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MITANI Takakazu

Academic OrganizationGraduate School of AgricultureTEL
Education and Research OrganizationFaculty of Agriculture Department of Agricultural and Life SciencesFAX
PositionAssistant ProfessorMail Address
Address8304, Minamiminowa-Village, Kamiina-County 399-4598Web site


Assigned Class
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Research Field
molecular nutrition
Functional Food Science
Academic Societies
Academic Societies
Japanese society for Food Factors
The vitamin Society of Japan
The Molecular Biology Society of Japan
The Japan Society of Nutirtion and Food Science
Japan Society for Bioscience, Biotechnology, and Agrochemistry
The Japanese Biochemical Society
Academic Background
Graduate School
Osaka Prefecture University , (Environmental Sciences and Technology , Graduate School of Life and Environmental Scienves) , 2013
Osaka Prefecture University , (Environmental Sciences and Technology , Graduate School of Life and Environmental Sciences) , 2010

Ph.D. , Osaka Prefecture University


Books, Articles, etc.
Anti-obesity Effect of Food Factors Based on Target Proteins: Novel Molecular Function of Methylxanthine
Kagaku to Seibutsu,60(11):587-594 2022(Nov. 01)
Author:Mitani T

25-Hydroxyvitamin D increases insulin-stimulated glucose uptake by enhancing adipocyte differentiation
Journal of Nutritional Science and Vitaminology,68(5):420-428 2022(Oct.)
Author:Nakashima M., Mitani T.

Isolation, identification, and in vivo evaluation of the novel antihypertensive peptide, VSKRLNGDA, derived from chicken blood cells
Process Biochemistry,115:169-177 2022(Feb. 15)
Author:Wongngama W., Roytrakulb S., Mitani T., Katayama S., Nakamura S., Yongsawatdigula J.

Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria.
Bioscience, Biotechnology, and Biochemistry, 2021(Nov. 29)
Author:Ikeda T, Watanabe S, Mitani T.

Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARgamma activation-dependent manner
The Journal of Nutritional Biochemistry 2021(Nov. 05)
Author:Tanaka E, Mitani T (corresponding author), Nakashima M, Yonemoto E, Fujii H, Ashida H.

Production and characterization of chicken blood hydrolysate with antihypertensive properties
Poultry Science,99(10):5163-5174 2020(Jul. 27)
Author:Wongngam W., Mitani T., Katayama S., Nakamura S., Yongsawatdigul J.

Enzymatically synthesized glycogen prevents UVB-induced cell damage in normal human epidermal keratinocytes
Journal of Clinical Biochemistry and Nutrition,67(1):36-42 2020(May 05)
Author:Yoshioka Y, Kitakaze T, Mitani T, Furuyashiki T, Ashida H.

Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes
Biochemical and Biophysical Research Communications,522(3):770-775 2019(Nov. 30)
Author:Mitani T, Watanabe S, Wada K, Fujii H, Nakamura S, Katayama S

Oral immunotherapy with a phosphorylated hypoallergenic allergen ameliorates allergic responses more effectively than intact allergen in a murine model of buckwheat allergy.
Molecular Nutrition & Food Research,62(21):e1800303 2018(Sep. 14)
Author:Katayama S, Yamaguchi D, Suzuki Y, Athamneh AMA, Mitani T, Satoh R, Teshima R, Mine Y, Nakamura S.

Soybean-derived glycine-arginine dipeptide administration promotes neurotrophic factor expression in the mouse brain
Journal of Agricultural and Food Chemistry,66(30):7935-7941 2018(Aug. 01)
Author:Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.

Long-term diet supplementation with lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8.
Nutrients,10(6):E762 2018(Jun. 13)
Author:Corpuz HM, Ichikawa S, Arimura M, Mihara T, Kumagai T, Mitani T, Nakamura S, Katayama S.

Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
Archives of Biochemistry and Biophysics,646:98-106 2018(May 15)
Author:Mitani T, Takaya T, Harada N, Katayama S, Yamaji R, Nakamura S, Ashida H

Methylxanthine derivative-rich cacao extract suppresses differentiation of adipocytes through down-regulation of PPARγ and C/EBPs
Journal of Nutritional Science and Vitaminology,64(2):151-160 2018(Apr. 30)
Author:Yamashita Y*, Mitani T*, Wang L, Ashida H. (*Co-first Author)

Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.
Scientific Reports,8(1):5625 2018(Apr. 04)
Author:Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N, Palaga T.

Rutinosylated ferulic acid attenuates food allergic response and colitis by up-regulating regulatory T cells in mouse models.
Journal of agricultural and food chemistry,65(49):10730-10737 2017(Dec. 13)
Author:Katayama S, Ohno F, Mitani T, Akiyama H, Nakamura S.

