佐藤 隆 (サトウ タカシ)   

農学部

先鋭領域融合研究群 バイオメディカル研究所 

特任教授(委嘱) 

学位

  • 博士(医学), 横浜市立大学
  • 学士(工学), 東京工業大学

研究キーワード

    ナノ粒子, 免疫調節性DNA, 免疫制御

研究分野

  • ライフサイエンス, 呼吸器内科学

電話番号

    0265-77-1403

経歴

  • 2022年
    富士電機株式会社 半導体事業本部, 松本工場, 専属産業医
  • 2020年 - 2022年
    東京品川病院 腫瘍内科部長・研究センター長
  • 2020年
    横浜市立大学, 医学部医学科 呼吸器病学, 客員教授
  • 2019年
    信州大学先鋭領域融合研究群・バイオメディカル研究所・特任教授
  • 2019年 - 2019年
    信州大学・農学部・特任准教授

学歴

  • 2012年 - 2014年, 米国国立衛生研究所(NIH)国立がん研究所(NCI)
  • 2007年 - 2008年, 米国国立衛生研究所(NIH)国立がん研究所(NCI)
  • 2005年 - 2006年, 米国食品医薬品局(FDA)生物製剤評価研究センター(CBER)
  • 2002年 - 2006年, 横浜市立大学, 医学研究科, 病態免疫制御内科学
  • 1994年 - 2000年, 横浜市立大学, 医学部, 医学科
  • 1990年 - 1994年, 東京工業大学, 工学部, 機械宇宙学科

委員歴

  • 2017年 - 2020年
    国際委員会委員, 日本呼吸器学会
  • 2012年 - 2015年
    プログラム委員, 米国胸部疾患学会
  • 2008年 - 2010年
    プログラム委員, 米国胸部疾患学会

受賞

  • 2013年
    米国国立衛生研究所(NIH)Fellows Award for Research Excellence (FARE) 2014
  • 2013年
    米国国立衛生研究所(NIH)Appreciation Award
  • 2009年
    横浜市立大学第一内科同門会賞
  • 2008年
    神奈川難病財団研究奨励賞
  • 2007年
    The Oak Ridge Institute for Science and Education (ORISE) Research Award
  • 2007年
    横浜総合医学振興財団呼吸器疾患研究賞

