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山田 充彦  ヤマダ ミツヒコ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 分子薬理学FAX番号
職名教授メールアドレスmyamada@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURLhttp://www.shinshu-u.ac.jp/faculty/medicine/chair/i-yakuri/index.html

更新日:2020/10/26

プロフィール

研究分野
薬理学一般
循環器内科学
神経生理学・神経科学一般
生理学一般
胎児医学、小児成育学
現在の研究課題
心筋L型カルシウムチャネルの生理学的、病態生理学的、薬理学的解析
キーワード:心臓 , L型カルシウムチャネル , 心不全 , 不整脈 , 作用薬・阻害薬
骨格筋の細胞内Ca2+代謝
キーワード:筋小胞体Ca2+ポンプ , 筋小胞体Ca2+遊離チャネル , L型Ca2+チャネル , ジャンクトフィリン
血管平滑筋L型カルシウムチャネルの生理学的、病態生理学的、薬理学的解析
キーワード:血管平滑筋 , L型カルシウムチャネル , 動脈硬化 , 作用薬・阻害薬
副腎髄質のアドレナリン分泌調節機構の解析
キーワード:副腎髄質 , アドレナリン , L型カルシウムチャネル , アンジオテンシン受容体
心臓のエネルギー代謝の発達機序の解析
キーワード:心臓 , ミトコンドリア , 解糖系 , 発達
所属学会
所属学会
日本小児循環器学会
日本循環器学会
日本生理学会
日本心電学会
生物物理学会
米国生理学会
日本新生児成育医学会

所属学会役職担当
日本薬理学会 , 代議員
学歴
出身学校・専攻等(大学院を除く)
1984 , 神戸大学 , 医学部 , 医学科

取得学位
医学博士

免許・資格等
19840528 , 医師免許
受賞学術賞
2005 , 第5回医科学応用研究財団助成による日本心電学会論文賞
1993 , 財団法人循環器学研究振興財団内田賞
研究職歴等
研究職歴
2004- , 信州大学医学部分子薬理学講座教授
2002-2004 , 大阪大学大学院医学系研究科 情報薬理学講座 助教授
1998-2002 , 国立循環器病センター研究所心臓生理部、神経性調節研究室長
1994-1998 , 大阪大学医学部第二薬理学講座助手

留学歴
1992-1994 , メイヨークリニック内科心・血管病部門ポストドクタルフェロー

研究活動業績

研究業績(著書・
発表論文等)
著書
新しい小児心不全治療薬の開発をめざして
洋學社 , 熱血 循環器学 洋學社 井上信孝編集 , :1-15 2019
Author:山田充彦


ヌクレオチドと薬物による心血管系ATP感受性K+チャネル活性化の分子機構
医歯薬出版株式会社,東京 , 倉智 嘉久編:別冊・医学のあゆみイオンチャネル最前線update , :pp 101-107 2005
Author:山田充彦


論文
Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism
HYPERTENSION RESEARCH,42(5):598-609 2019(May)
Author:Guo, Ran; Hu, Xiao; Yamada, Yosuke; Harada, Makoto; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;


Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice
GLYCOCONJUGATE JOURNAL,36(1):1-11 2019(Feb.)
Author:Yamada, Yosuke; Harada, Makoto; Hashimoto, Koji; Guo, Ran; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji;


Prostanoid EP4 receptor-mediated augmentation of Ih currents in A dorsal root ganglion neurons underlies neuropathic pain.
J Pharmacol Exp Ther,368:50–58 2019(Jan.)
Author:70. Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M., Yamada, M.


Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,368(1):50-58 2019
Author:Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko;


Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
Hypertension Research,42:598-609 2018(Dec. 10)
Author:Ran Guo, Xiao Hu, Yosuke Yamada, Makoto Harada, Takero Nakajima, Toshihide Kashihara, Mitsuhiko Yamada, Toshifumi Aoyama, Yuji Kamijo


Increase in phospholamban content in mouse skeletal muscle after denervation
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY,39(5-6):163-173 2018(Dec.)
Author:Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;


Sonic hedgehog signaling regulates the mammalian cardiac regenerative response
J Mol Cell Cardiol,:in press 2018(Sep. 17)
Author:Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BK, Yamada M, Finkel T


PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca(2+) channels with full-length Ca(V)1.2 C-terminus.
Pflugers Arch,470(6):909-921 2018(Jun.)
Author:Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.


Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction.
Proc Natl Acad Sci U S A,115(17):4507-4512 2018(Apr. 24)
Author:Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.


Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol,595(13):4207-4225 2017(Jul. 01)
Author:Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.


Angiotensin II activates CaV1.2 Ca2+ channels through -arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
J. Physiol. (Lond.) ,595:4207–4225 2017(Mar. 15)
Author:Kashihara, T., Nakada, T., Kojima, K., Takeshita, T., and Yamada, M.


Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model
J. Mol. Cell. Cardiol.,81:139-149 2015(Apr. 01)
Author:Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y


横紋筋L型Ca2+チャネルの結合膜局在機構
日本薬理学会雑誌 ,144(5):217-221 2014(Nov. 01)
Author:中田勉、山田充彦


Cardiac overexpression of constitutively active Galpha q causes angiotensin II type 1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
PlosOne,9:e106354 2014(Sep. 01)
Author:Matsushita, N., Kashihara, T., Shimojo, H., Suzuki, S., Nakada, T., Takeishi, Y., Mende, U., Taira, E., Yamada, M., Sanbe, A., Hirose, M.


Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts.
Biol. and Pharm. Bull.,37:1168-1176 2014(May 01)
Author:Hirose, M., Shibazaki, T., Nakada, T., Kashihara, T., Yano, S., Okamoto, Y., Isaji, M. , Matsushita, N., Taira, E., Yamada, M.


TRPM4 Channels Mediate Hypertonicity-induced, Ca2+-impermeable, Non-selective Cation Currents in a Cervical Cancer Cell Line, HeLa Cells
Shinshu Med. J.,62:33-44 2014(Feb. 01)
Author:Gomi, S., Nakada, T., Kashihara, T., Ikeda, U. and Yamada, M.


β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
Eur. J. Pharmacol.,724:122-131 2014(Feb.)
Author:Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M


Nicorandil prevents Gaq-induced progressive heart failure and ventricular arrhythmias in transgenic mice
PLOS ONE,7:e52667 2012(Dec. 00)
Author:56. M. Hirose, Y. Takeishi, T. Nakada, H. Shimojo, T. Kashihara, A. Nishio, S. Suzuki, U. Mende, K. Matsumoto, N. Matsushita, E. Taira, M. Yamada


Proximal C-terminus of alpha1C subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channels
Biochem. J.,448:221-23 2012(Dec. 00)
Author:Nakada, T., Flucher, B.E., Kashihara, T., Sheng, X., Shibazaki, T., Horiuchi-Hirose, M., Gomi, S., Hirose, M., and Yamada, M.


KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models.
J. Pharmacol. Exp. Ther.,342:288-296 2012(Aug. 00)
Author:Shibazaki, T., Tomae, M., Ishikawa-Takemura, Y., Fushimi, N., Itoh, F., Yamada, M., Isaji, M.


Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation.
Eur. J. Pharmacol.,685(1-3):15-23 2012
Author:Sheng, X., Nakada, T., Kobayashi, M., Kashihara, T., Shibazaki, T., Horiuchi-Hirose, M., Gomi, S., Hirose, M., Aoyama, T., Yamada, M.


Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Am. J. Physiol. Heart Circ. Physiol.,302:H1645-H1654 2012
Author:Kashihara, T., Nakada, T., Shimojo, H., Horiuchi-Hirose, M., Gomi, S., Shibazaki, T., Sheng, X., Hirose, M., Hongo, M., and Yamada, M.


