Shimosato Takeshi

Academic Assembly School of Science and Technology Institute of Agriculture

Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences 

Professor 

Degree

  • Ph.D., Tohoku University

Research Keyword

    Biochemistry and Technology of Animal Products, Dairy Science

Field Of Study

  • Animal production science, Dairy Science

Career

  • 2019
    Professor, Faculty of Agriculture, Shinshu University
  • 2019
    Department Head, Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University
  • 2016 - 2019
    Director, Research Center for Fungal and Microbial Dynamism, Shinshu University
  • 2012 - 2019
    Associate Professor, Faculty of Agriculture, Shinshu University
  • 2007 - 2012
    Assistant Professor, Fiber-Nanotech Young Researcher Empowerment Center, Shinshu University
  • 2007 - 2007
    Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, National Cancer Institute (NCI) at Frederick
  • 2006 - 2007
    Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration

Educational Background

  • 2003 - 2006, Tohoku University, Graduate School ofAgricultural Science, Division of Bioscience and Biotechnology for Future Bioindustries
  • 2001 - 2003, Tohoku University, Graduate School of Agricultural Science, Division of Biological Resource Science
  • 1997 - 2001, Tohoku University, Faculty of Agriculture, Applied Bio-Sciences

Member History

  • 2023
    評議員, 日本酪農科学会
  • 2021 - 2024
    Director, Japan Society for Lactic Acid Bacteria
  • 2020
    評議員, 北信越畜産学会
  • 2020
    大会長, 酪農科学シンポジウム2020
  • 2019 - 2022
    監事, 日本酪農科学会
  • 2017 - 2019
    監事, 北信越畜産学会
  • 2016 - 2021
    Councilor, Japan Society for Lactic Acid Bacteria

Award

  • 2017
    Agriculture, Forestry and Fisheries Research Council, Award for Young Agricultural Researchers
  • 2015
    The Foundation of Agricultural Sciences of Japan, Japan Prize in Agricultural Science, Achievement Award for Young Scientists
  • 2011
    Japanese Society of Animal Science, Japanese Society of Animal Science Young Investigator's Award
  • 2011
    Animal Science Journal Excellent Paper Award 2011
  • 2008
    Animal Science Journal Excellent Paper Award 2008
  • 2006
    Dean’s Award of Graduate School of Agricultural Science of Tohoku University
  • 2006
    President’s Award of Tohoku University
  • 2005
    Award for Young Scientist from The Japanese Society of Dairy and Foodscience
  • 2004
    The Best Presentation Award for the 103rd annual meeting of Japanese Society of Animal Science

