OTA MASAO

School of Medicine Department of Medicine 

Professor 

Researcher Information

Degree

  • Doctor of Medicine

Field Of Study

  • DNA polymorphism

Educational Background

  • 1976, Shinshu University, Faculty of Engineering
Research activity information

Paper

  • Quantitative changes of lipoprotein(a) in chronic hepatitis C patients achieving a sustained virological response by direct-acting antivirals
    Okumura T, Joshita S, Sugiura A, Ota M, Umemura T
    Clin Res Hepatol Gastroenterol, 46(8), 102011, Aug. 2022
  • The levels of IL-1beta and soluble IL-1 receptors in patients with IgG4-related periaortitis/periarteritis
    Ashihara N, Ota M, Fujinaga Y, Ozawa M, Kuraishi Y, Watanabe T, Hamano H, Joshita S, Kawa S, Umemura T
    Adv Med Sci, 67(2), 257-261, Jul. 2022
  • IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease
    Umemura T, Fujinaga Y, Ashihara N, Ozawa M
    GENE, 820, 146212, Feb. 2022
  • Association analysis of KIR/HLA genotype with liver cirrhosis, hepatocellular carcinoma, and NUC freedom in chronic hepatitis B patients
    Joshita S, Ota M, Kobayashi H, Wakabayashi SI, Yamashita Y, Sugiura A, Yamazaki T, Tanaka E, Umemura T
    Sci Rep, 11(1), 21424, Nov. 2021
  • Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals
    Joshita S, Yamashita Y, Okamoto T, Usami Y, Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T, Umemura T
    Hepatol Res, 51(7), 758-766, Jul. 2021
  • Investigation of the Effect of KIR-HLA Pairs on Hepatocellular Carcinoma in Hepatitis C Virus Cirrhotic Patients
    Umemura T, Joshita S, Saito H, Wakabayashi SI, Kobayashi H, Yamashita Y, Sugiura A, Yamazaki T, Ota M
    Cancers (Basel), 13(13), 3267, Jul. 2021
    Last
  • Polymorphism at rs9264942 is associated with HLA-C expression and inflammatory bowel disease in the Japanese
    Suzuki H, Joshita S, Hirayama A, Shinji A, Mukawa K, Sako M, Yoshimura N, Suga T, Umemura T, Ashihara N, Yamazaki T, Ota M
    Sci Rep, 10(1), 12424, 24 Jul. 2020
    Last
  • Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing
    Sakamoto K, Umemura T, Ito K, Okumura A, Joshita S, Ota M, Sugiyama M, Mizokami M, Yoneda M, Tanaka E
    J Infect Dis, 221(3), 400-407, Jan. 2020
  • KIR/HLA genotypes confer susceptibility and progression in patients with autoimmune hepatitis
    Umemura T, Joshita S, Saito H, Yoshizawa K, Norman GL, Tanaka E, Ota M
    JHEP Rep, 1(5), 353-360, Nov. 2019
  • Quantitative analysis of serum chemokines associated with treatment failure of direct-acting antivirals in chronic hepatitis C
    Umemura T, Yamazaki T, Joshita S, Sugiura A, Fujimori N, Matsumoto A, Ota M, Tanaka E
    CYTOKINE, 111, 357-363, Oct. 2018
  • A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis
    Yamazaki T, Umemura T, Joshita S, Yoshizawa K, Tanaka E, Ota M
    Sci Rep, 8(1), 11924, Aug. 2018
  • Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis
    Joshita S, Umemura T, Usami Y, Yamashita Y, Norman GL, Sugiura A, Yamazaki T, Fujimori N, Kimura T, Matsumoto A, Igarashi K, Yoshizawa K, Ota M, Tanaka E
    Sci Rep, 8(1), 8159, May 2018
  • KIR2DL2 combined with HLA-C1 confers risk of hepatitis C virus-related hepatocellular carcinoma in younger patients
    Saito H, Umemura T, Joshita S, Yamazaki T, Fujimori N, Kimura T, Komatsu M, Matsumoto A, Tanaka E, Ota M
    Oncotarget, 9(28), 19650-19661, Apr. 2018
  • Serum autotaxin is a useful liver fibrosis marker in patients with chronic hepatitis B virus infection