Diacylglycerol kinase ζ Inhibits ventricular tachyarrhythmias in a mouse model of heart failure.-Role of canonical transient receptor potential (TRPC) channels-
Circ J.,75(10):2333-2342 2011
Author:51. Hirose, M., Takeishi, Y., Niizeki, T., Nakada, T., Shimojo, H., Kashihara, T., Horiuchi-Hirose, M., Kubota, I., Mende, U., Yamada, M.


Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells.
Shinshu Med. J.,59:13-26 2011
Author:Tsujino, N, Nakada, T., Tsubouchi, K., Kobayashi, M., Kawai, Y., Yano, S., Matsunaga, T., Hirose, M., Ohmori, S., Ohhashi, T., Yamada, M.


Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol.,300(3):H978-88 2011
Author:Horiuchi-Hirose, M., Kashihara, T., Nakada, T., Kurebayashi, N., Shimojo, H., Shibazaki, T., Sheng, X., Yano, S., Hirose, M., Hongo, M., Sakurai, T., Moriizumi, T., Ueda, H., and Yamada,


Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Int. J. Cardiol.,146:37-43 2011
Author:Hirose, M., Yano, S., Nakada, T., Horiuchi-Hirose, M., Tsujino, N., Yamada, M.


Acid-sensing ion channels in blood volume regulation.
Circ. J.,(in press) 2011
Author:Yamada, M.


Selective alpha 1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation
Curr. Eye Res.,35(5):363-369 2010
Author:Yano, S., Hirose, M., Nakada, T., Nakayama, J., Matsuo, K., Yamada, M.


Mitochondrial ATP-sensitive K+ channels, protectors of the heart
JOURNAL OF PHYSIOLOGY-LONDON,588(2):283-286 2010
Author:Yamada, Mitsuhiko


Effects of hormone-sensitive lipase-disruption on cardiac energy metabolism in response to fasting and refeeding.
Am. J. Physiol. Endocrinol. Metab.,297:E1115-E1124 2009
Author:Suzuki, J., Ueno, M., Uno, M., Hirose, Y., Zenimaru, Y., Takahashi, S., Osuga, J.I., Ishibashi, S., Takahashi, M., Hirose, M., Yamada, M., Kraemer, F.B., Miyamori, I.


Diacylglycerol kinase zeta inhibits G-alpha q-induced atrial remodeling in transgenic mice.
Heart Rhythm,6:78-84 2009
Author:Hirose, M., Takeishi, Y., Niizeki, T., Shimojo, H., Nakada, T., Kubota, I., Nakayama, J., Mende, U., Yamada, M.


Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
J. Membr. Biol.,222:151-166 2008
Author:Yamada, M., Ohta, K., Niwa, A., Tsujino, N., Nakada, T., and Hirose, M.


Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
Basic Clin. Pharmacol. Toxicol.,102:504-514 2008
Author:Hirose, M., Tsujino, N., Nakada, T., Yano, S., Imamura, H., and Yamada, M


MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species.
Cardiovasc. Res.,78:554-562 2008
Author:Morimoto, H., Hirose, M., Takahashi, M., Kawaguchi, M., Ise, H., Kolattukudy, P.E., Yamada, M., and Ikeda, U.


Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes
JOURNAL OF MEMBRANE BIOLOGY,222(3):151-166 2008
Author:Yamada, M; Ohta, K; Niwa, A; Tsujino, N; Nakada, T; Hirose, M


MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species
CARDIOVASCULAR RESEARCH,78(3):554-562 2008
Author:Morimoto, H; Hirose, M; Takahashi, M; Kawaguchi, M; Ise, H; Kolattukudy, PE; Yamada, M; Ikeda, U


Mechanisms of preventive effect of pilsicainide on the atrial fibrillation originating from the pulmonary vein.
Circ J,71:1805-1814 2007
Author:Hirose, M., Ohkubo, Y., Takano, M., Hamasaki, M., Sekido, T., and Yamada, M.


Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant.
Channels,1:198-208 2007
Author:Hosaka, Y., Iwata, M., Kamiya, N., Yamada, M., Kinoshita, K., Fukunishi, Y., Tsujimae, K., Hibino, H., Aizawa, Y., Inanobe, A., Nakamura, H., and Kurachi, Y.


Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein
CIRCULATION JOURNAL,71(11):1805-1814 2007
Author:Hirose, M; Ohkubo, Y; Takano, M; Hamazaki, M; Sekido, T; Yamada, M


Sodium channel blocker, pilsicainide, prevents atrial fibrillation originating from the pulmonary veins by pulmonary vein isolation in isolated arterially-perfused canine atria
CIRCULATION,114(18):745-745 2006
Author:Hirose, M; Yamada, M


Effects of nicorandil on the transmural conduction slowing during ischemia in canine left ventricles
JOURNAL OF PHARMACOLOGICAL SCIENCES,100:116P-116P 2006
Author:Hirose, M; Yamada, M


Mechanisms of protection against ischemia-induced transmural reentry by nicorandil
CIRCULATION,114(18):746-746 2006
Author:Hirose, M; Yamada, M


A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels.
J. Mol. Cell. Cardiol,39:1-6 2005
Author:Yamada, M. and Kurachi, Y.


PtdIns(3,4,5)P3 and Ca2+/calmodulin competitively bind to the RGS domain of RGS4 and reciprocally regulate its action.
Biochem. J.,385:65-73 2005
Author:Ishii, M., Fujita, S., Yamada, M., Hosaka, Y., Kurachi, Y.


Effects of K-ATP channel modulation on transmural dispersion of action potential duration in canine left ventricle
JOURNAL OF PHARMACOLOGICAL SCIENCES,97:105P-105P 2005
Author:Hirose, M; Imamura, H; Yamada, M


A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels
J Mol Cell Cardiol,39:1-6 2005
Author:Yamada M, Kurachi Y


Investigation of the block and facilitation effects by nifekalant in a HERG channel
JOURNAL OF PHARMACOLOGICAL SCIENCES,97:235P-235P 2005
Author:Hosaka, Y; Yamada, M; Ishii, M; Kurachi, Y


Molecular cloning of the protein interacting with heart-restricted leucine-rich repeat protein, HRLRRP
JOURNAL OF PHARMACOLOGICAL SCIENCES,97:239P-239P 2005
Author:Nakane, T; Inada, Y; Yamada, M


Investigation of the block and facilitation effects by nifekalant in a HERG channel
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,39(6):1018-1018 2005
Author:Hosaka, Y; Yamada, M; Kurachi, Y


Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action
Biochem J,385:65-73 2005
Author:Ishii M, Fujita S, Yamada M, Hosaka Y,Kurachi Y


Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.
J Biol Chem.,279:44065-44073 2004
Author:Hibino, H., Fujita, A., Iwai, K., Yamada, M., Kurachi, Y.


Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: Implication for dimerization of nucleotide-binding domains to induce channel opening.
Mol. Pharmacol.,66:807-816 2004
Author:Yamada, M., Ishii, M., Hibino, H., and Kurachi, Y.


Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.
Eur. J. Pharmacol.,493:29-40 2004
Author:Tsujimae, K., Suzuki,S., Yamada, M., and Kurachi, Y.


The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels.
Mol. Pharmacol.,65:1198-1207 2004
Author:Yamada, M. and Kurachi, Y.


