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柴祐司  シバ ユウジ

教員組織学術研究院(医学系)電話番号
教育組織先鋭領域融合研究群 バイオメディカル研究所 バイオテクノロジー・生体医工学部門FAX番号
職名教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
循環器内科学、幹細胞生物学
所属学会
所属学会
日本循環器学会
日本内科学会
学歴
出身大学院
2007 , 信州大学 , 医学研究科

出身学校・専攻等(大学院を除く)
1998 , 信州大学 , 医学部 , 医学科
受賞学術賞
2017 , 井村臨床研究奨励賞
2013 , 日本循環器学会循環器再生医科学賞(基礎研究部門)

研究活動業績

研究業績(著書・
発表論文等)
著書
最新冠動脈疾患学(下)
日本臨牀社 , 日本臨牀増刊号 , 74(6):287-292 2016(Aug. 20)
Author:小笠原達樹、柴 祐司


心臓病に対する再生医療の現状と課題
The Shinshu Medical Society , 信州医学雑誌 , 63(3):173-175 2015
Author:柴 祐司;


循環器疾患における再生医療の展望
循環plus , 幹細胞を用いた心筋再生 , 14(2):10-12 2013
Author:柴 祐司


特集循環器再生医療の現状と展望
月刊循環器 , 心筋細胞移植と不整脈 , 3(9):77-84 2013
Author:柴 祐司


虚血性心疾患に対する細胞治療・遺伝子治療 (特集/我が国の虚血性心臓病 心筋梗塞と狭心症の診療の進歩) -- (先進医療の開発)
大道学館出版部 , 臨牀と研究 , 84(1):67-72 2007(Jan.)
Author:池田 宇一; 柴 祐司; 高橋 将文;


肺結核で発症したAcquired immunodeficiency syndrome (AIDS)の1例
信州医学会 , 信州医学雑誌 , 48(1):21-25 2000(Feb. 10)
Author:柴 祐司; 小泉 知展; 山本 洋; 蜂谷 勤; 高師 修治; 久保 惠嗣; 本田 孝行; 五味 英一; 小山 関哉;
Abstract:A 57-year-old Japanese male was admitted to our hospital because of high fever and productive cough. The chest radiograph and computed tomography showed consolidation in the right lower lung field and hilar and mediastinal lymphadenopathy. Mycobacterium tuberculosis was positive in his sputum specimen and pulmonary tuberculosis (TB)was diagnosed.Human immunodeficiency virus (HIV)antibody was tested for, because of rapid progression and the radiographic appearance.HIV antibody was positive.He was successfully treated with 3TC,AZT, and protease inhibitor in addition to anti-TB drugs. We have to take the possibility of pulmonary tuberculosis and HIV infection into consideration when rapid progression and an unusual radiographic appearance are observed on the chest radiograph.
Keywords:後天性免疫不全症候群; 肺結核;


論文
Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells
CIRCULATION JOURNAL,81(12):1764-1765 2017(Dec.)
Author:Kadota, Shin; Shiba, Naoko; Shiba, Yuji;


Recent Progress Using Pluripotent Stem Cells for Cardiac Regenerative Therapy
CIRCULATION JOURNAL,81(7):929-935 2017(Jul.)
Author:Ichimura, Hajime; Shiba, Yuji;


多能性幹細胞を用いた心筋再生治療
信州医学雑誌,65(3):143-152 2017(Jun. 10)
Author:門田 真; 柴 祐司


多能性幹細胞を用いた心筋再生治療の開発 (特集 革新的バイオ医療と化学)
化學工業,68(5):324-328 2017(May)
Author:岡野 怜己; 柴 祐司;


JAPANESE AUTHOR iPS細胞を用いた新アプローチで心機能改善
Natureダイジェスト,14(1):17-19 2017(Jan.)
Author:柴 祐司;


Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
SCIENTIFIC REPORTS,7:- 2017
Author:Ogasawara, Tatsuki; Okano, Satomi; Ichimura, Hajime; Kadota, Shin; Tanaka, Yuki; Minami, Itsunari; Uesugi, Motonari; Wada, Yuko; Saito, Naoto; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;


Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
STEM CELL REPORTS,9(5):1546-1559 2017
Author:Li, Junjun; Minami, Itsunari; Shiozaki, Motoko; Yu, Leqian; Yajima, Shin; Miyagawa, Shigeru; Shiba, Yuji; Morone, Nobuhiro; Fukushima, Satsuki; Yoshioka, Momoko; Li, Sisi; Qiao, Jing; Li, Xin; Wang, Lin; Kotera, Hidetoshi; Nakatsuji, Norio; Sawa, Yoshiki; Chen, Yong; Liu, Li;


A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(7):1765-1770 2017
Author:Mao, Di; Ando, Shin; Sato, Shin-ichi; Qin, Ying; Hirata, Nao; Katsuda, Yousuke; Kawase, Eihachiro; Kuo, Ting-Fang; Minami, Itsunari; Shiba, Yuji; Ueda, Kazumitsu; Nakatsuji, Norio; Uesugi, Motonari;


Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
NATURE,538(7625):388-+ 2016
Author:Shiba, Yuji; Gomibuchi, Toshihito; Seto, Tatsuichiro; Wada, Yuko; Ichimura, Hajime; Tanaka, Yuki; Ogasawara, Tatsuki; Okada, Kenji; Shiba, Naoko; Sakamoto, Kengo; Ido, Daisuke; Shiina, Takashi; Ohkura, Masamichi; Nakai, Junichi; Uno, Narumi; Kazuki, Yasuhiro; Oshimura, Mitsuo; Minami, Itsunari; Ikeda, Uichi;


Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1852(10):2170-2182 2015(Oct.)
Author:Shiba, Naoko; Miyazaki, Daigo; Yoshizawa, Takahiro; Fukushima, Kazuhiro; Shiba, Yuji; Inaba, Yuji; Imamura, Michihiro; Takeda, Shin'ichi; Koike, Kenichi; Nakamura, Akinori;


Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,81:139-149 2015(Apr.)
Author:Gautam, Milan; Fujita, Daiki; Kimura, Kazuhiro; Ichikawa, Hinako; Izawa, Atsushi; Hirose, Masamichi; Kashihara, Toshihide; Yamada, Mitsuhiko; Takahashi, Masafumi; Ikeda, Uichi; Shiba, Yuji;


New Strategy for the Treatment of Myocarditis by Cell-Sheet Technology
CIRCULATION JOURNAL,79(1):51-52 2015(Jan.)
Author:Shiba, Yuji;


Association between estimated glomerular filtration rate and peripheral arterial disease
JOURNAL OF CARDIOLOGY,66(5-6):430-434 2015
Author:Yamasaki, Saeko; Izawa, Atsushi; Koshikawa, Megumi; Saigusa, Tatsuya; Ebisawa, Soichiro; Miura, Takashi; Shiba, Yuji; Tomita, Takeshi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi;


Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model.
J Cardiovasc Pharmacol Ther,19(4):368-381 2014
Author:Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD.


Importance of fatty acid compositions in patients with peripheral arterial disease.
PLoS One,9(9):e107003 2014
Author:Gautam M, Izawa A, Shiba Y, Motoki H, Takeuchi T, Okada A, Tomita T, Miyashita Y, Koyama J, Ikeda U.


Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms.
Angiology,65(8):710-715 2014
Author:Saigusa T, Izawa A, Miura T, Ebisawa S, Shiba Y, Miyashita Y, Tomita T, Koyama J, Fukui D, Takano T, Amano J, Ikeda U.


Crucial role of hyaluronan in neointimal formation after vascular injury.
PLoS One,8(3):e58760 2013
Author:Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.


Presence of diastolic dysfunction in patients with peripheral artery disease.
Angiology,64(7):540-543 2013
Author:Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.


Prostacyclin - a potential new target for endothelial progenitor cell-mediated angiogenesis -.
Circ J,77(4):906-907 2013
Author:Shiba Y, Ikeda U.


hESC-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
Nature,489(7415):322-325 2012
Author:Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA


Creation of human cardiac cell sheets using pluripotent stem cells
Biochem Biophys Res Commun,425(2):321-327 2012
Author:Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T


Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells.
J Artif Organs,14:301-309 2011
Author:Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.


Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,381(4):654-659 2009
Author:Doi, Hiroshi; Iso, Tatsuya; Shiba, Yuji; Sato, Hiroko; Yamazaki, Miki; Oyama, Yoshiaki; Akiyama, Hideo; Tanaka, Toru; Tomita, Tomoyuki; Arai, Masashi; Takahashi, Masafumi; Ikeda, Uichi; Kurabayashi, Masahiko;


Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis.
Cardiovasc Res,81:169-177 2009
Author:Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.


Models for the study of angiogenesis.
Curr Pharm Design,14:371-377 2008
Author:Shiba Y, Takahashi M, Ikeda U.


Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice.
Circulation,117:3079-3087 2008
Author:Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.


Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury.
Cardiovasc Res,80:175-180 2008
Author:Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.


Bone marrow-derived CXCR4(+) cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice
AMERICAN JOURNAL OF PATHOLOGY,171(3):755-766 2007(Sep.)
Author:Morimoto, Hajime; Takahashi, Masafumi; Shiba, Yuji; Izawa, Atsushi; Ise, Hirohiko; Hongo, Minoru; Hatake, Kiyohiko; Motoyoshi, Kazuo; Ikeda, Uichi;


M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system.
Arterioscler Thromb Vasc Biol,27:283-289 2007
Author:Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.


その他
幹細胞由来心筋細胞移植による不整脈抑制作用
週刊医学のあゆみ , 248(2):161-162 2014
Author:柴 祐司