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片山茂  カタヤマ シゲル

教員組織学術研究院(農学系)電話番号
教育組織農学部 農学生命科学科 生命機能科学コースFAX番号
職名准教授メールアドレス
住所〒399-4598 長野県上伊那郡南箕輪村8304ホームページURLhttp://karamatsu.shinshu-u.ac.jp/lab/fs/index.htm

プロフィール

研究分野
食品化学
現在の研究課題
食品由来の機能性成分の更なる高度利用のための分子設計

所属学会
所属学会
日本農芸化学会
日本栄養・食糧学会
日本食品化学学会
老化促進モデルマウス(SAM)学会

所属学会役職担当
2018- , 日本食品化学学会 , 評議員
2018- , 日本栄養・食糧学会 中部支部 , 参与
2016- , 老化促進モデルマウス(SAM)学会 , 評議員
2011-2012 , 日本農芸化学会 , 代議員
学歴
出身大学院
2004 , 北海道大学大学院 , 水産科学研究科 , 生命資源科学専攻
2001 , 北海道大学大学院 , 水産科学研究科 , 水産食品学専攻

出身学校・専攻等(大学院を除く)
1999 , 北海道大学 , 水産学部 , 海洋生物資源化学科

取得学位
博士(水産科学) , 北海道大学
受賞学術賞
2017 , 日本食品化学学会奨励賞
2015 , 日本食品化学学会第21回学術大会若手優秀発表賞
2014 , 日本農芸化学会2014年度大会トピックス賞
2013 , 日本栄養・食糧学会第67回大会トピックス演題
2012 , 日本栄養・食糧学会第66回大会トピックス演題
研究職歴等
研究職歴
2016- , 菌類・微生物ダイナミズム創発研究センター・部門長
2015- , 信州大学学術研究院(農学系) 准教授
2014- , バイオメディカル研究所代謝ゲノミクス部門・併任教員
2014-2015 , 信州大学学術研究院(農学系) 助教
2008-2014 , 信州大学農学部 助教
2006-2008 , 北海道大学大学院 博士研究員
2004-2006 , カナダGuelph大学 博士研究員

研究職歴以外の職歴
2014-2015 , タイMae Fah Luang大学 客員教授

研究活動業績

研究業績(著書・
発表論文等)
著書
Modulation of neuroprotective genes by bioactive food components in senescence-accelerated mice
CRC Press , Phytopharmaceuticals for Brain Health , :323-332 2017
Author:Katayama, S., Nakamura, S.


培養細胞株を用いた抗原感作性の評価法
シーエムシー出版 , 食物アレルギーの現状とリスク低減化食品素材の開発 , :154-158 2015
Author:片山茂


Amyloidogenic proteins and peptides
Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals , :101-120 2010
Author:Nakamura, S., Owaki, T., Maeda, Y., Katayama, S., Nakamura, K.


Antioxidative stress peptides
Functional Foodand Health , :213-228 2008
Author:Mine, Y., Katayama, S.


論文
Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain
Journal: Journal of Agricultural and Food Chemistry 2018
Author:Shimizu, Ayano; Mitani, Takakazu; Tanaka, Sachi; Fujii, Hiroshi; Maebuchi, Motohiro; Amiya, Yusuke; Tanaka, Mitsuru; Matsui, Toshiro; Nakamura, Soichiro; Katayama, Shigeru


Long-term diet supplementation with Lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8
Nutrients 2018
Author:Henry M. Corpuz, Saki Ichikawa, Misa Arimura, Toshihiro Mihara, Takehisa Kumagai, Takakazu Mitani, Soichiro Nakamura, Shigeru Katayama*


Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
Archives of Biochemistry and Biophysics,646:98-106 2018
Author:Mitani T, Takaya T, Harada N, Katayama S (corresponding author), Yamaji R, Nakamura S, Ashida H


Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway
Scientific Reports,8:5625 2018
Author:S., Chawalitpong, R., Chokchaisiri, A., Suksamrarn, S., Katayama, T., Mitani, S., Nakamura, A., AI Athamneh, P., Ritprajak, A., Leelahavanichkul, R., Aeimlapa, N., Charoenphandhu, T., Palaga


Kale supplementation up-regulates HSP70 and suppresses cognitive decline in a mouse model of accelerated senescence
Journal of Functional Foods,44:292-298 2018
Author:Kushimoto, S. Uchibori, Y., Yanai, S., Makabe, H., Nakamura, S., Katayama, S.