Paper

  • Development of a single-chain fragment variable that binds to the SARS-CoV-2 spike protein produced by genetically modified lactic acid bacteria
    Oshima S, Namai F, Sato T, Shimosato T..*
    Molecular Biotechnology, 66(1), 151-160, Jan. 2024
    Last, Corresponding電子ジャーナル
  • Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation.
    Umezawa K, Ikeda R, Sakamoto T, Enomoto Y, Nihashi Y, Shinji S, Shimosato T, Kagami H, Takaya T.
    BioTech, 13(2), 11, 2024, Refereedリポジトリ電子ジャーナル
  • Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics
    Sirisopapong S, Shimosato T., Okrathok S, Khempaka S.
    ANIMAL BIOSCIENCE, 36(8), 1209-1220, Aug. 2023電子ジャーナル
  • Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
    Namai F, Sumiya S, Nomura N, Sato T, Shimosato T.*
    AMB Express, 13(4), 2023
    Last, Corresponding電子ジャーナル
  • Oral administration of Brevibacterium linens from washed cheese increases short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice
    Murakami A, Toyomoto K, Namai F, Sato T, Fujii T, Tochio T, Shimosato T.
    ANIMAL SCIENCE JOURNAL, 94(1), e13905, 2023
    Last, Corresponding電子ジャーナル
  • Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells.
    Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.
    Int J Mol Sci, 24(18), 14380, 2023, Refereedリポジトリ電子ジャーナル
  • Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
    Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
    Nanomaterials, 12(10), 1680, 14 May 2022, Refereedリポジトリ電子ジャーナル
  • Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells.
    Nohira N, Shinji S, Nakamura S, Nihashi Y, Shimosato T, Takaya T.
    BIOMEDICINES, 10(11), 2691, 2022, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium
    Nihashi Y, Yamamoto M, Shimosato T, Takaya T.
    Muscles, 1(2), 111-120, 2022, Refereedリポジトリ電子ジャーナル
  • Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
    Okajima, T., Shigemori S*, Namai F, Ogita T, Sato T, Shimosato T.*
    Frontiers in immunology, 12, 738041, 19 Nov. 2021
    Last, Corresponding電子ジャーナル
  • A soybean resistant protein-containing diet increased the production of Reg3g through the regulation of the gut microbiota and enhanced the intestinal barrier function in mice
    Ogita T, Namai F, Mikami A, Ishiguro T, Umezawa K, Uyeno Y, Shimosato T.*
    Frontiers in Nutrition, 8, 701466, 19 Aug. 2021
    Last, Corresponding電子ジャーナル
  • Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts.
    Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
    ANIMAL SCIENCE JOURNAL, 92(1), e13597, 25 Jul. 2021, Refereedリポジトリ電子ジャーナル
  • Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
    Nakamura S, Yonekura S, Shimosato T, Takaya T.
    Frontiers in Physiology, 12, 679152, 24 May 2021リポジトリ
  • Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
    Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
    Frontiers in Cell and Developmental Biology, 6, 616706, 11 Jan. 2021リポジトリ電子ジャーナル
  • Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-17
    Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
    Frontiers in Nutrition, 7:610946, 2021WebofScience電子ジャーナル
  • Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
    Yumoto K, Sato T*, Nakashima K, Namai F, Shigemori S, Shimosato T, Kaneko T.
    Antioxidants, 9(1049), 27 Oct. 2020WebofScience電子ジャーナル
  • Ribosome-engineered Lacticaseibacillus rhamnosus GG exhibits cell surface GAPDH accumulation and enhanced adhesion to human colonic mucin
    Ishida M, Namai F, Shigemori S, Kajikawa S, Tsukagoshi M, Sato T, Ogita T, Shimosato T.*
    Applied and Environmental Microbiology, 86(20), e01448-20, 01 Oct. 2020WebofScience電子ジャーナル
  • Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice
    Shigemori S, Namai F, Ogita T, Sato T, Shimosato T.*
    ANIMAL SCIENCE JOURNAL, 91(1), e13468, Oct. 2020WebofScience電子ジャーナル
  • Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
    Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
    Experimental & Molecular Medicine, 52(9), 1627-1636, 28 Sep. 2020WebofScience電子ジャーナル
  • Construction of genetically modified Lactococcus lactis producing anti-human-CTLA-4 single-chain fragment variable
    Namai F, Murakami A, Ueda A, Tsukagoshi M, Shigemori S, Ogita T, Sato T, Shimosato T.*
    Molecular Biotechnology, 62(11), 572-579, 23 Sep. 2020WebofScience電子ジャーナル
  • Editorial: Nutrition, Immunity and Viral Infections
    Villena J*, Shimosato T, Vizoso-Pinto MG, Kitazawa H.*
    Frontiers in Nutrition, 7(125), 08 Sep. 2020WebofScience電子ジャーナル
  • Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
    Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
    Molecular Biology Reports, 47(9), 7039-7047, Sep. 2020WebofScience電子ジャーナル
  • Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
    Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
    Molecular Biology Reports, 47(9), 6717-6725, Sep. 2020WebofScience電子ジャーナル
  • Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages
    Tsukagoshi M, Sirisopapong M, Namai F, Ishida M, Okrathok S, Shigemori S, Ogita T, Sato T, Khempaka S*, Shimosato T.*
    ANIMAL SCIENCE JOURNAL, 91:e13436, 30 Aug. 2020WebofScience電子ジャーナル
  • Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice
    Ogita T, Yamamoto Y, Mikami A, Shigemori S, Sato T, Shimosato T.*
    Frontiers in immunology, 11:379, 28 Feb. 2020WebofScience電子ジャーナル
  • Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
    Nigar S, Shimosato T.*
    Frontiers in Nutrition, 6, 140, 27 Aug. 2019WebofScience電子ジャーナル
  • Septicemia fromLactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
    Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagiwara M, Yamazaki E, Tomita N, Nakajima H.
    Probiotics and Antimicrobial Proteins, 11(1), 295-298, 2019, RefereedWebofScience電子ジャーナル
  • Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
    Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T.*
    ANIMAL SCIENCE JOURNAL, 89(12), 1707-1711, 04 Dec. 2018WebofScience電子ジャーナル
  • Silicosis and lung cancer: current perspectives
    Sato T, Shimosato T, Klinman DM
    Lung Cancer: Targets and Therapy, 26 Oct. 2018WebofScience電子ジャーナル
  • Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
    Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T.
    Respiratory Research, 19, 114, 01 Aug. 2018WebofScience電子ジャーナル
  • Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
    Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T.*
    CURRENT MICROBIOLOGY, 75(1), 92-98, 2018WebofScience電子ジャーナル
  • Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
    Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T*
    ANIMAL SCIENCE JOURNAL, 89(10), 1504-1511, 2018WebofScience電子ジャーナル
  • Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7 cells
    Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T.*
    JOURNAL OF DAIRY SCIENCE, 100(9), 7007-7015, 2017WebofScience電子ジャーナル
  • Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
    Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T.*
    Frontiers in immunology, 8, Article ID:1049, 2017WebofScience電子ジャーナル
  • Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
    Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T.*
    BMC Immunology, 18, 44, 2017WebofScience電子ジャーナル
  • Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
    Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T*.
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101(1), 341-349, 2017WebofScienceリポジトリ電子ジャーナル
  • Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
    Shigemori S, Shimosato T*.
    Frontiers in immunology, 8, Article ID:22, 2017WebofScienceリポジトリ電子ジャーナル
  • Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
    Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T,Shimosato T*.
    ANIMAL SCIENCE JOURNAL, 87(5), 710-717, 2016WebofScience電子ジャーナル
  • The use of nanoparticles to delivery immunomodulatory oligonucleotides
    Klinman DM, Sato T, Shimosato T.
    Wiley Interdisciplinary Reviews (WIREs): Nanomedicine and Nanobiotechnology, 8(4), 631-637, 2016WebofScience電子ジャーナル
  • ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
    Tokutake Y, Gushima K, Miyazaki H,Shimosato T, Yonekura S.
    Biochemical and biophysical research communications, 460(3), 831-837, 2015WebofScience電子ジャーナル
  • Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
    Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM.
    Molecular cancer therapeutics, 14(10), 2198-2205, 2015WebofScience電子ジャーナル
  • Effect of probiotics/prebiotics on cattle health and productivity
    Uyeno Y, Shigemori S,Shimosato T.
    Microbes and Environments, 30(2), 126-132, 2015WebofScienceリポジトリ電子ジャーナル
  • Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
    Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H,Shimosato T*.
    Microbial Cell Factories, 14(1), 189, 2015WebofScienceリポジトリ電子ジャーナル
  • Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
    Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H,Shimosato T*.
    MOLECULAR THERAPY, 23(2), 297-309, 2015WebofScienceリポジトリ電子ジャーナル
  • Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
    Watanabe T, Nishimura K, Hosaka Y,Shimosato T, Yonekura S, Suzuki D, Takemoto C, Monir M, Hiramatsu K.
    CELL AND TISSUE RESEARCH, 357(1), 55-61, 2014WebofScience電子ジャーナル
  • Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
    Shimosato T*, Kanoh J, Otani H.
    Food and Agricultural Immunology, 25(4), 510-522, 2014WebofScienceリポジトリ電子ジャーナル
  • Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
    Shigemori S, Ohshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y,Shimosato T*.
    BioMed Research International, 393598, 2014WebofScienceリポジトリ電子ジャーナル
  • Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
    Takahashi R, Sato T, Klinman DM,Shimosato T, Kaneko T, Ishigatsubo Y.
    INTERNATIONAL JOURNAL OF ONCOLOGY, 42(2), 429-436, 2013WebofScience電子ジャーナル
  • Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
    Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H,Shimosato T*.
    FEBS Open Bio, 3, 41-45, 2013WebofScienceリポジトリ電子ジャーナル
  • Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
    Shigemori S, Yonekura S, Sato T, Otani H,Shimosato T*.
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 97(8), 3603-3611, 2013WebofScienceリポジトリ電子ジャーナル
  • Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice
    Ikuno Y, Banno M,Shimosato T, Otani H.
    Milchwissenshaft-Milk Science International, 67(3), 289-292, Jul. 2012, RefereedWebofScience
  • Serum heme oxygenase-1 as a marker of lung function declinein patients with chronic silicosis
    Sato T, Saito Y, Inoue S,Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y.
    Journal of Occupational and Environmental Medicine, 54(12), 1461-1466, 2012, RefereedWebofScience電子ジャーナル
  • Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis
    Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H,Shimosato T*.
    CURRENT MICROBIOLOGY, 64(6), 569-575, 2012WebofScienceリポジトリ電子ジャーナル
  • Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
    Shimosato T*, Tomida K, Otani H.
    Journal of Agricultural and Food Chemistry, 59(6), 2646-2651, 2011WebofScience電子ジャーナル
  • Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
    Fujie, H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y,Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H.
    FEMS Immunology and Medical Microbiology, 63, 129-139, 2011, RefereedWebofScience電子ジャーナル
  • Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
    Tohno M,Shimosato T, Aso H, Kitazawa H.
    Veterinary Immunology and Immunopathology, 144(3-4), 410-416, 2011, RefereedWebofScience電子ジャーナル
  • Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway.
    Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S,Shimosato T, Aso H, Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H,Kitazawa H.
    Infection and Immunity, 80(1), 276-288, 2011WebofScience電子ジャーナル
  • Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells.
    Hosoya S, Villena J, Shimazu T,Tohno M, Fujie H, Chiba E,Shimosato T, Aso H,Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H, Kitazawa H.
    Veterinary Research, 42(1), 111, 2011WebofScience電子ジャーナル
  • Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat’s milk immunoglobulin G-rich fraction on ovalbumin-sensitized BALB/c mice
    Sekimura Y,Shimosato T, Otani H.
    Milchwissenshaft-Milk Science International, 66(1), 7-10, 2011WebofScienceリポジトリ
  • Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
    Nagasawa C, Nishimura-Uemura J, Tohno M,Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H.
    Asian-Australasian Journal of Animal Science, 23(1), 106-115, 2010WebofScience
  • Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 9.
    Sato T, Yamamoto M,Shimosato T, Klinman DM.
    WoundRepair and Regeneration, 18(6), 586-593, 2010WebofScience電子ジャーナル
  • CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
    Shimosato T*, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H*.
    Biochemical and biophysical research communications, 394(1), 81-86, 2010WebofScienceリポジトリ電子ジャーナル
  • Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue.
    Shimazu T, Tohno M, Katoh S,Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H.
    Biochemical Genetics, 47(1-2), 126-136, 2009WebofScience電子ジャーナル
  • Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
    Shimosato T*, Tohno M, SatoT, Nishiura J, Kawai Y, Saito T, Kitazawa H.
    ANIMAL SCIENCE JOURNAL, 80(5), 597-604, 2009WebofScienceリポジトリ電子ジャーナル
  • Suppressive Oligodeoxynucleotides Inhibit Silica-induced Pulmonary Inflammation
    Sato T,Shimosato T, Alvord WG, Klinman DM.
    The Journal of Immunology, 180(11), 7648-7654, 2008WebofScience
  • Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA specific IgE production in mice.
    Iliev ID, Tohno M, Kurosaki D,Shimosato T, He F, Hosoda M, Saito T, Kitazawa H.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 67(4), 370-376, 2008WebofScience電子ジャーナル
  • Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.
    Kitazawa H, Yonezawa K, Tohno M,Shimosato T, Kawai Y, Saito T, Wang JM.
    International Immunopharmacology, 7(9), 1150-1159, 2007WebofScience電子ジャーナル
  • Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology.
    Kitazawa H, Tohno M,Shimosato T, Saito T.
    ANIMAL SCIENCE JOURNAL, 79(1), 11-21, 2007WebofScience電子ジャーナル
  • Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2.
    Tohno M,Shimosato T, Kawai Y Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.
    ANIMAL SCIENCE JOURNAL, 78(2), 195-205, 2007WebofScience電子ジャーナル
  • Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine.
    Tohno M,Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H.
    Veterinary Research, 37(6), 791-812, 2006WebofScience電子ジャーナル
  • An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro.
    Takahashi N, Kitazawa H,Shimosato T, Iwabuchi N,Xiao JZ, IwatsukiK, KokuboS Saito T.
    FEMS Immunology and Medical Microbiology, 46(3), 461-469, 2006WebofScience電子ジャーナル
  • Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C…G-3'stem structure.
    Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Itoh Y, Kawai Y, Sasaki T, Saito T, Kitazawa H.
    CELLULAR MICROBIOLOGY, 8(3), 485-495, 2006WebofScience電子ジャーナル
  • Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.
    Shimosato T, Tohno M, KitazawaH, Katoh S, Watanabe K, KawaiY, Aso H, YamaguchiT, Saito T.
    Immunology Letters, 98(1), 83-89, 2005WebofScience電子ジャーナル
  • Augmentation of TH-1 type responseby immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
    Shimosato T, Kitazawa H, Tohno M, Katoh S, Iliev ID, Nagasawa C, Kawai Y, Saito T.
    Biochemical and biophysical research communications, 326(4), 782-787, 2005WebofScience電子ジャーナル
  • Toll-like receptor2 is expressed on the intestinal M cells in swine.
    Tohno M*,Shimosato T*, Kitazawa H, Katoh S,Iliev ID, Watanabe K, Kawai Y,Aso H, Yamaguchi T, Saito T. *Tohno M. and Shimosato T. contributed equally to this work.
    Biochemicaland BiophysicalResearch Communications, 330(2), 547-554, 2005WebofScience電子ジャーナル
  • Strong immunostimulation inmurine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern.
    Iliev ID, Kitazawa H,Shimosato T, Katoh S, Saito T.
    CELLULAR MICROBIOLOGY, 7(3), 403-414, 2005WebofScience電子ジャーナル
  • A swine Toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms.
    Tohno M, Kitazawa H,Shimosato T, Matsumoto M, Katoh S, Kawai Y,Saito T.
    FEMS Immunology and Medical Microbiology, 44(3), 283-288, 2005WebofScience電子ジャーナル
  • Development of immune assay system for both CpG and non-CpG DNA from lacticacid bacteria using a transfectant of swine Toll-like receptor 9
    Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.
    ANIMAL SCIENCE JOURNAL, 75, 377-382, 2004
  • Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups.
    Sato T, Nishimura-Uemura J,Shimosato T, Kawai Y, Kitazawa H, Saito T.
    Journal of Food Protection, 67(8), 1719-1724, 2004WebofScience
  • Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines.
    Katoh S, Kitazawa H,Shimosato T, Tohno M, KawaiY, Saito T.
    Journal of Interferon and Cytokine Research, 24(9), 553-559, 2004WebofScience電子ジャーナル
  • Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant.
    Shimosato T, Kitazawa H, Katoh S, Tomioka Y, Karima R, Ueha S, Kawai Y, Hishinuma T, Matsushima K, Saito T.
    Biochemica et Biophysica Acta, 1627(1), 56-61, 2003WebofScience電子ジャーナル
  • Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6.
    Kitazawa H, WatanabeH,Shimosato T, Kawai Y, Itoh T, Saito T.
    International journal of food microbiology, 85(1-2), 11-21, 2003WebofScience電子ジャーナル

