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下里剛士  シモサト タケシ

教員組織学術研究院(農学系)電話番号
教育組織農学部 農学生命科学科 動物資源生命科学コースFAX番号
職名准教授メールアドレス
住所〒399-4598 長野県上伊那郡南箕輪村8304ホームページURLhttp://www.shinshu-u.ac.jp/faculty/agriculture/lab/shimolab/
http://www.shinshu-u.ac.jp/institution/cfmd/

プロフィール

COE・クラスタ・
研究グループ
先鋭領域融合研究群・バイオメディカル研究所/代謝ゲノミクス部門 , 菌類・微生物ダイナミズム創発研究センター/超分子複合体部門
研究分野
動物生命科学
分子生命工学
現在の研究課題
オリゴDNAの機能性解析
キーワード:食品免疫学 , オリゴDNA
乳酸菌粘膜ワクチンの開発
キーワード:粘膜ワクチン , 乳酸菌
所属学会
所属学会
日本栄養・食糧学会
アメリカ遺伝子細胞治療学会
北信越畜産学会
日本食品免疫学会
アメリカ酪農科学会
日本乳酸菌学会
日本酪農科学会
日本畜産学会
日本農芸化学会

所属学会役職担当
2016-2020 , 日本乳酸菌学会 , 評議員
学歴
出身大学院
2006 , 東北大学 , 農学研究科 , 生物産業創成科学専攻
2003 , 東北大学 , 農学研究科 , 資源生物科学専攻

出身学校・専攻等(大学院を除く)
2001 , 東北大学 , 農学部 , 生物生産科学科

取得学位
博士(農学) , 東北大学
受賞学術賞
2017 , 農林水産省 若手農林水産研究者表彰・農林水産技術会議会長賞
2015 , 公益財団法人農学会 日本農学進歩賞
2011 , 日本畜産学会奨励賞
2011 , Animal Science Journal Excellent Paper Award 2011
2008 , Animal Science Journal Excellent Paper Award 2008
2006 , 東北大学農学研究科長賞
2006 , 東北大学総長賞
2005 , 日本酪農科学会奨励賞
2004 , 日本畜産学会第103回大会優秀発表賞
研究職歴等
研究職歴
2016- , 菌類・微生物ダイナミズム創発研究センター センター長
2014- , 信州大学学術研究院農学系・准教授
2014- , バイオメディカル研究所・准教授(併任)
2012-2017 , 信州大学大学院農学研究科・准教授
2007-2012 , 信州大学ファイバーナノテク国際若手研究者育成拠点・特任助教
2007-2007 , 米国国立癌研究所(NCI)・日本学術振興会海外特別研究員
2006-2007 , 米国食品医薬局/生物製剤評価研究センター(FDA/CBER)・日本学術振興会海外特別研究員

研究活動業績

研究業績(著書・
発表論文等)
著書
月刊BIOINDUSTRY「機能性オリゴDNAの経口投与を可能にするDNAナノカプセルの開発」
株式会社シーエムシー出版 , 32(8):61-65 2015(Aug. 12)
Author:下里剛士


PROBIOTICS: IMMUNOBIOTICS AND IMMUNOGENICS「Chapter 13, Immunogenics: immunoestimulatory oligodeoxynucleotides from probiotics」
CRC Press , :336-353 2013(Sep. 24)
Author:Takeshi Shimosato, Haruki Kitazawa


アジュバント開発研究の新展開「プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開」
株式会社シーエムシー出版 , :100-106 2011(Aug. 24)
Author:下里剛士, 北澤春樹


論文
Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Animal Science Journal 2018
Author:Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T.


Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
Respiratory Research,19:114 2018
Author:Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T.


Silicosis and lung cancer: current perspectives
Lung Cancer: Targets and Therapy 2018
Author:Sato T, Shimosato T, Klinman DM


Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
Animal Science Journal,:in press 2018
Author:Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T*


Septicemia fromLactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
Probiotics and Antimicrobial Proteins 2018
Author:Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagiwara M, Yamazaki E, Tomita N, Nakajima H.


Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
Current Microbiology,75(1):92-98 2018
Author:Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T.*


Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology,18:44 2017
Author:Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T.*


Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology,8:Article ID:1049 2017
Author:Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T.*


Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7 cells
Journal of Dairy Science,100(9):7007-7015 2017
Author:Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T.*


Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
Frontiers in Immunology,8:Article ID:22 2017
Author:Shigemori S, Shimosato T*.


Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Applied Microbiology and Biotechnology,101(1):341-349 2017
Author:Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T*.


The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdisciplinary Reviews (WIREs): Nanomedicine and Nanobiotechnology,8(4):631-637 2016
Author:Klinman DM, Sato T, Shimosato T.


Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Animal Science Journal,87(5):710-717 2016
Author:Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T,Shimosato T*.


Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Microbial Cell Factories,14(1):189 2015
Author:Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H,Shimosato T*.


Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Molecular Cancer Therapeutics,14(10):2198-2205 2015
Author:Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM.


ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Biochemical and Biophysical Research Communications,460(3):831-837 2015
Author:Tokutake Y, Gushima K, Miyazaki H,Shimosato T, Yonekura S.


Effect of probiotics/prebiotics on cattle health and productivity
Microbes and Environments,30(2):126-132 2015
Author:Uyeno Y, Shigemori S,Shimosato T.


Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice
Molecular Therapy,23(2):297-309 2015
Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H,Shimosato T*.


Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
BioMed Research International,:393598 2014
Author:Shigemori S, Ohshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y,Shimosato T*.


Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Cell and Tissue Research,357(1):55-61 2014
Author:Watanabe T, Nishimura K, Hosaka Y,Shimosato T, Yonekura S, Suzuki D, Takemoto C, Monir M, Hiramatsu K.


Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
Food and Agricultural Immunology,25(4):510-522 2014
Author:Shimosato T*, Kanoh J, Otani H.


Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
International Journal of Oncology,42(2):429-436 2013
Author:Takahashi R, Sato T, Klinman DM,Shimosato T, Kaneko T, Ishigatsubo Y.


Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Applied Microbiology and Biotechnology,97(8):3603-3611 2013
Author:Shigemori S, Yonekura S, Sato T, Otani H,Shimosato T*.


Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
FEBS Open Bio,3:41-45 2013
Author:Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H,Shimosato T*.


Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice
Milchwissenshaft-Milk Science International,67(3):289-292 2012(Jul.)
Author:Ikuno Y, Banno M,Shimosato T, Otani H.


Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis
Current Microbiology,64(6):569-575 2012
Author:Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H,Shimosato T*.


Serum heme oxygenase-1 as a marker of lung function declinein patients with chronic silicosis
Journal of Occupational and Environmental Medicine,54(12):1461-1466 2012
Author:Sato T, Saito Y, Inoue S,Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y.


Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells.
Veterinary Research,42(1):111 2011
Author:Hosoya S, Villena J, Shimazu T,Tohno M, Fujie H, Chiba E,Shimosato T, Aso H,Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H, Kitazawa H.


Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway.
Infection and Immunity,80(1):276-288 2011
Author:Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S,Shimosato T, Aso H, Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H,Kitazawa H.


Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
Veterinary Immunology and Immunopathology,144(3-4):410-416 2011
Author:Tohno M,Shimosato T, Aso H, Kitazawa H.


Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
FEMS Immunology and Medical Microbiology,63:129-139 2011
Author:Fujie, H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y,Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H.


Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
Journal of Agricultural and Food Chemistry,59(6):2646-2651 2011
Author:Shimosato T*, Tomida K, Otani H.


Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat’s milk immunoglobulin G-rich fraction on ovalbumin-sensitized BALB/c mice
Milchwissenshaft-Milk Science International,66(1):7-10 2011
Author:Sekimura Y,Shimosato T, Otani H.


Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 9.
WoundRepair and Regeneration,18(6):586-593 2010
Author:Sato T, Yamamoto M,Shimosato T, Klinman DM.


Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
Asian-Australasian Journal of Animal Science,23(1):106-115 2010
Author:Nagasawa C, Nishimura-Uemura J, Tohno M,Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H.


CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Biochemical and Biophysical Research Communications,394(1):81-86 2010
Author:Shimosato T*, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H*.


Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Animal Science Journal,80(5):597-604 2009
Author:Shimosato T*, Tohno M, SatoT, Nishiura J, Kawai Y, Saito T, Kitazawa H.


Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue.
Biochemical Genetics,47(1-2):126-136 2009
Author:Shimazu T, Tohno M, Katoh S,Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H.


Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA specific IgE production in mice.
Scandinavian Journal of Immunology,67(4):370-376 2008
Author:Iliev ID, Tohno M, Kurosaki D,Shimosato T, He F, Hosoda M, Saito T, Kitazawa H.


Suppressive Oligodeoxynucleotides Inhibit Silica-induced Pulmonary Inflammation
The Journal of Immunology,180(11):7648-7654 2008
Author:Sato T,Shimosato T, Alvord WG, Klinman DM.


Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2.
Animal Science Journal,78(2):195-205 2007
Author:Tohno M,Shimosato T, Kawai Y Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.


Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology.
Animal Science Journal,79(1):11-21 2007
Author:Kitazawa H, Tohno M,Shimosato T, Saito T.


Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.
International Immunopharmacology,7(9):1150-1159 2007
Author:Kitazawa H, Yonezawa K, Tohno M,Shimosato T, Kawai Y, Saito T, Wang JM.


Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C…G-3'stem structure.
Cellular Microbiology,8(3):485-495 2006
Author:Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Itoh Y, Kawai Y, Sasaki T, Saito T, Kitazawa H.


An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro.
FEMS Immunology and Medical Microbiology,46(3):461-469 2006
Author:Takahashi N, Kitazawa H,Shimosato T, Iwabuchi N,Xiao JZ, IwatsukiK, KokuboS Saito T.


Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine.
Veterinary Research,37(6):791-812 2006
Author:Tohno M,Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H.


A swine Toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms.
FEMS Immunology and Medical Microbiology,44(3):283-288 2005
Author:Tohno M, Kitazawa H,Shimosato T, Matsumoto M, Katoh S, Kawai Y,Saito T.


Strong immunostimulation inmurine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern.
Cellular Microbiology,7(3):403-414 2005
Author:Iliev ID, Kitazawa H,Shimosato T, Katoh S, Saito T.


Toll-like receptor2 is expressed on the intestinal M cells in swine.
Biochemicaland BiophysicalResearch Communications,330(2):547-554 2005
Author:Tohno M*,Shimosato T*, Kitazawa H, Katoh S,Iliev ID, Watanabe K, Kawai Y,Aso H, Yamaguchi T, Saito T. *Tohno M. and Shimosato T. contributed equally to this work.


Augmentation of TH-1 type responseby immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
Biochemical and Biophysical Research Communications,326(4):782-787 2005
Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Iliev ID, Nagasawa C, Kawai Y, Saito T.


Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.
Immunology Letters,98(1):83-89 2005
Author:Shimosato T, Tohno M, KitazawaH, Katoh S, Watanabe K, KawaiY, Aso H, YamaguchiT, Saito T.


Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups.
Journal of Food Protection,67(8):1719-1724 2004
Author:Sato T, Nishimura-Uemura J,Shimosato T, Kawai Y, Kitazawa H, Saito T.


Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines.
Journal of Interferon and Cytokine Research,24(9):553-559 2004
Author:Katoh S, Kitazawa H,Shimosato T, Tohno M, KawaiY, Saito T.


Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6.
International Journal of Food Microbiology,85(1-2):11-21 2003
Author:Kitazawa H, WatanabeH,Shimosato T, Kawai Y, Itoh T, Saito T.


Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant.
Biochemica et Biophysica Acta,1627(1):56-61 2003
Author:Shimosato T, Kitazawa H, Katoh S, Tomioka Y, Karima R, Ueha S, Kawai Y, Hishinuma T, Matsushima K, Saito T.


