UEMURA, Takeshi | Shinshu University Researcher Directory

Academic Organization	Academic Assembly　School of Humanities and Social Sciences　Institute of Humanities	TEL	+81-263-37-3108
Education and Research Organization	Research Center for Advanced Science and Technology	FAX
Position	Professor	Mail Address
Address		Web site	https://www.shinshu-u.ac.jp/institution/kiban/generesmt/index.html

Profile

Research Field: Molecular Neuroscience / General neuroscience
Keywords:CNS , synapse , neural circuit formation , neurodevelopmental disorders

Current Subject: Elucidation of molecular mechanism of brain circuit formation and function, and of pathophysiology of neurodevelopmental disorders caused by abnormalities in brain circuit formation
Keywords:Brain, Synapse formation, neural circuit formation, neurodevelopmental disorders

Academic Societies: Academic Societies
日本神経科学学会

Research

Books, Articles, etc.: Books
シナプス形成を誘導する膜受容体の機能と構造, 実験医学増刊 32 10, 92－97
2014
Author:深井周也, 植村健, 吉田知之

シナプスオーガナイザーによるシナプス形成の制御機構, 生物物理 53 , 90－93
2013
Author:植村健

シナプス形成とグルタミン酸受容体δ２サブユニット, 細胞工学 30 2, 186-191
2011
Author:植村健, 三品昌美

Articles
Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
ELIFE 2023(Jan.)
Author:Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N

Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
NANOMATERIALS 2023(Jan.)
Author:Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H

IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
BIOLOGICAL PSYCHIATRY,91(9):821-831 2022
Author:Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
ADVANCED SCIENCE,:2201214 2022
Author:Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
Keywords:biomaterials; clinical application; nanocarbons; nanomaterials; biosafety;

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
CELL REPORTS,39(1):110624 2022
Author:Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(14) 2021(Jul.)
Author:Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
Keywords:biomaterials; vitamin C; osteoblast; calcification; cell culture; collagen; alkaline phosphatase;

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
NATURE COMMUNICATIONS,12(1):1848 2021
Author:Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,534:179-185 2021
Author:Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
The Journal of Biochemistry,Apr 5;mvab046. 2021
Author:Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;

Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
EXPERIMENTAL GERONTOLOGY,141 2020(Nov.)
Author:Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
BIOMEDICINES,8(11) 2020(Nov.)
Author:Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
NANOMATERIALS,10(7) 2020(Jul.)
Author:Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
Scientific Reports,10(1) 2020(Feb. 28)
Author:Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu

Carbon fibers for treatment of cancer metastasis in bone
RSC ADVANCES,10(55):33071-33079 2020
Author:Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;

Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
ELIFE,9 2020
Author:Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;

DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,524(3):621-628 2020
Author:Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
BMC CANCER,20(1) 2020
Author:Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;

Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
MOLECULAR PSYCHIATRY,24(7):1093-1093 2019(Jul.)
Author:Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
ONCOTARGETS AND THERAPY,12:2513-2518 2019
Author:Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;

Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
NATURE COMMUNICATIONS,9 2018
Author:Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;

MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
Cell Rep,24:95-106 2018
Author:Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Nature Communications,9:269 2018
Author:Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai

In situ screening for postsynaptic cell adhesion molecules during synapse formation
Journal of Biochemistry,162:295-302 2017
Author:Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
SCIENTIFIC REPORTS,6 2016
Author:Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;

Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
NATURE COMMUNICATIONS,6 2015(Apr.)
Author:Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;

Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
SCIENTIFIC REPORTS,5 2015
Author:Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;

Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
ULTRAMICROSCOPY,143:52-66 2014(Aug.)
Author:Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;

Striatal dopamine D1 receptor is essential for contextual fear conditioning
SCIENTIFIC REPORTS,4 2014
Author:Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
SCIENTIFIC REPORTS,4 2014
Author:Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;

Striatal dopamine D1 receptor is essential for contextual fear conditioning
Scientific Reports,4:3976 2014
Author:Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M

Synapse formation in the brain
Cortical Development,282:229－248 2013
Author:Mishina M, Yoshida T, Yasumura M, Uemura T

Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Mol. Brain,6:17 2013
Author:Kishioka A, Uemura T, Fukushima F, Mishina M

Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
J Neurochem,121(5):705-716 2012
Author:Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M

Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
J Neurosci,32(8):2588-2600 2012
Author:Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M

GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
J Neurosci,32(13):4688-4701 2012
Author:Lee SJ, Uemura T, Yoshida T, Mishina M

Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Frontiers in Neural Circuits,6(90):doi: 10.3389/fncir.2012.00090 2012
Author:Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida

Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Biochem Biophys Res Commun,406(4):627-632 2011
Author:Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M

IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
J Neurosci,31(88):13485-13499 2011
Author:Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M

Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Cell,141(6):1068-1079 2010
Author:Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M

Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
Neurosci Lett,433(2):146-151 2008
Author:Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina

The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Biochem Biophys Res Commun,377(4):1315-1319 2008
Author:Uemura T, Mishina M

Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
J Neurosci,27(44):12096-12108 2007
Author:Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M

Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
Mol Cell Neurosci,26(2):330-341 2004
Author:Uemura T, Mori H, Mishina M

Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
J Biol Chem,278(7):4431-4434 2003
Author:Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D

Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
Biochem Biophys Res Commun,296(2):492-496 2002
Author:Uemura T, Mori H, Mishina M

Shinshu University Researcher Directory

UEMURA Takeshi

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UEMURA　Takeshi