MISC

  • 機能強化乳酸菌の創製研究
    生井楓,下里剛士
    日本乳酸菌学会誌, 33(1), 5-11, Mar. 2022
    Last, Corresponding
  • 乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
    下里剛士
    JATAFFジャーナル, 6(3), 27-33, 01 Mar. 2018
  • ビール酵母とその牛乳抗体のマウスにおけるアレルギー軽減作用と急性毒性に関する検討
    森崎健太郎,松田孝裕,須賀正喜,荻田 佑,平松浩二,下里剛士,大谷 元
    北信越畜産学会報, 106, 35-47, 2013
  • イムノジェニクスとしての免疫刺激性DNA研究の最前線
    下里剛士,北澤春樹.
    北信越畜産学会報, (100), 1-9, 2010
  • 免疫刺激性オリゴヌクレオチドの2次構造特性
    下里剛士
    Journal of the Faculty of Agriculture SHINSHU UNIVERSITY, 46(1-2), 1-5, 2010
  • Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction
    Sekimura Y, Onodera N, Banno M, Hata I, HamanoK,Shimosato T, Hajime O.
    Milk Science, 58(3), 119-128, 2009
  • イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性
    下里剛士,北澤春樹.
    Milk Science, 57(3), 103-107, 2009
  • Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology.
    Kitazawa H,Shimosato T, Tohno M, Saito T.
    Journal of Integrated Field Science, 3, 9-14, 2006
  • 豚腸管におけるToll様受容体の機能発現と食品免疫学への応用.
    北澤春樹,遠野雅徳,下里剛士,齋藤忠夫.
    獣医畜産新報, 59(7), 559-561, 2006
  • Toll様受容体9を介するイムノバイオティック乳酸菌DNAの免疫活性とその将来性.
    下里剛士,北澤春樹,齋藤忠夫.
    Milk Science, 54(1), 9-15, 2005
  • Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors.
    Kitazawa H,Shimosato T, TohnoM, Saito T.
    Japanese Journal of Lactic Acid Bacteria, 16(1), 11-20, 2005