学会発表
Construction of Oligodeoxynucleotide Particles using Glycosylated Carbonate Apatite and Targeted Delivery to Macrophages
18th AAAP Congress 2018(Aug. 01)
Author:Shuichiro Yamashina, Mitsuaki Goto, Takeshi Shimosato


Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide- induced inflammatory response in macrophages
18th AAAP Congress 2018(Aug. 01)
Author:Fu Namai, Tasuku Ogita, Takeshi Shimosato


Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG
18th AAAP Congress 2018(Aug. 01)
Author:Minori Ishida, Fu Namai, Tasuku Ogita, Takeshi Shimosato


Immunoregulatory function of Flavonifractor palutii
18th AAAP Congress 2018(Aug. 01)
Author:Tasuku Ogita, Fu Namai, Ayane Mikami, Takeshi Shimosato


Construction of genetically modified Lactococcus lactis secreting bioactive osteocalcin
International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01)
Author:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato


Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus
International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01)
Author:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato


Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community in Bangladesh: A Study of Adolescent girl
Proceedings of the 17th AAAP Congress , :919-923 2016(Aug. 25)
Author:Shireen Nigar, Takeshi Shimosato, Abu Torab Md. Abdur Rahim


Immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes the anaphylaxis to ovalbumin in mice
Proceedings of the 17th AAAP Congress , :582-584 2016(Aug. 25)
Author:Yoshinari Yamamoto, Takuma Okajima, Tasuku Ogita, Takeshi Shimosato


Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
Proceedings of the 17th AAAP Congress , :579-581 2016(Aug. 25)
Author:Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato


CpG oligodeoxynucleotide from Streptococcus thermophilus induces type 2 innate lymphoid cells(Young Scientists Award/JSAS Excellent Presentation Award受賞)
Proceedings of the 17th AAAP Congress , :82-84 2016(Aug. 23)
Author:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato


乳酸菌由来オリゴ核酸のアナフィラキシーショック亢進メカニズム(若手優秀ポスター賞受賞)
日本酪農科学会 , 平成27年度酪農科学シンポジウム 2015(Sep. 25)
Author:山本祥也, 岡島拓真, Nigar Shireen, 重盛駿, 下里剛士


ヘムオキシゲナーゼ-1を分泌する乳酸菌組換え体はマウスにおける急性大腸炎を軽減する(日本畜産学会第120回大会優秀発表賞 受賞)
日本畜産学会 , 日本畜産学会第120回大会 2015(Sep. 11)
Author:重盛駿, 山本祥也, 下里剛士


Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity
2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14)
Author:Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato


Production of recombinant β-lactoglobulin in Lactococcus lactis and generation of a bioactive peptide with incretin-inactivation activity
2015 ADSA-ASAS JointAnnual Meeting (JAM) 2015(Jul. 14)
Author:Kazushi Oshiro, Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato


Development of an anaphylactic model of buckwheat using B-type CpG oligodeoxynucleotides from lactic acid bacteria
2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14)
Author:Yoshinari Yamamoto, Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato


Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis
Proceedings of the 16th AAAP Congress , Vol. 2:Page 851-853 2014(Nov. 12)
Author:Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato


Strong immunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria
Proceedings of the 16th AAAP Congress , Vol. 2:Page 854-857 2014(Nov. 12)
Author:Yoshinari Yamamoto, Suguru Shigemori, Pengfei Wang, Yeqin Wang,Takeshi Shimosato


インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築(若手優秀ポスター賞受賞)
平成26年度日本酪農科学シンポジウム 2014(Sep. 12)
Author:重盛駿, 大城和士, Wang Pengfei, 山本祥也, Wang Yeqin, 下里剛士


Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy
International Dairy Federation , International Dairy Federation, World Dairy Summit 2013 , :41 2013(Oct. 28)
Author:Suguru Shigemori, Hajime Otani,Takeshi Shimosato