イオンチャネルと不整脈
臨床科学,33:113-118 2004
Author:山田充彦,倉智嘉久


Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP- sensitive K+ channels: implication for dimeraiza nucleotide-binding domains to induce channel opening
Mol Pharmacol,66:807-816 2004
Author:Yamada M, Ishii M, Hibino H, Kurachi Y


Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic b-cell-type KATP channels.
J. Pharmacol. Exp. Ther.,304(3):1025-1032 2003
Author:Chachin M., Yamada, M., Fujita A., Matsuoka, T., Matsuoka, T., and Kurachi, Y.


b-Adrenergic modulation of prepulse facilitation of L-type calcium channels in rabbit ventricular myocytes.
Pflügers Archiv,444(1-2):89-98 2002
Author:Yamada, M.


The role of muscarinic K+ channels in the negative chronotropic effect of a muscarinic agonist.
J. Pharmacol. Exp. Ther,300(1):681-687 2002
Author:Yamada, M.


Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes.
J. Pharmacol. Exp. Ther,293(1):196-205 2000
Author:Kitamura, H., Yokoyama, M., Akita, H., Matsushita, K., Kurachi, Y. and Yamada, M.


Epinastin, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.
Eur. J. Pharmacol.,374(3):457 - 460 1999
Author:Chachin, M., Katayama Y., Yamada, M., Horio, Y., Ohmura T., Kitagawa, H, Uchida S., and Kurachi, Y.


G protein regulation ofpotassium ion channels.
Pharmacol. Rev.,50(4):723-757 1998
Author:Yamada, M., Inanobe, A., and Kurachi, Y.


Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.
J. Physiol. (Lond.),511(3):663-674 1998
Author:Satoh, E., Yamada, M., Kondo, C., Repunte, V. P., Horio, Y., Iijima, T., and Kurachi, Y.


Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.
Diabetes,47(3):476-481 1998
Author:Ohta, Y., Tanizawa, Y., Inoue, H., Hosaka, T., Ueda, K., Matsutani, A., Repunte, V. P., Yamada, M., Kurachi, Y., Bryan, J., Aguilar-Bryan, L., Permutt, M. A., and Oka, Y.


The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells.
Pflügers. Arch.,435(5):595-603 1998
Author:Okuyama, Y., Yamada. M., Kondo, C., Satoh, E., Isomoto, S., Shindo, T., Horio, Y., Kitakaze, M., Hori, M., and Kurachi, Y.


Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels.
Receptors and Channels,6(2):129-140 1998
Author:Kondo, C., Repunte, V. P., Satoh,E., Yamada, M., Horio, Y., Matsuzawa, Y., Pott, L., and Kurachi, Y.


SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
Br. J. Pharmacol.,124(5):985-991 1998
Author:Shindo, T., Yamada, M., Isomoto, S., Horio, Y., and Kurachi, Y.


An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4.1), in cochlear stria vascularis of inner ear: Its specific subcellular localization and correlation with the formation of endocochlear potential.
J. Neurosci.,17(12):4711-4721 1997
Author:Hibino, H., Horio, Y., Inanobe, A., Doi, K., Ito, M., Yamada, M., Gotow, T., Uchiyama, Y., Kawamura, M., Kubo, T., and Kurachi, Y.


Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.
J. Biol. Chem.,272(16):12885-12888 1997
Author:Horio, Y., Hibino, H., Inanobe, A., Yamada, M., Ishii, M., Tada, Y., Satoh, E., Hata, Y., Takai, Y., and Kurachi, Y.


Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
J. Physiol.(Lond.),499(3):715-720 1997
Author:Yamada, M., Isomoto, S., Mastumoto, S., Kondo, C., Shindo, T., Horio, Y., and Kurachi, Y.


Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse Chromosome6.
Mammalian Genome,8(10):790-791 1997
Author:Isomoto, S., Horio, Y., Matsumoto, S., Kondo, C., Yamada, M., Gilbert, D.J., Copeland, N. G., Jenkins, N. A., and Kurachi, Y.


Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Müller cell membrane: Theirregulation by insulin and laminin signals.
J. Neurosci.,17(20):7725-7735 1997
Author:Ishii, M., Horio, Y., Tada, Y., Hibino, H., Inanobe, A., Ito, M., Yamada, M., Gotow, T., Uchiyama, Y., and Kurachi, Y.