論文

  • Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
    Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
    Animal Science Journal, 94(1), 2023年12月, 査読有りリポジトリ電子ジャーナル
  • CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes
    Taishi Onodera; Nicolas Sax; Takashi Sato; Yu Adachi; Ryutaro Kotaki; Takeshi Inoue; Ryo Shinnakasu; Takayuki Nakagawa; Shuetsu Fukushi; Tommy Terooatea; Mai Yoshikawa; Keisuke Tonouchi; Takaki Nagakura; Saya Moriyama; Takayuki Matsumura; Masanori Isogawa; Kazutaka Terahara; Tomohiro Takano; Lin Sun; Ayae Nishiyama; Shinnya Omoto; Masaharu Shinkai; Tomohiro Kurosaki; Kazuo Yamashita; Yoshimasa Takahashi
    Science Advances, 9(24), 2023年06月, 査読有りリポジトリ電子ジャーナル
  • High Fever, Wide Distribution of Viral Pneumonia, and Pleural Effusion are More Critical Findings at the First Visit in Predicting the Prognosis of COVID-19: A Single Center, retrospective, Propensity Score-Matched Case–Control Study
    Masahiro Shinoda; Shinichiro Ota; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Naoki Ishii; Masaharu Shinkai
    International Journal of General Medicine, Volume 16, 2337-2348, 2023年06月, 査読有りリポジトリ電子ジャーナル
  • Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria
    Suzuka Oshima; Fu Namai; Takashi Sato; Takeshi Shimosato
    Molecular Biotechnology, 2023年04月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain.
    Tomohiro Takano; Takashi Sato; Ryutaro Kotaki; Saya Moriyama; Shuetsu Fukushi; Masahiro Shinoda; Kiyomi Kabasawa; Nagashige Shimada; Mio Kousaka; Yu Adachi; Taishi Onodera; Kazutaka Terahara; Masanori Isogawa; Takayuki Matsumura; Masaharu Shinkai; Yoshimasa Takahashi
    Nature communications, 14(1), 1451-1451, 2023年03月, 査読有り
    筆頭著者リポジトリ電子ジャーナル
  • Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
    Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
    AMB Express, 13(1), 2023年01月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • SARS-CoV-2 specific CD4+ T cell longevity correlates with Th17-like phenotype
    Kazutaka Terahara; Takashi Sato; Yu Adachi; Keisuke Tonouchi; Taishi Onodera; Saya Moriyama; Lin Sun; Tomohiro Takano; Ayae Nishiyama; Ai Kawana-Tachikawa; Tetsuro Matano; Takayuki Matsumura; Masaharu Shinkai; Masanori Isogawa; Yoshimasa Takahashi
    iScience, 104959-104959, 2022年08月, 査読有りリポジトリ電子ジャーナル
  • Immunogenicity and safety of booster dose of S-268019-b or BNT162b2 in Japanese participants: An interim report of phase 2/3, randomized, observer-blinded, noninferiority study
    Masaharu Shinkai; Takuhiro Sonoyama; Akari Kamitani; Risa Yokokawa Shibata; Naomi M. Seki; Shinya Omoto; Masahiro Shinoda; Takashi Sato; Naoki Ishii; Kenji Igarashi; Mari Ariyasu
    Vaccine, 2022年06月, 査読有りリポジトリ電子ジャーナル
  • Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir
    Kanako Shinada; Takashi Sato; Saya Moriyama; Yu Adachi; Masahiro Shinoda; Shinichiro Ota; Miwa Morikawa; Masamichi Mineshita; Takayuki Matsumura; Yoshimasa Takahashi; Masaharu Shinkai
    Viruses, 14(4), 670-670, 2022年03月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients
    Xiuyuan Lu; Yuki Hosono; Masamichi Nagae; Shigenari Ishizuka; Eri Ishikawa; Daisuke Motooka; Yuki Ozaki; Nicolas Sax; Yuichi Maeda; Yasuhiro Kato; Takayoshi Morita; Ryo Shinnakasu; Takeshi Inoue; Taishi Onodera; Takayuki Matsumura; Masaharu Shinkai; Takashi Sato; Shota Nakamura; Shunsuke Mori; Teru Kanda; Emi E. Nakayama; Tatsuo Shioda; Tomohiro Kurosaki; Kiyoshi Takeda; Atsushi Kumanogoh; Hisashi Arase; Hironori Nakagami; Kazuo Yamashita; Yoshimasa Takahashi; Sho Yamasaki
    Journal of Experimental Medicine, 218(12), 2021年12月, 査読有りリポジトリ電子ジャーナル
  • Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses
    Ryo Shinnakasu; Shuhei Sakakibara; Hiromi Yamamoto; Po-hung Wang; Saya Moriyama; Nicolas Sax; Chikako Ono; Atsushi Yamanaka; Yu Adachi; Taishi Onodera; Takashi Sato; Masaharu Shinkai; Ryosuke Suzuki; Yoshiharu Matsuura; Noritaka Hashii; Yoshimasa Takahashi; Takeshi Inoue; Kazuo Yamashita; Tomohiro Kurosaki
    Journal of Experimental Medicine, 218(12), 2021年12月, 査読有りリポジトリ電子ジャーナル
  • Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
    Takuma Okajima, Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato and Takeshi Shimosato
    Frontiers in Immunology, 2021年11月, 査読有り
  • Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