Immunostimulatory oligodeoxynucleotide from yogurt starter bacteria Streptococcus thermophilus, strongly induces interleukin 33
International Dairy Federation , International Dairy Federation, World Dairy Summit 2013 , :38 2013(Oct. 28)
Author:Yusuke Ito, Suguru Shigemori, Hajime Otani, Haruki Kitazawa,Takeshi Shimosato


CpG oligodeoxynucleotides promote wound healing in airway epithelial cells
American Thoracic Society Annual Meeting 2011 2011
Author:Sato T, Miyazawa N, KlinmanDM,Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y.


Toll-like receptor 4recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris
4th congress of european microbiologists FEMS 2011
Author:Tohno M,Shimosato T, Aso H, Kitazawa H.


Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells
American Thoracic Society Annual Meeting 2011 2011
Author:Takahashi R, Sato T, Miyazawa N, Klinman DM,Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y.


Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells
International ScientificConference on Probiotics andPrebiotics - IPC2010 2010
Author:Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y,Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T.


Effect of immunobiotics on the immune performance and productivity of pigs
International Scientific Conference on Probiotics and Prebiotics - IPC2010 2010
Author:SudaY, TakahashiY, Tohno M, Villena Julio, Hosoya S, Fujie H,Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H.


Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide.
97th AAI Annual Meeting 2010
Author:Sato T,Shimosato T, Klinman DM.


The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus
ADSA-PSA-AMPA-CSAS-ASAS Joint Annual Meeting (JAM) 2010
Author:Shimosato T, Fujimoto M, Tohno M, Sato T, Otani H, Kitazawa H.


Immunoregulation of immunobiotic lactic acid bacterial DNA and their advanced application to Food Science
Shinshu University International Symposium 2010 in Ina, Sustainable Agriculture and Environment: Asian Network II, proceedings , :93-97 2010
Author:Takeshi Shimosato


CpG oligodeoxynucleotide from Streptococcus thermophilus regulates anti-inflammatory responses
ADSA-CSAS-ASAS 2009 Joint Annual Meeting 2009
Author:Shimosato T, Tohno M, Sato T, Kitazawa H


REGULATION OF INFLAMMATORY RESPONSE BY IMMUNOBIOTICS IN SWINE INTESTINAL EPITHELIAL CELLS VIA MKP-1
The 9th World Congress on Inflammation , 58:120 2009
Author:ShimazuT, Tohno M, Hosoya S, Fujie H,Shimosato T, Aso H, Suda Y, KawaiY, Saito T, Kitazawa H.


CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
The 9th World Congress on Inflammation , 58:120-121 2009
Author:Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H


CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
96th AAI Annual Meeting 2009
Author:Sato T,Shimosato T, Klinman DM


Suppressive oligodeoxynucleotides improve outcome in murine silicosis
American Thoracic Society Annual Meeting 2008 2008
Author:SatoT,Shimosato T, Klinman DM


Immuno-stimulatory AT oligodeoxynucleotide from Lactobacillus gasseri requires a specific self-stabilized structure
ADSA-ASAS 2008 Joint Annual Meeting 2008
Author:Shimosato T, Tohno M, Sato T, Kawai Y, Saito T, Kitazawa H


Immune responses of Immunobiotics and Immunogenics via Toll-like receptors and their advancedapplication to Food immunology
2nd International Bio-microcosmos Workshop 2006
Author:Kitazawa H,Shimosato T, Tohno M, Saito T


Development of a novel immunoassay system for immunobiotics that modulate intestinal immunity through Toll-likereceptor 2
ADSA-ASAS 2006 Joint Annual Meeting , 84:109 2006
Author:Tohno M,Shimosato T, Kawai, Y, Saito T. Kitazawa H,


Immunobiotic lactic acid bacteria induce immune responses in immature gut-associatedlymphoid tissues via Toll-likereceptors 2 and 9
ADSA-ASAS 2006 Joint Annual Meeting , 84:278 2006
Author:Kitazawa H, Tohno M,Shimosato T, Aso H, Kawai, Y, Saito T.