Specialized release zones in chromaffin cells examined with pulsed-laser imaging.
Cell Calcium,20(2):181-201 1996
Author:Robinson, I. M., Yamada, M., Carrion-Vazquez, M., Lennon, V. A., and Fernandez J. M.


Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kir1.1f).
FEBS Letts.,399(1-2):122-126 1996
Author:Kondo, C., Isomoto, S., Matsumoto, S., Yamada, M., Horio, Y., Yamashita, S., Takemura-Kameda, K., Matsuzawa, Y., and Kurachi, Y.


A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes.
Biochem. Biophys. Res. Commun.,218(1):286-291 1996
Author:Isomoto, S., Kondo, C., Takahashi, N., Matsumoto, S., Yamada, M., Takumi, T., Horio, Y., and Kurachi, Y.


A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes: Spectral analysis of the effect of GTP on single-channel kinetics.
J. Gen. Physiol.,108(6):485-495 1996
Author:Hosoya, Y., Yamada, M., Ito H., and Kurachi Y.


Competition between Mg2+and spermine for a cloned IRK2 channel expressed in a human cell line.
J. Physiol. (Lond.),493(1):143-156 1996
Author:Yamashita, T., Horio, Y., Yamada, M., Takahashi, N., Kondo, C., and Kurachi, Y.


A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
J. Biol.Chem.,271(40):24321-24324 1996
Author:Isomoto,S., Kondo, C., Yamada, M., Matsumoto, S., Higashiguchi, O., Horio, Y., Matsuzawa, Y., and Kurachi, Y.


Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart.
Heart Vessels,Suppl. 9:8-11 1995
Author:Takahashi, N., Morishige, K.-I., Yamada, M., Takumi, T., and Kurachi, Y.


Spermine gates inward-rectifying muscarinic but not ATP-sensitive K+ channels in rabbit atrial myocytes.
J. Biol. Chem.,270(16):9289-9294 1995
Author:Yamada, M., and Kurachi, Y.


Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart.
Heart Vessels,Suppl. 9:8-11 1995
Author:Takahashi, N., Morishige, K.-I., Yamada, M., Takumi, T., and Kurachi, Y.


A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.
J. Biol. Chem.,270(27):16339-16346 1995
Author:Takumi, T., Ishii, T., Horio, Y., Morishige, K.-I., Takahashi, N., Yamada, M., Yamashita, T., Kiyama, H., Sohmiya, K., Nakanishi, S., and Kurachi, Y.


Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ Channel, GIRK1.
Biochem. Biophys. Res. Commun,212(3):1022-1028 1995
Author:Inanobe, A., Morishige, K.-I., Takahashi, N., Ito, H., Yamada, M., Takumi, T., Nishina, H., Takahashi, K.,Kanaho, Y., Katada, T., and Kurachi, Y.


Regulation of potassium channels by G-protein subuni000000ts and arachidonic acid metabolites.
Methods Enzymol.,238:394-422 1994
Author:Yamada, M., Terzic, A., and Kurachi, Y.


Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.
J. Biol. Chem.,269(37):23274-23279 1994
Author:Takahashi, N., Morishige, K.-I., Jahangir, A., Yamada, M., Findlay, I., Koyama, H., and Kurachi, Y.


Muscarinic K+ channels are activated by bg subunits and inhibited by the GDP-bound form of a subunit of transducin.
Biochem. Biophys. Res. Commun.,200(3):1484-1490 1994
Author:Yamada, M., Ho, Y.-K., Lee, R. H., Kontani, K., Takahashi, K., Katada, T., and Kurachi, Y.


Molecular cloning, functional expression of a novel brain-specific inward rectifier potassium channel.
FEBS Letts.,346(2-3):251-256 1994
Author:Morishige, K.-I., Takahashi, N., Jahangir, A., Yamada, M., Koyama, H., Zanelli, J. S., and Kurachi, Y.