Books and other publications

  • Encyclopedia of Food Immunology
    Contributor, 細胞性免疫にかかわるサイトカイン[134-135頁]
    Asakura Publishing Co., Ltd., 01 Nov. 2021
    ISBN:978-4-254-43126-1
  • BIO INDUSTRY
    Suguru Shigemori, Takeshi Shimosato, Joint work, gmLAB as a Tool for Microbial Therapeutics: Current Perspectives
    株式会社シーエムシー出版, 12 May 2020
  • BIO INDUSTRY
    下里剛士, 機能性オリゴDNAの経口投与を可能にするDNAナノカプセルの開発[61-65頁]
    株式会社シーエムシー出版, 12 Aug. 2015
  • PROBIOTICS: IMMUNOBIOTICS AND IMMUNOGENICS「Chapter 13, Immunogenics: immunoestimulatory oligodeoxynucleotides from probiotics」
    Takeshi Shimosato, Haruki Kitazawa, Joint work
    CRC Press, 336-353 24 Sep. 2013
    ISBN:978-1-48-220684-5
  • Advanced Technologies for Adjuvant Research and Development
    下里剛士, 北澤春樹, Joint work, プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開[100-106頁]
    株式会社シーエムシー出版, 24 Aug. 2011

Lectures, oral presentations, etc.

