柴 祐司 (シバ ユウジ)
学術研究院（医学系）
先鋭領域融合研究群 バイオメディカル研究所
教授
研究者情報
研究活動情報
受賞
論文
- Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Sato M, Shiba N, Miyazaki D, Shiba Y, Nakamura A.
Methods Mol Biol., 2587, 141-151, 2023年 - Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration
Kobayashi H, Tohyama S, Kanazawa H, Ichimura H, Chino S, Tanaka Y, Suzuki Y, Zhao J, Shiba N, Kadota S, Narita K, Naito T, Seto T, Kuwahara K, Shiba Y, Fukuda K.
J Mol Cell Cardiol., 174, 77-87, 2023年 - Cardiac Regeneration Using Pluripotent Stem Cells and Controlling Immune Responses
Ichimura H, Chino S, Shiba Y.
Heart Lung Circ., 32(7), 836-843, 2023年 - Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin
anaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y, Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Kuwahara K, Shiba Y.
Stem Cell Res Ther., 14(240), 2023年 - Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey
Kobayashi H, Ichimura H, Ohashi N, Shiba Y.
Methods Mol Biol., 2320, 295-302, 2021年
- Chemical Genetics Reveals a Role of Squalene Synthase in TGF beta Signaling and Cardiomyogenesis
Takemoto, Yasushi; Kadota, Shin; Minami, Itsunari; Otsuka, Shinya; Okuda, Satoshi; Abo, Masahiro; Punzalan, Louvy Lynn; Shen, Yan; Shiba, Yuji; Uesugi, Motonari;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60(40), 21824-21831, 2021年
- Pluripotent Stem Cells for Cardiac Regeneration - Current Status, Challenges, and Future Perspectives-
Shiba, Yuji;
CIRCULATION JOURNAL, 84(12), 2129-2135, 2020年12月
- Heart regeneration using pluripotent stem cells
Kadota, Shin; Tanaka, Yuki; Shiba, Yuji;
Journal of cardiology, 76(5), 459-463, 2020年11月 - beta-Arrestin Biased AT(1) Agonist TRVO27 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
Kashihara, Toshihide; Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Kadota, Shin; Wolf, Elena E.; Du, Cheng-Kun; Shiba, Yuji; Morimoto, Sachio; Yamada, Mitsuhiko;
JACC-BASIC TO TRANSLATIONAL SCIENCE, 5(11), 1057-1069, 2020年11月 - Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo
Ichimura, Hajime; Kadota, Shin; Kashihara, Toshihide; Yamada, Mitsuhiko; Ito, Kuniaki; Kobayashi, Hideki; Tanaka, Yuki; Shiba, Naoko; Chuma, Shinichiro; Tohyama, Shugo; Seto, Tatsuichiro; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
SCIENTIFIC REPORTS, 10(1), 2020年 - Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
Li, Junjun; Zhang, Lu; Yu, Leqian; Minami, Itsunari; Miyagawa, Shigeru; Hoerning, Marcel; Dong, Ji; Qiao, Jing; Qu, Xiang; Hua, Ying; Fujimoto, Nanae; Shiba, Yuji; Zhao, Yang; Tang, Fuchou; Chen, Yong; Sawa, Yoshiki; Tang, Chao; Liu, Li;
Communications Biology, 3(1), 2020年 - Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
Abulaiti, Mosha; Yalikun, Yaxiaer; Murata, Kozue; Sato, Asako; Sami, Mustafa M.; Sasaki, Yuko; Fujiwara, Yasue; Minatoya, Kenji; Shiba, Yuji; Tanaka, Yo; Masumoto, Hidetoshi;
SCIENTIFIC REPORTS, 10(1), 2020年 - Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment
Kadota, Shin; Shiba, Yuji;
Current cardiology reports, 21(8), 2019年08月 - Therapeutic Potential of Pluripotent Stem Cells for Cardiac Repair after Myocardial Infarction
Okano, Satomi; Shiba, Yuji;
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(4), 524-530, 2019年04月 - Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes
Sato, Mitsuto; Shiba, Naoko; Miyazaki, Daigo; Shiba, Yuji; Echigoya, Yusuke; Yokota, Toshifumi; Takizawa, Hotake; Aoki, Yoshitsugu; Takeda, Shin'ichi; Nakamura, Akinori;