Caffeine-stimulated intestinal epithelial cells suppress lipid accumulation in adipocytes
Journal of Nutritional Science and Vitaminology,63(5):333-340 2017(Dec. 08)
Author:Mitani T, Nagano T, Harada K, Yamashita Y, Ashida H

Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research,1864(12):2438-2448 2017(Sep. 28)
Author:Mitani T, Watanabe S, Yoshioka Y, Katayama S, Nakamura S, Ashida H

Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities
Food Chemistry,221:1388-1393 2017(Apr. 15)
Author:Heng MY, Katayama S, Mitani T, Ong ES, Nakamura S.

Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus.
Journal of the Science of Food and Agriculture,97(6):1939-1944 2017(Apr. 01)
Author:Lebetwa N, Mitani T, Nakamura S, Katayama S

Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress.
Free Radical Biology and Medicine,106:355-367 2017(Feb. 28)
Author:Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H.

Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells
Journal of Clinical Biochemistry and Nutrition,60(2):108-114 2016(Dec. 06)
Author:Yoshioka Y, Li X, Zhang T, Mitani T, Yasuda M, Nanba F, Toda T, Yamashita Y, Ashida H.

Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
Scientific reports,6:23001 2016(Mar. 10)
Author:Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, Yamaji R.

Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia
Cellular Signalling,27(10):1994-2001 2015(Oct.)
Author:Mitani T, Minami M, Harada N, Ashida H, Yamaji R.

Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model
Pesticide Biochemistry and Physiology,120:14-20 2015(May)
Author:Ashida H, Harada K, Mishima S, Mitani T, Yamashita Y, Matsumura F.

Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer
Journal of Nutritional Science and Vitaminology,60(4):276-282 2014(Aug.)
Author:Mitani T, Harada N, Tanimori S, Nakano Y, Inui H, Yamaji R.

Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells
Journal of Nutritional Science and Vitaminology,60(2):122-128 2014(Apr.)
Author:Mitani T, Ito Y, Harada N, Nakano Y, Inui H, Ashida H, Yamaji R.

Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4 '-amino-3,5-dihydroxy-trans-stilbene
Journal of Nutritional Science and Vitaminology,59(4):358-364 2013(Aug.)
Author:Ito Y*, Mitani T*, Harada N, Isayama A, Tanimori S, Takenaka S, Nakano Y, Inui H, Yamaji R. (*Co-first Author)

Coordinated action of hypoxia-inducible factor-1 alpha and beta-catenin in androgen receptor signaling
Journal of Biological Chemistry,287(40):33594-33606 2012(Sep. 28)
Author:Mitani T, Harada N, Nakano Y, Inui H, Yamaji R.

Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2 alpha through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms
Biochemical and Biophysical Research Communications,413(2):201-205 2011(Sep. 23)
Author:Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, Nakano Y.

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1 alpha in a low androgen environment
Journal of Steroid Biochemistry and Molecular Biology,123(1-2):58-64 2011(Jan.)
Author:Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, Inui H.

A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor
Bioscience Biotechnology and Biochemistry,74(9):1965-1968 2010(Sep.)
Author:Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H,

Involvement of three glutamine tracts in human androgen receptor transactivation
Journal of Steroid Biochemistry and Molecular Biology,118(1-2):77-84 2010(Jan.)
Author:Harada N, Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, Inui H.

Anti-obesity Effect of Food Factors Based on Target Proteins: Novel Molecular Function of Methylxanthines
化学と生物「解説」,60(11):586 2022
Author:Mitani Takakazu
Abstract:食品には栄養的機能,嗜好的機能,生体調節機能の 3 つの機能が存在し,中でも生体調節機能は健康や疾病との関わりが深いことから,研究者だけでなく一般消費者にも広く注目されている.しかしながら,食品に含まれる成分がどのような生体分子と相互作用することで,機能を発現しているのかが不明な場合が多く存在する.筆者は,食品成分の標的分子として特に標的タンパク質の同定を介してその機能性発現メカニズムを解明することに取り組んでいる.本解説では,食品の中でも嗜好品に多く含まれているメチルキサンチン類を主題として,その標的タンパク質を介した肥満およびその関連症状の改善効果について紹介する.

Research Activities
Journal Reviewer
2022-2022 , Bioscience Reports
2022-2022 , Bioscience, Biotechnology, and Biochemistry
2021-2021 , International Journal of Molecular Sciences
2021-2021 , Molecules
2021-2021 , Bioscience, Biotechnology, and Biochemistry
2020-2020 , Antioxidants
2020-2020 , Molecules
2020-2020 , Bioscience, Biotechnology, and Biochemistry
2019-2019 , Bioscience, Biotechnology, and Biochemistry