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太田 正穂  オオタ マサオ

教員組織電話番号
教育組織医学部 医学科 内科学第二FAX番号
職名特任教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2020/10/26

プロフィール

研究分野
DNA多型
血液型学
MHC(主要組織適合性抗原)
分子遺伝学
現在の研究課題
ヒトDNA多型の医学への応用

HLA(ヒト主要組織適合性抗原)と疾患感受性

SNP解析と疾患感受性遺伝子の検索

多因子性遺伝子疾患原因遺伝子のゲノムワイドな解析

所属学会
所属学会
日本法医学会
日本組織適合性学会
日本DNA多型学会
日本実験動物学会
The American Society of Human Genetics
The American Society for Histocompatibility and Immunogenetics
学歴
出身学校・専攻等(大学院を除く)
1976 , 信州大学 , 工学部

取得学位
医学博士
研究職歴等
研究職歴
2017- , 信州大学医学部特任教授・第Ⅱ内科学教室
2014- , Shinshu University/University of Strasbourg/ Inserm 共同研究員日本代表
2009- , 横浜市立大学医学部客員教授・大学院視覚病態学講座
2004- , INSERM/JSPS 研究員
2002- , INSERM/JSPS 研究員
1998- , INSERM/JSPS 研究員
1991- , 信州大学 講師
1977- , 信州大学 助手

留学歴
1992- , BRI Wisconsin Blood Center USA

研究活動業績

研究業績(著書・
発表論文等)
論文
Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing
J Infect Dis,221(3):400-407 2020(Jan.)
Author:Sakamoto K, Umemura T, Ito K, Okumura A, Joshita S, Ota M, Sugiyama M, Mizokami M, Yoneda M, Tanaka E


KIR/HLA genotypes confer susceptibility and progression in patients with autoimmune hepatitis
JHEP Rep,1(5):353-360 2019(Nov.)
Author:Umemura T, Joshita S, Saito H, Yoshizawa K, Norman GL, Tanaka E, Ota M


Quantitative analysis of serum chemokines associated with treatment failure of direct-acting antivirals in chronic hepatitis C
Cytokine,111:357-363 2018(Oct.)
Author:Umemura T, Yamazaki T, Joshita S, Sugiura A, Fujimori N, Matsumoto A, Ota M, Tanaka E


A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis
Sci Rep,8(1):11924 2018(Aug.)
Author:Yamazaki T, Umemura T, Joshita S, Yoshizawa K, Tanaka E, Ota M


Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis
Sci Rep,8(1):8159 2018(May)
Author:Joshita S, Umemura T, Usami Y, Yamashita Y, Norman GL, Sugiura A, Yamazaki T, Fujimori N, Kimura T, Matsumoto A, Igarashi K, Yoshizawa K, Ota M, Tanaka E


KIR2DL2 combined with HLA-C1 confers risk of hepatitis C virus-related hepatocellular carcinoma in younger patients
Oncotarget,9(28):19650-19661 2018(Apr.)
Author:Saito H, Umemura T, Joshita S, Yamazaki T, Fujimori N, Kimura T, Komatsu M, Matsumoto A, Tanaka E, Ota M


Serum autotaxin is a useful liver fibrosis marker in patients with chronic hepatitis B virus infection
Hepatol Res,48(4):275-285 2018(Mar.)
Author:Joshita S, Ichikawa Y, Umemura T, Usami Y, Sugiura A, Shibata S, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A, Igarashi K, Ota M, Tanaka E


Genetics and epigenetics in the pathogenesis of primary biliary cholangitis
Clin J Gastroenterol,11(1):11-18 2018(Feb.)
Author:Joshita S, Umemura T, Tanaka E, Ota M


Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C
PLoS One,13(4):e0195632 2018
Author:Yamazaki T, Joshita S, Umemura T, Usami Y, Sugiura A, Fujimori N, Kimura T, Matsumoto A, Igarashi K, Ota M, Tanaka E


Association between KIR-HLA combination and ulcerative colitis and Crohn's disease in a Japanese population
PLoS One,13(4):e0195778 2018
Author:Saito H, Hirayama A, Umemura T, Joshita S, Mukawa K, Suga T, Tanaka E, Ota M


Lack of Association of Serotonin 2A Receptor Gene in Japanese Patients with Obstructive Sleep Apnea Syndrome
信州医学雑誌,65(3):153-162 2017(Jun. 10)
Author:Ikegawa K, Ota M, Kobayashi N, Droma Yunden, Yaegashi H, Nishizawa M, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M


Human leukocyte antigen class II haplotypes affect clinical characteristics and progression of type 1 autoimmune hepatitis in Japan.
PLoS One,9(6):e100565 2014
Author:Umemura T, Katsuyama Y, Yoshizawa K, et al.