    Saya Moriyama; Yu Adachi; Takashi Sato; Keisuke Tonouchi; Lin Sun; Shuetsu Fukushi; Souichi Yamada; Hitomi Kinoshita; Kiyoko Nojima; Takayuki Kanno; Minoru Tobiume; Keita Ishijima; Yudai Kuroda; Eun-Sil Park; Taishi Onodera; Takayuki Matsumura; Tomohiro Takano; Kazutaka Terahara; Masanori Isogawa; Ayae Nishiyama; Ai Kawana-Tachikawa; Masaharu Shinkai; Natsuo Tachikawa; Shigeki Nakamura; Takahiro Okai; Kazu Okuma; Tetsuro Matano; Tsuguto Fujimoto; Ken Maeda; Makoto Ohnishi; Takaji Wakita; Tadaki Suzuki; Yoshimasa Takahashi
    Immunity, 54(8), 1841-1852.e4, 2021年08月, 査読有りリポジトリ電子ジャーナル
  • Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
    Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
    Frontiers in Nutrition, 7, 2021年02月, 査読有りリポジトリ電子ジャーナル
  • Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
    Fu Namai; Aito Murakami; Asami Ueda; Masami Tsukagoshi; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
    Molecular Biotechnology, 62(11-12), 572-579, 2020年12月, 査読有りリポジトリ電子ジャーナル
  • Clinical Features of 154 COVID-19 Patients and the Parameters for the Effective Detection of Pneumonia at the Time of the Initial Diagnosis in Japan
    Miwa Morikawa; Masahiro Shinoda; Shinichiro Ohta; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Osamu Sasaki; Takashi Sato; Kenichi Kamachi; Masaharu Shinkai
    Internal Medicine, 2020年11月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
    Kentaro Yumoto; Takashi Sato; Kentaro Nakashima; Fu Namai; Suguru Shigemori; Takeshi Shimosato; Takeshi Kaneko
    Antioxidants, 9(11), 1049-1049, 2020年10月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
    Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
    Molecular Biology Reports, 47(9), 7039-7047, 2020年09月, 査読有りリポジトリ電子ジャーナル
  • Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
    Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
    Experimental & Molecular Medicine, 52(9), 1627-1636, 2020年09月, 査読有りリポジトリ電子ジャーナル
  • Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
    Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
    Molecular Biology Reports, 47(9), 6717-6725, 2020年09月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
    Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
    Applied and Environmental Microbiology, 86(20), 2020年08月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • The clinical significance of CXCL16 in the treatment of advanced non‐small cell lung cancer
    Yuji Shibata; Nobuaki Kobayashi; Takashi Sato; Kentaro Nakashima; Takeshi Kaneko
    Thoracic Cancer, 11(5), 1258-1264, 2020年05月, 査読有り
    責任著者リポジトリ電子ジャーナル
  • Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
    Tasuku Ogita; Yoshinari Yamamoto; Ayane Mikami; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
    Frontiers in Immunology, 11, 2020年02月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
    Suguru Shigemori; Fu Namai; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
    Animal Science Journal, 91(1), 2020年01月, 査読有りリポジトリ電子ジャーナル
  • Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
    Masami Tsukagoshi; Merisa Sirisopapong; Fu Namai; Minori Ishida; Supattra Okrathok; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Sutisa Khempaka; Takeshi Shimosato
    Animal Science Journal, 91(1), 2020年01月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture-negative.
    Ken Tashiro; Masaki Yamamoto; Ryota Ushio; Nobuaki Kobayashi; Takashi Sato; Makoto Kudo; Takeshi Kaneko
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 86, 47-54, 2019年09月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Clinical significance of Charlson comorbidity index as a prognostic parameter for patients with acute or subacute idiopathic interstitial pneumonias and acute exacerbation of collagen vascular diseases-related interstitial pneumonia.
    Kota Murohashi; Yu Hara; Yusuke Saigusa; Nobuaki Kobayashi; Takashi Sato; Masaki Yamamoto; Makoto Kudo; Takeshi Kaneko
    Journal of thoracic disease, 11(6), 2448-2457, 2019年06月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages.
    Fu Namai; Yoshinari Yamamoto; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
    Animal science journal = Nihon chikusan Gakkaiho, 89(12), 1707-1711, 2018年12月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Silicosis and lung cancer: current perspectives
    Sato T; Shimosato T; Klinman DM
    Lung Cancer (Auckl), 9, 91-101, 2018年10月, 査読有り, 招待有り
  • Regulatory role of heme oxygenase-1 in silica-induced lung injury
    Kentaro Nakashima; Takashi Sato; Suguru Shigemori; Takeshi Shimosato; Masaharu Shinkai; Takeshi Kaneko
    Respiratory Research, 19(1), 2018年08月, 査読有り
    責任著者WebofScienceリポジトリ電子ジャーナル
  • Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components.
    Nigar S; Yamamoto Y; Okajima T; Sato T; Ogita T; Shimosato T