  • The rpsL K56N mutation in Lacticaseibacillus rhamnosus GG enhances immune response via cell surface proteins
    Soyolmaa Jamiyanpurev, Fu Namai, Takashi Sato, Takeshi Shimosato
    ISAPP 2023 annual meeting, 27 Jun. 2023
  • Effect of local intratracheal therapy using particleized nintedanib in a murine model of pulmonary fibrosis
    Kaho Suzuki, Fu Namai, Natsumi Nomura, Yuichi Sato, Akihiro Kotsugai, Takeshi Shimosato, Takashi Sato
    American Thoracic Society 2023 International Conference, 24 May 2023
  • Intranasal administration of genetically modified Lactococcus lactis producing PD-L1scFv improves survival in lung cancer model mice (American Thoracic Society 2023・ATS Abstract Scholarship Award)
    Natsumi Nomura, Fu Namai, Takashi Sato, Takeshi Shimosato
    American Thoracic Society 2023 International Conference, 23 May 2023
  • Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG
    Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Takeshi Shimosato
    The 11th Asian Conference for Lactic Acid Bacteria, 06 Nov. 2021
  • Lacticaseibacillus rhamnosus GGが高脂肪飼料断続給餌マウスに与える影響(若手優秀発表賞受賞)
    鳥居創、重盛駿、下里剛士
    酪農科学シンポジウム2021, 24 Sep. 2021
  • Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable (English Presentation Award)
    Aito Murakami, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
    The 129th Annual Meeting of Japanese Society of Animal Science, 15 Sep. 2021
  • Lactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages (English Presentation Award)
    Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
    The 129th Annual Meeting of Japanese Society of Animal Science, 15 Sep. 2021
  • 「乳酸菌、腸内細菌およびミルクオリゴ糖の健康機能科学」-イムノバイオティクス由来核酸成分を用いた経口用微粒子の創製と機能性食品・飼料素材への展開-[招待講演]
    下里剛士
    日本食品科学工学会第66回大会, 29 Aug. 2019, Invited
  • PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組換え体の構築と肺ガンモデルマウスを用いた検証
    上田麻未, 生井楓, 村上愛斗, 重盛駿, 荻田佑, 佐藤隆, 下里剛士
    2019年度酪農科学シンポジウム, 23 Aug. 2019
  • 抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築(若手優秀ポスター賞受賞)
    村上愛斗, 生井楓, 上田麻未, 重盛駿, 荻田佑, 佐藤隆, 下里剛士
    2019年度酪農科学シンポジウム, 23 Aug. 2019
  • Oral administration of a genetically modified osteocalcin-secreting Lactococcus lactis improves carbohydrate metabolism in high-fat diet-induced obese mice
    Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
    13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019
  • Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains
    Shoko Kajikawa, Minori Ishida, Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
    13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019
  • Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor
    Masami Tsukagoshi, Fu Namai, Kohei Watanabe, Minako Iwai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
    13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019
  • Flavonifractor plautii inhibits inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 cells and alleviates acute-colitis in mice
    Ayane Mikami, Tasuku Ogita, Takeshi Shimosato
    2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018
  • Flavonifractor plautii exerts Th1/Th2 immunomodulatory effects in mice
    Chika Fukasawa, Tasuku Ogita, Takeshi Shimosato
    2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018
  • Oral delivery of CpG-oligodeoxynucleotide from lactic acid bacteria ameliorates high-fat-diet-induced obesity in mice
    Ryu Sugimura, Tasuku Ogita, Takeshi Shimosato
    2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018
  • 「スマートバイオデザイン:ナノからマクロスケールまでの様々な階層レベルにおけるバイオ関連機能と構造の合理的創出を目指して」-オリゴDNAの腸管送達系の構築と経口用素材への展開-[招待講演]
    下里剛士
    第70回日本生物工学会大会, 31 Aug. 2018, Invited
  • Class-B Oligodeoxynucleotide Derived from a Lactic Acid Bacterium Induces Apoptosis in Spleen Cells
    Nobuhiro Ambe, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
    18th AAAP Congress 2018, 01 Aug. 2018
  • Immunoregulatory function of Flavonifractor plautii
    Tasuku Ogita, Fu Namai, Ayane Mikami, Takeshi Shimosato
    18th AAAP Congress, 01 Aug. 2018
  • Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG
    Minori Ishida, Fu Namai, Tasuku Ogita, Takeshi Shimosato
    18th AAAP Congress, 01 Aug. 2018
  • Recombinant mouse calcitonin gene-related peptidesecreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
    Fu Namai, Tasuku Ogita, Takeshi Shimosato
    18th AAAP Congress, 01 Aug. 2018
  • Construction of Oligodeoxynucleotide Particles using Glycosylated Carbonate Apatite and Targeted Delivery to Macrophages
    Shuichiro Yamashina, Mitsuaki Goto, Takeshi Shimosato
    18th AAAP Congress, 01 Aug. 2018
  • Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus
    Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
    International Dairy Federation (IDF) World Dairy Summit 2017, 01 Nov. 2017
  • Construction of genetically modified Lactococcus lactissecreting bioactive osteocalcin
    Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
    International Dairy Federation (IDF) World Dairy Summit 2017, 01 Nov. 2017
  • Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
    Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
    Proceedings of the 17th AAAP Congress, 25 Aug. 2016
  • Immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes the anaphylaxis to ovalbumin in mice
    Yoshinari Yamamoto, Takuma Okajima, Tasuku Ogita, Takeshi Shimosato
    Proceedings of the 17th AAAP Congress, 25 Aug. 2016
  • Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community in Bangladesh: A Study of Adolescent girl
    Shireen Nigar, Takeshi Shimosato, Abu Torab Md. Abdur Rahim
    Proceedings of the 17th AAAP Congress, 25 Aug. 2016
  • CpG oligodeoxynucleotide from Streptococcus thermophilus induces type 2 innate lymphoid cells(Young Scientists Award/JSAS Excellent Presentation Award受賞)
    Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
    Proceedings of the 17th AAAP Congress, 23 Aug. 2016
  • 乳酸菌由来オリゴ核酸のアナフィラキシーショック亢進メカニズム(若手優秀ポスター賞受賞)
    山本祥也, 岡島拓真, Nigar Shireen, 重盛駿, 下里剛士
    平成27年度酪農科学シンポジウム, 25 Sep. 2015, 日本酪農科学会
  • ヘムオキシゲナーゼ-1を分泌する乳酸菌組換え体はマウスにおける急性大腸炎を軽減する(日本畜産学会第120回大会優秀発表賞 受賞)
    重盛駿, 山本祥也, 下里剛士
    日本畜産学会第120回大会, 11 Sep. 2015, 日本畜産学会
  • Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity
    Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
    2015 ADSA-ASAS Joint Annual Meeting (JAM), 14 Jul. 2015
  • Development of an anaphylactic model of buckwheat using B-type CpG oligodeoxynucleotides from lactic acid bacteria
    Yoshinari Yamamoto, Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
    2015 ADSA-ASAS Joint Annual Meeting (JAM), 14 Jul. 2015
  • Production of recombinant β-lactoglobulin in Lactococcus lactis and generation of a bioactive peptide with incretin-inactivation activity
    Kazushi Oshiro, Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
    2015 ADSA-ASAS JointAnnual Meeting (JAM), 14 Jul. 2015
  • Strong immunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria
    Yoshinari Yamamoto, Suguru Shigemori, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
    Proceedings of the 16th AAAP Congress, 12 Nov. 2014
  • Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis
    Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
    Proceedings of the 16th AAAP Congress, 12 Nov. 2014
  • インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築(若手優秀ポスター賞受賞)
    重盛駿, 大城和士, Wang Pengfei, 山本祥也, Wang Yeqin, 下里剛士
    平成26年度日本酪農科学シンポジウム, 12 Sep. 2014
  • Immunostimulatory oligodeoxynucleotide from yogurt starter bacteria Streptococcus thermophilus, strongly induces interleukin 33
    Yusuke Ito, Suguru Shigemori, Hajime Otani, Haruki Kitazawa,Takeshi Shimosato
    International Dairy Federation, World Dairy Summit 2013, 28 Oct. 2013, International Dairy Federation
  • Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy
    Suguru Shigemori, Hajime Otani,Takeshi Shimosato
    International Dairy Federation, World Dairy Summit 2013, 28 Oct. 2013, International Dairy Federation
  • Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells
    Takahashi R, Sato T, Miyazawa N, Klinman DM,Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y.
    American Thoracic Society Annual Meeting 2011, 2011
  • Toll-like receptor 4recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris
    Tohno M,Shimosato T, Aso H, Kitazawa H.
    4th congress of european microbiologists FEMS, 2011
  • CpG oligodeoxynucleotides promote wound healing in airway epithelial cells
    Sato T, Miyazawa N, KlinmanDM,Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y.
    American Thoracic Society Annual Meeting 2011, 2011
  • Immunoregulation of immunobiotic lactic acid bacterial DNA and their advanced application to Food Science
    Takeshi Shimosato
    Shinshu University International Symposium 2010 in Ina, Sustainable Agriculture and Environment: Asian Network II, proceedings, 2010, Invited
  • The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus
    Shimosato T, Fujimoto M, Tohno M, Sato T, Otani H, Kitazawa H.
    ADSA-PSA-AMPA-CSAS-ASAS Joint Annual Meeting (JAM), 2010
  • Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide.
    Sato T,Shimosato T, Klinman DM.
    97th AAI Annual Meeting, 2010
  • Effect of immunobiotics on the immune performance and productivity of pigs
    SudaY, TakahashiY, Tohno M, Villena Julio, Hosoya S, Fujie H,Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H.
    International Scientific Conference on Probiotics and Prebiotics - IPC2010, 2010
  • Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells
    Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y,Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T.
    International ScientificConference on Probiotics andPrebiotics - IPC2010, 2010
  • CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
    Sato T,Shimosato T, Klinman DM
    96th AAI Annual Meeting, 2009
  • CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
    Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H
    The 9th World Congress on Inflammation, 2009
  • REGULATION OF INFLAMMATORY RESPONSE BY IMMUNOBIOTICS IN SWINE INTESTINAL EPITHELIAL CELLS VIA MKP-1
    ShimazuT, Tohno M, Hosoya S, Fujie H,Shimosato T, Aso H, Suda Y, KawaiY, Saito T, Kitazawa H.
    The 9th World Congress on Inflammation, 2009
  • CpG oligodeoxynucleotide from Streptococcus thermophilus regulates anti-inflammatory responses
    Shimosato T, Tohno M, Sato T, Kitazawa H
    ADSA-CSAS-ASAS 2009 Joint Annual Meeting, 2009
  • 「イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性」[招待講演]
    下里剛士
    平成20年度酪農科学シンポジウム, 29 Aug. 2008
  • Immuno-stimulatory AT oligodeoxynucleotide from Lactobacillus gasseri requires a specific self-stabilized structure
    Shimosato T, Tohno M, Sato T, Kawai Y, Saito T, Kitazawa H
    ADSA-ASAS 2008 Joint Annual Meeting, 2008
  • Suppressive oligodeoxynucleotides improve outcome in murine silicosis
    SatoT,Shimosato T, Klinman DM
    American Thoracic Society Annual Meeting 2008, 2008
  • Immunobiotic lactic acid bacteria induce immune responses in immature gut-associatedlymphoid tissues via Toll-likereceptors 2 and 9
    Kitazawa H, Tohno M,Shimosato T, Aso H, Kawai, Y, Saito T.
    ADSA-ASAS 2006 Joint Annual Meeting, 2006
  • Development of a novel immunoassay system for immunobiotics that modulate intestinal immunity through Toll-likereceptor 2
    Tohno M,Shimosato T, Kawai, Y, Saito T. Kitazawa H,
    ADSA-ASAS 2006 Joint Annual Meeting, 2006
  • Immune responses of Immunobiotics and Immunogenics via Toll-like receptors and their advancedapplication to Food immunology
    Kitazawa H,Shimosato T, Tohno M, Saito T
    2nd International Bio-microcosmos Workshop, 2006
  • Swine intestinal immunity via Toll-like receptors and its advanced application to Food immunology
    Kitazawa H,Shimosato T, Tohno M, Saito T
    International Symposium on Recent Advances in Animal Science, 2005
  • Immunostimulatory activities of a novel AT oligonucleotide from "Immunobiotic" Lactobacillus gasseri on swine Peyer's patch cells
    Kitazawa H,Shimosato T, Katoh S, Tohno M, Kawai, Y, Saito T.
    Journal of Dairy Science 87 417, 2004, ADSA-ASAS 2004 Joint Annual Meeting
  • AT oligonucleotide from"Immunobiotic"Lactobacillus gasseri augments immune responses via Toll-like receptor 9 signaling
    Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai, Y, Saito T.
    ADSA-ASAS 2004 Joint Annual Meeting, 2004