Rutinosylated ferulic acid attenuates food allergic response and colitis by up-regulating regulatory T cells in mouse models
Journal of Agricultural and Food Chemistry,65(49):10730-10737 2017
Author:Katayama, S., Ohno, F., Mitani, T., Akiyama, H., Nakamura, S.


Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1
BBA Molecular Cell Research,1864:2438-2448 2017
Author:Mitani T, Watanabe S, Yoshioka Y Katayama S, Nakamura S, Ashida H


Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities
Food Chemistry,221:1388-1393 2017
Author:MY Heng, S Katayama, T Mitania, ES Ong, S Nakamura


Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus
Journal of the Science of Food and Agriculture,97:1939-1944 2017
Author:Lebetwa, N., Mitani, T., Nakamura, S., Katayama, S.


Biophysical characterization of the domain association between cytosolic A and B domains of the mannitol transporter enzymes IIMtl in the presence and absence of a connecting linker
Protein Science,25(10):1803-1811 2016
Author:KO Lee, EH Kim, G Kim, JY Jung, S Katayama, S Nakamura, JY Suh


Intestinal immunomodulatory effects of a hypoallergenic buckwheat Fag e 1 prepared by Maillard-type glycation with a mannan type-polysaccharide
Japanese Journal of Food Chemistry and Safety,23(2):72-79 2016
Author:Katayama, S., Tazawa, S., Kassai, M., Mitani, T., Nakamura, S.


Effects of sesaminol feeding on brain Aβ accumulation in a senescence-accelerated mouse-prone 8
Journal of Agricultural and Food Chemistry,64(24):4908-4913 2016
Author:Katayama, S., Sugiyama, H., Kushimoto, S., Uchiyama, Y., Hirano, M., Nakamura, S.


Antioxidant and cytoprotective activities of extracts prepared from fruit and vegetable wastes and by-products
Food Chemistry,15(167):358-362 2015
Author:Kabir F, Tow WW, Hamauzu Y, Katayama S, Tanaka S, Nakamura S


Oral Administration of Soy Peptides Suppresses Cognitive Decline by Induction of Neurotrophic Factors in SAMP8 Mice
Journal of Agricultural and Food Chemistry,62(16):3563-3569 2014
Author:S Katayama, R Imai, H Sugiyama, S Nakamura


Improvement of surface functionalities including attenuation of allergenicity of whole buckwheat protein fraction by Maillard-type glycation with dextran.
Preventive Nutrition and Food Science,19(4):327-332 2014
Author:Tazawa S, Katayama S, Hirabayashi M, Yamaguchi D, Nakamura S.


Antimicrobial effects of chlorogenic acid and related compounds.
Applied Biological Chemistry,57(3):359-365 2014
Author:Kabir F, Katayama S, Tanji N, Nakamura S


Changes in mouse gastrointestinal microbial ecology with the ingestion of kale
Beneficial Microbes,5(3):345-349 2014
Author:Uyeno, Y, Katayama, S, Nakamura, S.


Enhanced anti-amyloidal activity of hydroxy cinnamic acids by enzymatic esterification with alkyl alcohols
Biotechnology and Applied Biochemistry,61(4):401-407 2014
Author:Kondo, H., Sugiyama, H., Katayama, S.*, Nakamura, S.*


Effects of ovalbumin glycoconjugates on alleviation of orally induced egg allergy in mice via dendritic-cell maturation and T-cell activation
Molecular Nutrition&Food Research,58(2):405-417 2014
Author:Rupa, S., Katayama, S., Nakamura, S., Mine, Y.