    Anim Sci J, 89(10), 1504-1511, 2018年07月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells.
    Fu Namai; Suguru Shigemori; Koichi Sudo; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
    Current microbiology, 75(1), 92-98, 2018年01月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
    Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
    Internal Medicine, 57(10), 1391-1397, 2018年, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
    Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
    BMC IMMUNOLOGY, 18, 44, 2017年10月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Genetically modified Lactococcus lactis producing a green fluorescent protein bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
    S. Shigemori; F. Namai; Y. Yamamoto; S. Nigar; T. Sato; T. Ogita; T. Shimosato
    JOURNAL OF DAIRY SCIENCE, 100(9), 7007-7015, 2017年09月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
    Yoshinari Yamamoto; Ryu Sugimura; Takafumi Watanabe; Suguru Shigemori; Takuma Okajima; Shireen Nigar; Fu Namai; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
    FRONTIERS IN IMMUNOLOGY, 8, 1049, 2017年08月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • HbA1c level cannot predict the treatment outcome of smearpositive non-multi-drug-resistant HIV-negative pulmonary tuberculosis inpatients
    Ken Tashiro; Nobuyuki Horita; Kenjiro Nagai; Misako Ikeda; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Atsuya Narita; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
    SCIENTIFIC REPORTS, 7, 46488, 2017年04月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
    Suguru Shigemori; Masaki Ihara; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101(1), 341-349, 2017年01月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
    Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
    INTERNAL MEDICINE, 56(24), 3277-3282, 2017年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Diagnostic test accuracy of loop-mediated isothermal amplification assay for Mycobacterium tuberculosis: systematic review and meta-analysis
    Kenjiro Nagai; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
    SCIENTIFIC REPORTS, 6, 39090, 2016年12月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells
    Akimichi Nagashima; Masaharu Shinkai; Masahiro Shinoda; Tadasuke Shimokawaji; Yasuhiro Kimura; Kei Mishina; Takashi Sato; Mariko Toda; Yoshiaki Inayama; Bruce K. Rubin; Takeshi Kaneko
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(11), 6585-6590, 2016年11月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Diagnostic test accuracy of anti-glycopeptidolipid-core IgA antibodies for Mycobacterium avium complex pulmonary disease: systematic review and meta-analysis
    Yuji Shibata; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
    SCIENTIFIC REPORTS, 6, 29325, 2016年07月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Digital PCR assay detection of circulating Mycobacterium tuberculosis DNA in pulmonary tuberculosis patient plasma
    Ryota Ushio; Masaki Yamamoto; Kentaro Nakashima; Hiroki Watanabe; Kenjiro Nagai; Yuji Shibata; Ken Tashiro; Toshinori Tsukahara; Hideyuki Nagakura; Nobuyuki Horita; Takashi Sato; Masaharu Shinkai; Makoto Kudo; Atsuhisa Ueda; Takeshi Kaneko
    TUBERCULOSIS, 99, 47-53, 2016年07月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Use of nanoparticles to deliver immunomodulatory oligonucleotides
    Dennis M. Klinman; Takashi Sato; Takeshi Shimosato
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 8(4), 631-637, 2016年07月, 査読有り, 招待有りWebofScienceリポジトリ電子ジャーナル
  • Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
    Yoshinari Yamamoto; Suguru Shigemori; Shireen Nigar; Kazushi Oshiro; Yeqin Wang; Takashi Sato; Takeshi Shimosato
    ANIMAL SCIENCE JOURNAL, 87(5), 710-717, 2016年05月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Multiple nodular pulmonary metastases of lung adenocarcinoma with epidermal growth factor receptor mutation
    Natsuki Kawata; Miyo Inoue; Nobuyuki Horita; Koji Tomaru; Masaki Yamamoto; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko
    Respiratory Investigation, 54(2), 133-135, 2016年03月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
    Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko
    Scientific Reports, 6, 21610, 2016年02月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Amrubicin for relapsed small-cell lung cancer: a systematic review and meta-analysis of 803 patients
    Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Nobuaki Kobayashi; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