Cardiovascular profile of E4080 and its analogue ER001533: Novel potassium channel openers with bradycardiac properties.
Cardiovasc. Drug Rev.,11(2):223-233 1993
Author:Terzic, A., Tung, R. T., Shen, W. K., Yamada, M., and Kurachi, Y.


YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes.
J. Pharmacol. Exp. Ther,267(3):1544-1549 1993
Author:Yamada, M., Terzic, A., Findlay, I., Jahangir, A., Shen, W. K., and Kurachi, Y.


GK* and brain Gbg activate muscarinic K+ channel through the same mechanism.
J. Biol. Chem.,268(33):24551-24554 1993
Author:Yamada, M., Jahangir, A., Hosoya, Y., Inanobe, A., Katada, T., and Kurachi, Y.


Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.
Circ. Res.,71(6):1410-1421 1992
Author:Inoue, N., Hirata, K.-I., Yamada, M., Hamamori, Y., Matsuda, Y., Akita, H., and Yokoyama, M.


Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.
Circ. Res.,71(6):1410-1421 1992
Author:3. Inoue, N., Hirata, K.-I., Yamada, M., Hamamori, Y., Matsuda, Y., Akita, H., and Yokoyama, M.


P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in culturedventricular myocytes.
Circ. Res.,70(3):477-485 1992
Author:Yamada, M., Hamamori, Y., Akita, H., and Yokoyama, M.


5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
Circ. Res.,66(6):1474-1483 1990
Author:Hamamori, Y., Yokoyama, M., Yamada, M., Akita, H., Goshima, K., and Fukuzaki, H.


学会発表
新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
筋生理の集い 2019(Dec. 21)
Author:川岸裕幸、Maite LARRA AGA、冨田(沼賀)拓郎、中田勉、山田充彦


A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation.
The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology 2019(Dec. 04)
Author:Yamada, M.


βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
第29回日本循環薬理学会 2019(Nov. 29)
Author:川岸裕幸、柏原俊英、中田勉、冨田拓郎、山田充彦


心室筋活動電位内でのL型Ca2+電流波形を決定する分子機構の検討
学術セミナー「分子から個体へ:俯瞰と接近の生命科学」 2019(Oct. 18)
Author:山田充彦、西村仁志、柏原俊英


Molecular mechanisms underlying the agonistic effect of FPL64176 on CaV1.2 Ca2+ channels
第141回日本薬理学会関東部会 2019(Oct. 12)
Author:冨田拓郎、五味志文、柏原俊英、中田勉、山田充彦


小胞体CaセンサーSTIM1によるCav1.2チャネル制御機構の解明
第66回中部日本生理学会 2019(Oct. 04)
Author:冨田拓郎、高橋弘毅、山田充彦


除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加
第66回中部日本生理学会 2019(Oct. 04)
Author:中田勉、小松雅俊、山田充彦


マウス心筋細胞の生下後の機能的最終分化のメカニズムの解析
第140回日本薬理学会関東部会 2019(Jul. 06)
Author:川岸裕幸、中田勉、山田充彦


EP4 receptor-mediated augmentation of Ih currents in A DRG neurons underlies neuropathic pain.
FAOPS 2019 2019(Mar. 29)
Author:Yamada, M., Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M.


Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction.
FAOPS 2019 2019(Mar. 29)
Author:Nakada, T., Kashihara, T., Komatsu, M., Yamada, M.


