Nakada, Tsutomu | Shinshu University Researcher Directory

Academic Organization	Academic Assembly　School of Medicine and Health Sciences　Institute of Medicine	TEL	+81-263-37-3414
Education and Research Organization	Research Center for Advanced Science and Technology	FAX	+81-263-37-3085
Position	Associate Professor	Mail Address
Address	Asahi 3-1-1 Matsumoto Nagano	Web site

Profile

Research Field: Pharmacology
Molecular biology
Keywords:心筋 , カルシウムチャネル

Current Subject: 心筋L型カルシウムチャネルの細胞内局在決定機構の解明

Academic Societies: Academic Societies
日本薬理学会
日本生理学会

Academic Background: Degree
博士（理学） , 東京工業大学

Research

Books, Articles, etc.: Articles
Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,323(1):H103-H120 2022(Jul.)
Author:Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Larranaga, Maite; Guo, Ang; Song, Long-Sheng; Yamada, Mitsuhiko;
Keywords:cardiomyocyte; gp130; interleukin-6; neonate; proliferation;

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
CIRCULATION RESEARCH,130(2):234-248 2022
Author:Inazumi, Hideaki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Numaga-Tomita, Takuro; Kashihara, Toshihide; Nakada, Tsutomu; Kurebayashi, Nagomi; Oya, Miku; Nonaka, Miki; Sugihara, Masami; Kinoshita, Hideyuki; Moriuchi, Kenji; Yanagisawa, Hiromu; Nishikimi, Toshio; Motoki, Hirohiko; Yamada, Mitsuhiko; Morimoto, Sachio; Otsu, Kinya; Mortensen, Richard M.; Nakao, Kazuwa; Kimura, Takeshi;
Keywords:calcium; GTP-binding proteins; heart failure; homeostasis; mice;

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Endocrinology.,162(3):bqab001 2021(Mar.)
Author:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.

β-Arrestin-Biased AT 1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
JACC Basic Transl Sci.,5(11):1057-1069 2020(Nov.)
Author:Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.

Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,368(1):50-58 2019
Author:Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko;

Increase in phospholamban content in mouse skeletal muscle after denervation
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY,39(5-6):163-173 2018(Dec.)
Author:Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,470(6):909-921 2018(Jun.)
Author:Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko;

Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(17):4507-4512 2018(Apr.)
Author:Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;

Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol,595(13):4207-4225 2017(Jul.)
Author:Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.

Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch
JOURNAL OF EXPERIMENTAL BIOLOGY,220(16):2916-2931 2017
Author:Chen, Xiu L.; Zhang, Biyan; Chng, You R.; Ong, Jasmine L. Y.; Chew, Shit F.; Wong, Wai P.; Lam, Siew H.; Nakada, Tsutomu; Ip, Yuen K.;

マイクロRNAを標的とした核酸医薬による骨格筋サルコペニア予防・治療法の開発
医科学応用研究財団研究報告,33:296-300 2016(Feb.)
Author:中田勉

β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
EUROPEAN JOURNAL OF PHARMACOLOGY,724:122-131 2014(Feb.)
Author:Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M

横紋筋L型カルシウムチャネルの結合膜局在化機構
日本薬理学雑誌,144:217-221 2014
Author:中田勉，山田充彦

TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
Shinshu Med J,62:33-44 2014
Author:Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Biol Pharm Bull,37(7):1168-1176 2014
Author:Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M

Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
PLoS One ,9(8):e106354 2014
Author:Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M

Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium.
American journal of physiology. Regulatory, integrative and comparative physiology,304(10):R865-76 2013(May)
Author:Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Hypertension (Dallas, Tex. : 1979),61(2):341-351 2013(Feb.)
Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T

The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
BIOCHEMICAL JOURNAL,448(2):221-231 2012(Dec.)
Author:Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko

Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
Eur J Pharmacol,685(1-3):15-23 2012(Jun. 15)
Author:Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada

Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
J Histochem Cytochem,60(5):397-407 2012(Apr. 25)
Author:Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
Am J Physiol Heart Circ Physiol,302(8):H1645-1654 2012(Apr. 15)
Author:Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada

Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
PloS one,7(12):e52667 2012
Author:Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Am. J. Physiol. Heart Circ. Physiol.,300(3):H978–H988 2011(Mar.)
Author:Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Int. J. Cardiol.,146(1):37–43 2011
Author:Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M

Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels.
Circ. J.,75(10):2333–2342 2011
Author:Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kubota I, Mende U, Yamada M.

Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
J. Exp. Biol.,213(Pt 18):3150-3160 2010(Sep.)
Author:Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.

Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
Curr. Eye Res.,35(5):363–369 2010(May)
Author:Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.

From blood typing to a transport metabolon at a crossroad. Focus on "Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae".
American journal of physiology. Cell physiology,298(2):C209-10 2010(Feb.)
Author:Hirose S, Nakada T

Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
J. Biol. Chem.,285(4):2653-2664 2010(Jan.)
Author:Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S

Identification of renal transporters involved in sulfate excretion in marine teleost fish.
American journal of physiology. Cell physiology,297(6):R1647–R1659 2009(Dec.)
Author:Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.

Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
Heart rhythm,6(1):78-84 2009(Jan.)
Author:Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.

Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
Basic Clin. Pharmacol. Toxiocol.,102(6):504-514 2008(Jun.)
Author:Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.

Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,294(4):R1402-R1412 2008(Apr.)
Author:Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.

Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
J. Membr. Biol.,222(3):151-166 2008(Apr.)
Author:Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.

Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,293:1743-1753 2007(Oct.)
Author:Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.

Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
FASEB J.,21(4):1067-1074 2007(Apr.)
Author:NakadaT, Westhoff CM, Kato A, Hirose S.

Molecular and functional characterization of adrenomedullin receptors in pufferfish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,290(2):R467-R478 2006(Feb.)
Author:Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.

Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation.
BMC physiology,5:18 2005(Dec.)
Author:Kato A, Doi H, Nakada T, Sakai H, Hirose S

Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater.
American journal of physiology. Regulatory, integrative and comparative physiology,289(2):R575-R585 2005(Aug.)
Author:Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S

Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Biochemical and biophysical research communications,301(4):1079-1085 2003(Feb.)
Author:Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H

Presentations
生活習慣病に対する治療戦略　循環器疾患幼若心筋細胞におけるAT1受容体/βアレスチン2を介した新しい陽性変力反応の機序の解析
応用薬理 89 1-2 42 2015(Aug.)
Presenter:山田充彦, 柏原俊英, 中田勉

Shinshu University Researcher Directory

Nakada Tsutomu

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Nakada　Tsutomu