Doctor of Philosophy in Medical Science, Shinshu University

Tumor diagnostics and therapeutics, Cancer immunotherapy

Embryonic medicine and pediatrics, Oncology

Embryonic medicine and pediatrics, pediatrics

Embryonic medicine and pediatrics, hematology

2022
信州大学医学部附属病院　小児科　講師

2020 - 2022
信州大学医学部附属病院　小児科　助教

2019 - 2020
伊那中央病院　小児科　医長

2016 - 2016
信州大学医学部附属病院　小児科　助教

2014 - 2016
信州大学医学部附属病院　輸血部　助教（診療）

2011 - 2014
信州大学医学部附属病院　小児科　医員

2009 - 2011
長野県立こども病院　総合診療部　医員

2007 - 2009
伊那中央病院　小児科　医員

2006 - 2007
信州大学医学部附属病院　小児科　医員

2005 - 2006
信州大学医学部附属業院　研修医

2004 - 2005
国立病院機能長野病院　研修医

2016 - 2019, University of North Carolina at Chapel Hill

2011 - 2014, Shinshu University

1998 - 2004, 旭川医科大学, 医学部, 医学科

評議員, 日本小児血液がん学会

Ligand-Based CAR-T Cells Targeting EGFR Exhibit Favorable Antitumor Effects Against Gynecologic Malignancies
Cancer Science, 116(8), 2243-2255, Aug. 2025, Refereed
Corresponding

Dynamics of EBV-DNA load across sample types in pediatric EBV-HLH
International Journal of Hematology, 122(2), 310-312, Aug. 2025, Refereed

Efficacy of Noninvasive Neurally Adjusted Ventilatory Assist (NIV-NAVA) for Neonates With Transient Tachypnea of the Newborn: A Retrospective Analysis
Pediatric Pulmonology, 60(8), e71246, Aug. 2025, Refereed

Development of a Serious Game to Simulate Neonatal Intensive Care Unit Experiences: Collaborative Quasi-Experimental Study
JMIR Formative Research, 18(9), e73009, Jul. 2025, Refereed

Long-Term Outcomes of Reduced-Toxicity Conditioning Using 8-Gray Total Body Irradiation, Fludarabine, and Cyclophosphamide in Children, Adolescents, and Young Adults With Hematological Malignancies
Hematological Oncology, 43(1), e70026, Jan. 2025, Refereed
Corresponding

Ruxolitinib for preventing relapse of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
Pediatrics International, 67(1), e70032, Jan. 2025, Refereed

Epstein-Barr virus-associated lymphoproliferative disease in a patient with Shimke immuno-osseous dysplasia
Pediatrics International, 67(1), e70159, Jan. 2025, Refereed

Successful ibrutinib treatment for pulmonary involvement in a post-transplant patient with inherited bone marrow failure syndrome and very short telomeres
Pediatric Blood & Cancer, 71(12), e31314, Dec. 2024, Refereed

Paediatric acute lymphoblastic leukaemia-associated haemophagocytic lymphohistiocytosis develops during prednisolone prephase
British Journal of Haematology, 205(5), 2031-2035, Nov. 2024, Refereed

Successful haploidentical bone marrow transplantation in Griscelli syndrome type 2 with non-busulfan-based regimen and post-transplantation cyclophosphamide: a case report and review of the literature
Pediatric Hematology and Oncology, 41(4), 296-300, Jun. 2024, Refereed

Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers
Molecular Therapy Oncolytics, 16(31), 100728, Sep. 2023, Refereed
Corresponding

Factors Affecting Day-to-Day Variations in Tacrolimus Concentration among Children and Young Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Yuta Maruyama, Yuya Maejima, Koichi Hirabayashi, Hirokazu Morokawa, Eri Okura, Shoji Saito, Yozo Nakazawa
Transplantation and Cellular Therapy, 29(4), 270e1-270e8, 19 Jan. 2023, Refereed, Not invited
Corresponding

Follow-up System for Childhood Cancer Survivors Via Germline Clinical Sequencing
Watanabe Tatsuo, Hirabayashi Koichi, Morita Daisuke, Yamaguchi Tomomi, Okura Eri, Morokawa Hirokazu, Saito Shoji, Tanaka Miyuki, Nakazawa Yozo, Kosho Tomoki
Shinshu Medical Journal, 70(3), 157-167, Jun. 2022, Refereed
Corresponding

Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration
Hongxia Li, Emily B Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S Parker, Chad V Pecot, Gianpietro Dotti, Hongwei Du
NATURE COMMUNICATIONS, 13, 2154, 20 Apr. 2022

Skin and soft tissue infections in adolescent chronic myeloid leukemia under dasatinib treatment
Eriko Uchida, Shoji Saito, Daisuke Morita, Eri Okura, Koichi Hirabayashi, Miyuki Tanaka, Hideyuki Nakazawa, Akane Minagawa, Yozo Nakazawa
Pediatric blood & cancer, 69(8), e29714, 20 Apr. 2022, Refereed, Not invited

Intraoperative Placement of an Absorbable Spacer Prior to Radiation Therapy for a Malignant Peripheral Nerve Sheath Tumor
Yuki Endo, Taichi Fukuzawa, Masahiro Irie, Hideyuki Sasaki, Hironori Kudo, Ryo Ando, Ryuji Okubo, Saori Katayama, Masatoshi Hashimoto, Kosuke Sato, Masahito Tachibana, Hidekazu Aoki, Masayuki Araya, Koichi Hirabayashi, Shoji Saito, Hidekazu Masaki, Yozo Nakazawa, Yoji Sasahara, Motoshi Wada
Case Reports in Oncology, 15(2), 541-546, 20 Mar. 2022, Refereed, Not invited

Comment on: Assessment of kidney function using inulin-based and estimated glomerular filtration rates before and after allogeneic hematopoietic stem cell transplantation in pediatric patients
Daisuke Matsuoka, Koichi Hirabayashi, Tsubasa Murase, Shoji Saito, Yozo Nakazawa
Pediatric blood & cancer, 69(9), e29634, 02 Mar. 2022, Refereed, Not invited
Corresponding

Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors
Koichi Hirabayashi, Hongwei Du, Yang Xu, Peishun Shou, Xin Zhou, Giovanni Fucá, Elisa Landoni, Chuang Sun, Yuhui Chen, Barbara Savoldo, Gianpietro Dotti
Nature Cancer, 2(9), 904-918, Sep. 2021, Refereed, Not invited
Lead

Impact of acute kidney injury on overall survival in children and young adults undergoing allogeneic hematopoietic stem cell transplantation
Matsuoka, Daisuke; Hirabayashi, Koichi; Murase, Tsubasa; Saito, Shoji; Nakazawa, Yozo;
Pediatric blood & cancer, 68(9), Sep. 2021
Corresponding

Assessment of kidney function using inulin-based and estimated glomerular filtration rates before and after allogeneic hematopoietic stem cell transplantation in pediatric patients
Matsuoka, Daisuke; Hirabayashi, Koichi; Murase, Tsubasa; Saito, Shoji; Hidaka, Yoshihiko; Nakazawa, Yozo;
Pediatric blood & cancer, 67(12), Dec. 2020
Corresponding

Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation
Shigemura, Tomonari; Sakashita, Kazuo; Okura, Eri; Morita, Daisuke; Komori, Kazutoshi; Kurata, Takashi; Hirabayashi, Koichi; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Nakazawa, Yozo;
INTERNATIONAL JOURNAL OF HEMATOLOGY, 111(5), 702-710, May 2020

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
Sun, Chuang; Shou, Peishun; Du, Hongwei; Hirabayashi, Koichi; Chen, Yuhui; Herring, Laura E.; Ahn, Sarah; Xu, Yang; Suzuki, Kyogo; Li, Guangming; Tsahouridis, Ourania; Su, Lishan; Savoldo, Barbara; Dotti, Gianpietro;
CANCER CELL, 37(2), 216-+, 2020, Refereed

In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination
Shimodaira, Shigetaka; Yanagisawa, Ryu; Koya, Terutsugu; Hirabayashi, Koichi; Higuchi, Yumiko; Sakamoto, Takuya; Togi, Misa; Kato, Tomohisa, Jr.; Kobayashi, Takashi; Koizumi, Tomonobu; Koido, Shigeo; Sugiyama, Haruo;
Vaccines, 7(3), Sep. 2019

Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies
Ahn, Sarah; Li, Jingjing; Sun, Chuang; Gao, Keliang; Hirabayashi, Koichi; Li, Hongxia; Savoldo, Barbara; Liu, Rihe; Dotti, Gianpietro;
Cancer immunology research, 7(5), 773-783, May 2019

Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8-Gy total body irradiation-based reduced-toxicity myeloablative conditioning
Komori, Kazutoshi; Hirabayashi, Koichi; Morita, Daisuke; Hara, Yosuke; Kurata, Takashi; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Sakashita, Kazuo; Koike, Kenichi; Nakazawa, Yozo;
PEDIATRIC TRANSPLANTATION, 23(3), May 2019

Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors
Krokhotin, Andrey; Du, Hongwei; Hirabayashi, Koichi; Popov, Konstantin; Kurokawa, Tomohiro; Wan, Xinhui; Ferrone, Soldano; Dotti, Gianpietro; Dokholyan, Nikolay, V;
MOLECULAR THERAPY-ONCOLYTICS, 15, 30-37, 2019, Refereed

Proton Beam Therapy for Adolescent Primary Central Nervous System Lymphoma With Residual Tumor After Intensive Chemotherapy: A Case Report
Komori, Kazutoshi; Saito, Shoji; Araya, Masayuki; Morita, Daisuke; Kurata, Takashi; Hirabayashi, Koichi; Tanaka, Miyuki; Koiwai, Keiichiro; Tauchi, Katsunori; Masaki, Hidekazu; Nakazawa, Yozo;
PRACTICAL RADIATION ONCOLOGY, 9(5), 333-337, 2019, Refereed

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells
Du, Hongwei; Hirabayashi, Koichi; Ahn, Sarah; Kren, Nancy Porterfield; Montgomery, Stephanie Ann; Wang, Xinhui; Tiruthani, Karthik; Mirlekar, Bhalchandra; Michaud, Daniel; Greene, Kevin; Herrera, Silvia Gabriela; Xu, Yang; Sun, Chuang; Chen, Yuhui; Ma, Xingcong; Ferrone, Cristina Rosa; Pylayeva-Gupta, Yuliya; Yeh, Jen Jen; Liu, Rihe; Savoldo, Barbara; Ferrone, Soldano; Dotti, Gianpietro;
CANCER CELL, 35(2), 221-+, 2019

Panobinostat inhibits the proliferation of CD34(+)CD38(-)cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia
Kurata, Takashi; Matsuda, Kazuyuki; Hirabayashi, Koichi; Shigemura, Tomonari; Sakashita, Kazuo; Nakahata, Tatsutoshi; Koike, Kenichi;
Pediatric blood & cancer, 65(11), Nov. 2018

Successful induction of therapeutic urinary concentration by intravenous ganciclovir and oral valganciclovir with remission of adenoviral hemorrhagic cystitis after cord blood transplantation
Yanagisawa, Toshimitsu; Saito, Shoji; Katsuyama, Yoshihiko; Hirabayashi, Koichi; Shigemura, Tomonari; Tanaka, Miyuki; Sakashita, Kazuo; Nakazawa, Yozo;
PEDIATRIC TRANSPLANTATION, 22(6), Sep. 2018

Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors
Hirabayashi, Koichi; Yanagisawa, Ryu; Saito, Shoji; Higuchi, Yumiko; Koya, Terutsugu; Sano, Kenji; Koido, Shigeo; Okamoto, Masato; Sugiyama, Haruo; Nakazawa, Yozo; Shimodaira, Shigetaka;
Anticancer Research, 38(4), 2227-2234, Apr. 2018
Lead

Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia
Hirabayashi, Koichi; Takatsuki, Mitsuho; Motobayashi, Mitsuo; Kurata, Takashi; Saito, Shoji; Shigemura, Tomonari; Nakazawa, Yozo; Sakashita, Kazuo; Ishizone, Satoshi; Ota, Hiroyoshi; Koike, Kenichi;
PEDIATRICS AND NEONATOLOGY, 58(1), 81-84, Feb. 2017

Anaplastic large-cell lymphoma of the left ventricle presenting with arrhythmia and cerebral infarction due to cardiogenic embolism (vol 63, pg 755, 2016)
Hirabayashi, Koichi; Yamauchi, Shoko; Matsuzaki, Satoshi; Komatsu, Kazunori; Sano, Kenji; Koike, Kenichi; Nakazawa, Yozo;
Pediatric blood & cancer, 63(6), 1132-1132, Jun. 2016

