YAMADA MITSUHIKO

School of Medicine Department of Medicine (Cardiovascular) 

Professor 

Degree

  • MD

Research Keyword

    Heart, Ion channels, Intracellular calcium metabolism, Excitation-contraction coupling, G protein-coupled receptors, Intracellular signal transduction system, Pkarmacodynamics, Pediatric heart failure, Metanephrogenesis, Drug develpment

Field Of Study

  • Pharmacology, General pharmacology
  • Cardiology, Cardiovascular Medicine
  • Neuroscience-general, Neurophysiology / General neuroscience
  • Clinical pharmacy, General physiology
  • Embryonic medicine and pediatrics, Embryonic medicine and pediatrics

Mail Address

    myamada★shinshu-u.ac.jp

Career

  • 2004
    Professor, Dept. Mol. Pharamacol. Shinshu Univ. Sch. Med.
  • 2002 - 2004
    Associate Professor, Dept. Pharamacol. II, Osaka Univ. Grad. Sch. Med.
  • 1998 - 2002
    Assitant Professor, Dept. Card. Physiol., National Cardiovasc. Ctr. Res. Inst.
  • 1991 - 1992
    兵庫病院内科医師
  • 1990 - 1991
    佐用共立病院内科医師
  • 1989 - 1990
    兵庫病院内科医師
  • 1987 - 1989
    医員
  • 1984 - 1987
    医員(研修医)
  • 1998
    Assistant Professor, Dept. Pharmacol. II, Osaka Univ. Sch. Med.

Educational Background

  • 1992 - 1994, Postdoctal fellow, Dev. Of Cardiovascular Diseases, Dept. Intern. Med., Mayo Clinic
  • 1978 - 1984, Kobe University, Faculty of Medicine, School of Medicine

