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FUJII Chifumi

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical Sciences , Department of Advanced Medicine for Health PromotionFAX
PositionAssistant ProfessorMail Address
AddressAsahi3-1-1 Matsumoto, NaganoWeb site



Research Field
Molecular Oncology
Academic Societies
Academic Societies
Academic Background
Graduate School
金沢大学大学院 , (生命科学専攻 , 自然科学研究科) , 2001
金沢大学大学院 , (化学専攻 , 理学研究科) , 1998

金沢大学 , (理学部) , 1996
Research Career
Research Career
2014- , 信州大学学術研究院(医学系)助教 バイオメディカル研究所主担当
2013- , 信州大学大学院医学系研究科助教
2007-2013 , 信州大学医学部医学科助教
2006-2007 , 信州大学医学部医学科助手
2003-2006 , 金沢大学がん研究所助手
2001-2003 , 金沢大学がん研究所非常勤研究員


Books, Articles, etc.
Biological Defenses and Regulation of Epithelial Tumor Development by the Gastric Gland Mucus-type Glycan
Shinshu Medical Journal,70(5):257-269 2022(Oct.)
Author:FUJII Chifumi, NAKAYAMA Jun

α1,4-linked N-acetylglucosamine suppresses gastric cancer development by inhibiting Mucin-1-mediated signaling.
Cancer Sci.,in press 2022
Author:Fujii C (corresponding author), Harumiya S, Sato Y, Kawakubo M, Matoba H, Nakayama J.

MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung.
Histochem. Cell Biol.,157:671-684 2022
Author:Yamanoi K, Fujii C (co-first author), Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J.

Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.
Cancer Sci.,113:576-586 2022
Author:Yuki A, Fujii C (co-first author, corresponding author), Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J.

Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL
Proc. Natl. Acad. Sci. USA,118:e2016469118 2021
Author:Kobayashi J, Kawakubo M, Fujii C, Arisaka N, Miyashita M, Sato Y, Komura H, Matoba H, and Nakayama J

Cecal tumorigenesis in Aryl hydrocarbon receptor-deficient mice depends on cecum-specific mitogen-activated protein kinase pathway activation and inflammation
Am. J. Pathol.,190:253-268 2020
Author:Matoba H, Takamoto M*, Fujii C*,Kawakubo M, Kasuga E, Matsumura T, Natori T,Misawa K, Taniguchi S, and Nakayama J (*: Corresponding author)

Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda
J. Histtochem. & Cytochem.,67:759-770 2019
Author:Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, and Nakayama J

Annexin A1 expression is correlated with malignant potential of renal cell carcinoma
Int. J. Urol.,26:284-290 2019
Author:Yamanoi M, Yamanoi K1, Fujii C1,2, Fukuda MN, and Nakayama J (1: Contributed equally, 2: Corresponding author)

Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer
J. Bilo. Chem.,293:6329-6336 2018
Author:Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI

Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells
Tohoku J Exp Med,244:133-144 2018
Author:Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S

Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer.
Cancer Sci,108:1897-1902 2017
Author:Ohya A, Yamanoi K, Shimojo H, Fujii C, Nakayama J

ASC induces apoptosis via activation of caspase-9 by enhancing gap junction-mediated intercellular communication.
PLoS ONE,12:e0169340 2017
Author:Kitazawa M, Hida S, Fujii C, Taniguchi S, Ito K, Matsumura T, Okada N, Sakaizawa T, Kobayashi A, Takeoka M, and Miyagawa S

Novel role of ASC as a regulator of metastatic phenotype.
Cancer Med.,5:2487-2500 2016
Author:Okada N1, Fujii C1,2, Matsumura T, Kitazawa M, Okuyama R, Taniguchi S, and Hida S. (1: Contributed equally, 2: Corresponding author)

NFkB2 gene as a novel candidate that epigenetically responds to interval walking training.
Int. J. Sports. Med.,36:769-775 2015
Author:Y. Zhang, S. Hashimoto, C. Fujii, S. Hida, K. Ito, T. Matsumura, T. Sakaizawa, M. Morikawa, S. Masuki, H. Nose, K. Higuchi, K. Nakajima, S. Taniguchi

Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.
Oncogene,29:2228-2237 2010
Author:Y. Wu, Y. Y. Wang, Y. Nakamoto, Y-Y. Li, T. Baba, S. Kaneko, C. Fujii, and N. Mukaida

