博士（医学）, 東京大学

Neuroscience-general, 分子神経生物学/

2023 - Present
Shinshu University, Research Center for Advanced Science and Technology, Professor

2017 - 2023
Shinshu University, Research Center for Advanced Science and Technology, 准教授

2014 - 2017
Shinshu University, 学術研究院医学系, 准教授

2013 - 2014
Shinshu University, School of Medicine, Department of Molecular and Cellular Physiology, 講師

2007 - 2012
The University of Tokyo, Graduate School of Medicine, 助教

2005 - 2007
The University of Tokyo, Graduate School of Medicine, 助手

2003 - 2004
The University of Tokyo, Graduate School of Medicine, 研究拠点形成特任研究員

Enhancement of memory and emotional functions by long-term ingestion of protease-treated porcine liver extract in mice.
Taiga Kurihara; Masanori Sasanuma; Masahiro Kato; Toshio Inoue; Naoko Okada; Teruki Shirayama; Yusuke Tanikawa; Taiki Kawahara; Kazuhiro Sohya; Hiroki Yasuda; Yoshikazu Matsuda; Takeshi Uemura
Scientific reports, 15(1), 18694-18694, May 2025, Refereed
Last, Corresponding

Differential effects of structurally different lysophosphatidylethanolamine species on proliferation and differentiation in pre-osteoblast MC3T3-E1 cells.
Fumiaki Makiyama; Shiori Kawase; Aoi William Omi; Yusuke Tanikawa; Taishi Kotani; Teruki Shirayama; Naoyuki Nishimura; Taiga Kurihara; Naoto Saito; Jun Takahashi; Takeshi Uemura
Scientific reports, 15(1), 466-466, Jan. 2025, Refereed
Last, Corresponding

Development of phosphate-treated PEEK implants with high osseointegration
Yu Usuda; Takumi Okihara; Shigeaki Moriyama; Takeshi Uemura; Takayuki Kamanaka; Aoi William Omi; Naoto Saito; Jun Takahashi; Kaoru Aoki; Naoyuki Nishimura
Materials Today Communications, 38, 107717-107717, Mar. 2024, Refereed

Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors.
Amy Cheung; Kotaro Konno; Yuka Imamura; Aya Matsui; Manabu Abe; Kenji Sakimura; Toshikuni Sasaoka; Takeshi Uemura; Masahiko Watanabe; Kensuke Futai
eLife, 12, Jan. 2023, Refereed

Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues.
Katsuya Ueda; Chuang Ma; Makoto Izumiya; Chika Kuroda; Haruka Ishida; Takeshi Uemura; Naoto Saito; Kaoru Aoki; Hisao Haniu
Nanomaterials (Basel, Switzerland), 13(2), Jan. 2023

Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches
Tamotsu Tsukahara; Hisao Haniu; Takeshi Uemura; Yoshikazu Matsuda
Biomedicines, 149-162, Nov. 2022, Refereed, Not invited

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes.
Naoto Saito; Hisao Haniu; Kaoru Aoki; Naoyuki Nishimura; Takeshi Uemura
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(24), e2201214, Aug. 2022, Refereed
Last

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
Takeshi Uemura; Emi Suzuki-Kouyama; Shiori Kawase; Taiga Kurihara; Misato Yasumura; Tomoyuki Yoshida; Shuya Fukai; Maya Yamazaki; Peng Fei; Manabu Abe; Masahiko Watanabe; Kenji Sakimura; Masayoshi Mishina; Katsuhiko Tabuchi
Cell Reports, 39(1), 110624-110624, Apr. 2022, Refereed
Lead, Corresponding

IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
Dongwook Kim; Hyeji Jung; Yoshinori Shirai; Hyeonho Kim; Jinhu Kim; Dongseok Lim; Takuma Mori; Hyojeong Lee; Dongseok Park; Hee Young Kim; Qi Guo; Bo Pang; Wen Qiu; Xueshan Cao; Emi Kouyama-Suzuki; Takeshi Uemura; Enas Kasem; Yu Fu; Seungjoon Kim; Akinori Tokunaga; Takahiro Yoshizawa; Tatsuo Suzuki; Hiroyuki Sakagami; Kea Joo Lee; Jaewon Ko; Katsuhiko Tabuchi; Ji Won Um
Biological Psychiatry, 91(9), 821-831, Dec. 2021, Refereed