Genetic polymorphism in IFNL4 and response to pegylated interferon-α and ribavirin in Japanese chronic hepatitis C patients.
Tissue Antigens,83:45-48 2014
Author:Nozawa Y, Umemura T, Katsuyama Y, et al.


STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
DISEASE MARKERS,2014:727393 2014
Author:Joshita, S; Umemura, T; Nakamura, M; Katsuyama, Y; Shibata, S; Kimura, T; Morita, S; Komatsu, M; Matsumoto, A; Yoshizawa, K; Ishibashi, H; Tanaka, E; Ota, M


Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy.
Hepatol Res,43(7):801-807 2013
Author:Joshita S, Shirahata K, Yazaki Y, Okaniwa S, Nakamura Y, Kimura T, Noami S, Horigome R, Yagi H, Ito N, Yamazaki A, Akahane Y, Umemura T, Yoshizawa K, Tanaka E, Ota M


Two siblings with type 1 autoimmune pancreatitis.
Intern Med,52:895-899 2013
Author:Watanabe T, Maruyama M, Ito T, Kanai K, Oguchi T, Muraki T, Hamano H, Arakura N, Ota M, Kawa S


Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.
Hum Immunol,74(2):219-222 2013
Author:Morita S, Joshita S, Umemura T, Katsuyama Y, Kimura T, Komatsu M, Matsumoto A, Yoshizawa K, Kamijo A, Yamamura N, Tanaka E, Ota M.


Genetic Variants in EPAS1 Contribute to Adaptation to High-Altitude Hypoxia in Sherpas.
PLoS One,7(12):e50566 2012
Author:Hanaoka M, Droma Y, Basnyat B, Ito M, Kobayashi N, Katsuyama Y, Kubo K, Ota M


Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection.
Hum Immunol.,73(3):298-300 2012
Author:Joshita S, Umemura T, Katsuyama Y, Ichikawa Y, Kimura T, Morita S, Kamijo A, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Kamijo N, Ota M, Tanaka E.


Human leukocyte antigen class II molecules confer both susceptibility and progression in japanese patients with primary biliary cirrhosis.
Hepatology,55(2):506-511 2012
Author:Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M


Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.
Dis Markers,31(4):223-229 2011
Author:Ota M, Ito T, Umemura T, Katsuyama Y, Yoshizawa K, Hamano H, Kawa S.


Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C.
Antivir Ther.,16(7):1073-1080 2011
Author:Umemura T, Joshita S, Yoneda S, Katsuyama Y, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E


Serum Cytokine Levels are associated with the outcome of pegylated interferon and ribabirin therapy in patients with chronic hepatitis C.
Hepatol Res,41(6):587-593 2011
Author:Yoneda S, Umemura T, Joshita S, Ichijo T, Matsumoto A, Yoshizawa K, Katsuyama Y, Ota M, Tanaka E


Association of Serum Cytokine Levels with Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients.
J Infect Dis.,203(8):1087-1095 2011
Author:Yoneda S, Umemura T, Katsuyama Y, Kamijo A, Joshita S, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E


Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.
J Gastroenterol,46(supp 1):48-55 2011
Author:Umemura T, Zen Y, Hamano H, Joshita S, et al.


Genetic background of autoimmune hepatitis in Japan.
J Gastroenterol,46(supp 1):42-47 2011
Author:Yoshizawa K, Umemura T, Ota M


Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.
Ophthalmology,117:1331-1338 2010
Author:Meguro A, Inoko H, Ota M, Mizuki N, et al.


Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
J Hepatol.,53:537-541 2010
Author:Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, et al.


Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
Nat Genet,42(8):703-706 2010
Author:Mizuki N, Meguro A, Ota M, Ohno S, et al.


Mitochondial DNA Diversity Among Three Subpopulations of Cynomologus Macaques (Macaca fascicularis) Originating from the Indochinese Region.
Exp Anim,59:567-578 2010
Author:Shiina T, Tanaka K, Katsuyama Y, Otabe K, et al.


A Novel Heterophilic Antibody Interaction Involves IgG4
SCANDINAVIAN JOURNAL OF IMMUNOLOGY,71(2):109-114 2010
Author:Ito, T.; Kitahara, K.; Umemura, T.; Ota, M.; Shimozuru, Y.; Kawa, S.; Bahram, S.


A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
HUMAN IMMUNOLOGY,71(5):520-524 2010
Author:Joshita, Satoru; Umemura, Takeji; Yoshizawa, Kaname; Katsuyama, Yoshihiko; Tanaka, Eiji; Ota, Masao


New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3.
Eye,23:222-229 2009
Author:Nishizaki R, Ota M, Inoko H, Meguro A, et al.