    Joshita S, Ichikawa Y, Umemura T, Usami Y, Sugiura A, Shibata S, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A, Igarashi K, Ota M, Tanaka E
    Hepatol Res, 48(4), 275-285, Mar. 2018
  • Genetics and epigenetics in the pathogenesis of primary biliary cholangitis
    Joshita S, Umemura T, Tanaka E, Ota M
    Clin J Gastroenterol, 11(1), 11-18, Feb. 2018
  • Association between KIR-HLA combination and ulcerative colitis and Crohn's disease in a Japanese population
    Saito H, Hirayama A, Umemura T, Joshita S, Mukawa K, Suga T, Tanaka E, Ota M
    PLOS ONE, 13(4), e0195778, 2018
  • Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C
    Yamazaki T, Joshita S, Umemura T, Usami Y, Sugiura A, Fujimori N, Kimura T, Matsumoto A, Igarashi K, Ota M, Tanaka E
    PLOS ONE, 13(4), e0195632, 2018
  • Lack of Association of Serotonin 2A Receptor Gene in Japanese Patients with Obstructive Sleep Apnea Syndrome
    Ikegawa K, Ota M, Kobayashi N, Droma Yunden, Yaegashi H, Nishizawa M, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M
    信州医学雑誌, 65(3), 153-162, 10 Jun. 2017リポジトリ
  • Genetic polymorphism in IFNL4 and response to pegylated interferon-α and ribavirin in Japanese chronic hepatitis C patients.
    Nozawa Y, Umemura T, Katsuyama Y, et al.
    Tissue Antigens, 83, 45-48, 2014
  • STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
    Joshita, S; Umemura, T; Nakamura, M; Katsuyama, Y; Shibata, S; Kimura, T; Morita, S; Komatsu, M; Matsumoto, A; Yoshizawa, K; Ishibashi, H; Tanaka, E; Ota, M
    DISEASE MARKERS, 2014, 727393, 2014WebofScienceリポジトリ電子ジャーナル
  • Human leukocyte antigen class II haplotypes affect clinical characteristics and progression of type 1 autoimmune hepatitis in Japan.
    Umemura T, Katsuyama Y, Yoshizawa K, et al.
    PLOS ONE, 9(6), e100565, 2014WebofScienceリポジトリ電子ジャーナル
  • Polymorphisms of the Tissue Inhibitor of Metalloproteinase 3 Gene Are Associated with Resistance to High-Altitude Pulmonary Edema (HAPE) in a Japanese Population: A Case Control Study Using Polymorphic Microsatellite Markers.
    Kobayashi N, Hanaoka M, Droma Y, Ito M, Katsuyama Y, Kubo K, Ota M
    PLoS One., 8, e71993, 2013
  • Two siblings with type 1 autoimmune pancreatitis.
    Watanabe T, Maruyama M, Ito T, Kanai K, Oguchi T, Muraki T, Hamano H, Arakura N, Ota M, Kawa S
    Intern Med, 52, 895-899, 2013WebofScienceリポジトリ電子ジャーナル
  • Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy.
    Joshita S, Shirahata K, Yazaki Y, Okaniwa S, Nakamura Y, Kimura T, Noami S, Horigome R, Yagi H, Ito N, Yamazaki A, Akahane Y, Umemura T, Yoshizawa K, Tanaka E, Ota M
    Hepatol Res, 43(7), 801-807, 2013WebofScienceリポジトリ電子ジャーナル
  • Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.
    Morita S, Joshita S, Umemura T, Katsuyama Y, Kimura T, Komatsu M, Matsumoto A, Yoshizawa K, Kamijo A, Yamamura N, Tanaka E, Ota M.
    Hum Immunol, 74(2), 219-222, 2013WebofScienceリポジトリ電子ジャーナル
  • Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection.
    Joshita S, Umemura T, Katsuyama Y, Ichikawa Y, Kimura T, Morita S, Kamijo A, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Kamijo N, Ota M, Tanaka E.
    Hum Immunol., 73(3), 298-300, 2012WebofScienceリポジトリ電子ジャーナル
  • Human leukocyte antigen class II molecules confer both susceptibility and progression in japanese patients with primary biliary cirrhosis.
    Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M
    Hepatology, 55(2), 506-511, 2012WebofScienceリポジトリ電子ジャーナル
  • Genetic Variants in EPAS1 Contribute to Adaptation to High-Altitude Hypoxia in Sherpas.
    Hanaoka M, Droma Y, Basnyat B, Ito M, Kobayashi N, Katsuyama Y, Kubo K, Ota M
