UMEZAWA Koji
Academic Assembly School of Science and Technology Institute of Agriculture
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Assistant Professor
Researcher Information
Research activity information
Paper
- Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation.
Umezawa K, Ikeda R, Sakamoto T, Enomoto Y, Nihashi Y, Shinji S, Shimosato T, Kagami H, Takaya T.
BioTech, 13(2), 11, 2024, Refereed
- Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells.
Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.
Int J Mol Sci, 24(18), 14380, 2023, Refereed - Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
Nanomaterials, 12(10), 1680, 14 May 2022, Refereed - Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts.
Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
ANIMAL SCIENCE JOURNAL, 92(1), e13597, 25 Jul. 2021, Refereed - Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
Frontiers in Cell and Developmental Biology, 8, 616706, Jan. 2021, Refereed - Hyperstable De Novo Protein with a Dimeric Bisecting Topology
Kimura N., Mochizuki K., Umezawa K., Hecht MH., Arai R.
ACS Synthetic Biology, 9(2), 254-259, 17 Jan. 2020 - Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.
Shinji, S; Nakamura, S; Nihashi, Y; Umezawa, K; Takaya, T
Biosci Biotechnol Biochem, 84(1), 63-75, 2020, Refereed
- Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens
Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, Ono T, Kagami H, Takaya T
SCIENTIFIC REPORTS, 9, 16527, 11 Nov. 2019, Refereed - Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells.
Ichikawa M, Yamamoto S, Ishihara C, Nonobe S, Hattori Y, Umezawa K, Fujii H, Makabe H
Tetrahedron, 74(27), 3534-3542, 05 Jul. 2018, Refereed - Structural and dynamical characteristics of tropomyosin epitopes as the major allergens in shrimp.
Ozawa H, Umezawa K, Takano M, Ishizaki S, Watabe S, Ochiai Y
Biochemical and biophysical research communications, 498(1), 25 Mar. 2018, Refereed - Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts
Takanashi K, Suda M, Matsumoto K, Ishihara C, Toda K, Kawaguchi K, Senga S, Kobayashi N, Ichikawa M, Katoh M, Hattori Y, Kawahara S, Umezawa K, Fujii H, and Makabe H
SCIENTIFIC REPORTS, 7(1), 7791, 10 Aug. 2017, Refereed - Over-Destabilization of Protein-Protein Interaction in Generalized Born Model and Utility of Energy Density Integration Cutoff
Mizuhara Y, Parkin D, Umezawa K, Ohnuki J, Takano M
JOURNAL OF PHYSICAL CHEMISTRY B, 121, 4669-4677, 20 Apr. 2017, Refereed - 分子動力学シミュレーションで探る天然変性タンパク質の準安定複合体構造と結合解離調節機構
梅澤公二
信州大学農学部紀要, 53, 34-43, 21 Mar. 2017 - Intrinsic disorder accelerates dissociation rather than association
Koji Umezawa, Jun Ohnuki, Junichi Higo, Mitsunori Takano
Proteins: Structure, Function, and Bioinformatics, -(-), 18 May 2016, Refereed - Enhanced sampling simulations to construct free-energy landscape of protein–partner substrate interaction
Jinzen Ikebe, Koji Umezawa, Junichi Higo
Biophysical Reviews, 8(1), 45-62, 11 Jan. 2016, Refereed - virtual-system coupled multicanonical molecular dynamics simulation: Principles and applications to free-energy landscape of protein–protein interaction with an all-atom model in explicit solvent
Junichi Higo, Koji Umezawa, Haruki Nakamura
The Journal of Chemical Physics, 138, 184106, 10 May 2013, Refereed - Conformational ensembles of an intrinsically disordered protein pKID with and without a KIX domain in explicit solvent investigated by all-atom multicanonical molecular dynamics
Koji Umezawa, Jinzen Ikebe, Mitsunori Takano, Haruki Nakamura, Junichi Higo
BIOMOLECULES, 2(1), 104-121, 22 Feb. 2012, Refereed - Theory for trivial trajectory parallelization of multicanonical molecular dynamics and application to a polypeptide in water
Jinzen Ikebe, Koji Umezawa, Narutoshi Kamiya, Takanori Sugihara, Yasushige Yonezawa, Yu Takano, Haruki Nakamura, Junichi Higo
JOURNAL OF COMPUTATIONAL CHEMISTRY, 32(7), 1286-1297, 15 Dec. 2010, Refereed - Solvent flow patterns fluctuating largely around a protein and correlation with solvent density fluctuations: A molecular dynamics study
Koji Umezawa, Ryota Morikawa, Haruki Nakamura, Junichi Higo
The Journal of Chemical Physics, 132, 155103, 16 Apr. 2010, Refereed - Conformational requirement on peptides to exert laminin's activities and search for protein segments with laminin's activities
Koji Umezawa, Jinzen Ikebe, Motoyoshi Nomizu, Haruki Nakamura, Junichi Higo
Biopolymers, 92(2), 124-131, 29 Jan. 2009, Refereed - Solvent Site-Dipole Field Accompanying Protein-Ligand Approach Process
Norikazu Takano, Koji Umezawa, et al.
Chem-Bio Informatics Journal, 8(1), 14-24, 29 Apr. 2008, Refereed - Structure dependency of a 24-residue peptide humanin on solvent and preferential solvation by trifluoroethanol studied by multicanonical sampling
Ryosuke Yagisawa, Narutoshi Kamiya, Jinzen Ikebe, Koji Umezawa, Junichi Higo
Chemical Physics Letters, 455(4-6), 293-296, 10 Apr. 2008, Refereed - Collective solvent flows around a protein investigated by molecular dynamics simulation
Koji Umezawa, Junichi Higo, Sakurako Shimotakahara, Heisaburo Shindo
The Journal of Chemical Physics, 127(4), 045101, 26 Jul. 2007, Refereed - Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin α3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity
Kozue Kato-Takagaki, Nobuharu Suzuki, Fumiharu Yokoyama, Shu Takaki, Koji Umezawa, Junichi Higo, Marumi Mochizuki, Yamato Kikkawa, Shinya Oishi, Atsushi Utani, Motoyoshi Nomizu
Biochemistry, 46(7), 1952-1960, 30 Jan. 2007, Refereed
Books and other publications
- Protein Conformational Dynamics: Advances in Experimental Medicine and Biology 805
Junichi Higo, Koji Umezawa, Joint work, Free-Energy Landscape of Intrinsically Disordered Proteins Investigated by All-Atom Multicanonical Molecular Dynamics
Springer, 331-351 16 Dec. 2013
ISBN:10.1007/978-3-319-02970-2_14