Clinical and Laboratory Outcomes After Umbilical Cord Blood Transplantation in a Patient with Mucolipidosis II Alpha/Beta
Shibazaki, Takumi; Hirabayashi, Koichi; Saito, Shoji; Shigemura, Tomonari; Nakazawa, Yozo; Sakashita, Kazuo; Takagi, Mineo; Shiohara, Masaaki; Adachi, Kaori; Nanba, Eiji; Sakai, Norio; Koike, Kenichi;
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 170(5), 1278-1282, May 2016

Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction
Hirabayashi, Koichi; Kurata, Takashi; Horiuchi, Kazuki; Saito, Shoji; Shigemura, Tomonari; Tanaka, Miyuki; Yanagisawa, Ryu; Matsuda, Kazuyuki; Sakashita, Kazuo; Koike, Kenichi; Nakazawa, Yozo;
Pediatric blood & cancer, 63(4), 709-711, Apr. 2016

Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms' Tumor 1 in Patients with Advanced Colorectal Cancer.
Shimodaira S, Sano K, Hirabayashi K, Koya T, Higuchi Y, Mizuno Y, Yamaoka N, Yuzawa M, Kobayashi T, Ito K, Koizumi T.
Vaccines (Basel), 3(4), 1004-18, Dec. 2015

Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: a case report and review of the literature
Saito, Shoji; Yanagisawa, Ryu; Yoshikawa, Kentaro; Higuchi, Yumiko; Koya, Terutsugu; Yoshizawa, Kiyoshi; Tanaka, Miyuki; Sakashita, Kazuo; Kobayashi, Takashi; Kurata, Takashi; Hirabayashi, Koichi; Nakazawa, Yozo; Shiohara, Masaaki; Yonemitsu, Yoshikazu; Okamoto, Masato; Sugiyama, Haruo; Koike, Kenichi; Shimodaira, Shigetaka;
CYTOTHERAPY, 17(3), 330-335, Mar. 2015

Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Shigemura, Tomonari; Nakazawa, Yozo; Hirabayashi, Koichi; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Koike, Kenichi;
JOURNAL OF CLINICAL IMMUNOLOGY, 35(1), 84-86, Jan. 2015

Mudd's disease (MAT I/III deficiency): a survey of data for MAT1A homozygotes and compound heterozygotes
Chien, Yin-Hsiu; Abdenur, Jose E.; Baronio, Federico; Bannick, Allison Anne; Corrales, Fernando; Couce, Maria; Donner, Markus G.; Ficicioglu, Can; Freehauf, Cynthia; Frithiof, Deborah; Gotway, Garrett; Hirabayashi, Koichi; Hofstede, Floris; Hoganson, George; Hwu, Wuh-Liang; James, Philip; Kim, Sook; Korman, Stanley H.; Lachmann, Robin; Levy, Harvey; Lindner, Martin; Lykopoulou, Lilia; Mayatepek, Ertan; Muntau, Ania; Okano, Yoshiyuki; Raymond, Kimiyo; Rubio-Gozalbo, Estela; Scholl-Buergi, Sabine; Schulze, Andreas; Singh, Rani; Stabler, Sally; Stuy, Mary; Thomas, Janet; Wagner, Conrad; Wilson, William G.; Wortmann, Saskia; Yamamoto, Shigenori; Pao, Maryland; Blom, Henk J.;
ORPHANET JOURNAL OF RARE DISEASES, 10, 2015, Refereed

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia
Matsuda, K; Nakazawa, Y; Iwashita, C; Kurata, T; Hirabayashi, K; Saito, S; Tanaka, M; Yoshikawa, K; Yanagisawa, R; Sakashita, K; Sasaki, S; Honda, T; Koike, K
Leukemia, 28(7), 1545-1548, Jul. 2014

Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies
Hirabayashi, Kanae; Nakazawa, Yozo; Matsuura, Hiroki; Hara, Yosuke; Kurata, Takashi; Hirabayashi, Koichi; Saito, Shoji; Yoshikawa, Kentaro; Tanaka, Miyuki; Yanagisawa, Ryu; Sakashita, Kazuo; Koike, Kenichi;
INTERNATIONAL JOURNAL OF HEMATOLOGY, 99(4), 477-486, Apr. 2014

Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
Shigemura, Tomonari; Nakazawa, Yozo; Yoshikawa, Kentaro; Hirabayashi, Koichi; Saito, Shoji; Kobayashi, Norimoto; Sakashita, Kazuo; Shiohara, Masaaki; Wada, Taizo; Shimodaira, Shigetaka; Agematsu, Kazunaga; Koike, Kenichi;
TRANSFUSION, 54(3), 516-521, Mar. 2014

Reduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies
Hirabayashi, Koichi; Nakazawa, Yozo; Sakashita, Kazuo; Kurata, Takashi; Saito, Shoji; Yoshikawa, Kentaro; Tanaka, Miyuki; Yanagisawa, Ryu; Koike, Kenichi;
SCIENTIFIC REPORTS, 4, 2014, Refereed
Lead

Usefulness of Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission for Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm With Skin Involvement: A Case Report and Review of Literature
Sakashita, Kazuo; Saito, Shoji; Yanagisawa, Ryu; Tanaka, Miyuki; Yoshikawa, Kentaro; Hirabayashi, Koichi; Tsukahara, Keiko; Motobayashi, Mitsuo; Nakazawa, Yozo; Koike, Kenichi;
Pediatric blood & cancer, 60(11), E140-E142, Nov. 2013

Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid.
Hirabayashi K, Nakazawa Y, Katsuyama Y, Yanagisawa T, Saito S, Yoshikawa K, Shigemura T, Sakashita K, Ichikawa M, Koike K
Infection, 41(1), 219-223, Feb. 2013
Lead, Corresponding

Neurologically normal development of a patient with severe methionine adenosyltransferase I/III deficiency after continuing dietary methionine restriction
Hirabayashi, Koichi; Shiohara, Masaaki; Yamada, Kazuhiro; Sueki, Akane; Ide, Yuichiro; Takeuchi, Koichi; Hagimoto, Rokuro; Kinoshita, Tatsuya; Yabuhara, Akihiko; Mudd, S. Harvey; Koike, Kenichi;
GENE, 530(1), 104-108, 2013

Food allergy after cord blood transplantation in children
Sakashita, Kazuo; Nakazawa, Yozo; Yanagisawa, Ryu; Tanaka, Miyuki; Saito, Shoji; Yoshikawa, Kentaro; Hirabayashi, Koichi; Kusakari, Mai; Kato, Sawako; Hidaka, Nao; Nakayama, Yoshiko; Shigemura, Tomonari; Kobayashi, Norimoto; Kobayashi, Mikiko; Shiohara, Masaaki; Koike, Kenichi;
BRITISH JOURNAL OF HAEMATOLOGY, 158(5), 672-676, Sep. 2012

Critical Illness Polyneuropathy and Myopathy Caused by Bacillus Cereus Sepsis in Acute Lymphoblastic Leukemia
Hirabayashi, Koichi; Shiohara, Masaaki; Suzuki, Takefumi; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Tsuruta, Goro; Fukuyama, Tetsuhiro; Hidaka, Yoshihiko; Nakazawa, Yozo; Shimizu, Takashi; Sakashita, Kazuo; Koike, Kenichi;
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 34(3), E110-E113, Apr. 2012
Lead

Retrospective analysis of risk factors for development of liver dysfunction in transient leukemia of Down syndrome
Hirabayashi, Koichi; Shiohara, Masaaki; Takahashi, Daijiro; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Sakashita, Kazuo; Nakamura, Tomohiko; Ishii, Eizaburo; Koike, Kenichi;
LEUKEMIA & LYMPHOMA, 52(8), 1523-1527, Aug. 2011
Lead

Polymyxin-Direct Hemoperfusion for Sepsis-Induced Multiple Organ Failure
Hirabayashi, Koichi; Shiohara, Masaaki; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Tsuruta, Goro; Fukuyama, Tetsuhiro; Hidaka, Yoshihiko; Nakazawa, Yozo; Shimizu, Takashi; Sakashita, Kazuo; Koike, Kenichi;
Pediatric blood & cancer, 55(1), 202-205, 2010

日本造血・免疫細胞療法学会

日本小児血液がん学会

日本小児科学会

Development of double-targeting CAR-T cell for heterogeneity of cancers
2021 - 2025