Prevention of Allergic Disease Development and Symptoms by Food Factors
Current Pharmaceutical Design,20(6):892-905 2014
Author:Akiyama, H., Katayama, S., Kanda, T., Maeda-Yamamoto, M., Totsuka, M., Takahashi, S., Shoji, T., Inakuma, T., Nakamura, S.


Enzymatic synthesis of novel phenol acid rutinosides using rutinase and their antiviral activity in vitro
Journal of Agricultural and Food Chemistry,61(40):9617-9622 2013
Author:Katayama, S., Ohno, F., Yamauchi, Y., Kato, M., Makabe, H., Nakamura, S.


Functional expression of amyloidogenic human stefins A and B in Pichia pastoris using codon optimization
Biotechnology and Applied Biochemistry,60(3):283-288 2013
Author:Nakamura, K., Maeda, Y., Morimoto, K., Katayama, S., Kondo, K., Nakamura, S.


Apple polyphenols suppress antigen presentation of ovalbumin by THP-1-derived dendritic cells
Food Chemistry,138(2-3):757-761 2013
Author:Katayama, S., Kukita, T., Ishikawa, E., Nakashima, S., Masuda, S., Kanda, T., Akiyama, H., Teshima, R., Nakamura, S.


Improving Surface Functional Properties of Tofu Whey-Derived Peptides by Chemical Modification with Fatty Acids
Journal of Food Science,77(4):C333-339 2012
Author:Matemu, A.O., Katayama, S., Kayahara, H., Murasawa, H., Nakamura, S.


Immunomodulatory Properties of Highly Viscous Polysaccharide Extract from the Gagome Alga (Kjellmaniella crassifolia)
Plant Foods for Human Nutrition,67(1):76-81 2012
Author:Katayama, S., Nishio, T., Kishimura, H., Saeki, H.


A trypsin inhibitor in the viscera of Japanese common squid (Todarodes pacificus) elicits insulinotropic effects in diabetic GK rats
Journal of Food Biochemistry,36(1):93-98 2012
Author:Kishimura, H., Fukumorita, K., Adachi, K., Chiba, S., Nagai, Y., Katayama, S., Nakajima, S., Saeki, H.


Changes in solubility and thermal stability of chicken myofibrillar protein by glycosylation
Food Science and Technology Research,17(1):69-75 2011
Author:Nishimura, K., Murakoshi, M., Katayama, S., Saeki, H.


Enhanced antiviral activity of soybean b-conglycinin-derived peptides by acylation with saturated fatty acids
Journal of Food Science,76(6):299-304 2011
Author:Matemu, A.O., Nakamura, K., Kayahara, H., Murasawa, H., Katayama, S., Nakamura, S.


Apricot carotenoids possess potent anti-amyloidogenic activity in vitro
Journal of Agricultural and Food Chemistry,59(23):12691-12696 2011
Author:Katayama, S., Ogawa, H., Nakamura, S.


Antioxidative Ability in Chicken Myofibrillar Protein developed by Glycosylation and Changes in the Solubility and Thermal Stability
Bioscience, Biotechnology, and Biochemistry,75(2):247-254 2011
Author:Nishimura, K., Murakoshi, M., Katayama, S., Saeki, H.


Improved emulsifying properties of soy proteins by acylation with fatty acids
Food Chemistry,124(2):596-602 2011
Author:Matemu, A.O., Kayahara, H., Murasawa, H., Katayama, S., Nakamura, S.


Effects of manufacturing factors on the viscosity of a polysaccharide solution extracted from Gagome Kjellmaniella crassifolia
Fisheries Science,75(2):491-497 2009
Author:Katayama, S., Nishio, T., Iseya, Z., Kishimura, H., Saeki, H.


Modulation of immunoresponse in BALB/c mice by oral administration of Fag e 1-glucomannan conjugate.
Journal of Agricultural and Food Chemistry,57(20):9787-9792 2009
Author:Suzuki, Y., Kassai, M., Hirose, T., Katayama, S., Nakamura, K., Akiyama, H., Teshima, R., Nakamura, S.