Member History

  • 代議員, 日本薬理学会

Award

  • 2005
    第5回医科学応用研究財団助成による日本心電学会論文賞
  • 1993
    財団法人循環器学研究振興財団内田賞

Paper

  • Role of Cytokine Receptor gp130 in Functional Development of the Neonatal Mouse Heart
    KAWAGISHI Hiroyuki;YAMADA Mitsuhiko
    The Shinshu Medical Journal, 70(6), 373-382, 10 Dec. 2022リポジトリ電子ジャーナル
  • A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
    Murayama T, Kurebayashi N, Numaga-Tomita T, Kobayashi T, Okazaki S, Yamashiro K, Nakada T, Mori S, Ishida R, Kagechika H, Yamada M, Sakurai T.
    J Gen Physiol., 154(12), e202213230, Nov. 2022, Refereed電子ジャーナル
  • 小児期特有のアンジオテンシンシグナルと、その小児心不全治療への応用
    山田充彦
    Cardiac Practice, 32, 128-133, 2022, Invited
    Lead, Last, Corresponding
  • NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
    Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T.
    Circ Res., 130, 234-248, 2022
  • Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
    Kawagishi H, Nakada T, Numaga-Tomita T, Larranaga M, Guo A, Song LS, Yamada M.
    Am J Physiol Heart Circ Physiol., 323, H103-H120, 2022
  • Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress.
    Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
    Endocrinology, 162, bqab001, 2021
  • Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
    Ichimura H, Kadota S, Kashihara T, Yamada M, Ito K, Kobayashi H, Tanaka Y, Shiba N, Chuma S, Tohyama S, Seto T, Okada K, Kuwahara K, Shiba Y.
    Sci Rep., 10, 11883, 2020
  • Beta-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
    Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
    JACC Basic Transl Sci, 5, 1057-1069, 2020電子ジャーナル
  • Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
    Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
    Hypertens Res, 42, 598-609, 2019WebofScience電子ジャーナル
  • Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
    Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
    Glycoconj J., 36, 1-11, 2019WebofScience電子ジャーナル
  • Prostanoid EP4 Receptor-Mediated Augmentation of Ih Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain.
    Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M.
    J Pharmacol Exp Ther., 368, 50-58, 2019WebofScience電子ジャーナル
  • Increase in phospholamban content in mouse skeletal muscle after denervation.
    Komatsu M, Nakada T, Kawagishi H, Kato H, Yamada M.
    J Muscle Res Cell Motil., 39, 163-173, 2018WebofScience電子ジャーナル
  • PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus.
    Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.
    Pflugers Arch., 470, 909-921, 2018電子ジャーナル
  • Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.
    Kawagishi H, Xiong J, Rovira, II, Pan H, Yan Y, Fleischmann BK, Yamada M, Finkel T.
    J Mol Cell Cardiol., 123, 180-184, 2018電子ジャーナル
  • Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction.
    Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.
    Proc Natl Acad Sci U S A., 115, 4507-4512, 2018電子ジャーナル
  • Angiotensin II activates CaV1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
    Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
    J Physiol. (Lond.), 595, 4207-4225, 2017電子ジャーナル
  • Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.
    Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y.
    J Mol Cell Cardiol., 81, 139-149, 2015
  • TRPM4 Channels Mediate Hypertonicity-induced, Ca2+-impermeable, Non-selective Cation Currents in a Cervical Cancer Cell Line, HeLa Cells.
    Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M.
    Shinshu Med J., 62, 33-44, 2014
  • Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts.
    Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.
    Biol Pharm Bull., 37, 1168-1176, 2014
  • Cardiac overexpression of constitutively active Galpha q Causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
    Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M.
    PLoS One., 9, e106354, 2014
  • Beta2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.
    Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongo M, Yamada M.
    Eur J Pharmacol., 724, 122-131, 2014WebofScienceリポジトリ電子ジャーナル
  • Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
    Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
    Hypertension., 6, 341-351, 2013
  • Nicorandil prevents Galphaq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
    Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M.
    PLoS One., 7, e52667, 2012
  • KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models.
    Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M.
    J Pharmacol Exp Ther., 342, 288-296, 2012
  • Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
    Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M.
    Am J Physiol Heart Circ Physiol., 302, H1645-H1654, 2012WebofScience電子ジャーナル
  • The proximal C-terminus of 1C subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.
    Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M.
    Biochem J., 448, 221-231, 2012WebofScienceリポジトリ電子ジャーナル
  • Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation.
    Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
    Eur J Pharmacol., 685, 15-23, 2012WebofScienceリポジトリ電子ジャーナル
  • Diacylglycerol kinase zeta inhibits ventricular tachyarrhythmias in a mouse model of heart failure.
    Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M.
    Circ J., 75, 2333-2342, 2011
  • Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells.
    Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M.
    Shinshu Med J., 59, 13-26, 2011
  • Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
    Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M.
    Int J Cardiol., 146, 37-43, 2011
  • Acid-sensing ion channels in blood volume regulation.
    Yamada M.
    Circ J., 75, 781-782, 2011
  • Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
    Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M.
    Am J Physiol Heart Circ Physiol., 300, H978-H988, 2011電子ジャーナル
  • Selective alpha1A-adrenoceptor stimulation induces Mueller's smooth muscle contraction in an isolated canine upper eyelid preparation.
    Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
    Curr Eye Res, 35, 363-369, 2010WebofScienceリポジトリ電子ジャーナル
  • Mitochondrial ATP-sensitive K+ channels, protectors of the heart.
    Yamada M.
    J Physiol. (Lond.), 588, 283-286, 2010WebofScienceリポジトリ電子ジャーナル
  • Diacylglycerol kinase zeta inhibits Galphsq-induced atrial remodeling in transgenic mice.
    Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
    Heart Rhythm., 6, 78-84, 2009
  • Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding.
    Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga J, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I.
    Am J Physiol Endocrinol Metab., 297, E1115-E1124, 2009
  • Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
    Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
    Basic Clin Pharmacol Toxicol., 102, 504-514, 2008
  • MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species.
    Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U.
    Cardiovasc Res., 78, 554-562, 2008WebofScienceリポジトリ電子ジャーナル
  • Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes.
    Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
    J Membr Biol., 222, 151-166, 2008WebofScienceリポジトリ電子ジャーナル
  • Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant.
    Hosaka Y, Iwata M, Kamiya N, Yamada M, Kinoshita K, Fukunishi Y, Tsujimae K, Hibino H, Aizawa Y, Inanobe A, Nakamura H, Kurachi Y.
    Channels (Austin)., 1, 198-208, 2007
  • Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein.
    Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M.
    Circ J., 71, 1805-1814, 2007WebofScienceリポジトリ電子ジャーナル
  • Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action.
    Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y.
    Biochem J., 385, 65-73, 2005