Biochemical and biophysical research communications, 520(1), 179-185, 2019年 - Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells
Kadota, Shin; Shiba, Naoko; Shiba, Yuji;
CIRCULATION JOURNAL, 81(12), 1764-1765, 2017年12月 - Recent Progress Using Pluripotent Stem Cells for Cardiac Regenerative Therapy
Ichimura, Hajime; Shiba, Yuji;
CIRCULATION JOURNAL, 81(7), 929-935, 2017年07月 - 多能性幹細胞を用いた心筋再生治療
門田 真; 柴 祐司
信州医学雑誌, 65(3), 143-152, 2017年06月10日 - 多能性幹細胞を用いた心筋再生治療の開発 (特集 革新的バイオ医療と化学)
岡野 怜己; 柴 祐司;
化學工業, 68(5), 324-328, 2017年05月 - JAPANESE AUTHOR iPS細胞を用いた新アプローチで心機能改善
柴 祐司;
Natureダイジェスト, 14(1), 17-19, 2017年01月 - A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures
Mao, Di; Ando, Shin; Sato, Shin-ichi; Qin, Ying; Hirata, Nao; Katsuda, Yousuke; Kawase, Eihachiro; Kuo, Ting-Fang; Minami, Itsunari; Shiba, Yuji; Ueda, Kazumitsu; Nakatsuji, Norio; Uesugi, Motonari;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(7), 1765-1770, 2017年 - Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
Li, Junjun; Minami, Itsunari; Shiozaki, Motoko; Yu, Leqian; Yajima, Shin; Miyagawa, Shigeru; Shiba, Yuji; Morone, Nobuhiro; Fukushima, Satsuki; Yoshioka, Momoko; Li, Sisi; Qiao, Jing; Li, Xin; Wang, Lin; Kotera, Hidetoshi; Nakatsuji, Norio; Sawa, Yoshiki; Chen, Yong; Liu, Li;
Stem Cell Reports, 9(5), 1546-1559, 2017年 - Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Ogasawara, Tatsuki; Okano, Satomi; Ichimura, Hajime; Kadota, Shin; Tanaka, Yuki; Minami, Itsunari; Uesugi, Motonari; Wada, Yuko; Saito, Naoto; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
SCIENTIFIC REPORTS, 7, 2017年 - Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Shiba, Yuji; Gomibuchi, Toshihito; Seto, Tatsuichiro; Wada, Yuko; Ichimura, Hajime; Tanaka, Yuki; Ogasawara, Tatsuki; Okada, Kenji; Shiba, Naoko; Sakamoto, Kengo; Ido, Daisuke; Shiina, Takashi; Ohkura, Masamichi; Nakai, Junichi; Uno, Narumi; Kazuki, Yasuhiro; Oshimura, Mitsuo; Minami, Itsunari; Ikeda, Uichi;
Nature, 538(7625), 388-+, 2016年 - Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy
Shiba, Naoko; Miyazaki, Daigo; Yoshizawa, Takahiro; Fukushima, Kazuhiro; Shiba, Yuji; Inaba, Yuji; Imamura, Michihiro; Takeda, Shin'ichi; Koike, Kenichi; Nakamura, Akinori;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(10), 2170-2182, 2015年10月 - Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model
Gautam, Milan; Fujita, Daiki; Kimura, Kazuhiro; Ichikawa, Hinako; Izawa, Atsushi; Hirose, Masamichi; Kashihara, Toshihide; Yamada, Mitsuhiko; Takahashi, Masafumi; Ikeda, Uichi; Shiba, Yuji;
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 81, 139-149, 2015年04月 - New Strategy for the Treatment of Myocarditis by Cell-Sheet Technology
Shiba, Yuji;
CIRCULATION JOURNAL, 79(1), 51-52, 2015年01月 - Association between estimated glomerular filtration rate and peripheral arterial disease
Yamasaki, Saeko; Izawa, Atsushi; Koshikawa, Megumi; Saigusa, Tatsuya; Ebisawa, Soichiro; Miura, Takashi; Shiba, Yuji; Tomita, Takeshi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi;
Journal of cardiology, 66(5-6), 430-434, 2015年 - Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms.
Saigusa T, Izawa A, Miura T, Ebisawa S, Shiba Y, Miyashita Y, Tomita T, Koyama J, Fukui D, Takano T, Amano J, Ikeda U.
Angiology, 65(8), 710-715, 2014年 - Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model.
Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD.