Swine intestinal immunity via Toll-like receptors and its advanced application to Food immunology
International Symposium on Recent Advances in Animal Science 2005
Author:Kitazawa H,Shimosato T, Tohno M, Saito T


AT oligonucleotide from"Immunobiotic"Lactobacillus gasseri augments immune responses via Toll-like receptor 9 signaling
ADSA-ASAS 2004 Joint Annual Meeting , 82:417 2004
Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai, Y, Saito T.


Immunostimulatory activities of a novel AT oligonucleotide from "Immunobiotic" Lactobacillus gasseri on swine Peyer's patch cells
ADSA-ASAS 2004 Joint Annual Meeting , Journal of Dairy Science , 87:417 2004
Author:Kitazawa H,Shimosato T, Katoh S, Tohno M, Kawai, Y, Saito T.


その他
乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
JATAFFジャーナル , 6(3):27-33 2018(Mar. 01)
Author:下里剛士


ビール酵母とその牛乳抗体のマウスにおけるアレルギー軽減作用と急性毒性に関する検討
北信越畜産学会報 , 106:35-47 2013
Author:森崎健太郎,松田孝裕,須賀正喜,荻田 佑,平松浩二,下里剛士,大谷 元


免疫刺激性オリゴヌクレオチドの2次構造特性
Journal of the Faculty of Agriculture SHINSHU UNIVERSITY , 46(1-2):1-5 2010
Author:下里剛士


イムノジェニクスとしての免疫刺激性DNA研究の最前線
北信越畜産学会報 , (100):1-9 2010
Author:下里剛士,北澤春樹.


Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction
Milk Science , 58(3):119-128 2009
Author:Sekimura Y, Onodera N, Banno M, Hata I, HamanoK,Shimosato T, Hajime O.


イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性
Milk Science , 57(3):103-107 2009
Author:下里剛士,北澤春樹.


豚腸管におけるToll様受容体の機能発現と食品免疫学への応用.
獣医畜産新報 , 59(7):559-561 2006
Author:北澤春樹,遠野雅徳,下里剛士,齋藤忠夫.


Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology.
Journal of Integrated Field Science , 3:9-14 2006
Author:Kitazawa H,Shimosato T, Tohno M, Saito T.


Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors.
Japanese Journal of Lactic Acid Bacteria , 16(1):11-20 2005
Author:Kitazawa H,Shimosato T, TohnoM, Saito T.


Toll様受容体9を介するイムノバイオティック乳酸菌DNAの免疫活性とその将来性.
Milk Science , 54(1):9-15 2005
Author:下里剛士,北澤春樹,齋藤忠夫.


Development of immune assay system for both CpG and non-CpG DNA from lacticacid bacteria using a transfectant of swine Toll-like receptor 9.
Animal Science Journal , 75:377-382 2004
Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.

特許等知的財産
登録済特許
US8163506: USE OF TOLL-LIKE RECEPTOR-EXPRESSING CELLS
4562123: Toll様レセプター強制発現細胞の利用
5403457: ATオリゴヌクレオチドを有効成分とする免疫応答増強性薬剤及び食品組成物
研究費
科学研究費補助金(研究代表者)
2017 - 2021 , 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明 , 基盤研究B
2012 - 2015 , 乳酸菌DNAのナノカプセル体を用いた新規食品および飼料素材開発のための基盤構築 , 基盤研究C
2010 - 2012 , プロバイオティック乳酸菌DNAの機能性食品および飼料素材としての利用法の開発 , 若手研究B
2008 - 2010 , ナノ粒子を用いた抗アレルギーDNAワクチンの腸管粘膜系における免疫応答機構の解明 , 若手研究B

科学研究費補助金(研究分担者)
2018 - 2019 , 吸入療法イノベーションの実現:高分子・抗体医薬の経気道投与による肺癌治療戦略 , 挑戦的研究(萌芽)
2016 - 2018 , ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究 , 基盤研究C