    SCIENTIFIC REPORTS, 6, 2016年01月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis of 26999 specimens from 17 Studies.
    Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Kentaro Sakamaki; Takashi Yoshiyama; Takeshi Kaneko
    Scientific reports, 5, 18113-18113, 2015年12月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
    Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato
    MICROBIAL CELL FACTORIES, 14(1), 189, 2015年11月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients
    Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Miyo Inoue; Kentaro Nakashima; Ryota Ushio; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
    SCIENTIFIC REPORTS, 5, 15437, 2015年10月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
    Takashi Sato; Takeshi Shimosato; Atsuhisa Ueda; Yoshiaki Ishigatsubo; Dennis M. Klinman
    MOLECULAR CANCER THERAPEUTICS, 14(10), 2198-2205, 2015年10月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
    Yeqin Wang; Yoshinari Yamamoto; Suguru Shigemori; Takafumi Watanabe; Kazushi Oshiro; Xinyu Wang; Pengfei Wang; Takashi Sato; Shinichi Yonekura; Sachi Tanaka; Haruki Kitazawa; Takeshi Shimosato
    MOLECULAR THERAPY, 23(2), 297-309, 2015年02月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • An Autopsy Case Report of Malignant Pleural Mesothelioma with Deciduoid Features
    Ryota Ushio; Masaki Yamamoto; Yuji Shibata; Hiroshi Ishii; Keisuke Watanabe; Ryohei Takahashi; Takashi Sato; Makoto Kudo; Akio Miyake; Takeshi Kaneko; Yoshiaki Ishigatsubo
    INTERNAL MEDICINE, 54(22), 2915-2917, 2015年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • The effectiveness of sputum pH analysis in the prediction of response to therapy in patients with pulmonary tuberculosis.
    Makoto Masuda; Takashi Sato; Kentaro Sakamaki; Makoto Kudo; Takeshi Kaneko; Yoshiaki Ishigatsubo
    PeerJ, 3, e1448, 2015年, 査読有り, 招待無しリポジトリ電子ジャーナル
  • IKKα negatively regulates ASC-dependent inflammasome activation.
    Martin BN; Wang C; Willette-Brown J; Herjan T; Gulen MF; Zhou H; Bulek K; Franchi L; Sato T
    Nat Commun, 5, 4977, 2014年09月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
    Shigemori S; Oshiro K; Wang P; Yamamoto Y; Wang Y; Sato T; Uyeno Y; Shimosato T
    BioMed Research International, 2014, 393598, 2014年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
    Suguru Shigemori; Shinichi Yonekura; Takashi Sato; Hajime Otani; Takeshi Shimosato
    Applied Microbiology and Biotechnology, 97(8), 3603-3611, 2013年04月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
    Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo
    International Journal of Oncology, 42(2), 429-436, 2013年02月, 査読有り, 招待無しリポジトリ電子ジャーナル
  • Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
    N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 17(1), 54-60, 2013年01月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
    Yusuke Ito; Suguru Shigemori; Takashi Sato; Tomoyuki Shimazu; Konomi Hatano; Hajime Otani; Haruki Kitazawa; Takeshi Shimosato
    FEBS OPEN BIO, 3, 41-45, 2013年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis
    Takashi Sato; Yoshiaki Saito; Satoshi Inoue; Takeshi Shimosato; Shigeto Takagi; Takeshi Kaneko; Yoshiaki Ishigatsubo
    JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 54(12), 1461-1466, 2012年12月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Expression of a biologically active GFP-α(S1)-casein fusion protein in Lactococcus lactis.
    Shigemori S; Yonekura S; Sato T; Nakanishi M; Otani H; Shimosato T
    Curr Microbiol, 64(6), 569-575, 2012年06月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
    Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo
    Journal of Medical Case Reports, 6, 266, 2012年, 査読有り, 招待無しリポジトリ電子ジャーナル
  • The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides
    Masaki Yamamoto; Takashi Sato; Joel Beren; Daniela Verthelyi; Dennis M. Klinman
    BIOMATERIALS, 32(18), 4238-4242, 2011年06月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
    Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima
    BMJ OPEN, 1(1), e000105, 2011年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Serum Heme Oxygenase-1 As Marker Of Lung Function Decline In Patients With Chronic Silicosis
    T. Sato; N. Miyazawa; Y. Saito; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(12), 1461, 2011年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Accelerated wound healing mediated by activation of Toll-like receptor 9
    Takashi Sato; Masaki Yamamoto; Takeshi Shimosato; Dennis M. Klinman
