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長瀬 尚志  ナガセ ヒサシ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 病理学FAX番号
職名助教メールアドレス
住所ホームページURL

更新日:2021/09/22

プロフィール

研究分野
感染免疫学
現在の研究課題
寄生虫感染時のTH2分化のメカニズムの解析

所属学会
所属学会
日本免疫学会
学歴
出身大学院
1998 , 東京大学 , 医学研究科
1995 , 東京大学 , 医学研究科

出身学校・専攻等(大学院を除く)
1993 , 東京大学 , 医学部

取得学位
保健学博士 , 東京大学
研究職歴等
研究職歴
1998- , 信州大学 助手

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
Present and future therapies for Alzheimer’s disease, Immunoregulatory Aspects of Immunotherapy , 177
IntechOpen 2018
Author:Hisashi Nagase, Kohzo Nakayama


Amyloid precursor protein: its signaling aspect and Alzheimer's disease., Nova Science Publishers, Inc.
Nova Science Publishers, Inc. 2012
Author:Nakayama K, Nagase H, Koh CS, Ohkawara T.


γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein., Intech Publishers, Inc.
Intech Publishers, Inc. 2011
Author:Nakayama K, Nagase H, Koh CS, Ohkawara T.


論文
Present and Future Therapies in Alzheimer's Disease
,:177-197 2018
Author:長瀬尚志 中山耕三


γ-Secretase-regulated signaling: Notch, APP and Alzheimer's disease.
Current Psychopharmacology,1:155-166 2012
Author:Nakayama K, Nagase H, Koh CS, Ohkawara T.


γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease.
Cellular and Molecular Neurobiology,31:887 2011
Author:Nakayama K, Nagase H, Koh CS, Ohkawara T.


The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.
Gene,475:1 2011
Author:Ohkawara T, Nagase H, Koh CS, Nakayama K.


γ-secretase-regulated signaling pathways, such as Notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses.
Current Stem Cell Research and Therapy,6:131 2011
Author:Nagase H, Koh CS, Nakayama K.


Do similar mechanisms regulated by γ-secretase play a potential role in signaling events involving type 1 transmembrane proteins including Notch, Delta andAPP?
Research Advances in Nucleic Acids Research,3:55 2009
Author:Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.


Similar mechanisms regulated by γ-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
Current Stem Cell Research and Therapy,3:288 2008
Author:Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.


The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.
Neuroscience Letters,444:127 2008
Author:Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H.


Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.
Journal of Immunology,179:2435 2007
Author:Nagase H, Jones KM, Anderson CF, Noben-Trauth N.


The Delta intracellular domain mediates TGFβ/ Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.
Nucleic Acids Research,35:912 2007
Author:Hiratochi M, Nagase H, Kuramochi Y, Koh CS, Ohkawara T, Nakayama K.


The different process of class switching and somatic hypermutation; a novel analysis by CD27- naive B cells
Blood,99(2):567-575 2002
Author:Nagumo H, Agematsu K, Kobayashi N, Shinozaki K, Hokibara S, Nagase H, Takamoto M, Yasui K, Sugane K, and Komiyama A


Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor
Exp Lung Res,28(2):123-139 2002
Author:Tsukadaira A, Okubo Y, Koyama S, Sato E,Nagase H, Agematsu K, Nakazawa K


Characterization of mouse mammary tumour virus-induced migration of lymphoid cells into lymph nodes
SCANDINAVIAN JOURNAL OF IMMUNOLOGY,53(6):553-562 2001
Author:Matsuzawa, A; Yasuda, T; Sakamoto, S; Nagase, H; Nakano, H; Yoshimoto, T


Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
CLINICAL IMMUNOLOGY,100(2):250-259 2001
Author:Nagase, H; Agematsu, K; Kitano, K; Takamoto, M; Okubo, Y; Komiyama, A; Sugane, K


Immunological characterization of C3H mice congenic for Fas(lprcg), C3H/HeJ-Fas(lprcg)/Fas(lprcg)
LABORATORY ANIMALS,34(1):46-55 2000
Author:Yasuda, T; Zhang, Y; Nagase, H; Kaneko, T; Sayama, K; Hashimoto, H; Matsuzawa, A


Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4
IMMUNOLOGY,100(3):309-316 2000
Author:Wang, CR; Hino, A; Yoshimoto, T; Nagase, H; Kato, T; Hirokawa, K; Matsuzawa, A; Nariuchi, H


A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice
CLINICAL AND EXPERIMENTAL IMMUNOLOGY,122(1):124-132 2000
Author:Zhang, Y; Yasuda, T; Wang, CR; Yoshimoto, T; Nagase, H;Takamoto, M; Tsubura, A; Kimura, M; Matsuzawa, A