    PLOS ONE, 7(12), e50566, 2012WebofScienceリポジトリ電子ジャーナル
  • Genetic background of autoimmune hepatitis in Japan.
    Yoshizawa K, Umemura T, Ota M
    J Gastroenterol, 46(supp 1), 42-47, 2011WebofScienceリポジトリ電子ジャーナル
  • Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.
    Umemura T, Zen Y, Hamano H, Joshita S, et al.
    J Gastroenterol, 46(supp 1), 48-55, 2011WebofScienceリポジトリ電子ジャーナル
  • Serum Cytokine Levels are associated with the outcome of pegylated interferon and ribabirin therapy in patients with chronic hepatitis C.
    Yoneda S, Umemura T, Joshita S, Ichijo T, Matsumoto A, Yoshizawa K, Katsuyama Y, Ota M, Tanaka E
    Hepatol Res, 41(6), 587-593, 2011WebofScienceリポジトリ電子ジャーナル
  • Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.
    Ota M, Ito T, Umemura T, Katsuyama Y, Yoshizawa K, Hamano H, Kawa S.
    Dis Markers, 31(4), 223-229, 2011WebofScienceリポジトリ電子ジャーナル
  • Association of Serum Cytokine Levels with Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients.
    Yoneda S, Umemura T, Katsuyama Y, Kamijo A, Joshita S, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E
    J Infect Dis., 203(8), 1087-1095, 2011WebofScienceリポジトリ電子ジャーナル
  • Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C.
    Umemura T, Joshita S, Yoneda S, Katsuyama Y, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E
    Antivir Ther., 16(7), 1073-1080, 2011WebofScienceリポジトリ電子ジャーナル
  • Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
    Mizuki N, Meguro A, Ota M, Ohno S, et al.
    Nat Genet, 42(8), 703-706, 2010
  • Mitochondial DNA Diversity Among Three Subpopulations of Cynomologus Macaques (Macaca fascicularis) Originating from the Indochinese Region.
    Shiina T, Tanaka K, Katsuyama Y, Otabe K, et al.
    Exp Anim, 59, 567-578, 2010
  • Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
    Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, et al.
    J Hepatol., 53, 537-541, 2010
  • Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.
    Meguro A, Inoko H, Ota M, Mizuki N, et al.
    OPHTHALMOLOGY, 117, 1331-1338, 2010
  • A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
    Joshita, Satoru; Umemura, Takeji; Yoshizawa, Kaname; Katsuyama, Yoshihiko; Tanaka, Eiji; Ota, Masao
    HUMAN IMMUNOLOGY, 71(5), 520-524, 2010WebofScienceリポジトリ電子ジャーナル
  • A Novel heterophilic antibody interaction involves IgG4
    Ito, T.; Kitahara, K.; Umemura, T.; Ota, M.; Shimozuru, Y.; Kawa, S.; Bahram, S.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 71(2), 109-114, 2010WebofScienceリポジトリ電子ジャーナル
  • Restriction enzyme analysis of PCR products.
    Ota M, Asamura H, Oki T, Sada M
    Methods Mol Biol, 578, 405-414, 2009
  • Complex divergence at a microsatellite marker C1_2_5 in the lineage of HLA-Cw/-B haplotype.
    Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse TK, Kimura A.
    J Hum Genet, 54, 224-229, 2009
  • New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3.
    Nishizaki R, Ota M, Inoko H, Meguro A, et al.
    Eye, 23, 222-229, 2009
  • Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
    Umemura, Takeji; Katsuyama, Yoshihiko; Hamano, Hideaki; Kitahara, Kei; Takayama, Mari; Arakura, Norikazu; Kawa, Shigeyuki; Tanaka, Eiji; Ota, Masao
    HUMAN IMMUNOLOGY, 70(9), 742-746, 2009WebofScience電子ジャーナル
  • Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in japanese patients.
    Kitahara K, Kawa S, Katsuyama Y, Umemura T, et al.
    Dis Markers, 25, 175-180, 2008
  • Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.
