar. 2009, Refereed, Invited

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Takeshi Shimosato; Masanori Tohno; Takashi Sato; Junko Nishimura; Yasushi Kawai; Tadao Saito; Haruki Kitazawa
ANIMAL SCIENCE JOURNAL, 80(5), 597-604, 2009, Refereed, Not invited

Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides
Dennis M. Klinman; Debbie Tross; Sven Klaschik; Hidekazu Shirota; Takeshi Sato
OLIGONUCLEOTIDE THERAPEUTICS, 1175, 80-88, 2009, Refereed, Invited

Synthetic oligonucleotides as modulators of inflammation
Dennis Klinman; Hidekazu Shirota; Debra Tross; Takashi Sato; Sven Klaschik
JOURNAL OF LEUKOCYTE BIOLOGY, 84(4), 958-964, Oct. 2008, Refereed, Invited

Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
Takashi Sato; Takeshi Shimosato; W. Gregory Alvord; Dennis M. Klinman
JOURNAL OF IMMUNOLOGY, 180(11), 7648-7654, Jun. 2008, Refereed, Not invited

Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 174(8), 906-914, Oct. 2006, Refereed, Not invited

Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo
INFLAMMATION RESEARCH, 54(5), 229-234, May 2005, Refereed, Not invited

Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation
A Tagawa; T Kaneko; H Nishiyama; T Shinohara; T Sato; P Geppetti; Y Ishigatsubo
EUROPEAN JOURNAL OF PHARMACOLOGY, 507(1-3), 223-228, Jan. 2005, Refereed, Not invited

Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
Corresponding

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato

Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato

The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato

Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko

Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato

Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo

Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo

Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo

Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima

Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo

Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo

Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato

Intratracheal therapy using nintedanib amorphous particles in murine pulmonary fibrosis
Kaho Suzuki; Fu Namai; Aito Murakami; Yuichi Sato; Akihiro Kotsugai; Takeshi Shimosato; Takashi Sato
European Respiratory Journal, 64(suppl 68), OA4557 - OA4557, 14 Sep. 2024
https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2024.OA4557

Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis
K. Suzuki; F. Namai; N. Nomura; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
D29. TRANSLATIONAL RESEARCH IN IPF, 207, A6476, 01 May 2023

Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice
N. Nomura; F. Namai; T. Sato; T. Shimosato
C70. COPD (AND LUNG CANCER) CLINICAL AND TRANSLATIONAL STUDIES, 207, A5754, 01 May 2023

SARS-CoV-2スパイク組換えタンパク質ワクチンによる異種ブースター接種は,受容体結合ドメインに対して持続的な広域中和抗体応答を誘導する
松村隆之; 高野智弘; 佐藤隆; 上滝隆太郎; 森山彩野; 福士秀悦; 篠田雅宏; 樺澤清美; 高坂美央; 安達悠; 小野寺大志; 寺原和孝; 五十川正記; 新海正晴; 高橋宜聖
日本ワクチン学会学術集会プログラム・抄録集, 27th, 2023

A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites.
Kentaro Nakashima; Yu Hara; Takashi Sato; Masaharu Shinkai; Takeshi Kaneko
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(8), 1227 - 1228, Aug. 2018, Refereed, Not invited

Toll-Like Receptor 9, A Key To Attenuate Disease Progression In A Murine Model Of COPD
T. Sato; K. Nakashima; Y. Shibata; H. Sasaki; M. Ikeda; A. Nagashima; H. Watanabe; K. Nagai; H. Nagakura; N. Horita; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017, Not invited

Serum Cxcl16 As A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer
Y. Shibata; T. Sato; M. Ikeda; H. Sasaki; A. Nagashima; R. Ushio; K. Nakashima; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; Y. Hara; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017, Not invited

Toll-Like Receptor 9, A Key To Attenuation Of Disease Progression In A Mouse Model Of Chronic Obstructive Pulmonary Disease
T. Sato; K. Nakashima; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; D. Klinman; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016, Not invited

Heme Oxygenase-1 Regulates Ros-Erk1/2 Signaling In Silica-Induced Lung Injury
K. Nakashima; T. Sato; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016, Not invited

Serum Cxcl16, A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer: A Preliminary Report
Y. Shibata; T. Sato; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015, Not invited

Effect Of Intratracheal Immunostimulatory-Oligonucleotides With Biodegradable Polyketal Nanoparticles On Murine Lung Cancer
T. Sato; Y. Shibata; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo; D. Klinman
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015, Not invited

Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-Cancer Drug In Human Lung Cancer Cells
R. Takahashi; T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; M. Hayashi; M. Yamamoto; K. Tomaru; T. Tsukahara; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011, Not invited

CPG Oligodeoxynucleotides Promote Wound Healing In Airway Epithelial Cells
T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011, Not invited

Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide
Takashi Sato; Takeshi Shimosato; Masaki Yamamoto; Nobuaki Kobayashi; Naoki Miyazawa; Yoshiaki Ishigatsubo; Dennis Klinman
JOURNAL OF IMMUNOLOGY, 184, Apr. 2010, Not invited

CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
Takashi Sato; Takeshi Shimosato; Dennis M. Klinman
JOURNAL OF IMMUNOLOGY, 182, Apr. 2009, Not invited

Innovative therapy for lung cancer - intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment -
Takashi Sato, Single work
Precision Medicine 2024;7(7):554-58, Jun. 2024

Development of microbial therapeutics for the prevention/suppression of cancer and beyond
Takashi Sato, Single work
BIO Clinica 2024;39(6):531-35, Jun. 2024

Innovative therapy for lung cancer - intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment -
Takashi Sato, Single work, クリニカルトピックス
BIO Clinica 2023;38(7):638-42, Jun. 2023

Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
Takashi Sato; Takeshi Shimosato, Contributor, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
IntechOpen, 17 Aug. 2022, Refereed

Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
Takashi Sato; Takeshi Shimosato, Contributor, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
IntechOpen, Aug. 2022, Refereed
ISBN:9781803567679
https://www.intechopen.com/online-first/83110

Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
SATO Takashi; SHIMOSATO Takeshi
Science Impact Ltd, Mar. 2019

Respiratory Disease Series: Diagnostic Tools and Disease Managements
SATO Takashi, Single work, Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
Springer, 255-271 Jul. 2018
ISBN:9789811081439

ガイトン生理学（原著第13版）
佐藤 隆, Single translation, 第40章 肺胞を拡散する酸素と二酸化炭素のガス交換の原理、第41章 血液や組織液中の酸素と二酸化炭素の輸送
ELSEVIER, Mar. 2018
ISBN:9784860347741

Intratracheal therapy using oligodeoxynucleotides and/or genetically modified lactic acid bacteria-derived biological molecules
Takashi Sato
The Korean Society of Toxicology/The Korean Environmental Mutagen Society 2022 KSOT/KEMS Spring International Symposium, May 2022, Invited,

Innovative therapy for lung cancer ～Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment～
SATO Takashi
NIH/NCI Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman, Jun. 2019, Invited

吸入治療イノベーション～吸入薬で肺癌の制御を目指す研究開発の取り組み～
佐藤 隆
横浜市立大学先端医科学研究センター 第54回市民講座, Oct. 2018, Not invited

Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect of long-term immune responses on murine lung cancer
Takashi Sato
THE 14TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, Dec. 2017,

Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect on murine lung cancer
Takashi Sato
THE 13TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, Dec. 2015,

日本臨床腫瘍学会

日本感染症学会

日本アレルギー学会

日本酪農科学会

日本呼吸器学会

日本内科学会

日本化学療法学会

American Thoracic Society

免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証
科学研究費補助金, テキサス大学MDアンダーソンがんセンター, 国際共同研究加速基金（国際共同研究強化（B））
Oct. 2019 - Mar. 2023

吸入療法イノベーションの実現：高分子・抗体医薬の経気道投与による肺癌治療戦略
科学研究費補助金, 挑戦的研究（萌芽）
Jun. 2018 - Mar. 2020

ライフイノベーションプラットフォーム横浜推進プロジェクト・圧電素子を用いた経気道投与用パーソナル吸入デバイスの開発研究
横浜市経済局
Sep. 2017 - Mar. 2020

乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明
科学研究費補助金, 基盤B
Apr. 2017 - Mar. 2021

日本医療研究開発機構（AMED)・創薬基盤推進研究事業・Fine Droplet Dryingテクノロジーによる経気道治療用ナノマイクロ粒子包埋医薬品の創出を目指した研究
日本医療研究開発機構（AMED）
Apr. 2017 - Mar. 2020

ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究
科学研究費補助金, 基盤C
Apr. 2015 - Mar. 2018

微生物由来 DNA を利用した吸入型炎症性肺疾患治療薬の開発
科学研究費補助金, 若手B
Apr. 2011 - May 2012

免疫調節性DNAとナノ・マイクロ粒子キャリアーを用いた吸入型DNA治療薬の開発
科学研究費補助金, 若手B
Apr. 2009 - Mar. 2011

Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer, 9919058, 2015039574, 15326387, Patent right
Takashi Sato, Dennis Klinman

Method of treating pneumoconiosis with oligodeoxynucleotides, 8222225, 2009044739, 12993809, Patent right
Takashi Sato, Dennis Klinman

Use of CpG oligodeoxynucleotides to induce epithelial cell growth, 8466116, 20090099122, 12205756, Patent right
Takashi Sato、Dennis Klinman