中田 勉 (ナカダ ツトム)   

学術研究院(総合人間科学系)

基盤研究支援センター 

准教授 

学位

  • 博士(理学), 東京工業大学

研究キーワード

    心筋, カルシウムチャネル

研究分野

  • 薬理学, 薬理学
  • 分子生物学, 分子生物学

電話番号

    0263-37-3414

メールアドレス

    tnakada★shinshu-u.ac.jp

経歴

  • 2018年
    基盤研究支援センター機器分析支援部門 准教授
  • 2012年
    信州大学医学部医学科分子薬理学教室 講師
  • 2007年
    信州大学医学部医学科分子薬理学教室 助教

学歴

  • 2007年, 東京工業大学
  • 2002年, 東京理科大学

論文

  • Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
    Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Larranaga, Maite; Guo, Ang; Song, Long-Sheng; Yamada, Mitsuhiko;
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(1), H103-H120, 2022年07月WebofScience電子ジャーナル
  • NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
    Inazumi, Hideaki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Numaga-Tomita, Takuro; Kashihara, Toshihide; Nakada, Tsutomu; Kurebayashi, Nagomi; Oya, Miku; Nonaka, Miki; Sugihara, Masami; Kinoshita, Hideyuki; Moriuchi, Kenji; Yanagisawa, Hiromu; Nishikimi, Toshio; Motoki, Hirohiko; Yamada, Mitsuhiko; Morimoto, Sachio; Otsu, Kinya; Mortensen, Richard M.; Nakao, Kazuwa; Kimura, Takeshi;
    Circulation Research, 130(2), 234-248, 2022年WebofScience電子ジャーナル
  • Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
    Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
    Endocrinology., 162(3), bqab001, 2021年03月
  • β-Arrestin-Biased AT 1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
    Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
    JACC Basic Transl Sci., 5(11), 1057-1069, 2020年11月
  • Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
    Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko;
    Journal of Pharmacology and Experimental Therapeutics, 368(1), 50-58, 2019年WebofScience電子ジャーナル
  • Increase in phospholamban content in mouse skeletal muscle after denervation
    Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;
    JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 39(5-6), 163-173, 2018年12月WebofScience電子ジャーナル
  • PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
    Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko;
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 470(6), 909-921, 2018年06月, 査読有りWebofScience電子ジャーナル
  • Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
    Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
    Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, 2018年04月, 査読有りWebofScience電子ジャーナル
  • Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
    Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
    J Physiol, 595(13), 4207-4225, 2017年07月, 査読有り電子ジャーナル
  • Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch
    Chen, Xiu L.; Zhang, Biyan; Chng, You R.; Ong, Jasmine L. Y.; Chew, Shit F.; Wong, Wai P.; Lam, Siew H.; Nakada, Tsutomu; Ip, Yuen K.;
    JOURNAL OF EXPERIMENTAL BIOLOGY, 220(16), 2916-2931, 2017年, 査読有りWebofScience電子ジャーナル
  • マイクロRNAを標的とした核酸医薬による骨格筋サルコペニア予防・治療法の開発
    中田勉
    医科学応用研究財団研究報告, 33, 296-300, 2016年02月
  • β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
    Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M
    European Journal of Pharmacology, 724, 122-131, 2014年02月, 査読有りWebofScienceリポジトリ電子ジャーナル
  • 横紋筋L型カルシウムチャネルの結合膜局在化機構
    中田勉,山田充彦
    日本薬理学雑誌, 144, 217-221, 2014年
  • TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
    Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M
    shinshu med J, 62, 33-44, 2014年, 査読有り
  • Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
    Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M
    Biol Pharm Bull, 37(7), 1168-1176, 2014年, 査読有り
  • Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
    Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M
    PLOS ONE, 9(8), e106354, 2014年, 査読有りWebofScience電子ジャーナル
  • Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium.
    Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S
    American journal of physiology. Regulatory, integrative and comparative physiology, 304(10), R865-76, 2013年05月, 査読有り電子ジャーナル
  • Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
    Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
    Hypertension (Dallas, Tex. : 1979), 61(2), 341-351, 2013年02月, 査読有り電子ジャーナル
  • The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
    Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko
    Biochemical Journal, 448(2), 221-231, 2012年12月, 査読有りWebofScienceリポジトリ電子ジャーナル
  • Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
    Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada
    Eur J Pharmacol, 685(1-3), 15-23, 2012年06月15日, 査読有りWebofScienceリポジトリ電子ジャーナル
  • Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
    Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama
    J Histochem Cytochem, 60(5), 397-407, 2012年04月25日, 査読有りWebofScienceリポジトリ電子ジャーナル
  • Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
    Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada
    Am J Physiol Heart Circ Physiol, 302(8), H1645-1654, 2012年04月15日, 査読有りWebofScience電子ジャーナル
  • Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
    Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
    PLOS ONE, 7(12), e52667, 2012年, 査読有りWebofScience電子ジャーナル
  • Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
    Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M
    Am. J. Physiol. Heart Circ. Physiol., 300(3), H978–H988, 2011年03月, 査読有り電子ジャーナル
  • Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels.
    Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kubota I, Mende U, Yamada M.
    Circ. J., 75(10), 2333–2342, 2011年, 査読有り
  • Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
    Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M
    Int. J. Cardiol., 146(1), 37–43, 2011年, 査読有りWebofScience電子ジャーナル
  • Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
    Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
    J. Exp. Biol., 213(Pt 18), 3150-3160, 2010年09月, 査読有り電子ジャーナル
  • Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
    Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
    Curr. Eye Res., 35(5), 363–369, 2010年05月, 査読有りWebofScienceリポジトリ電子ジャーナル
  • From blood typing to a transport metabolon at a crossroad. Focus on "Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae".
    Hirose S, Nakada T
    American journal of physiology. Cell physiology, 298(2), C209-10, 2010年02月, 査読有り電子ジャーナル
  • Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
    Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S
    J. Biol. Chem., 285(4), 2653-2664, 2010年01月, 査読有り電子ジャーナル
  • Identification of renal transporters involved in sulfate excretion in marine teleost fish.
    Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
    American journal of physiology. Cell physiology, 297(6), R1647–R1659, 2009年12月, 査読有り電子ジャーナル
  • Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
    Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
    Heart Rhythm, 6(1), 78-84, 2009年01月, 査読有り電子ジャーナル
  • Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
    Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
    Basic Clin. Pharmacol. Toxiocol., 102(6), 504-514, 2008年06月, 査読有り電子ジャーナル
  • Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
    Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
    J. Membr. Biol., 222(3), 151-166, 2008年04月, 査読有り電子ジャーナル
  • Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
    Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 294(4), R1402-R1412, 2008年04月, 査読有り電子ジャーナル
  • Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
    Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, 1743-1753, 2007年10月, 査読有り電子ジャーナル
  • Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
    NakadaT, Westhoff CM, Kato A, Hirose S.
    FASEB J., 21(4), 1067-1074, 2007年04月, 査読有り電子ジャーナル
  • Molecular and functional characterization of adrenomedullin receptors in pufferfish.
    Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 290(2), R467-R478, 2006年02月, 査読有り電子ジャーナル
  • Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation.
    Kato A, Doi H, Nakada T, Sakai H, Hirose S
    BMC physiology, 5, 18, 2005年12月, 査読有り電子ジャーナル
  • Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater.
    Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S
    American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R575-R585, 2005年08月, 査読有り電子ジャーナル
  • Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
    Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H
    Biochemical and biophysical research communications, 301(4), 1079-1085, 2003年02月, 査読有り

講演・口頭発表等

  • 生活習慣病に対する治療戦略 循環器疾患 幼若心筋細胞におけるAT1受容体/βアレスチン2を介した新しい陽性変力反応の機序の解析
    山田充彦, 柏原俊英, 中田勉
    応用薬理 89 1-2 42, 2015年08月

所属学協会

  • 日本薬理学会
  • 日本生理学会

共同研究・競争的資金等の研究課題

  • 心筋L型カルシウムチャネルの細胞内局在決定機構の解明