SHIBA Yuji

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences 

Professor 

Degree

  • 医学博士, 信州大学

Field Of Study

  • Cardiology, Cardiology, Stem cell biology

Educational Background

  • 2007, 信州大学, 医学研究科
  • 1998, 信州大学, 医学部, 医学科

Award

  • 2020
    公益財団法人 日本心臓財団, 日本心臓財団 佐藤賞
  • 2017
    公益財団法人 成人血管病研究振興財団, 井村臨床研究奨励賞
  • 2013
    Japanese Circulation Society, Cardiovascular Regeneration Medical Science Award

Paper

  • Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
    Sato M, Shiba N, Miyazaki D, Shiba Y, Nakamura A.
    Methods Mol Biol., 2587, 141-151, 2023
  • Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration
    Kobayashi H, Tohyama S, Kanazawa H, Ichimura H, Chino S, Tanaka Y, Suzuki Y, Zhao J, Shiba N, Kadota S, Narita K, Naito T, Seto T, Kuwahara K, Shiba Y, Fukuda K.
    J Mol Cell Cardiol., 174, 77-87, 2023
  • Cardiac Regeneration Using Pluripotent Stem Cells and Controlling Immune Responses
    Ichimura H, Chino S, Shiba Y.
    Heart Lung Circ., 32(7), 836-843, 2023
  • Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin
    anaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y, Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Kuwahara K, Shiba Y.
    Stem Cell Res Ther., 14(240), 2023
  • Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey
    Kobayashi H, Ichimura H, Ohashi N, Shiba Y.
    Methods Mol Biol., 2320, 295-302, 2021電子ジャーナル
  • Chemical Genetics Reveals a Role of Squalene Synthase in TGF beta Signaling and Cardiomyogenesis
    Takemoto, Yasushi; Kadota, Shin; Minami, Itsunari; Otsuka, Shinya; Okuda, Satoshi; Abo, Masahiro; Punzalan, Louvy Lynn; Shen, Yan; Shiba, Yuji; Uesugi, Motonari;
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60(40), 21824-21831, 2021WebofScience電子ジャーナル
  • Pluripotent Stem Cells for Cardiac Regeneration - Current Status, Challenges, and Future Perspectives-
    Shiba, Yuji;
    CIRCULATION JOURNAL, 84(12), 2129-2135, Dec. 2020リポジトリ電子ジャーナル
  • Heart regeneration using pluripotent stem cells
    Kadota, Shin; Tanaka, Yuki; Shiba, Yuji;
    Journal of cardiology, 76(5), 459-463, Nov. 2020リポジトリ電子ジャーナル
  • beta-Arrestin Biased AT(1) Agonist TRVO27 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
    Kashihara, Toshihide; Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Kadota, Shin; Wolf, Elena E.; Du, Cheng-Kun; Shiba, Yuji; Morimoto, Sachio; Yamada, Mitsuhiko;
    JACC-BASIC TO TRANSLATIONAL SCIENCE, 5(11), 1057-1069, Nov. 2020リポジトリ電子ジャーナル
  • Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo
    Ichimura, Hajime; Kadota, Shin; Kashihara, Toshihide; Yamada, Mitsuhiko; Ito, Kuniaki; Kobayashi, Hideki; Tanaka, Yuki; Shiba, Naoko; Chuma, Shinichiro; Tohyama, Shugo; Seto, Tatsuichiro; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
    SCIENTIFIC REPORTS, 10(1), 2020WebofScience電子ジャーナル
  • Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
    Li, Junjun; Zhang, Lu; Yu, Leqian; Minami, Itsunari; Miyagawa, Shigeru; Hoerning, Marcel; Dong, Ji; Qiao, Jing; Qu, Xiang; Hua, Ying; Fujimoto, Nanae; Shiba, Yuji; Zhao, Yang; Tang, Fuchou; Chen, Yong; Sawa, Yoshiki; Tang, Chao; Liu, Li;
    Communications biology, 3(1), 2020WebofScience電子ジャーナル
  • Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
    Abulaiti, Mosha; Yalikun, Yaxiaer; Murata, Kozue; Sato, Asako; Sami, Mustafa M.; Sasaki, Yuko; Fujiwara, Yasue; Minatoya, Kenji; Shiba, Yuji; Tanaka, Yo; Masumoto, Hidetoshi;
    SCIENTIFIC REPORTS, 10(1), 2020リポジトリ電子ジャーナル
  • Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment
    Kadota, Shin; Shiba, Yuji;
    Current cardiology reports, 21(8), Aug. 2019WebofScience電子ジャーナル
  • Therapeutic Potential of Pluripotent Stem Cells for Cardiac Repair after Myocardial Infarction
    Okano, Satomi; Shiba, Yuji;
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(4), 524-530, Apr. 2019WebofScience
  • Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes
    Sato, Mitsuto; Shiba, Naoko; Miyazaki, Daigo; Shiba, Yuji; Echigoya, Yusuke; Yokota, Toshifumi; Takizawa, Hotake; Aoki, Yoshitsugu; Takeda, Shin'ichi; Nakamura, Akinori;
    Biochemical and biophysical research communications, 520(1), 179-185, 2019WebofScience電子ジャーナル
  • Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells
    Kadota, Shin; Shiba, Naoko; Shiba, Yuji;
    CIRCULATION JOURNAL, 81(12), 1764-1765, Dec. 2017WebofScience電子ジャーナル
  • Recent Progress Using Pluripotent Stem Cells for Cardiac Regenerative Therapy
    Ichimura, Hajime; Shiba, Yuji;
    CIRCULATION JOURNAL, 81(7), 929-935, Jul. 2017WebofScience電子ジャーナル
  • 多能性幹細胞を用いた心筋再生治療
    門田 真; 柴 祐司
    信州医学雑誌, 65(3), 143-152, 10 Jun. 2017リポジトリ
  • 多能性幹細胞を用いた心筋再生治療の開発 (特集 革新的バイオ医療と化学)
    岡野 怜己; 柴 祐司;
    化學工業, 68(5), 324-328, May 2017リポジトリ
  • JAPANESE AUTHOR iPS細胞を用いた新アプローチで心機能改善
    柴 祐司;
    Natureダイジェスト, 14(1), 17-19, Jan. 2017リポジトリ
  • A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures
    Mao, Di; Ando, Shin; Sato, Shin-ichi; Qin, Ying; Hirata, Nao; Katsuda, Yousuke; Kawase, Eihachiro; Kuo, Ting-Fang; Minami, Itsunari; Shiba, Yuji; Ueda, Kazumitsu; Nakatsuji, Norio; Uesugi, Motonari;
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(7), 1765-1770, 2017WebofScience電子ジャーナル
  • Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