  • A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels.
    Yamada M, Kurachi Y.
    J Mol Cell Cardiol., 39, 1-6, 2005
  • Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.
    Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y.
    J Biol Chem., 279, 44065-44073, 2004
  • Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.
    Tsujimae K, Suzuki S, Yamada M, Kurachi Y.
    Eur J Pharmacol., 493, 29-40, 2004
  • Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.
    Yamada M, Ishii M, Hibino H, Kurachi Y.
    Mol Pharmacol., 66, 807-816, 2004
  • The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels.
    Yamada M, Kurachi Y.
    Mol Pharmacol., 65, 1198-11207, 2004
  • Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type KATP channels.
    Chachin M, Yamada M, Fujita A, Matsuoka T, Matsushita K, Kurachi Y.
    J Pharmacol Exp Ther., 304, 1025-1032, 2003
  • The role of muscarinic K+ channels in the negative chronotropic effect of a muscarinic agonist.
    Yamada M.
    J Pharmacol Exp Ther., 300, 681-687, 2002
  • Beta-adrenergic modulation of prepulse facilitation of L-type calcium channels in rabbit ventricular myocytes.
    Yamada M.
    Pflugers Arch., 444, 89-98, 2002
  • The strongly inwardly rectifying background potassium channel (IK1) in cardiac myocytes is composed of Kir2.2 (IRK2): RT-PCR analysis of single cardiac myocyte mRNA.
    Matsumoto Y, Isomoto S, Saito H, Inanobe A, Hibino H, Chachin M, Yamada M, Horio Y, Kurachi Y.
    Med J Osaka Univ., 44, 15-22, 2001
  • Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes.
    Kitamura H, Yokoyama M, Akita H, Matsushita K, Kurachi Y, Yamada M.
    J Pharmacol Exp Ther., 293, 196-205, 2000
  • Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.
    Chachin M, Katayama Y, Yamada M, Horio Y, Ohmura T, Kitagawa H, Uchida S, Kurachi Y.
    Eur J Pharmacol., 374, 457-460, 1999
  • Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels.
    Kondo C, Repunte VP, Satoh E, Yamada M, Horio Y, Matsuzawa Y, Pott L, Kurachi Y.
    Recept Channels., 6, 129-140, 1998
  • Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.
    Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt MA, Oka Y.
    Diabetes., 47, 476-481, 1998
  • The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells.
    Okuyama Y, Yamada M, Kondo C, Satoh E, Isomoto S, Shindo T, Horio Y, Kitakaze M, Hori M, Kurachi Y.
    Pflugers Arch., 435, 595-603, 1998
  • Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.
    Satoh E, Yamada M, Kondo C, Repunte VP, Horio Y, Iijima T, Kurachi Y.
    J Physiol. (Lond.), 511, 663-674, 1998
  • SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
    Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y.
    Br J Pharmacol., 124, 985-991, 1998
  • G protein regulation of potassium ion channels.
    Yamada M, Inanobe A, Kurachi Y.
    Pharmacol Rev., 50, 723-760, 1998
  • Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.
    Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Satoh E, Hata Y, Takai Y, Kurachi Y.
    J Biol Chem., 272, 12885-12888, 1997
  • Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Muller cell membrane: their regulation by insulin and laminin signals.
    Ishii M, Horio Y, Tada Y, Hibino H, Inanobe A, Ito M, Yamada M, Gotow T, Uchiyama Y, Kurachi Y.
    J Neurosci., 17, 7725-7735, 1997
  • Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
    Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y.
    J Physiol. (Lond.), 499, 715-720, 1997
  • An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4. 1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential.
    Hibino H, Horio Y, Inanobe A, Doi K, Ito M, Yamada M, Gotow T, Uchiyama Y, Kawamura M, Kubo T, Kurachi Y.
    J Neurosci., 17, 4711-4721, 1997
  • Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6.
    Isomoto S, Horio Y, Matsumoto S, Kondo C, Yamada M, Gilbert DJ, Copeland NG, Jenkins NA, Kurachi Y.
    Mamm Genome., 8, 790-791, 1997
  • Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system.
    Isomoto S, Yamada M, Horio Y, Kurachi Y.
    Jpn J Physiol., 47 Suppl., S4-S6, 1997
  • A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Spectral analysis of the effect of GTP on single-channel kinetics.
    Hosoya Y, Yamada M, Ito H, Kurachi Y.
    J Gen Physiol., 108, 485-495, 1996
  • A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes.
    Isomoto S, Kondo C, Takahashi N, Matsumoto S, Yamada M, Takumi T, Horio Y, Kurachi Y.
    Biochem Biophys Res Commun., 218, 286-291, 1996
  • A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
    Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y.
    J Biol Chem., 271, 24621-24324, 1996
  • Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kir1.1f).
    Kondo C, Isomoto S, Matsumoto S, Yamada M, Horio Y, Yamashita S, Takemura-Kameda K, Matsuzawa Y, Kurachi Y.
    FEBS Lett., 399, 122-126, 1996
  • Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line.
    Yamashita T, Horio Y, Yamada M, Takahashi N, Kondo C, Kurachi Y.
    J Physiol. (Lond.), 493, 143-156, 1996
  • Specialized release zones in chromaffin cells examined with pulsed-laser imaging.
    Robinson IM, Yamada M, Carrion-Vazquez M, Lennon VA, Fernandez JM.
    Cell Calcium., 20, 181-201, 1996
  • Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1
    Inanobe A, Morishige KI, Takahashi N, Ito H, Yamada M, Takumi T, Nishina H, Takahashi K, Kanaho Y, Katada T, et al.
    Biochem Biophys Res Commun., 212, 1022-1028, 1995
  • Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart.
    Takahashi N, Morishige K-I, Yamada M, Takumi T, Kurachi Y.
    Heart Vessels., Supple. 9, 8-11, 1995
  • A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.
    Takumi T, Ishii T, Horio Y, Morishige K, Takahashi N, Yamada M, Yamashita T, Kiyama H, Sohmiya K, Nakanishi S, et al.
    J Biol Chem., 270, 16339-16346, 1995
  • Spermine gates inward-rectifying muscarinic but not ATP-sensitive K+ channels in rabbit atrial myocytes. Intracellular substance-mediated mechanism of inward rectification.
    Yamada M, Kurachi Y.
    J Biol Chem., 270, 9289-9294, 1995
  • Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.
    Takahashi N, Morishige K, Jahangir A, Yamada M, Findlay I, Koyama H, Kurachi Y.
    J Biol Chem., 269, 23274-23279, 1994
  • Muscarinic K+ channels are activated by beta gamma subunits and inhibited by the GDP-bound form of alpha subunit of transducin.
    Yamada M, Ho YK, Lee RH, Kontanill K, Takahashill K, Katadall T, Kurachi Y.
    Biochem Biophys Res Commun., 200, 1484-1490, 1994
  • Regulation of potassium channels by G-protein subunits and arachidonic acid metabolites.
    Yamada M, Terzic A, Kurachi Y.
    Methods Enzymol., 238, 394-422, 1994
  • Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel.
    Morishige K, Takahashi N, Jahangir A, Yamada M, Koyama H, Zanelli JS, Kurachi Y.
    FEBS Lett., 346, 251-256, 1994
  • GK* and brain Gbg activate muscarinic K+ channel through the same mechanism.
    Yamada M, Jahangir A, Hosoya Y, Inanobe A, Katada T, Kurachi Y.
    J Biol Chem., 268, 24551-24554, 1993
  • YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes.
    Yamada M, Terzic A, Findlay I, Jahangir A, Shen WK, Kurachi Y.
    J Pharmacol Exp Ther., 267, 1544-1549, 1993
  • Cardiovascular profile of E4080 and its analogue ER001533: Novel potassium channel openers with bradycardiac properties.
    Terzic A, Tung RT, Shen WK, Yamada M, Kurachi Y.
    Drug Rev., 11, 223-233, 1993
  • P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes.
    Yamada M, Hamamori Y, Akita H, Yokoyama M.
    Circ Res., 70, 477-485, 1992
  • Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.
    Inoue N, Hirata K, Yamada M, Hamamori Y, Matsuda Y, Akita H, Yokoyama M.
    Circ Res., 71, 1410-1421, 1992
  • 5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
    Hamamori Y, Yokoyama M, Yamada M, Akita Makin, Goshima K, Fukuzaki H.
    Circ Res., 66, 1474-1483, 1990