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Tomoyuki Yoshida; Atsushi Yamagata; Ayako Imai; Juhyon Kim; Hironori Izumi; Shogo Nakashima; Tomoko Shiroshima; Asami Maeda; Shiho Iwasawa-Okamoto; Kenji Azechi; Fumina Osaka; Takashi Saitoh; Katsumi Maenaka; Takashi Shimada; Yuko Fukata; Masaki Fukata; Jumpei Matsumoto; Hisao Nishijo; Keizo Takao; Shinji Tanaka; Shigeo Okabe; Katsuhiko Tabuchi; Takeshi Uemura; Masayoshi Mishina; Hisashi Mori; Shuya Fukai
Nature Communications, 12(1), Dec. 2021, Refereed

Antitumor Effect of Sclerostin against Osteosarcoma
Hirokazu Ideta; Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Munehisa Kito; Kaoru Aoki; Yasuo Yoshimura; Shuichiro Suzuki; Atsushi Tanaka; Akira Takazawa; Hisao Haniu; Takeshi Uemura; Takashi Takizawa; Atsushi Sobajima; Takayuki Kamanaka; Jun Takahashi; Hiroyuki Kato; Naoto Saito
Cancers, 13(23), 6015-6015, Nov. 2021, Refereed

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Makoto Izumiya; Miyu Haniu; Katsuya Ueda; Haruka Ishida; Chuang Ma; Hirokazu Ideta; Atsushi Sobajima; Koki Ueshiba; Takeshi Uemura; Naoto Saito; Hisao Haniu
International Journal of Molecular Sciences, 22(14), 7752-7752, Jul. 2021, Refereed

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
Kazutoshi Hisano; Hironori Yoshida; Shiori Kawase; Tetsuhiko Mimura; Hisao Haniu; Tamotsu Tsukahara; Taiga Kurihara; Yoshikazu Matsuda; Naoto Saito; Takeshi Uemura
The Journal of Biochemistry, 170, 327-336, Apr. 2021, Refereed
Last, Corresponding

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
Kazutoshi Hisano; Shiori Kawase; Tetsuhiko Mimura; Hironori Yoshida; Hiroki Yamada; Hisao Haniu; Tamotsu Tsukahara; Taiga Kurihara; Yoshikazu Matsuda; Naoto Saito; Takeshi Uemura
Biochemical and Biophysical Research Communications, 534, 179-185, Jan. 2021, Refereed
Last, Corresponding

Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Motokazu Uchigashima; Kohtarou Konno; Emily Demchak; Amy Cheung; Takuya Watanabe; David G Keener; Manabu Abe; Timmy Le; Kenji Sakimura; Toshikuni Sasaoka; Takeshi Uemura; Yuka Imamura Kawasawa; Masahiko Watanabe; Kensuke Futai
eLife, 9, Dec. 2020, Refereed

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases.
Tamotsu Tsukahara; Hisao Haniu; Takeshi Uemura; Yoshikazu Matsuda
Biomedicines, 8(11), Oct. 2020, Refereed

Carbon fibers for treatment of cancer metastasis in bone.
Takayuki Kamanaka; Hisao Haniu; Manabu Tanaka; Takashi Takizawa; Kaoru Aoki; Masanori Okamoto; Atsushi Sobajima; Kazushige Yoshida; Hirokazu Ideta; Tetsuhiko Mimura; Haruka Ishida; Katsuya Ueda; Takeshi Uemura; Jin Hee Kim; Yoong Ahm Kim; Hiroyuki Kato; Naoto Saito
RSC advances, 10(55), 33071-33079, Sep. 2020, Refereed

Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study.
Yoshikazu Matsuda; Hisao Haniu; Tamotsu Tsukahara; Takeshi Uemura; Toshio Inoue; Ken-Ichi Sako; Jun Kojima; Tatsuro Mori; Kazusaburou Sato
Experimental gerontology, 141, 111064-111064, Aug. 2020, Refereed

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials.
Mahoko Sano; Makoto Izumiya; Hisao Haniu; Katsuya Ueda; Kosuke Konishi; Haruka Ishida; Chika Kuroda; Takeshi Uemura; Kaoru Aoki; Yoshikazu Matsuda; Naoto Saito
Nanomaterials (Basel, Switzerland), 10(7), Jul. 2020, Refereed

DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons.
Taiga Kurihara; Emi Kouyama-Suzuki; Michiru Satoga; Xue Li; Moataz Badawi; Thiha; Deeba Noreen Baig; Toru Yanagawa; Takeshi Uemura; Takuma Mori; Katsuhiko Tabuchi
Biochemical and biophysical research communications, 524(3), 621-628, Apr. 2020, Refereed

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro.
Tamotsu Tsukahara; Hisao Haniu; Takeshi Uemura; Yoshikazu Matsuda
Scientific reports, 10(1), 3748-3748, Feb. 2020, Refereed, Not invited

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Chika Kuroda; Haruka Ishida; Katsuya Ueda; Hirokazu Ideta; Takayuki Kamanaka; Atsushi Sobajima; Takashi Takizawa; Manabu Tanaka; Kaoru Aoki; Takeshi Uemura; Hiroyuki Kato; Hisao Haniu; Naoto Saito
BMC cancer, 20(1), 25-25, Jan. 2020

Correction: Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (Molecular Psychiatry, (2019), 24, 7, (1079-1092), 10.1038/s41380-018-0338-4)
Takuma Mori; Enas A. Kasem; Emi Suzuki-Kouyama; Xueshan Cao; Xue Li; Taiga Kurihara; Takeshi Uemura; Toru Yanagawa; Katsuhiko Tabuchi
Molecular Psychiatry, 24(7), 1093, Jul. 2019

Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B.
Takuma Mori; Enas A Kasem; Emi Suzuki-Kouyama; Xueshan Cao; Xue Li; Taiga Kurihara; Takeshi Uemura; Toru Yanagawa; Katsuhiko Tabuchi
Molecular psychiatry, 24(7), 1079-1092, Jul. 2019, Refereed, Not invited

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Chika Kuroda; Haruka Ishida; Katsuya Ueda; Satomi Okano; Hirokazu Ideta; Takayuki Kamanaka; Atsushi Sobajima; Takashi Takizawa; Munehisa Kito; Kaoru Aoki; Takeshi Uemura; Hisao Haniu; Hiroyuki Kato; Naoto Saito
OncoTargets and therapy, 12, 2513-2518, 2019

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Sakurako Goto-Ito; Atsushi Yamagata; Yusuke Sato; Takeshi Uemura; Tomoko Shiroshima; Asami Maeda; Ayako Imai; Hisashi Mori; Tomoyuki Yoshida; Shuya Fukai
Nature Communications, 9(1), 269, Dec. 2018, Refereed, Not invited

Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Atsushi Yamagata; Sakurako Goto-Ito; Yusuke Sato; Tomoko Shiroshima; Asami Maeda; Masahiko Watanabe; Takashi Saitoh; Katsumi Maenaka; Tohru Terada; Tomoyuki Yoshida; Takeshi Uemura; Shuya Fukai
Nature communications, 9(1), 3964-3964, Sep. 2018, Refereed, Not invited
Corresponding

MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Kawabata Galbraith K; Fujishima K; Mizuno H; Lee SJ; Uemura T; Sakimura K; Mishina M; Watanabe N; Kengaku M
Cell reports, 24(1), 95-106.e9, Jul. 2018, Refereed, Not invited

In situ screening for postsynaptic cell adhesion molecules during synapse formation
Takeshi Uemura; Tomoko Shiroshima; Asami Maeda; Misato Yasumura; Takashi Shimada; Yuko Fukata; Masaki Fukata; Tomoyuki Yoshida
JOURNAL OF BIOCHEMISTRY, 162(4), 295-302, Oct. 2017, Refereed, Not invited

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Takeshi Uemura; Takuma Mori; Taiga Kurihara; Shiori Kawase; Rie Koike; Michiru Satoga; Xueshan Cao; Xue Li; Toru Yanagawa; Takayuki Sakurai; Takayuki Shindo; Katsuhiko Tabuchi
Scientific Reports, 6(1), 35861, Oct. 2016, Refereed, Not invited

Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
Atsushi Yamagata; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Tomoyuki Yoshida; Shuya Fukai
SCIENTIFIC REPORTS, 5, 9686, May 2015, Refereed, Not invited

Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
Atsushi Yamagata; Tomoyuki Yoshida; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Shiho Iwasawa-Okamoto; Hisashi Mori; Masayoshi Mishina; Shuya Fukai
NATURE COMMUNICATIONS, 6, 6926, Apr. 2015, Refereed, Not invited

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
Misato Yasumura; Tomoyuki Yoshida; Maya Yamazaki; Manabu Abe; Rie Natsume; Kouta Kanno; Takeshi Uemura; Keizo Takao; Kenji Sakimura; Takefumi Kikusui; Tsuyoshi Miyakawa; Masayoshi Mishina
SCIENTIFIC REPORTS, 4, 6613, Oct. 2014, Refereed, Not invited

The atmospheric scanning electron microscope (ASEM) observes axonal segmentation and synaptic induction in solution
Chikara Sato; Takaaki Kinoshita; Takeshi Uemura; Kazumi Hiarno; Masaaki Kawata; Hidetoshi Nishiyama; Mari Sato; Tatsuhiko Ebihara; Mitsuo Suga; Shoko Nishihara
Microscopy and Microanalysis, 20(3), 972-973, Aug. 2014, Refereed, Not invited

Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
Kazumi Hirano; Takaaki Kinoshita; Takeshi Uemura; Hozumi Motohashi; Yohei Watanabe; Tatsuhiko Ebihara; Hidetoshi Nishiyama; Mari Sato; Mitsuo Suga; Yuusuke Maruyama; Noriko M. Tsuji; Masayuki Yamamoto; Shoko Nishihara; Chikara Sato
ULTRAMICROSCOPY, 143, 52-66, Aug. 2014, Refereed, Not invited

Striatal dopamine D1 receptor is essential for contextual fear conditioning
Masaru Ikegami; Takeshi Uemura; Ayumi Kishioka; Kenji Sakimura; Masayoshi Mishina
SCIENTIFIC REPORTS, 4(4), 3976, Feb. 2014, Refereed, Not invited

Synapse formation in the brain
Masayoshi Mishina; Misato Yasumura; Takeshi Uemura
Cortical Development: Neural Diversity and Neocortical Organization, 229-248, Jan. 2013, Refereed, Not invited

Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Ayumi Kishioka; Takeshi Uemura; Fumiaki Fukushima; Masayoshi Mishina
Molecular Brain, 6(1), 2013, Refereed, Not invited

Molecular mechanism of parallel fiber-Purkinje cell synapse formation
Masayoshi Mishina; Takeshi Uemura; Misato Yasumura; Tomoyuki Yoshida
FRONTIERS IN NEURAL CIRCUITS, 6, Nov. 2012, Refereed, Not invited

Glutamate receptor delta 1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes
Misato Yasumura; Tomoyuki Yoshida; Sung-Jin Lee; Takeshi Uemura; Jae-Yeol Joo; Masayoshi Mishina
JOURNAL OF NEUROCHEMISTRY, 121(5), 705-716, Jun. 2012, Refereed, Not invited

GluR delta 2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
Sung-Jin Lee; Takeshi Uemura; Tomoyuki Yoshida; Masayoshi Mishina
JOURNAL OF NEUROSCIENCE, 32(13), 4688-4701, Mar. 2012, Refereed, Not invited

Interleukin-1 Receptor Accessory Protein Organizes Neuronal Synaptogenesis as a Cell Adhesion Molecule
Tomoyuki Yoshida; Tomoko Shiroshima; Sung-Jin Lee; Misato Yasumura; Takeshi Uemura; Xigui Chen; Yoichiro Iwakura; Masayoshi Mishina
JOURNAL OF NEUROSCIENCE, 32(8), 2588-2600, Feb. 2012, Refereed, Not invited

IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase delta
Tomoyuki Yoshida; Misato Yasumura; Takeshi Uemura; Sung-Jin Lee; Moonjin Ra; Ryo Taguchi; Yoichiro Iwakura; Masayoshi Mishina
JOURNAL OF NEUROSCIENCE, 31(38), 13485-13499, Sep. 2011, Refereed, Not invited

Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons
Jae-Yeol Joo; Sung-Jin Lee; Takeshi Uemura; Tomoyuki Yoshida; Misato Yasumura; Masahiko Watanabe; Masayoshi Mishina
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 406(4), 627-632, Mar. 2011, Refereed, Not invited