    WOUND REPAIR AND REGENERATION, 18(6), 586-593, 2010年11月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
    Takeshi Shimosato; Megumi Fujimoto; Masanori Tohno; Takashi Sato; Mariko Tateo; Hajime Otani; Haruki Kitazawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(1), 81-86, 2010年03月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • High frequency of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
    Inoue S; Watanuki Y; Miyazawa N; Kudo M; Sato T; Kobayashi N; Mishina K; Sasaki M; Kaneko T; Ishigatsubo Y
    J Infect Chemother, 16(1), 72-75, 2010年02月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Esophagomediastinal and esophagobronchial fistulas associated with invasive aspergillosis.
    Kato S; Inoue S; Inamori M; Miyazawa N; Sato T; Kobayashi N; Mishina K; Sasaki M; Ishigatsubo Y; Nakajima A
    Endoscopy, 42 Suppl 2, E48-9, 2010年, 査読有り, 招待無しリポジトリ電子ジャーナル
  • [The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease].
    Kobayashi N; Watanuki Y; Miyazawa N; Kudo M; Inoue S; Sato T; Mishina K; Takahashi H; Kaneko T; Ishigatsubo Y
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(12), 1063-1069, 2009年12月, 査読有り, 招待無しリポジトリ
  • CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
    Dennis M. Klinman; Sven Klaschik; Takashi Sato; Debbie Tross
    ADVANCED DRUG DELIVERY REVIEWS, 61(3), 248-255, 2009年03月, 査読有り, 招待有りWebofScienceリポジトリ電子ジャーナル
  • Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
    Takeshi Shimosato; Masanori Tohno; Takashi Sato; Junko Nishimura; Yasushi Kawai; Tadao Saito; Haruki Kitazawa
    ANIMAL SCIENCE JOURNAL, 80(5), 597-604, 2009年, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides
    Dennis M. Klinman; Debbie Tross; Sven Klaschik; Hidekazu Shirota; Takeshi Sato
    OLIGONUCLEOTIDE THERAPEUTICS, 1175, 80-88, 2009年, 査読有り, 招待有りWebofScienceリポジトリ電子ジャーナル
  • Synthetic oligonucleotides as modulators of inflammation
    Dennis Klinman; Hidekazu Shirota; Debra Tross; Takashi Sato; Sven Klaschik
    JOURNAL OF LEUKOCYTE BIOLOGY, 84(4), 958-964, 2008年10月, 査読有り, 招待有りWebofScienceリポジトリ電子ジャーナル
  • Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
    Takashi Sato; Takeshi Shimosato; W. Gregory Alvord; Dennis M. Klinman
    JOURNAL OF IMMUNOLOGY, 180(11), 7648-7654, 2008年06月, 査読有り, 招待無しWebofScienceリポジトリ
  • Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
    Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 174(8), 906-914, 2006年10月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
    A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo
    INFLAMMATION RESEARCH, 54(5), 229-234, 2005年05月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation
    A Tagawa; T Kaneko; H Nishiyama; T Shinohara; T Sato; P Geppetti; Y Ishigatsubo
    EUROPEAN JOURNAL OF PHARMACOLOGY, 507(1-3), 223-228, 2005年01月, 査読有り, 招待無しWebofScienceリポジトリ電子ジャーナル
  • Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
    Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
    責任著者
  • Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
    Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
  • Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
    Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
  • The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
    Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
  • Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
    Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
  • Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
    Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
  • Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
    Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko
  • Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
    Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato
  • Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
    Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo
  • Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
    N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo
  • Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
    Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo
  • Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
    Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima
  • Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
    Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo
  • Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
    A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo
  • Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
    Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato

