NAGASE HISASHI
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Assistant Professor
Researcher Information
Research activity information
Paper
- Present and Future Therapies in Alzheimer's Disease
Hisashi Nagase, Kohzo Nakayama
Immunoregulatory Aspects of Immunotherapy, 177-197, 2018 - γ-Secretase-regulated signaling: Notch, APP and Alzheimer's disease.
Nakayama K, Nagase H, Koh CS, Ohkawara T.
Current Psychopharmacology, 1, 155-166, 2012 - γ-secretase-regulated signaling pathways, such as Notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses.
Nagase H, Koh CS, Nakayama K.
Current Stem Cell Research and Therapy, 6, 131, 2011 - The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.
Ohkawara T, Nagase H, Koh CS, Nakayama K.
GENE, 475, 1, 2011 - γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease.
Nakayama K, Nagase H, Koh CS, Ohkawara T.
Cellular and Molecular Neurobiology, 31, 887, 2011
- Do similar mechanisms regulated by γ-secretase play a potential role in signaling events involving type 1 transmembrane proteins including Notch, Delta andAPP?
Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.
Research Advances in Nucleic Acids Research, 3, 55, 2009 - The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.
Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H.
NEUROSCIENCE LETTERS, 444, 127, 2008 - Similar mechanisms regulated by γ-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.
Current Stem Cell Research and Therapy, 3, 288, 2008 - The Delta intracellular domain mediates TGFβ/ Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.
Hiratochi M, Nagase H, Kuramochi Y, Koh CS, Ohkawara T, Nakayama K.
Nucleic Acids Research, 35, 912, 2007 - Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.
Nagase H, Jones KM, Anderson CF, Noben-Trauth N.
JOURNAL OF IMMUNOLOGY, 179, 2435, 2007 - Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor
Tsukadaira A, Okubo Y, Koyama S, Sato E,Nagase H, Agematsu K, Nakazawa K
Exp Lung Res, 28(2), 123-139, 2002 - The different process of class switching and somatic hypermutation; a novel analysis by CD27- naive B cells
Nagumo H, Agematsu K, Kobayashi N, Shinozaki K, Hokibara S, Nagase H, Takamoto M, Yasui K, Sugane K, and Komiyama A
BLOOD, 99(2), 567-575, 2002 - Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Nagase, H; Agematsu, K; Kitano, K; Takamoto, M; Okubo, Y; Komiyama, A; Sugane, K
Clinical Immunology, 100(2), 250-259, 2001 - Characterization of mouse mammary tumour virus-induced migration of lymphoid cells into lymph nodes
Matsuzawa, A; Yasuda, T; Sakamoto, S; Nagase, H; Nakano, H; Yoshimoto, T
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 53(6), 553-562, 2001 - A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice
Zhang, Y; Yasuda, T; Wang, CR; Yoshimoto, T; Nagase, H;Takamoto, M; Tsubura, A; Kimura, M; Matsuzawa, A
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 122(1), 124-132, 2000 - Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4
Wang, CR; Hino, A; Yoshimoto, T; Nagase, H; Kato, T; Hirokawa, K; Matsuzawa, A; Nariuchi, H
IMMUNOLOGY, 100(3), 309-316, 2000 - Immunological characterization of C3H mice congenic for Fas(lprcg), C3H/HeJ-Fas(lprcg)/Fas(lprcg)
Yasuda, T; Zhang, Y; Nagase, H; Kaneko, T; Sayama, K; Hashimoto, H; Matsuzawa, A
LABORATORY ANIMALS, 34(1), 46-55, 2000
Books and other publications
- Nova Science Publishers, Inc.
Nakayama K, Nagase H, Koh CS, Ohkawara T., Amyloid precursor protein: its signaling aspect and Alzheimer's disease.
Nova Science Publishers, Inc., 2012Intech Publishers, Inc.
Nakayama K, Nagase H, Koh CS, Ohkawara T., γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein.
Intech Publishers, Inc., 2011