Books and other publications

  • 熱血 循環器学 洋學社 井上信孝編集
    山田充彦, 新しい小児心不全治療薬の開発をめざして
    洋學社, 1-15 2019
  • 倉智 嘉久編:別冊・医学のあゆみイオンチャネル最前線update
    山田充彦, ヌクレオチドと薬物による心血管系ATP感受性K+チャネル活性化の分子機構
    医歯薬出版株式会社,東京, pp 101-107 2005

Lectures, oral presentations, etc.

  • 神経障害性疼痛へのHCN チャネルの関与
    山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、中村博之、清沢研一、川真田樹人
    第100回日本生理学会大会, 15 Mar. 2023
  • 心不全治療薬としてのレニン・アンジオテンシン・アルドステロン系抑制薬:その薬理と臨床(基礎編)
    山田充彦
    第96回日本薬理学会年会, 03 Dec. 2022, Invited
  • Molecular Mechanism underlying Initiation & Maturation of Heartbeat
    Mitsuhiko Yamada, Tomoe Nakamura-Nishitani
    第99回日本生理学会大会, 17 Mar. 2022
  • 低分子βアレスチンバイアスAT1受容体アゴニストの開発
    山田充彦、小松弘嗣
    第95回日本薬理学会年会, 07 Mar. 2022
  • T1アンジオテンシン受容体を利用した新たな胎児・新生児心不全治療法の開発
    山田充彦
    日本胎児心臓病学会第28回学術集会, 18 Feb. 2022, Invited
  • Cardiac AT Receptor/β-Arrestin Pathway is a Neonatal-Specific Druggable Target for Pediatric Heart Failure
    Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Yuji Shiba, Sachio Morimoto
    Experimental Biology 2021, 27 Apr. 2021
  • Cardiac AT1 receptor/-arrestin pathway is a neonatal-specific druggable target for pediatric heart failure.
    Mitsuhiko Yamada
    CVMV2021, 12 Mar. 2021
  • Cardiac AT1 receptor/-arrestin axis is a novel druggable target for pediatric heart failure
    Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto
    The 12th Annual Meeting of Japanese Safety Pharmacology Society, 12 Mar. 2021, Invited
  • 小児疾患治療薬の新たな薬物標的の探索
    山田充彦
    第94回日本薬理学会年会, 09 Mar. 2021
  • Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes.
    Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Mitsuhiko Yamada
    NIPS International Meeting on Cardiovascular Physiology 2020, 25 Dec. 2020
  • 小児心不全では、AT1アンジオテンシン受容体を抑制すべきか刺激すべきか?
    山田充彦
    第56回日本小児循環器学会総会・学術集会, 24 Nov. 2020
  • Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression.
    Yamada, M.
    The 11th Annual Meeting of Japanese Safety Pharmacology Society, 28 Feb. 2020, Invited
  • 新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
    川岸裕幸、Maite LARRA AGA、冨田(沼賀)拓郎、中田勉、山田充彦
    筋生理の集い, 21 Dec. 2019
  • A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation.
    Yamada, M.
    The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology, 04 Dec. 2019
  • βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
    川岸裕幸、柏原俊英、中田勉、冨田拓郎、山田充彦
    第29回日本循環薬理学会, 29 Nov. 2019
  • 心室筋活動電位内でのL型Ca2+電流波形を決定する分子機構の検討
    山田充彦、西村仁志、柏原俊英
    学術セミナー「分子から個体へ:俯瞰と接近の生命科学」, 18 Oct. 2019
  • Molecular mechanisms underlying the agonistic effect of FPL64176 on CaV1.2 Ca2+ channels
    冨田拓郎、五味志文、柏原俊英、中田勉、山田充彦
    第141回日本薬理学会関東部会, 12 Oct. 2019
  • 除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加
    中田勉、小松雅俊、山田充彦
    第66回中部日本生理学会, 04 Oct. 2019
  • 小胞体CaセンサーSTIM1によるCav1.2チャネル制御機構の解明
    冨田拓郎、高橋弘毅、山田充彦
    第66回中部日本生理学会, 04 Oct. 2019
  • マウス心筋細胞の生下後の機能的最終分化のメカニズムの解析
    川岸裕幸、中田勉、山田充彦
    第140回日本薬理学会関東部会, 06 Jul. 2019
  • Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction.
    Nakada, T., Kashihara, T., Komatsu, M., Yamada, M.
    FAOPS 2019, 29 Mar. 2019
  • EP4 receptor-mediated augmentation of Ih currents in A DRG neurons underlies neuropathic pain.
    Yamada, M., Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M.
    FAOPS 2019, 29 Mar. 2019
  • マウス個体を用いた心筋細胞成熟化因子の同定
    川岸裕幸、中田勉、山田充彦
    第92回日本薬理学会年会, 16 Mar. 2019
  • プロスタノイドEP4受容体を介する後根神経節A細胞のIh電流増強による神経障害性疼痛の発症
    山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、清沢研吉、川眞田樹人
    第92回日本薬理学会年会, 15 Mar. 2019
  • c-Srcによる全長型CaV1.2サブユニットを有するL型Ca2+チャネルの活性を介したPDGFによる増殖型血管平滑筋細胞の遊走
    中田勉、郭暁光、柏原俊英、青山俊文、山田充彦
    第92回日本薬理学会年会, 15 Mar. 2019
  • Molecular mechanisms underlying spatiotemporal regulation of L-type Ca2+ channels in muscles. Logic of life: ion channel structure, function and physiology.
    Yamada, M.
    International commemorative symposium in celebration of retirement of Professor Yoshihisa Kurachi, 13 Mar. 2019
  • G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
    稲住 英明, 桑原 宏一郎, 桑原 佳宏, 中川 靖章, 木下 秀之, 錦見 俊雄, 呉林 なごみ, 山田 充彦, 柏原 俊英, 中尾 一和, 木村 剛
    日本臨床分子医学会学術総会プログラム・抄録集 55回 51, Apr. 2018
  • HFpEFにおける心筋興奮収縮連関の変化
    山田 充彦, Kashihara Toshihide
    日本循環器学会学術集会抄録集 81回 TP7-4, Mar. 2017

Courses

  • Pharmacology
    Shinshu University
  • Pharmacology
    Shinshu University
  • 器官・組織・細胞機能研究方法特論
    Shinshu University

Affiliated academic society

  • The American Physiological Society
  • Physiological Society of Japan
  • The Japanese Circulation Society
  • The Japanese Society of Electrocardiology
  • Biophysical Society