    Droma Y, Ota M, Hanaoka M, Katsuyama Y, et al.
    Aviat Space Environ Med, 79, 1056-1060, 2008
  • The Association of Transforming Growth Factor Beta 1 Gene Polymorphisms with the Emphysema Phenotype of COPD in Japanese.
    Ito M, Hanaoka M, Droma Y, Hatayama O, Sato E, Katsuyama Y, Fujimoto K, Ota M.
    Intern Med, 47, 1387-1394, 2008
  • Human Endogenous Retrovirus (HERVK9) Structural Polymorphism with Haplotypic HLA-A Allelic Associations.
    Kulski JK, Shigenari A, Shiina T, Ota M, et al.
    Genetics, 180, 445-457, 2008
  • Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease.
    Meguro A, Ota M, Katsuyama Y, Oka A, et al.
    Ann Rheum Dis, 67, 725-727, 2008
  • Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.
    Umemura T, Ota M, Yoshizawa K, Katsuyama Y, et al.
    Hepatol Res, 38, 689-695, 2008
  • A novel immunoglobulin-immunoglobulin interaction in autoimmunity
    Kawa, Shigeyuki; Kitahara, Kei; Hamano, Hideaki; Ozaki, Yayoi; Arakura, Norikazu; Yoshizawa, Kaname; Umemura, Takeji; Ota, Masao; Mizoguchi, Sadaaki; Shimozuru, Yasunori; Bahram, Seiamak
    PLOS ONE, 3(2), e1637, 2008WebofScienceリポジトリ電子ジャーナル
  • Association of autoimmune pancreatitis with cyotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients.
    Umemura T, Ota M, Hamano H, Katsuyama Y, et al.
    Am J Gastroenterol, 103, 533-534, 2008WebofScienceリポジトリ電子ジャーナル
  • Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene.
    Droma Y, Hanaoka M, Basnyat B, Arjyal A, et al.
    Wilderness Environ Med, 19, 22-29, 2008WebofScienceリポジトリ電子ジャーナル
  • Allele frequencies for 15STR loci in Tibetan populations from Nepal.
    Ota M, Droma Y, Basnyat B, Katsuyama Y, et al.
    J Forensic Sci Int., 169, 234-238, 2007
  • A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1.
    Yokosawa S, Yoshizawa K, Ota M, Katsuyama Y, et al.
    Hepatology, 45, 384-390, 2007
  • Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis..
    Ota M, Katsuyama Y, Hamano H, Umemura T, et al.
    Immunogenetics, 59, 45-52, 2007
  • Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients
    Ito, A; Ota, M; Katsuyama, Y; Inoko, H; Ohno, S; Mizuki, N
    Tissue Antigens, 70(1-5), 423-426, 2007WebofScienceリポジトリ電子ジャーナル
  • Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis
    Umemura, T; Ota, M; Yoshizawa, K; Katsuyama, Y; Ichijo, T; Tanaka, E; Kawa, S; Kiyosawa, K
    Clinical Immunology, 122(3), 338-342, 2007WebofScienceリポジトリ電子ジャーナル
  • The COL1A1 gene and high myopia susceptibility in Japanese
    Inamori, Y; Ota, M; Inoko, H; Okada, E; Nishizaki, R; Shiota, T; Mok, J; Oka, A; Ohno, S; Mizuki, N
    Human Genetics, 122(1-2), 151-157, 2007WebofScienceリポジトリ電子ジャーナル
  • Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism
    Ota, M; Fukushima, H; Kulski, JK; Inoko, H
    NATURE PROTOCOLS, 2(11), 2857-2864, 2007WebofScienceリポジトリ電子ジャーナル
  • Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients
    Umemura, T; Ota, M; Hamano, H; Katsuyama, Y; Kiyosawa, K; Kawa, S
    Gut, 55(9), 1367-1368, 2006WebofScienceリポジトリ電子ジャーナル
  • High prevalence of hypothyroidism in patients with autoimmune pancreatitis
    Komatsu, K; Hamano, H; Ochi, Y; Takayama, M; Muraki, T; Yoshizawa, K; Sakurai, A; Ota, M; Kawa, S
    DIGESTIVE DISEASES AND SCIENCES, 50(6), 1052-1057, 2005WebofScienceリポジトリ電子ジャーナル
  • Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis
    Yoshizawa, K; Ota, M; Katsuyama, Y; Ichijo, T; Matsumoto, A; Tanaka, E; Kiyosawa, K
    JOURNAL OF HEPATOLOGY, 42(4), 578-584, 2005WebofScienceリポジトリ電子ジャーナル

Research Themes

  • ヒトDNA多型の医学への応用