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Nakada Tsutomu

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL+81-263-37-3414
Education and Research OrganizationResearch Center for Supports to Advanced Science (RCSAS)FAX+81-263-37-3085
PositionAssociate ProfessorMail Address
AddressAsahi 3-1-1 Matsumoto NaganoWeb site



Research Field
Molecular biology


Books, Articles, etc.
Increase in phospholamban content in mouse skeletal muscle after denervation
Author:Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
Author:Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko;

Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Author:Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;

Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol,595(13):4207-4225 2017(Jul.)
Author:Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.

Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch
Author:Chen, Xiu L.; Zhang, Biyan; Chng, You R.; Ong, Jasmine L. Y.; Chew, Shit F.; Wong, Wai P.; Lam, Siew H.; Nakada, Tsutomu; Ip, Yuen K.;

医科学応用研究財団研究報告,33:296-300 2016(Feb.)

β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
Author:Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M

日本薬理学雑誌,144:217-221 2014

TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
Shinshu Med J,62:33-44 2014
Author:Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Biol Pharm Bull,37(7):1168-1176 2014
Author:Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M

Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
PLoS One ,9(8):e106354 2014
Author:Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M

Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium.
American journal of physiology. Regulatory, integrative and comparative physiology,304(10):R865-76 2013(May)
Author:Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Hypertension (Dallas, Tex. : 1979),61(2):341-351 2013(Feb.)
Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T

The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
BIOCHEMICAL JOURNAL,448(2):221-231 2012(Dec.)
Author:Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko

Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
Eur J Pharmacol,685(1-3):15-23 2012(Jun. 15)
Author:Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada

Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
J Histochem Cytochem,60(5):397-407 2012(Apr. 25)
Author:Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
Am J Physiol Heart Circ Physiol,302(8):H1645-1654 2012(Apr. 15)
Author:Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada

Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
PloS one,7(12):e52667 2012
Author:Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Am. J. Physiol. Heart Circ. Physiol.,300(3):H978–H988 2011(Mar.)
Author:Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Int. J. Cardiol.,146(1):37–43 2011
Author:Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M

Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels.
Circ. J.,75(10):2333–2342 2011
Author:Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kubota I, Mende U, Yamada M.

Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
J. Exp. Biol.,213(Pt 18):3150-3160 2010(Sep.)
Author:Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.

Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
Curr. Eye Res.,35(5):363–369 2010(May)
Author:Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.

From blood typing to a transport metabolon at a crossroad. Focus on "Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae".
American journal of physiology. Cell physiology,298(2):C209-10 2010(Feb.)
Author:Hirose S, Nakada T

Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
J. Biol. Chem.,285(4):2653-2664 2010(Jan.)
Author:Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S

Identification of renal transporters involved in sulfate excretion in marine teleost fish.
American journal of physiology. Cell physiology,297(6):R1647–R1659 2009(Dec.)
Author:Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.

Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
Heart rhythm,6(1):78-84 2009(Jan.)
Author:Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.

Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
Basic Clin. Pharmacol. Toxiocol.,102(6):504-514 2008(Jun.)
Author:Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.

Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,294(4):R1402-R1412 2008(Apr.)
Author:Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.

Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
J. Membr. Biol.,222(3):151-166 2008(Apr.)
Author:Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.

Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,293:1743-1753 2007(Oct.)
Author:Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.

Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
FASEB J.,21(4):1067-1074 2007(Apr.)
Author:NakadaT, Westhoff CM, Kato A, Hirose S.

Molecular and functional characterization of adrenomedullin receptors in pufferfish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,290(2):R467-R478 2006(Feb.)
Author:Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.

Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation.
BMC physiology,5:18 2005(Dec.)
Author:Kato A, Doi H, Nakada T, Sakai H, Hirose S

Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater.
American journal of physiology. Regulatory, integrative and comparative physiology,289(2):R575-R585 2005(Aug.)
Author:Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S

Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Biochemical and biophysical research communications,301(4):1079-1085 2003(Feb.)
Author:Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H

生活習慣病に対する治療戦略 循環器疾患 幼若心筋細胞におけるAT1受容体/βアレスチン2を介した新しい陽性変力反応の機序の解析
応用薬理 , 89(1-2):42 2015(Aug.)
Author:山田充彦, 柏原俊英, 中田勉