マウス個体を用いた心筋細胞成熟化因子の同定
第92回日本薬理学会年会 2019(Mar. 16)
Author:川岸裕幸、中田勉、山田充彦


c-Srcによる全長型CaV1.2サブユニットを有するL型Ca2+チャネルの活性を介したPDGFによる増殖型血管平滑筋細胞の遊走
第92回日本薬理学会年会 2019(Mar. 15)
Author:中田勉、郭暁光、柏原俊英、青山俊文、山田充彦


プロスタノイドEP4受容体を介する後根神経節A細胞のIh電流増強による神経障害性疼痛の発症
第92回日本薬理学会年会 2019(Mar. 15)
Author:山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、清沢研吉、川眞田樹人


Molecular mechanisms underlying spatiotemporal regulation of L-type Ca2+ channels in muscles. Logic of life: ion channel structure, function and physiology.
International commemorative symposium in celebration of retirement of Professor Yoshihisa Kurachi 2019(Mar. 13)
Author:Yamada, M.


G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
日本臨床分子医学会学術総会プログラム・抄録集 , 55回:51 2018(Apr.)
Author:稲住 英明, 桑原 宏一郎, 桑原 佳宏, 中川 靖章, 木下 秀之, 錦見 俊雄, 呉林 なごみ, 山田 充彦, 柏原 俊英, 中尾 一和, 木村 剛


HFpEFにおける心筋興奮収縮連関の変化
日本循環器学会学術集会抄録集 , 81回:TP7-4 2017(Mar.)
Author:山田 充彦, Kashihara Toshihide

共同研究等希望テーマ
イオンチャネル作動薬の開発と解析 , 薬理学一般
研究費
受託研究
2008 - 2009 , Gqマウス心不全モデルを用いたニコランジルの心筋繊維化への抑制効果
2008 - 2009 , 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
2007 - 2009 , イオンチャネルとトランスポーターのクロストークに関するkrん旧
2007 - 2008 , 虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
2007 - 2008 , 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
2006 - 2007 , イヌ虚血心室筋の頻拍性不整脈発生に対するニコランジルの保護効果
2006 - 2007 , 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
2005 - 2006 , 虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果

科学研究費補助金(研究代表者)
2018 - 20200331 , 生下後の心筋分化誘導因子の同定:インビトロ心筋最終分化誘導法の開発 , 基盤研究(C)
2009 - 2011 , L型カルシウムチャネル阻害薬の開口状態親和性の定量的解析と阻害薬作用のモデル化 , 基盤研究(C)
2004 - 2006 , 薬物によるATP感受性K+チャネルの活性調節機構の立体構造基盤の解明 , 基盤研究(C)
2004 - 2006 , 薬物によるATP感受性K+チャネルの活性調節機構の立体構造基盤の解明 , 基盤研究(C)
2000 - 2002 , 副交感性心拍調節におけるムスカリン性Kチャネルの役割の検討 , 基盤研究(C)
1996 - 1997 , 内向き整流カリウムチャネルのポリアミン受容体の解析と新しい潜在的薬物作用点の検討 , 一般研究B
1995 - 1995 , 内向き整流カリウムチャネルの細胞内物質によるゲーテイング , 奨励研究A

科学研究費補助金(研究分担者)
1997 - 1998 , 動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K+チャネル , 特定領域研究A
1997 - 1998 , 動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K+チャネル , 特定領域研究A

奨学寄附金
2018 , AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
2018 , サルコペニアにおいて筋⼒低下が⽣じるメカニズムの解明
2018 , βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
2018 , ⼩児⼼不全の新しい薬物療法の開発
2018 , ⼩児⼼不全の新しい治療法の開発
2018 , βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
2018 , ⼩児⼼不全の新しい治療法の開発
2017 , βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
2017 , ⼩児⼼不全の新しい薬物療法の開発
2017 , AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
2017 , βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
2017 , βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
2016 , AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
2016 , 心不全の心室筋細胞でのL型Ca2+チャネルのリモデリングに関する研究

その他公的資金
2000 - 2002 , 心筋細胞の再生療法に関する研究:心筋細胞の電気生理学的分化とその制御因子の同定
1999 - 2001 , カルシウムチャネルによる心・血管細胞収縮調節機構とその異常