肺結核で発症したAcquired immunodeficiency syndrome (AIDS)の１例, 信州医学雑誌 48 1, 21-25 信州医学会 2000(Feb. 10) Author:柴 祐司; 小泉 知展; 山本 洋; 蜂谷 勤; 高師 修治; 久保 惠嗣; 本田 孝行; 五味 英一; 小山 関哉; Abstract:A 57-year-old Japanese male was admitted to our hospital because of high fever and productive cough. The chest radiograph and computed tomography showed consolidation in the right lower lung field and hilar and mediastinal lymphadenopathy. Mycobacterium tuberculosis was positive in his sputum specimen and pulmonary tuberculosis (TB)was diagnosed.Human immunodeficiency virus (HIV)antibody was tested for, because of rapid progression and the radiographic appearance.HIV antibody was positive.He was successfully treated with 3TC,AZT, and protease inhibitor in addition to anti-TB drugs. We have to take the possibility of pulmonary tuberculosis and HIV infection into consideration when rapid progression and an unusual radiographic appearance are observed on the chest radiograph. Keywords:後天性免疫不全症候群; 肺結核;
論文 Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin Stem Cell Res Ther. ,14(240) 2023 Author:anaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y, Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Kuwahara K, Shiba Y.
Cardiac Regeneration Using Pluripotent Stem Cells and Controlling Immune Responses Heart Lung Circ. ,32(7):836-843 2023 Author:Ichimura H, Chino S, Shiba Y.
Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration J Mol Cell Cardiol.,174:77-87 2023 Author:Kobayashi H, Tohyama S, Kanazawa H, Ichimura H, Chino S, Tanaka Y, Suzuki Y, Zhao J, Shiba N, Kadota S, Narita K, Naito T, Seto T, Kuwahara K, Shiba Y, Fukuda K.
Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Methods Mol Biol.,2587:141-151 2023 Author:Sato M, Shiba N, Miyazaki D, Shiba Y, Nakamura A.
Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey Methods Mol Biol.,2320:295-302 2021 Author:Kobayashi H, Ichimura H, Ohashi N, Shiba Y.
Chemical Genetics Reveals a Role of Squalene Synthase in TGF beta Signaling and Cardiomyogenesis ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(40):21824-21831 2021 Author:Takemoto, Yasushi; Kadota, Shin; Minami, Itsunari; Otsuka, Shinya; Okuda, Satoshi; Abo, Masahiro; Punzalan, Louvy Lynn; Shen, Yan; Shiba, Yuji; Uesugi, Motonari; Keywords:cardiomyogenesis; chemical genetics; SQS; TGF beta signaling;
Pluripotent Stem Cells for Cardiac Regeneration - Current Status, Challenges, and Future Perspectives- CIRCULATION JOURNAL,84(12):2129-2135 2020(Dec.) Author:Shiba, Yuji; Keywords:Cardiomyocytes; Heart failure; Pluripotent stem cells; Regeneration;
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function SCIENTIFIC REPORTS,10(1) 2020 Author:Abulaiti, Mosha; Yalikun, Yaxiaer; Murata, Kozue; Sato, Asako; Sami, Mustafa M.; Sasaki, Yuko; Fujiwara, Yasue; Minatoya, Kenji; Shiba, Yuji; Tanaka, Yo; Masumoto, Hidetoshi;
Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1852(10):2170-2182 2015(Oct.) Author:Shiba, Naoko; Miyazaki, Daigo; Yoshizawa, Takahiro; Fukushima, Kazuhiro; Shiba, Yuji; Inaba, Yuji; Imamura, Michihiro; Takeda, Shin'ichi; Koike, Kenichi; Nakamura, Akinori;
Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,81:139-149 2015(Apr.) Author:Gautam, Milan; Fujita, Daiki; Kimura, Kazuhiro; Ichikawa, Hinako; Izawa, Atsushi; Hirose, Masamichi; Kashihara, Toshihide; Yamada, Mitsuhiko; Takahashi, Masafumi; Ikeda, Uichi; Shiba, Yuji;
New Strategy for the Treatment of Myocarditis by Cell-Sheet Technology CIRCULATION JOURNAL,79(1):51-52 2015(Jan.) Author:Shiba, Yuji;
Association between estimated glomerular filtration rate and peripheral arterial disease JOURNAL OF CARDIOLOGY,66(5-6):430-434 2015 Author:Yamasaki, Saeko; Izawa, Atsushi; Koshikawa, Megumi; Saigusa, Tatsuya; Ebisawa, Soichiro; Miura, Takashi; Shiba, Yuji; Tomita, Takeshi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi;
Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model. J Cardiovasc Pharmacol Ther,19(4):368-381 2014 Author:Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD.
Importance of fatty acid compositions in patients with peripheral arterial disease. PLoS One,9(9):e107003 2014 Author:Gautam M, Izawa A, Shiba Y, Motoki H, Takeuchi T, Okada A, Tomita T, Miyashita Y, Koyama J, Ikeda U.
Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms. Angiology,65(8):710-715 2014 Author:Saigusa T, Izawa A, Miura T, Ebisawa S, Shiba Y, Miyashita Y, Tomita T, Koyama J, Fukui D, Takano T, Amano J, Ikeda U.
Crucial role of hyaluronan in neointimal formation after vascular injury. PLoS One,8(3):e58760 2013 Author:Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
Presence of diastolic dysfunction in patients with peripheral artery disease. Angiology,64(7):540-543 2013 Author:Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
Prostacyclin - a potential new target for endothelial progenitor cell-mediated angiogenesis -. Circ J,77(4):906-907 2013 Author:Shiba Y, Ikeda U.
hESC-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Nature,489(7415):322-325 2012 Author:Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA
Creation of human cardiac cell sheets using pluripotent stem cells Biochem Biophys Res Commun,425(2):321-327 2012 Author:Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T
Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells. J Artif Organs,14:301－309 2011 Author:Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.
Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,381(4):654-659 2009 Author:Doi, Hiroshi; Iso, Tatsuya; Shiba, Yuji; Sato, Hiroko; Yamazaki, Miki; Oyama, Yoshiaki; Akiyama, Hideo; Tanaka, Toru; Tomita, Tomoyuki; Arai, Masashi; Takahashi, Masafumi; Ikeda, Uichi; Kurabayashi, Masahiko;
Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis. Cardiovasc Res,81:169-177 2009 Author:Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.
Models for the study of angiogenesis. Curr Pharm Design,14:371-377 2008 Author:Shiba Y, Takahashi M, Ikeda U.
Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. Circulation,117:3079-3087 2008 Author:Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury. Cardiovasc Res,80:175-180 2008 Author:Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.
Bone marrow-derived CXCR4(+) cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice AMERICAN JOURNAL OF PATHOLOGY,171(3):755-766 2007(Sep.) Author:Morimoto, Hajime; Takahashi, Masafumi; Shiba, Yuji; Izawa, Atsushi; Ise, Hirohiko; Hongo, Minoru; Hatake, Kiyohiko; Motoyoshi, Kazuo; Ikeda, Uichi;
M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system. Arterioscler Thromb Vasc Biol,27:283-289 2007 Author:Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
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