Trans-Synaptic Interaction of GluR delta 2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum
Takeshi Uemura; Sung-Jin Lee; Misato Yasumura; Tomonori Takeuchi; Tomoyuki Yoshida; Moonjin Ra; Ryo Taguchi; Kenji Sakimura; Masayoshi Mishina
CELL, 141(6), 1068-1079, Jun. 2010, Refereed, Not invited

The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Takeshi Uemura; Masayoshi Mishina
Biochemical and Biophysical Research Communications, 377(4), 1315-1319, Dec. 2008, Refereed, Not invited

Role of the internal Shank-binding segment of glutamate receptor delta 2 in synaptic localization and cerebellar functions
Misato Yasumura; Takeshi Uemura; Miwako Yamasaki; Kenji Sakimura; Masahiko Watanabe; Masayoshi Mishina
NEUROSCIENCE LETTERS, 433(2), 146-151, Mar. 2008, Refereed, Not invited

P3-c2O Role of the internal Shank-binding segment of GluR delta 2 in cerebellar functions
Yasumura Misato; Uemura Takeshi; Yamasaki Miwako; Sakimura Kenji; Watanabe Masahiko; Mishina Masayoshi
NEUROSCIENCE RESEARCH, 61, S221, 2008, Refereed, Not invited

The C-terminal domain of GluR delta 2 is essential for cerebellar LTD and regulation of climbing fiber territory at parallel fiber synapses in cerebellar Purkinje cells
Uemura Takeshi; Kakizavva Sho; Yamasaki Miwako; Sakimura Kenji; Watanabe Masahiko; Iino Masamitsu; Mishina Masayoshi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 80P, 2008, Refereed, Not invited

Hole of the C-terminal PDZ binding domain of glutamate receptor delta 2 in synaptic plasticity and climbing fiber wiring
Uemura Takeshi; Kakizawa Sho; Yamasaki Miwako; Sakimura Kenji; Watanabe Masahiko; Lino Masamitsu; Mishina Masayoshi
NEUROSCIENCE RESEARCH, 61, S219, 2008, Refereed, Not invited

Roles of the internal PDZ-binding domain of GluR delta 2 in synaptic localization and cerebellar functions
Yasumura Misato; Uemura Takeshi; Yamasaki Miwako; Sakimura Kenji; Watanabe Masahiko; Mishina Masayoshi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 133P, 2008, Refereed, Not invited

Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
Takeshi Uemura; Sho Kakizawa; Miwako Yamasaki; Kenji Sakimura; Masahiko Watanabe; Masamitsu Iino; Masayoshi Mishina
Journal of Neuroscience, 27(44), 12096-12108, Oct. 2007, Refereed, Not invited

Direct interaction of GluR delta 2 with Shank scaffold proteins in cerebellar Purkinje cells
T Uemura; H Mori; M Mishina
MOLECULAR AND CELLULAR NEUROSCIENCE, 26(2), 330-341, Jun. 2004, Refereed, Not invited

Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope
R Mizuta; K Iwai; M Shigeno; M Mizuta; T Uemura; T Ushiki; D Kitamura
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(7), 4431-4434, Feb. 2003, Refereed, Not invited

Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
T Uemura; H Mori; M Mishina
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296(2), 492-496, Aug. 2002, Refereed, Not invited

Editorial: Regulators of synapse formation: understanding the molecular mechanisms and its dysregulation in neurodevelopmental disorders
Takeshi Uemura
Frontiers in Molecular Neuroscience, 17, 1521380, Dec. 2024, Refereed
Lead, Corresponding

シナプス形成を誘導する膜受容体の機能と構造
深井周也; 植村 健; 吉田知之
実験医学 増刊, 32, 92 - 97, 2014, Not invited

大気圧走査電子顕微鏡を用いたシナプス構造と分子局在の解析
植村健
顕微鏡, 49, 7 - 9, 2014, Refereed, Invited

Molecular Mechanism of Synapse Formation by Synaptic Organizer
UEMURA Takeshi
Seibutsu Butsuri, 53(2), 090 - 093, 2013, Refereed, Invited

GluR delta 2 induces tetramerization of Neurexins to Trigger Synapse Formation
Sung-Jin Lee; Takeshi Uemura; Tomoyuki Yoshida; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 66P - 66P, 2012, Not invited