MISC

  • Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis
    K. Suzuki; F. Namai; N. Nomura; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207, A6476, 2023年05月01日リポジトリ電子ジャーナル
  • Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice
    N. Nomura; F. Namai; T. Sato; T. Shimosato
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207, A5754, 2023年05月01日リポジトリ電子ジャーナル
  • A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites.
    Kentaro Nakashima; Yu Hara; Takashi Sato; Masaharu Shinkai; Takeshi Kaneko
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(8), 1227-1228, 2018年08月, 査読有りリポジトリ電子ジャーナル
  • Toll-Like Receptor 9, A Key To Attenuate Disease Progression In A Murine Model Of COPD
    T. Sato; K. Nakashima; Y. Shibata; H. Sasaki; M. Ikeda; A. Nagashima; H. Watanabe; K. Nagai; H. Nagakura; N. Horita; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017年WebofScienceリポジトリ
  • Serum Cxcl16 As A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer
    Y. Shibata; T. Sato; M. Ikeda; H. Sasaki; A. Nagashima; R. Ushio; K. Nakashima; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; Y. Hara; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017年WebofScienceリポジトリ
  • Toll-Like Receptor 9, A Key To Attenuation Of Disease Progression In A Mouse Model Of Chronic Obstructive Pulmonary Disease
    T. Sato; K. Nakashima; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; D. Klinman; T. Kaneko
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016年WebofScienceリポジトリ
  • Heme Oxygenase-1 Regulates Ros-Erk1/2 Signaling In Silica-Induced Lung Injury
    K. Nakashima; T. Sato; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; T. Kaneko
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016年WebofScienceリポジトリ
  • Serum Cxcl16, A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer: A Preliminary Report
    Y. Shibata; T. Sato; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015年WebofScienceリポジトリ
  • Effect Of Intratracheal Immunostimulatory-Oligonucleotides With Biodegradable Polyketal Nanoparticles On Murine Lung Cancer
    T. Sato; Y. Shibata; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo; D. Klinman
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015年WebofScienceリポジトリ
  • Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-Cancer Drug In Human Lung Cancer Cells
    R. Takahashi; T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; M. Hayashi; M. Yamamoto; K. Tomaru; T. Tsukahara; M. Sasaki; T. Kaneko; Y. Ishigatsubo
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011年WebofScienceリポジトリ
  • CPG Oligodeoxynucleotides Promote Wound Healing In Airway Epithelial Cells
    T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011年WebofScienceリポジトリ
  • Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide
    Takashi Sato; Takeshi Shimosato; Masaki Yamamoto; Nobuaki Kobayashi; Naoki Miyazawa; Yoshiaki Ishigatsubo; Dennis Klinman
    JOURNAL OF IMMUNOLOGY, 184, 2010年04月WebofScienceリポジトリ
  • CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
    Takashi Sato; Takeshi Shimosato; Dennis M. Klinman
    JOURNAL OF IMMUNOLOGY, 182, 2009年04月WebofScienceリポジトリ

書籍等出版物

  • 組換え乳酸菌による肺がん免疫治療
    佐藤 隆, 単著
    Precision Medicine 2024;7(7):554-58, 2024年06月
    リポジトリ
  • 組換え乳酸菌による医薬・ワクチン開発
    佐藤 隆, 単著
    BIO Clinica 2024;39(6):531-35, 2024年06月
    リポジトリ
  • 組換え乳酸菌による肺癌免疫治療
    佐藤 隆, 単著, クリニカルトピックス
    BIO Clinica 2023;38(7):638-42, 2023年06月
    リポジトリ
  • Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
    Takashi Sato; Takeshi Shimosato, 分担執筆, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
    IntechOpen, 2022年08月17日, 査読有り
  • Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
    Takashi Sato; Takeshi Shimosato, 分担執筆, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
    IntechOpen, 2022年08月, 査読有り
    ISBN:9781803567679
    https://www.intechopen.com/online-first/83110
    リポジトリ電子ジャーナル
  • Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
    佐藤 隆; 下里剛士
    Science Impact Ltd, 2019年03月
  • Respiratory Disease Series: Diagnostic Tools and Disease Managements: Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
    佐藤 隆, 単著, Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
    Springer, 255-271 2018年07月
    ISBN:9789811081439
  • ガイトン生理学(原著第13版)
    佐藤 隆, 単訳, 第40章 肺胞を拡散する酸素と二酸化炭素のガス交換の原理、第41章 血液や組織液中の酸素と二酸化炭素の輸送
    ELSEVIER, 2018年03月
    ISBN:9784860347741