    Li, Junjun; Minami, Itsunari; Shiozaki, Motoko; Yu, Leqian; Yajima, Shin; Miyagawa, Shigeru; Shiba, Yuji; Morone, Nobuhiro; Fukushima, Satsuki; Yoshioka, Momoko; Li, Sisi; Qiao, Jing; Li, Xin; Wang, Lin; Kotera, Hidetoshi; Nakatsuji, Norio; Sawa, Yoshiki; Chen, Yong; Liu, Li;
    Stem Cell Reports, 9(5), 1546-1559, 2017WebofScience電子ジャーナル
  • Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
    Ogasawara, Tatsuki; Okano, Satomi; Ichimura, Hajime; Kadota, Shin; Tanaka, Yuki; Minami, Itsunari; Uesugi, Motonari; Wada, Yuko; Saito, Naoto; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
    SCIENTIFIC REPORTS, 7, 2017WebofScienceリポジトリ電子ジャーナル
  • Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
    Shiba, Yuji; Gomibuchi, Toshihito; Seto, Tatsuichiro; Wada, Yuko; Ichimura, Hajime; Tanaka, Yuki; Ogasawara, Tatsuki; Okada, Kenji; Shiba, Naoko; Sakamoto, Kengo; Ido, Daisuke; Shiina, Takashi; Ohkura, Masamichi; Nakai, Junichi; Uno, Narumi; Kazuki, Yasuhiro; Oshimura, Mitsuo; Minami, Itsunari; Ikeda, Uichi;
    Nature, 538(7625), 388-+, 2016WebofScience電子ジャーナル
  • Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy
    Shiba, Naoko; Miyazaki, Daigo; Yoshizawa, Takahiro; Fukushima, Kazuhiro; Shiba, Yuji; Inaba, Yuji; Imamura, Michihiro; Takeda, Shin'ichi; Koike, Kenichi; Nakamura, Akinori;
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(10), 2170-2182, Oct. 2015WebofScience電子ジャーナル
  • Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model
    Gautam, Milan; Fujita, Daiki; Kimura, Kazuhiro; Ichikawa, Hinako; Izawa, Atsushi; Hirose, Masamichi; Kashihara, Toshihide; Yamada, Mitsuhiko; Takahashi, Masafumi; Ikeda, Uichi; Shiba, Yuji;
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 81, 139-149, Apr. 2015WebofScience電子ジャーナル
  • New Strategy for the Treatment of Myocarditis by Cell-Sheet Technology
    Shiba, Yuji;
    CIRCULATION JOURNAL, 79(1), 51-52, Jan. 2015WebofScience電子ジャーナル
  • Association between estimated glomerular filtration rate and peripheral arterial disease
    Yamasaki, Saeko; Izawa, Atsushi; Koshikawa, Megumi; Saigusa, Tatsuya; Ebisawa, Soichiro; Miura, Takashi; Shiba, Yuji; Tomita, Takeshi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi;
    Journal of cardiology, 66(5-6), 430-434, 2015WebofScience電子ジャーナル
  • Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms.
    Saigusa T, Izawa A, Miura T, Ebisawa S, Shiba Y, Miyashita Y, Tomita T, Koyama J, Fukui D, Takano T, Amano J, Ikeda U.
    Angiology, 65(8), 710-715, 2014
  • Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model.
    Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD.
    J Cardiovasc Pharmacol Ther, 19(4), 368-381, 2014
  • Importance of fatty acid compositions in patients with peripheral arterial disease.
    Gautam M, Izawa A, Shiba Y, Motoki H, Takeuchi T, Okada A, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    PLOS ONE, 9(9), e107003, 2014WebofScienceリポジトリ電子ジャーナル
  • Prostacyclin - a potential new target for endothelial progenitor cell-mediated angiogenesis -.
    Shiba Y, Ikeda U.
    Circ J, 77(4), 906-907, 2013
  • Presence of diastolic dysfunction in patients with peripheral artery disease.
    Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    Angiology, 64(7), 540-543, 2013
  • Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury.
    Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
    PLOS ONE, 8(3), e58760, 2013
  • Creation of human cardiac cell sheets using pluripotent stem cells
    Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T
    Biochem Biophys Res Commun, 425(2), 321-327, 2012
  • hESC-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
    Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA
    Nature, 489(7415), 322-325, 2012
  • Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells.
    Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.
    J Artif Organs, 14, 301-309, 2011
  • Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis.
    Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.
    Cardiovasc Res, 81, 169-177, 2009
  • Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation
    Doi, Hiroshi; Iso, Tatsuya; Shiba, Yuji; Sato, Hiroko; Yamazaki, Miki; Oyama, Yoshiaki; Akiyama, Hideo; Tanaka, Toru; Tomita, Tomoyuki; Arai, Masashi; Takahashi, Masafumi; Ikeda, Uichi; Kurabayashi, Masahiko;
    Biochemical and biophysical research communications, 381(4), 654-659, 2009WebofScience電子ジャーナル
  • Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury.
    Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.
    Cardiovasc Res, 80, 175-180, 2008
  • Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice.
    Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
    Circulation, 117, 3079-3087, 2008
  • Models for the study of angiogenesis.
    Shiba Y, Takahashi M, Ikeda U.
    Curr Pharm Design, 14, 371-377, 2008
  • Bone marrow-derived CXCR4(+) cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice
    Morimoto, Hajime; Takahashi, Masafumi; Shiba, Yuji; Izawa, Atsushi; Ise, Hirohiko; Hongo, Minoru; Hatake, Kiyohiko; Motoyoshi, Kazuo; Ikeda, Uichi;
    AMERICAN JOURNAL OF PATHOLOGY, 171(3), 755-766, Sep. 2007WebofScience電子ジャーナル
  • M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system.
    Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
    Arterioscler Thromb Vasc Biol, 27, 283-289, 2007