IL1RAPL1 associated with mental retardation and autism induces excitatory synapse formation through trans-synaptic interaction with PTP delta
Tomoyuki Yoshida; Misato Yasumura; Takeshi Uemura; Sung-Jin Lee; Moonjin Ra; Ryo Taguchi; Yoichiro Iwakura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 232P - 232P, 2012, Not invited

Synapse formation and glutamate receptor δ2 subunit
植村 健; 三品 昌美
Cell technology, 30(2), 186 - 191, Feb. 2011, Invited

Glutamate receptor delta 2 interacts with alpha- and beta-neurexins through Cbln1 for cerebellar synapse formation
Takeshi Uemura; Sung-Jin Lee; Misato Yasumura; Tomoyuki Yoshida; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 71, E108 - E108, 2011, Not invited

Characterization of the interaction between glutamate receptor delta 1 and Cbln family
Misato Yasumura; Tomoyuki Yoshida; Sung-Jin Lee; Jae-Yeol Joo; Takeshi Uemura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 239P - 239P, 2011, Not invited

Glutamate receptor delta 1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through Cbln subtypes
Misato Yasumura; Tomoyuki Yoshida; Sung-Jin Lee; Jae-Yeol Joo; Takeshi Uemura; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 71, E110 - E110, 2011, Not invited

Stoichiometry of GluR delta 2-Cbln1-Neurexin1 beta triad
Sung-Jin Lee; Takeshi Uemura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 70P - 70P, 2011, Not invited

Interaction of Cbln subtypes and neurexin variants for presynaptic differentiation in cortical neurons
Jae-Yeol Joo; Sung-Jin Lee; Takeshi Uemura; Tomoyuki Yoshida; Misato Yasumura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 131P - 131P, 2011, Not invited

Cerebellin precursor protein (Cbln) subtypes in the forebrain bind to specific neurexin variants and induce presynaptic differentiation
Jae-Yeol Joo; Sung-Jin Lee; Takeshi Uemura; Tomoyuki Yoshida; Misato Yasumura; Masahiko Watanabe; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 71, E216 - E216, 2011, Not invited

Roles of striatal D1 and D2 receptors in fear memory formation
Masaru Ikegami; Takeshi Uemura; Fumihiro Watanabe; Kenji Sakimura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 137P - 137P, 2011, Not invited

GluR delta 2-Cbln1-NRXN tripartite complex regulates synapse formation in the cerebellum
Takeshi Uemura; Sung-Jin Lee; Misato Yasumura; Tomonori Takeuchi; Tomoyuki Yoshida; Moonjin Ra; Ryo Taguchi; Kenji Sakimura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 116P - 116P, 2011, Not invited

High-affinity and selective binding of Cbln1 to glutamate receptor delta 2
Sung-Jin Lee; Takeshi Uemura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 184P - 184P, 2010, Not invited

Biochemical study of novel synaptic triad, GluR delta 2-Cbln1-Neurexin
Sungjin Lee; Takeshi Uemura; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 68, E60 - E60, 2010, Not invited

Identification of Cbln1 as a novel ligand for glutamate receptor delta 2
Takeshi Uemura; Sung-Jin Lee; Misato Yasumura; Tomoyuki Yoshida; Moonjin Ra; Ryo Taguchi; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 184P - 184P, 2010, Not invited

Control of synaptic connection by inducible and granule cell-specific knockout of Cbln1 in the adult cerebellum
Misato Yasumura; Tomonori Takeuchi; Takeshi Uemura; Kenji Sakimura; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 68, E85 - E85, 2010, Not invited

A study of the role of the layer 4 of the cerebral cortex in fear memory
Nozomi Endo; Takeshi Uemura; Kenji Sakimura; Shigeyoshi Itohara; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 222P - 222P, 2010, Not invited

Glutamate receptor delta 2 regulates cerebellar synapse formation by interacting with presynaptic Neurexin through Cbln1
Takeshi Uemura; Sung-Jin Lee; Misato Yasumura; Tomoyuki Yoshida; Moonjin Ra; Ryo Taguchi; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 68, E86 - E86, 2010, Not invited