Complex divergence at a microsatellite marker C1_2_5 in the lineage of HLA-Cw/-B haplotype.
J Hum Genet,54:224-229 2009
Author:Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse TK, Kimura A.


Restriction enzyme analysis of PCR products.
Methods Mol Biol,578:405-414 2009
Author:Ota M, Asamura H, Oki T, Sada M


Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
HUMAN IMMUNOLOGY,70(9):742-746 2009
Author:Umemura, Takeji; Katsuyama, Yoshihiko; Hamano, Hideaki; Kitahara, Kei; Takayama, Mari; Arakura, Norikazu; Kawa, Shigeyuki; Tanaka, Eiji; Ota, Masao


Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene.
Wilderness Environ Med,19:22-29 2008
Author:Droma Y, Hanaoka M, Basnyat B, Arjyal A, et al.


Association of autoimmune pancreatitis with cyotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients.
Am J Gastroenterol,103:533-534 2008
Author:Umemura T, Ota M, Hamano H, Katsuyama Y, et al.


Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.
Hepatol Res,38:689-695 2008
Author:Umemura T, Ota M, Yoshizawa K, Katsuyama Y, et al.


Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease.
Ann Rheum Dis,67:725-727 2008
Author:Meguro A, Ota M, Katsuyama Y, Oka A, et al.


Human Endogenous Retrovirus (HERVK9) Structural Polymorphism with Haplotypic HLA-A Allelic Associations.
Genetics,180:445-457 2008
Author:Kulski JK, Shigenari A, Shiina T, Ota M, et al.


The Association of Transforming Growth Factor Beta 1 Gene Polymorphisms with the Emphysema Phenotype of COPD in Japanese.
Intern Med,47:1387-1394 2008
Author:Ito M, Hanaoka M, Droma Y, Hatayama O, Sato E, Katsuyama Y, Fujimoto K, Ota M.


Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.
Aviat Space Environ Med,79:1056-1060 2008
Author:Droma Y, Ota M, Hanaoka M, Katsuyama Y, et al.


Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in japanese patients.
Dis Markers,25:175-180 2008
Author:Kitahara K, Kawa S, Katsuyama Y, Umemura T, et al.


A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity
PLOS ONE,3(2):e1637 2008
Author:Kawa, Shigeyuki; Kitahara, Kei; Hamano, Hideaki; Ozaki, Yayoi; Arakura, Norikazu; Yoshizawa, Kaname; Umemura, Takeji; Ota, Masao; Mizoguchi, Sadaaki; Shimozuru, Yasunori; Bahram, Seiamak


Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis..
Immunogenetics,59:45-52 2007
Author:Ota M, Katsuyama Y, Hamano H, Umemura T, et al.


A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1.
Hepatology,45:384-390 2007
Author:Yokosawa S, Yoshizawa K, Ota M, Katsuyama Y, et al.


Allele frequencies for 15STR loci in Tibetan populations from Nepal.
J Forensic Sci Int.,169:234-238 2007
Author:Ota M, Droma Y, Basnyat B, Katsuyama Y, et al.


Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis
CLINICAL IMMUNOLOGY,122(3):338-342 2007
Author:Umemura, T; Ota, M; Yoshizawa, K; Katsuyama, Y; Ichijo, T; Tanaka, E; Kawa, S; Kiyosawa, K


Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism
NATURE PROTOCOLS,2(11):2857-2864 2007
Author:Ota, M; Fukushima, H; Kulski, JK; Inoko, H


Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients
TISSUE ANTIGENS,70(1-5):423-426 2007
Author:Ito, A; Ota, M; Katsuyama, Y; Inoko, H; Ohno, S; Mizuki, N


The COL1A1 gene and high myopia susceptibility in Japanese
HUMAN GENETICS,122(1-2):151-157 2007
Author:Inamori, Y; Ota, M; Inoko, H; Okada, E; Nishizaki, R; Shiota, T; Mok, J; Oka, A; Ohno, S; Mizuki, N


Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients
GUT,55(9):1367-1368 2006
Author:Umemura, T; Ota, M; Hamano, H; Katsuyama, Y; Kiyosawa, K; Kawa, S


Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis
JOURNAL OF HEPATOLOGY,42(4):578-584 2005
Author:Yoshizawa, K; Ota, M; Katsuyama, Y; Ichijo, T; Matsumoto, A; Tanaka, E; Kiyosawa, K


High prevalence of hypothyroidism in patients with autoimmune pancreatitis
DIGESTIVE DISEASES AND SCIENCES,50(6):1052-1057 2005
Author:Komatsu, K; Hamano, H; Ochi, Y; Takayama, M; Muraki, T; Yoshizawa, K; Sakurai, A; Ota, M; Kawa, S

教育活動実績

授業等
2002 , 法医学
2002 , 免疫遺伝学