MISC

  • 幹細胞由来心筋細胞移植による不整脈抑制作用
    柴 祐司
    週刊医学のあゆみ, 248(2), 161-162, 2014

Books and other publications

  • 循環器ジャーナル 68 3
    門田 真; 柴 祐司, バイオペースメーカー
    医学書院, 422-427 2020
  • 心不全に対する再生医療の現状 eLetter 2019年 夏号
    柴 祐司
    日本心不全学会, 4-5 2019
  • 日本臨牀 75 増刊号4号
    柴 祐司; 池田宇一, 皮下脂肪由来間葉系前句細胞
    日本臨牀社, 256-260 2017
  • 化学工業 68 5
    岡野怜己; 柴 祐司, 多能性幹細胞を用いた心筋再生治療の開発
    小峰工業出版, 8/12 2017
  • 日本臨牀増刊号 74 6
    小笠原達樹、柴 祐司, 最新冠動脈疾患学(下)
    日本臨牀社, 287-292 20 Aug. 2016
  • 信州医学雑誌 63 3
    柴 祐司;, 心臓病に対する再生医療の現状と課題
    The Shinshu Medical Society, 173-175 2015
  • 心筋細胞移植と不整脈 3 9
    柴 祐司, 特集循環器再生医療の現状と展望
    月刊循環器, 77-84 2013
  • 幹細胞を用いた心筋再生 14 2
    柴 祐司, 循環器疾患における再生医療の展望
    循環plus, 10-12 2013
  • 臨牀と研究 84 1
    池田 宇一; 柴 祐司; 高橋 将文;, 虚血性心疾患に対する細胞治療・遺伝子治療 (特集/我が国の虚血性心臓病 心筋梗塞と狭心症の診療の進歩) -- (先進医療の開発)
    大道学館出版部, 67-72 Jan. 2007
  • 信州医学雑誌 48 1
    柴 祐司; 小泉 知展; 山本 洋; 蜂谷 勤; 高師 修治; 久保 惠嗣; 本田 孝行; 五味 英一; 小山 関哉;, 肺結核で発症したAcquired immunodeficiency syndrome (AIDS)の1例
    信州医学会, 21-25 10 Feb. 2000

Affiliated academic society

  • 日本循環器学会
  • 日本内科学会