Control of synaptic connection by Cbln1 in the adult cerebellum
Misato Yasumura; Tomonori Takeuchi; Takeshi Uemura; Kenji Sakimura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 183P - 183P, 2010, Not invited

The role of the N-terminal domain of glutamate receptor delta 2 in synapse formation
Takeshi Uemura; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 65, S143 - S143, 2009, Not invited

Induction of presynaptic differentiation by the extracellular N-terminal domain of glutamate receptor delta 2
Takeshi Uemura; Masayoshi Mishina
JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 130P - 130P, 2009, Not invited

Effects of inducible ablation of cerebellar granule or Purkinje cells on motor control
Eiko Kato; Takeshi Uemura; Xigui Chen; Fumihiro Watanabe; Misato Yasumura; Shigeyoshi Itohara; Kenji Sakimura; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 65, S233 - S233, 2009, Not invited

Establishment of a mouse line for inducible ablation of neurons in the layer 4 of the cerebral cortex
Nozomi Endo; Takeshi Uemura; Kenji Sakimura; Shigeyoshi Itohara; Masayoshi Mishina
NEUROSCIENCE RESEARCH, 65, S233 - S233, 2009, Not invited

C57BL/6系統由来のES細胞を用いたグルタミン酸受容体δ2の細胞質内領域C末端ドメイン欠損マウスの樹立
植村健; 柿澤昌; 山崎美和子; 崎村建司; 渡辺雅彦; 飯野正光; 三品昌美
日本薬理学雑誌, 131(1), 2008

Synapse formation in the brain
Masayoshi Mishina; Tomoyuki Yoshida; Misato Yasumura; Takeshi Uemura, Joint work, Cortical Development. Neural Diversity and Neocortical Organization In : Kageyama R and Yamamori T (eds), Chapter 11, pp229-247
Springer Japan, 2013

Society for Neuroscience

日本薬理学会

日本神経科学学会

シナプス形成を誘導する細胞接着分子複合体の調節因子の多様性と脳機能制御
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
信州大学
Apr. 2025 - Mar. 2028

シナプス形成因子によるシナプス個性決定の分子基盤
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
信州大学
01 Apr. 2022 - 31 Mar. 2025

Elucidation of unique biological reactions to carbon nanoparticles and world's first clinical application and safety assessment of an innovative biomaterials
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Shinshu University
Apr. 2022 - Mar. 2027

脊髄損傷性運動麻痺の機能回復におけるリゾリン脂質の役割とそのメカニズム
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
Apr. 2020 - Mar. 2023

Molecular basis of brain neural circuitry formation and function
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2019 - 31 Mar. 2022

Development of a technique to study signaling mechanism of synaptic adhesion molecules relevant to autism.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Shinshu University
Apr. 2016 - Mar. 2019

シナプス形成・成熟過程における分子動態・微細構造の解析技術の開発
日本学術振興会 挑戦的萌芽研究, 日本学術振興会
2014 - 2015

Study on molecular mechanism of cerebellar circuit formation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2013 - 31 Mar. 2017

Molecular mechanisms of presynaptic differentiation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
University of Toyama
Apr. 2013 - Mar. 2017

GluRδ2-Cbln1-NRXN複合体によるシナプス形成機構の構造基盤の解明
文部科学省：科学研究費補助金（新学術領域研究）
2013 - 2014

Investigation of mental disorder-related molecules through brain synapse formation mechanisms
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Ritsumeikan University
Apr. 2012 - Mar. 2015

シナプス形成におけるGluRδ2ーCbln1ーNRXN三者複合体の構造学的解析
科学研究費補助金（新学術領域研究）, 文部科学省
2011 - 2012

Neocortical layer structure and function
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Apr. 2010 - Mar. 2015

Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
The University of Tokyo
2010 - 2011

Study on the functional roles of the N-terminal domain of GluRδ2
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
The University of Tokyo
2008 - 2009

グルタミン酸受容体(GluR)δ2のシグナル伝達機構の解明
科学研究費助成事業 若手研究(B), 日本学術振興会, 若手研究(B)
東京大学
2006 - 2007

Molecular Analysis of Brain System Controls under the Pure Genetic Background
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Priority Areas
The University of Tokyo
2005 - 2009

Elucidation of molecular mechanism of brain circuit formation and function, and of pathophysiology of neurodevelopmental disorders caused by abnormalities in brain circuit formation