Feasibility study on water solubilization of spawned out salmon meat by conjugation with alginate oligosaccharide.
Fisheries Science,73(4):924-930 2007
Author:Takeda, H., Iida, O., Okada, A., Ootsuka, H., Ohshita, T., Masutani, E., Katayama, S., Saeki, H.


Water solubilization of glycated carp and scallop myosin rods, and their soluble state under physiological conditions.
Fisheries Science,73(2):446-452 2007
Author:Katayama, S., Saeki, H.


Antioxidant activity of tryptic digests of hen egg yolk phosvitin.
Journal of the Science of Food and Agriculture,87(14):2604-2608 2007
Author:Xu, X., Katayama, S., Mine, Y.


Antioxidative stress activity of amino acids on tissue oxidative stress in human intestinal epithelial cell model.
Journal of Agricultural and Food Chemistry,55(21):8458-8464 2007
Author:Katayama, S., Mine, Y.


Oligophosphopeptides derived from egg yolk phosvitin up-regulate g-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells.
Journal of Agricultural and Food Chemistry,55(8):2829-2835 2007
Author:Katayama, S., Ishikawa, S., Fan, M.Z., Mine, Y.


Immunomodulating effects of egg yolk low lipid peptic digests in a murine model.
Food and Agricultural Immunology,18(1):1-15 2007
Author:Nelson, R., Katayama, S., Mine, Y., Duarte, J.


Quillaja saponin can modulate ovalbumin-induced IgE allergic responses through regulation of Th1/Th2 balance in a murine model.
Journal of Agricultural and Food Chemistry,54(9):3271-6 2006
Author:Katayama, S., Mine, Y.


Antioxidative stress activity of oligophosphopeptides dereived from hen egg yolk phosvitin in Caco-2 cells.
Journal of Agricultural and Food Chemistry,54(3):773-8 2006
Author:Katayama, S., Xu, X., Fan, M.Z., Mine, Y.


Cooperative effect of relative humidity and glucose concentration on improved solubility of shellfish muscle protein by the Maillard reaction
Fisheries Science,70(1):159-166 2004
Author:Katayama, S.,Saeki, H.


Improved solubility and stability of carp myosin by conjugation with alginate oligosaccharide
Fisheries Science,70(5):896-902 2004
Author:Maitena, U., Katayama, S., Sato, R., Saeki, H.


Loss of filament-forming ability of myosin by non-enzymatic glycosylation and its molecular mechanism
FEBS Letters,575(1-3):9-13 2004
Author:Katayama, S., Haga, Y., Saeki, H.


Stability and Emulsion-Forming Ability of Water-Soluble Fish Myofibrillar Protein Prepared by Conjugation with Alginate Oligosaccharide
Journal of Agricultural and Food Chemistry,51(15):4376-4381 2003
Author:Sato, R., Katayama, S., Sawabe, T., Saeki, H.


Solubility Improvement of Shellfish Muscle Proteins by Reaction with Glucose and Its Soluble State in Low-Ionic-Strength Medium
Journal of Agricultural and Food Chemistry,50(15):4327-4332 2002
Author:Katayama, S., Saeki, H.


学会発表
Effects of soy peptides on cognitive performance in senescence-accelerated mice and elderly people
ISNFF2016 (Florida, USA) 2016
Author:S Katayama, A Shimizu, T Mitani, M Maebuchi, S Nakamura


Brain health benefits by natural dietary bioactive compounds: a mechanistic exploration (Invited)
KSABC2016 (Jeju, Korea) 2016
Author:Katayama, S.


脳機能改善ペプチド(Invited)
日本農芸化学会2016年度大会シンポジウム 2016
Author:片山茂


機能性食品因子による老化予防(Invited)
日本心理学会第79回大会シンポジウム 2015
Author:片山茂


大豆ペプチドの認知機能低下抑制作用とその作用機序(Invited)
第44回機能性食品用ペプチド研究会 2015
Author:片山茂


Modulation of neuroprotective genes by natural dietary bioactive compounds in senescence-accelerated mice
Pacifichem 2015 (Hawaii, USA) 2015
Author:Katayama, S.