Courses

  • 動物生命科学
    Shinshu University
  • 動物資源生命科学概論
    Shinshu University
  • 食と微生物
    Shinshu University
  • 畜産物利用学
    Shinshu University
  • 動物資源化学実験
    Shinshu University
  • 科学英語I
    Shinshu University
  • 細胞システム科学特論
    Shinshu University
  • 先端生命科学特論/生命産業科学特論
    Shinshu University
  • 分子生命工学特論
    Shinshu University
  • 先鋭領域融合研究群最先端研究特講
    Shinshu University
  • Advanced Study for Life Science
    Shinshu University
  • Animal Science
    Shinshu University

Affiliated academic society

  • 01 Apr. 2023
    JAPANESE SOCIETY FOR BACTERIOLOGY
  • 2001
    Japanese Society of Animal Science
  • 2001
    Japan Society for Biosicence, Biotechnology and Agrochemistry
  • 2005
    Japanese Association for Food Immunology
  • 2002
    Japanese Dairy Science Association
  • 2003
    Japan Society for Lactic Acid Bacteria
  • 01 Apr. 2020
    中部乳酸菌研究会
  • 2008
    北信越畜産学会
  • 2016
    日本栄養・食糧学会

Research Themes

  • 経口用乳酸菌オリゴDNA微粒子の最適化と腸管上皮を起点とする免疫制御機構の解明
    科学研究費補助金, 基盤研究B
    2020 - 2023
  • 国立研究開発法人新エネルギー・産業技術総合開発機構(NEDO)官民による若手研究者発掘支援事業・マッチングサポートフェーズ(代表)
    2020 - 2022
  • スマート乳酸菌の創製研究
    科学研究費補助金, 挑戦的研究(萌芽)
    2020 - 2021
  • 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証
    科学研究費補助金, 国際共同研究加速基金 国際共同研究強化B
    2019 - 2022
  • 吸入療法イノベーションの実現:高分子・抗体医薬の経気道投与による肺癌治療戦略
    科学研究費補助金, 挑戦的研究(萌芽)
    2018 - 2019
  • 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明
    科学研究費補助金, 基盤研究B
    2017 - 2020
  • 国立研究開発法人日本医療研究開発機構(AMED)創薬基盤推進研究事業(分担)
    2017 - 2019
  • ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究
    科学研究費補助金, 基盤研究C
    2016 - 2018
  • 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ(FS)・ステージ」探索タイプ(代表)
    2014 - 2015
  • 乳酸菌DNAのナノカプセル体を用いた新規食品および飼料素材開発のための基盤構築
    科学研究費補助金, 基盤研究C
    01 Apr. 2012 - 31 Mar. 2015
  • 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ(FS)・ステージ」探索タイプ(代表)
    2011 - 2012
  • プロバイオティック乳酸菌DNAの機能性食品および飼料素材としての利用法の開発
    科学研究費補助金, 若手研究B
    01 Apr. 2010 - 31 Mar. 2012
  • ナノ粒子を用いた抗アレルギーDNAワクチンの腸管粘膜系における免疫応答機構の解明
    科学研究費補助金, 若手研究B
    01 Apr. 2008 - 31 Mar. 2010
  • Functional analysis of oligodeoxynucleotides from bacteria
  • Development of mucosal vaccineusing lactic acid bacteria
  • Research on functional enhancement of lactic acid bacteria

Industrial Property Rights

  • US8163506: USE OF TOLL-LIKE RECEPTOR-EXPRESSING CELLS, US8163506, Patent right
    Tadao Saito, Takeshi Shimosato,Haruki Kitazawa
  • 4562123: Toll様レセプター強制発現細胞の利用, 特許4562123, Patent right
    齋藤忠夫, 下里剛士, 遠野雅徳, 北澤春樹
  • 5403457: ATオリゴヌクレオチドを有効成分とする免疫応答増強性薬剤及び食品組成物, 5403457, Patent right
    北澤春樹, 齋藤忠夫, 下里剛士, 佐々木隆, 伊藤喜之

Social Contribution Activities

  • 「食」と「健康」ラボ研究会第6回シンポジウム
    lecturer
    長野県, 長野県工業技術センター, 03 Mar. 2021
  • 令和元年度 第三回信州機能性食品開発研究会
    lecturer
    21 Aug. 2019
  • 平成30年度 第三回信州機能性食品開発研究会
    lecturer
    18 Dec. 2018
  • 安曇野市市民大学講座
    lecturer
    安曇野市, 豊科交流学習センター「きぼう」, 23 Aug. 2018
  • 第8回 化粧品開発展 -COSME Tech 2018-
    lecturer
    幕張メッセ, 26 Jan. 2018
  • 信州コロイド&界面科学研究会
    lecturer
    信州大学工学部, 27 Oct. 2017
  • アグリビジネス創出フェア2017
    lecturer
    東京ビックサイト, 04 Oct. 2017
  • 第14回日本農学進歩賞受賞講演会
    lecturer
    公益財団法人農学会, 東京大学弥生講堂 一条ホール, 27 Nov. 2015
  • 第二回信大見本市ミニプレゼンテーション「“食べる”機能性DNAの開発」
    lecturer
    松本市浅間温泉文化センター, 04 Mar. 2015
  • 健康食品管理士会長野県分科会講演会
    lecturer
    健康食品管理士会, 信州大学医学部保健学科, 04 Sep. 2011
  • 平成22年度「信州大学医農連携交流会」
    lecturer
    信州機能性食品研究会, 長野県松本勤労者福祉センター, 20 Jan. 2011

Acceptance of international students

  • 2020, 1, 2, モンゴル(2)
  • 2019, 2, 2, ベルギー(1),モンゴル(1)