In vivo immunological toxicity in mice of carbon nanotubes with impurities.
Carbon,47:1365-1372 2009
Author:S. Koyama, Y. A. Kim, T. Hayashi, K. Takeuchi, C. Fujii, N. Kuroiwa, H. Koyama, T. Tsukahara, and M. Endo

Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression.
J. Cancer Res. Clin. Oncol.,134:481-488 2008
Author:H. C. Zheng, K. Tsuneyama, H. Takahashi, S. Miwa, T, Sugiyama, B. K. Popivanova, C. Fujii, K. Nomoto, N. Mukaida, and Y. Takano

Blocking TNF-a in mice reduces colorectal carcinogenesis associated with chronic colitis.
J. Clin. Invest.,118:560-570 2008
Author:B. K. Popivanova, K. Kitamura, Y. Wu, T. Kondo, T. Kagaya, S. Kaneko, M. Oshima, C. Fujii, and N. Mukaida

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
Cancer Sci.,98:321-328 2007
Author:B. K. Popivanova, Y-Y Li, H. Zheng, K. Omura, C. Fujii, K. Tsuneyama, and N. Mukaida

Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages, and neovascularization.
Int. J. Cancer,118:335-345 2006
Author:X. Yang, P. Lu, Y. Ishida, W. A. Kuziel, C. Fujii, and N. Mukaida

Esssential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Int. J. Cancer,118:1869-1876 2006
Author:X. Yang, P. Lu, C. Fujii, Y. Nakamoto, J. Gao, S. Kaneko, P. M. Murphy, and N. Mukaida

Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines.
Cancer Res.,66:6741-6747 2006
Author:Y-Y. Li, B. K. Popivanova, Y. Nagai, H. Ishikura, C. Fujii, and N. Mukaida

Implication of ‘Down syndrome cell adhesion molecule’ in the hippocampal neurogenesis of ischemic monkeys.
Hippocampus,16:924-935 2006
Author:T. Yamashima, B. K. Popivanova, J. Guo, S. Kotani, T. Wakayama, S. Iseki, K. Sawamoto, H. Okano, C. Fujii, N. Mukaida, and A. B. Tonchev

Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.
Int. J. Cancer,114:209-218 2005
Author:C. Fujii, Y. Nakamoto, P. Lu, K. Tsuneyama, B. K. Popivanova, S. Kaneko, and N. Mukaida

hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitize cervical cancer cells to a low dose of cisplatin.
Cancer Gene Ther.,11:1-7 2004
Author:M. Nakamura, S. Kyo, T. Kanaya, N. Yatabe, Y. Maida, M. Tanaka, Y. Ishida, C. Fujii, T. Kondo, M. Inoue, and N. Mukaida

Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55.
Int. J. Cancer,112:927-933 2004
Author:Y. Tomita, X. Yang, Y. Ishida, Y. Nemoto-Sasaki, T. Kondo, M. Oda, G. Watanabe, G. N. Chaldakov, C. Fujii, and N. Mukaida

Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas.
Am. J. Pathol.,162:1249-1258 2003
Author:P. Lu, Y. Nakamoto, Y. Nemoto-Sasaki, C. Fujii, H. Wang, M. Hashii, Y. Ohmoto, S. Kaneko, K. Kobayashi, and N. Mukaida

Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis.
Lab. Invest.,82:571-583 2002
Author:K. Kitamura, Y. Nakamoto, M. Akiyama, C. Fujii, T. Kondo, K. Kobayashi, S. Kaneko, and N. Mukaida

Difference in the way of macrophage recognition of target cells depending on their apoptotic states.
Cell Death Differ.,8:1113-1122 2001
Author:C. Fujii, A. Shiratsuchi, J. Manaka, S. Yonehara, and Y. Nakanishi

Essential tyrosine residues in 3-ketosteroid-Δ1-dehydrogenase from Rhodococcus rhodochrous.
J. Biochem.,126:662-667 1999
Author:C. Fujii, S. Morii, M. Kadode, S. Sawamoto, M. Iwami, and E. Itagaki

3-Ketosteroid-Δ1-dehydrogenase of Rhodococcus rhodochrous:Sequencing of the genomic DNA and hyperexpression, purification, and characterization of the recombinant enzyme.
J. Biochem.,124:1026-1032 1998
Author:S. Morii, C. Fujii, T. Miyoshi, M. Iwami, and E. Itagaki

第109回日本泌尿器科学会総会 2021(Dec.)