Neurotrophic effects of soy peptides in senescence-accelerated mice
IUFoST2014 (Montreal, Canada) 2014
Author:Katayama, S., Maebuchi, M., Ishijima, T., Nakai, Y., Abe, K., Nakamura, S.


Anti-aging effects of kale (Brassica oleracea) in senescence-accelerated mice (Invited)
ICAAI2014 (Cheng Rai, Thailand) 2014
Author:Katayama, S., Kushimoto, S., Suto, Y., Nakamura, S.


THP-1由来樹状細胞を用いた食品成分のアレルゲン性および抗アレルギー作用の評価(Invited)
日本動物細胞工学会(福井) 2013
Author:片山茂


Development of human dendritic cell-based in vitro assays for assessment of the potential allergenicity of foods and its anti-allergic compounds
ISNFF2012 (Hawaii, USA) 2012
Author:Katayama, S., Kukita, T., Nakamura, S.


Immunomodulatory properties enhanced by highly viscous polysaccharides from the brown alga Gagome (Kjellmaniella crassifolia) (Invited)
KosFost 2011 (Daegu, Korea) 2011
Author:Katayama, S.


その他
脳老化抑制に資する調節因子と機能性ペプチド
FFIジャーナル , 222(3):210-215 2017
Author:片山茂


大豆ペプチドの認知機能低下抑制作用とその作用機序
食品加工技術 , 35(3):22-26 2015
Author:片山茂


Nrf2-ARE経路を活性化する大豆サポニンの抗酸化作用
Fragrance Journal , (2):57-63 2013
Author:片山茂

特許等知的財産
登録済特許
アミロイド形成阻害剤の製造方法
ガゴメ由来免疫賦活剤およびガゴメ由来の粘性多糖類の抽出方法
Hsp発現促進剤
花粉症症状軽減作用を有するキクイモの抽出物
研究費
科学研究費補助金(研究代表者)
2018 - 2020 , 低アレルゲン性リン酸化抗原による経口免疫寛容誘導機構の解明 , 基盤研究(C)
2015 - 2017 , 神経変性保護作用を有するフェノール類配糖体の創製 , 基盤研究(C)
2013 - 2014 , 抗原特異的な免疫寛容誘導能を有するポリフェノール配糖体の創製とその応用 , 若手研究(B)
2011 - 2012 , 酵素合成法を用いたTreg分化誘導能を有するポリフェノール配糖体の創製 , 若手研究(B)

奨学寄附金
2018 , 飯島藤十郎記念食品科学振興財団
2017 , ニッポンハム食の未来財団
2016 , ニッポンハム食の未来財団
2015 , 清水純夫研究助成基金
2015 , ホクト生物科学振興財団
2009 , 不二たん白質研究振興財団

その他公的資金
2012 - 2013 , キクイモ抽出物に含まれるスギ花粉症軽減物質の同定とその応用,独立行政法人科学技術振興機構 研究成果最適展開支援プロジェクト(A-STEP)探索タイプ
2011 - 2011 , キクイモサポニンの花粉症軽減効果とその応用,独立行政法人科学技術振興機構 研究成果最適展開支援プロジェクト(A-STEP)探索タイプ

教育活動実績

授業等
前期 , 栄養機能化学
前期 , 生物分析化学
前期 , 食品分子機能学特論
前期 , 生化学
前期 , 食品化学系実験
後期 , 食品化学
後期 , 食品機能開発学特論
通年 , Advanced Study for Food Science
通年 , 食品分子化学特論

社会活動実績

社会活動等
公開講座
20090805 - , 食物アレルギー教室

放送公開講座
201608 - , 超独創的×高校生 信大の食にまつわる大研究!第4回「食べ物で脳活性!?」
20130217 - , 「食とアンチエイジング ~ケールの老化抑制効果~」 

出前講座
2017.8 - , 花粉症と食物アレルギー -症状緩和の糸口とは?-
2017.4 - , 花粉症と食物アレルギー

その他社会活動
2013 - , 科学技術・学術政策研究所 , 科学技術動向研究センター , 専門調査員