J Cardiovasc Pharmacol Ther, 19(4), 368-381, 2014年 - Importance of fatty acid compositions in patients with peripheral arterial disease.
Gautam M, Izawa A, Shiba Y, Motoki H, Takeuchi T, Okada A, Tomita T, Miyashita Y, Koyama J, Ikeda U.
PLOS ONE, 9(9), e107003, 2014年 - Prostacyclin - a potential new target for endothelial progenitor cell-mediated angiogenesis -.
Shiba Y, Ikeda U.
Circ J, 77(4), 906-907, 2013年 - Presence of diastolic dysfunction in patients with peripheral artery disease.
Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
Angiology, 64(7), 540-543, 2013年 - Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury.
Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
PLOS ONE, 8(3), e58760, 2013年 - Creation of human cardiac cell sheets using pluripotent stem cells
Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T
Biochem Biophys Res Commun, 425(2), 321-327, 2012年 - hESC-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA
Nature, 489(7415), 322-325, 2012年 - Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells.
Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.
J Artif Organs, 14, 301－309, 2011年 - Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis.
Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.
Cardiovasc Res, 81, 169-177, 2009年 - Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation
Doi, Hiroshi; Iso, Tatsuya; Shiba, Yuji; Sato, Hiroko; Yamazaki, Miki; Oyama, Yoshiaki; Akiyama, Hideo; Tanaka, Toru; Tomita, Tomoyuki; Arai, Masashi; Takahashi, Masafumi; Ikeda, Uichi; Kurabayashi, Masahiko;
Biochemical and biophysical research communications, 381(4), 654-659, 2009年 - Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury.
Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.
Cardiovasc Res, 80, 175-180, 2008年 - Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice.
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
Circulation, 117, 3079-3087, 2008年 - Models for the study of angiogenesis.
Shiba Y, Takahashi M, Ikeda U.
Curr Pharm Design, 14, 371-377, 2008年 - Bone marrow-derived CXCR4(+) cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice
Morimoto, Hajime; Takahashi, Masafumi; Shiba, Yuji; Izawa, Atsushi; Ise, Hirohiko; Hongo, Minoru; Hatake, Kiyohiko; Motoyoshi, Kazuo; Ikeda, Uichi;
AMERICAN JOURNAL OF PATHOLOGY, 171(3), 755-766, 2007年09月 - M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system.
Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
Arterioscler Thromb Vasc Biol, 27, 283-289, 2007年
書籍等出版物
- 循環器ジャーナル 68 3
門田 真; 柴 祐司, バイオペースメーカー
医学書院, 422-427 2020年 - 心不全に対する再生医療の現状 eLetter 2019年 夏号
柴 祐司
日本心不全学会, 4-5 2019年 - 日本臨牀 75 増刊号4号
柴 祐司; 池田宇一, 皮下脂肪由来間葉系前句細胞
日本臨牀社, 256-260 2017年 - 化学工業 68 5
岡野怜己; 柴 祐司, 多能性幹細胞を用いた心筋再生治療の開発
小峰工業出版, 8/12 2017年 - 日本臨牀増刊号 74 6
小笠原達樹、柴 祐司, 最新冠動脈疾患学（下）
日本臨牀社, 287-292 2016年08月20日 - 信州医学雑誌 63 3
柴 祐司;, 心臓病に対する再生医療の現状と課題
The Shinshu Medical Society, 173-175 2015年 - 心筋細胞移植と不整脈 3 9
柴 祐司, 特集循環器再生医療の現状と展望
月刊循環器, 77-84 2013年 - 幹細胞を用いた心筋再生 14 2
柴 祐司, 循環器疾患における再生医療の展望
循環plus, 10-12 2013年 - 臨牀と研究 84 1
池田 宇一; 柴 祐司; 高橋 将文;, 虚血性心疾患に対する細胞治療・遺伝子治療 (特集/我が国の虚血性心臓病 心筋梗塞と狭心症の診療の進歩) -- (先進医療の開発)
大道学館出版部, 67-72 2007年01月 - 信州医学雑誌 48 1
柴 祐司; 小泉 知展; 山本 洋; 蜂谷 勤; 高師 修治; 久保 惠嗣; 本田 孝行; 五味 英一; 小山 関哉;, 肺結核で発症したAcquired immunodeficiency syndrome (AIDS)の１例
信州医学会, 21-25 2000年02月10日