第79回日本癌学会学術総会 2021(Oct.)

第79回日本癌学会学術総会 2021(Oct.)

第28回日本がん転移学会学術集会 2021(Jul.)

第118回日本内科学会講演会 2021(Apr.)

第110回日本病理学会総会 2021(Apr.)

第79回日本癌学会学術総会 2020(Oct.)

第79回日本癌学会学術総会 2020(Oct.)

第109回日本病理学会総会 2020(Jul.)

第29回日本がん転移学会 2020

Gastritis Cystica Profundaの発生抑制における胃スルホムチンの役割の解明(神戸)
第60回日本組織細胞化学会総会・学術集会および第13回日中組織細胞化学セミナー合同大会(神戸) 2019(Sep.)

Role of gastric gland mucin-specific O-glycan GlcNAc in gastric cancer development
ASCB|EMBO meeting 2018(San Diego, USA) 2018(Dec.)
Presenter:Chifumi Fujii, Atsuko Yuki, Satoru Harumiya, Kazuhiro Yamanoi, Masatomo Kawakubo, and Jun Nakayama

第77回日本癌学会学術集会(大阪) 2018(Sep.)
Presenter:的場久典, 藤井千文, 谷口俊一郎, 中山淳

第77回日本癌学会学術集会(大阪) 2018(Sep.)
Presenter:山ノ井万里子, 山ノ井一裕, 藤井千文, 福田道子, 中山淳

第91回日本生化学会大会(京都) 2018(Sep.)

第27回日本がん転移学会学術集会(横浜) 2018(Jul.)
Presenter:藤井千文, 中山淳

第107回日本病理学会総会(札幌) 2018(Jun.)
Presenter:的場久典, 藤井千文, 川久保雅友, 春日恵理子, 高本雅哉, 谷口俊一郎, 中山淳

第106回日本泌尿器科学会総会(京都) 2018(Apr.)
Presenter:山ノ井万里子, 藤井千文, 山ノ井一裕, 福田道子, 中山淳

第76回日本癌学会学術総会(横浜) 2017(Sep.)

Novel role of ASC as a regulator of metastatic phenotype
第41回研究皮膚科学会年次学術大会(仙台) 2016(Dec.)

第75回日本癌学会学術総会(横浜) 2016(Oct.)

第23回日本がん転移学会学術集会(大阪) 2015(Jul.)

第23回日本がん転移学会学術集会(金沢) 2014(Jul.)

The roles of ASC in cancer cell metastasis
15th International Biennial Congress Metastasis Research Society (Germany) 2014(Jun.)
Presenter:Chifumi Fujii, Tomio Matshmura, Takao Sakaizawa, Shigeaki Hida, and Shun’ichiro Taniguchi.

Actin binding protein fascin1 regulates innate immune responses in tumor cells
日本免疫学会総会・学術集会 2013(Dec.)

第72回日本癌学会学術総会 2013(Oct.)

第72回日本癌学会学術総会 2013(Oct.)

第22回日本がん転移学会学術集会 2013(Jul.)

第22回日本がん転移学会学術集会 2013(Jul.)

第22回日本がん転移学会学術集会 2013(Jul.)

第85回日本生化学会大会(福岡) 2012(Dec. 14)

Imvolvement of fascin in immune responses through inflammasome activation
第41回日本免疫学会総会・学術集会(神戸) 2012(Dec. 05)
Presenter:Tomio Matsumura, Chifumi Fujii, Shun’ichiro Taniguchi, and Shigeaki Hida

第71回日本癌学会学術総会(札幌) 2012(Sep. 19)

Potential involvement of ASC in cancer progression and metastasis.
14th International Biennial Congress of the Metastasis Research Society (Australia) 2012(Sep. 02)
Presenter:Chifumi Fujii, Shigeaki Hida, Masato Kitazawa, Kensuke Ito, and Shun’ichiro Taniguchi.

マクロファージの抗腫瘍作用におけるApoptosis-associated speck-like protein containing a CARD(ASC)の役割
第70回日本癌学会学術総会(名古屋) 2011(Oct.)

第70回日本癌学会学術総会(名古屋) 2011(Oct.)

第20回日本がん転移学会学術集会・総会(浜松) 2011(Jun. 30)