Research Themes

  • Application of a beta-arrestin-biased agonist, TRV027 to pediatric heart failure
    共同研究, Trevena Inc.
    26 Jul. 2021
  • 生下後の心筋分化誘導因子の同定:インビトロ心筋最終分化誘導法の開発
    科学研究費補助金, 基盤研究(C)
    01 Apr. 2018 - 31 Mar. 2020
  • AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
    ファイザー株式会社
    2018
  • サルコペニアにおいて筋⼒低下が⽣じるメカニズムの解明
    MSD株式会社
    2018
  • βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
    塩野義製薬
    2018
  • ⼩児⼼不全の新しい薬物療法の開発
    第一三共株式会社
    2018
  • ⼩児⼼不全の新しい治療法の開発
    アステラス製薬
    2018
  • βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
    バイエル薬品株式会社
    2018
  • ⼩児⼼不全の新しい治療法の開発
    ブリストル・マイヤーズ スクイブ株式会社
    2018
  • βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
    バイエル薬品株式会社
    2017
  • ⼩児⼼不全の新しい薬物療法の開発
    第一三共株式会社
    2017
  • AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
    ファイザー株式会社
    2017
  • βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
    塩野義製薬
    2017
  • βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
    武田薬品工業株式会社
    2017
  • AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
    ファイザー株式会社
    2016
  • 心不全の心室筋細胞でのL型Ca2+チャネルのリモデリングに関する研究
    アステラス製薬
    2016
  • L型カルシウムチャネル阻害薬の開口状態親和性の定量的解析と阻害薬作用のモデル化
    科学研究費補助金, 基盤研究(C)
    2009 - 2011
  • Gqマウス心不全モデルを用いたニコランジルの心筋繊維化への抑制効果
    受託研究, 中外製薬(株)
    2008 - 2009
  • 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
    受託研究, 小野薬品工業(株)
    2008 - 2009
  • イオンチャネルとトランスポーターのクロストークに関するkrん旧
    受託研究, キッセイ薬品工業(株)
    2007 - 2009
  • 虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
    受託研究, 中外製薬(株)
    2007 - 2008
  • 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
    受託研究, 小野薬品工業(株)
    2007 - 2008
  • イヌ虚血心室筋の頻拍性不整脈発生に対するニコランジルの保護効果
    受託研究, 中外製薬(株)
    2006 - 2007
  • 新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
    受託研究, 小野薬品工業(株)
    2006 - 2007
  • 虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
    受託研究, 中外製薬(株)
    2005 - 2006
  • 薬物によるATP感受性K+チャネルの活性調節機構の立体構造基盤の解明
    科学研究費補助金, 基盤研究(C)
    2004 - 2006
  • 薬物によるATP感受性K+チャネルの活性調節機構の立体構造基盤の解明
    科学研究費補助金, 基盤研究(C)
    2004 - 2006
  • 副交感性心拍調節におけるムスカリン性Kチャネルの役割の検討
    科学研究費補助金, 基盤研究(C)
    2000 - 2002
  • 心筋細胞の再生療法に関する研究:心筋細胞の電気生理学的分化とその制御因子の同定
    2000 - 2002
  • カルシウムチャネルによる心・血管細胞収縮調節機構とその異常
    1999 - 2001
  • 動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K+チャネル
    科学研究費補助金, 特定領域研究A
    1997 - 1998
  • 内向き整流カリウムチャネルのポリアミン受容体の解析と新しい潜在的薬物作用点の検討
    科学研究費補助金, 一般研究B
    1996 - 1997
  • 内向き整流カリウムチャネルの細胞内物質によるゲーテイング
    科学研究費補助金, 奨励研究A
    1995 - 1995
  • Physiological, pathophysiological and pharmacological analyses of cardiac L-type Ca2+ channels
  • Development of therapeutics for pediatric heart failure
  • Investigation of the mechanism underlying metanephrogenesis

Social Contribution Activities

  • 市民公開講座:心不全の予防・診療・リハビリテーションの最前線
    オンライン, 25 Oct. 2020 - 25 Oct. 2020

Media Coverage

  • ペプチドで小児心不全治療 小児用創薬のヒントに
    日本経済新聞, 07 Dec. 2020
  • 新生児や乳児の心臓 収縮力を高める仕組み解明
    信濃毎日新聞, 30 Nov. 2020

Academic Contribution Activities

  • 生理研研究会「心血管研究会」
    Planning etc
    松本, 13 Oct. 2022 - 14 Oct. 2022
  • Planning etc
    生理研研究会「心血管研究会」, オンライン, 18 Nov. 2021 - 19 Nov. 2021
  • Planning etc
    第143回日本薬理学会関東部会, オンライン, 24 Oct. 2020 - 24 Oct. 2020
  • Planning etc
    第26回日本循環薬理学会, 信州大学医学部附属病院外来棟 大会議室他, 02 Dec. 2016 - 02 Dec. 2016