その他公的資金
2017 - 2019 , 国立研究開発法人日本医療研究開発機構(AMED)創薬基盤推進研究事業(分担)
2014 - 2015 , 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ(FS)・ステージ」探索タイプ(代表)
2011 - 2012 , 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ(FS)・ステージ」探索タイプ(代表)

教育活動実績

授業等
前期 , 動物資源化学実験
前期 , 食料機能学総論
前期 , 細胞システム科学特論
前期 , 先端生命科学特論/生命産業科学特論
前期 , 食資源利用学総論
前期 , 科学英語I
前期 , 食と微生物
前期 , Animal Science
後期 , 畜産物利用学
後期 , 動物生命科学
後期 , 動物資源生命科学概論
通年 , 細胞システム科学特別実験実習
通年 , 分子生命工学特論
通年 , Advanced Study for Life Science
通年 , 先鋭領域融合研究群最先端研究特講
留学生受入
2018 , 前期人数:4 , バングラデシュ(1), タイ(2), モンゴル(1)
2017 , 前期人数:2 , 後期人数:3 , バングラデシュ(2), タイ(1), モンゴル(1)
2016 , 前期人数:2 , 後期人数:1 , バングラデシュ(2)
2015 , 前期人数:3 , 後期人数:3 , 中華人民共和国(2)・バングラデシュ(1)
2014 , 前期人数:4 , 後期人数:5 , 中華人民共和国(3)・マレーシア(1)・バングラデシュ(1)
2013 , 前期人数:2 , 後期人数:3 , 中華人民共和国
2012 , 前期人数:1 , 後期人数:1 , 中華人民共和国
2011 , 前期人数:1 , 後期人数:1 , 中華人民共和国

社会活動実績

社会活動等
放送公開講座
20160903 - 20160903 , 超独創的×高校生 信大の食にまつわる大研究!

出前講座
20150918 - , 信州大学農学部の紹介と模擬講義 , 松本深志高等学校

講演会
20180831 - , 第70回日本生物工学会大会シンポジウム「スマートバイオデザイン:ナノからマクロスケールまでの様々な階層レベルにおけるバイオ関連機能と構造の合理的創出を目指して」 , 招待講演 , オリゴDNAの腸管送達系の構築と経口用素材への展開
20180823 - , 安曇野市市民大学講座 , ヨーグルトの健康機能〜乳酸菌科学の最前線〜
20180126 - , 第8回 化粧品開発展 -COSME Tech 2018- , オリゴDNAの腸管送達系の開発と経皮素材への展開
20171027 - , 信州コロイド&界面科学研究会 , 招待講演 , オリゴDNAの腸管送達系の構築と全身免疫系の制御
20171004 - , アグリビジネス創出フェア2017 , 農林水産省・若手農林水産研究者表彰・農林水産技術会議会長賞 受賞講演 , 乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
20151127 - , 第14回日本農学進歩賞受賞講演会 , 受賞講演会 , 乳酸菌オリゴDNAの腸管送達系の構築と免疫制御に関する研究
20150304 - , 第二回信大見本市ミニプレゼンテーション「“食べる”機能性DNAの開発」
20110904 - , 健康食品管理士会長野県分科会講演会 , 招待講演 , 演題「ヨーグルトの保健機能〜プロバイオティクスの魅力とその研究最前線〜」
20110120 - , 平成22年度「信州大学医農連携交流会」 , 招待講演 , 乳酸菌オリゴヌクレオチドの免疫調節作用
20080829 - , 平成20年度酪農科学シンポジウム「イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性」 , 招待講演

メディア・報道
20171110 , 信濃毎日新聞 , 敗血症防ぐ働き-マウス実験で発見 安価な薬開発期待-
20150110 , 信濃毎日新聞 , 経口用ナノカプセル開発-飲み薬の実用化期待-
20110606 , 信濃毎日新聞 , 乳酸菌の塩基配列特定-食品や医薬品への応用期待-