講演・口頭発表等

  • Intratracheal therapy using oligodeoxynucleotides and/or genetically modified lactic acid bacteria-derived biological molecules
    Takashi Sato
    The Korean Society of Toxicology/The Korean Environmental Mutagen Society 2022 KSOT/KEMS Spring International Symposium, 2022年05月, 招待有り, リポジトリ
  • Innovative therapy for lung cancer ~Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment~
    佐藤 隆
    米国国立衛生研究所・国立癌研究所 Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman, 2019年06月, 招待有り
  • 吸入治療イノベーション~吸入薬で肺癌の制御を目指す研究開発の取り組み~
    佐藤 隆
    横浜市立大学先端医科学研究センター 第54回市民講座, 2018年10月, 招待無し
  • Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect of long-term immune responses on murine lung cancer
    Takashi Sato
    THE 14TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, 2017年12月, リポジトリ
  • Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect on murine lung cancer
    Takashi Sato
    THE 13TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, 2015年12月, リポジトリ

所属学協会

  • 日本臨床腫瘍学会
  • 日本感染症学会
  • 日本アレルギー学会
  • 日本酪農科学会
  • 日本呼吸器学会
  • 日本内科学会
  • 日本化学療法学会
  • 米国胸部疾患学会

共同研究・競争的資金等の研究課題

  • 組換え乳酸菌による新型コロナウイルス経気道粘膜ワクチン・治療薬の基盤構築
    科学研究費補助金, 日本学術振興会, 基盤研究(C)
    2022年04月 - 2025年03月
  • 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証
    科学研究費補助金, テキサス大学MDアンダーソンがんセンター, 国際共同研究加速基金(国際共同研究強化(B))
    2019年10月 - 2023年03月
  • 吸入療法イノベーションの実現:高分子・抗体医薬の経気道投与による肺癌治療戦略
    科学研究費補助金, 挑戦的研究(萌芽)
    2018年06月 - 2020年03月
  • ライフイノベーションプラットフォーム横浜推進プロジェクト・圧電素子を用いた経気道投与用パーソナル吸入デバイスの開発研究
    横浜市経済局
    2017年09月 - 2020年03月
  • 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明
    科学研究費補助金, 基盤B
    2017年04月 - 2021年03月
  • 日本医療研究開発機構(AMED)・創薬基盤推進研究事業・Fine Droplet Dryingテクノロジーによる経気道治療用ナノマイクロ粒子包埋医薬品の創出を目指した研究
    日本医療研究開発機構(AMED)
    2017年04月 - 2020年03月
  • ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究
    科学研究費補助金, 基盤C
    2015年04月 - 2018年03月
  • 微生物由来 DNA を利用した吸入型炎症性肺疾患治療薬の開発
    科学研究費補助金, 若手B
    2011年04月 - 2012年05月
  • 免疫調節性DNAとナノ・マイクロ粒子キャリアーを用いた吸入型DNA治療薬の開発
    科学研究費補助金, 若手B
    2009年04月 - 2011年03月

産業財産権

  • Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer, 9919058, 2015039574, 15326387, 特許権
    Takashi Sato, Dennis Klinman
  • Method of treating pneumoconiosis with oligodeoxynucleotides, 8222225, 2009044739, 12993809, 特許権
    Takashi Sato, Dennis Klinman
  • Use of CpG oligodeoxynucleotides to induce epithelial cell growth, 8466116, 20090099122, 12205756, 特許権
    Takashi Sato、Dennis Klinman

その他

  • 日本呼吸器学会呼吸器指導医
    2016年
  • 日本内科学会総合内科専門医
    2010年
  • 日本呼吸器学会呼吸器専門医
    2009年
  • 医師免許
    2000年