ISHIZUKA, OSAMU | Shinshu University Researcher Directory

Academic Organization		TEL	+81 263 372661
Education and Research Organization	Shinshu University Hospital　Clinical Division of Urology	FAX	+81 263 373082
Position	Honorary professor　Professor	Mail Address
Address	Department of Urology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan	Web site	http://www.shinshu-u.ac.jp/faculty/medicine/chair/urology/index.htm

Profile

Research Field: Neurourology
Tissue Engineering for Lower Urinary Tract System
Urological Minimal Invasive Surgery
Keywords:Neurourology

Current Subject: Tissue Engineering for Lower Urinary Tract
Keywords:再生医療
排尿における神経伝達物質の役割

腹腔鏡下泌尿器科手術の研究

ロボット支援手術の技術改良

Academic Societies: Academic Societies
日本排尿機能学会
日本泌尿器科学会
SocieteInterationale d'Urologie
日本癌治療学会
日本超音波医学会
日本移植学会
日本臨床腎移植学会
日本内視鏡外科学会
日本泌尿器内視鏡学会
日本ロボット外科学会
日本性感染症学会
老年泌尿器科学会
日本性機能学会
日本泌尿器腫瘍学会
日本内分泌外科学会
International Society for sexual and impotence research
Endourological Society
日本脊髄障害医学会
日本メンズヘルス医学会
日本ミニマム創泌尿器内視鏡学会

Committee of Academic Societies
2022-2022 , The 87th Annual Meeting of Japan Urological Associaion Western Section , President

Academic Background: College
Shinshu University , (Faculty of Medicine) , 1984

Degree
Doctor of Philosophy , Lund University
Doctor of Medicine , Shinshu University

Awards: 2020 , LUTS Best Reviewer Award for 2019
2017 , IJU Reviewers of the Year 2017
2016 , LUTS Best Reviewer Award for 2015-16
2015 , IJU Reviewers of the Year 2015
2007 , Japanese Urological Society Research Grant
2007 , 日本漢方生薬製剤協会研究助成
2004 , Detrol LA Research Grants 2004
2002 , 信州医学振興会研究費助成
2001 , Abbott Laboratories Erectile Dysfunction Research Awards
2000 , 日本泌尿器科学会信州地方会賞
1997 , 高齢者の医学医療に関する研究助成

Research Career: Research Career
2014-2023 , 信州大学医学部　泌尿器科学教室　教授
2012-2014 , 信州大学医学部附属病院泌尿器科　診療教授
2007-2012 , 信州大学医学部　泌尿器科学教室　准教授
2001-2007 , 信州大学医学部　泌尿器科学教室助教授
1996-2001 , 信州大学医学部附属病院　泌尿器科講師
1996-1996 , 信州大学医学部附属病院　泌尿器科助手
1995-1996 , 市立甲府病院泌尿器科医長
1992-1995 , 信州大学医学部　泌尿器科学教室助手
1990-1992 , 佐久総合病院泌尿器科医師
1988-1990 , 信州大学医学部附属病院　泌尿器科助手
1987-1988 , 篠ノ井総合病院　泌尿器科医師
1986-1987 , 信州大学医学部附属病院　泌尿器科助手
1985-1986 , 山梨県立中央病院　泌尿器科研修医
1984-1985 , 信州大学医学部附属病院　泌尿器科研修医

Overseas Education
1993-1995 , Department of Urology, Lund University, Sweden

Research

Books, Articles, etc.: Books
腹腔鏡手術がさらに進化　ロボット支援下による前立腺がん・腎がん手術.　第3部　さらなる高みを目指して―高度設備と最新の技術., 信州大学医学部附属病院編著, よりよい医療を届けたい― 信大病院の最新治療, 106-107
バリューメディカル 2021
Author:石塚　修

Surgical management of neurogenic bladder after spinal cord injury, A Joint SIU-ICUD International consultation , 209
2017
Author:Wyndaele, J.J., Birch, B., Burks, F., Catrro-Diaz, D., Chartier-Kastler, E., Drake, M., Ishizuka, O., Minagawa, T., Opisso, E., Padilla-Fernandez, B., Peters, K., Reus, C., Sekido, N.

Articles
Development of Bilayered Bone Marrow-derived Cell-Gelatin Grafts for Augmentation Cystoplasty and Reconstruction of Bladder Tissues in Rats
Shinshu Med J,71(3):167-177 2023(Jun. 10)
Author:Inoue, Yoshihiro; Imamura, Tetsuya; Ogawa, Noriyuki; Hara, Hiroaki; Matsumoto, Yuki; Ueno, Manabu; Minagawa, Tomonori; Ogawa, Teruyuki; Ishizuka, Osamu

過活動膀胱
日本臨床,80(6):959-964 2023(Jun.)
Author:斎藤徹一、石塚　修

Cold stress-induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of a M3-musucarinic antagonist and a β3-adrenergic agonist.
Low Urin Tract Symptoms 2022(Dec.)
Author:Hara, H., Imamura, T., Suzuki, A., Ueno, M., Minagawa, T., Ogawa, T., Ishizuka, O.

Initial clinical results of fluid dynamic approach for lower urinary tract function using a high-speed video camera.
Int J Urol 2022(Dec.)
Author:Minagawa, T., Saito, T, Ueno, M., Ogawa, T., Ishizuka, O.

A Pilot Prospective Randomized Trial with Cancer Fatigue Scale and Juzentaihoto for Cancer-related Fatigue during Cisplatin-based Chemotherapy for Advanced Urothelial Carcinoma
Shinshu Medical Journal ,70(5):275-284 2022(Oct.)
Author:Domen Takahisa, Minagawa Tomonori, Hara Hiroaki, Suzuki Ataru, Ogawa Teruyuki, Ishizuka Osamu

The Combination of α1-adrenergic Receptor Antagonist and Phosphodiesterase 5 Inhibitor Mitigates Cold Stress-induced Detrusor Overactivity through Resiniferatoxin-Sensitive Nerves in Bladder Outlet Obstructed Rats
Shinshu Medical Journal ,70(2):81-90 2022(Apr.)
Author:Suzuki Ataru, Imamura Tetsuya, Hara Hiroyuki, Ueno Manabu, Minagawa Tomonori, Ogawa Teruyuki, Ishizuka Osamu

The combination of a1-adrenergic receptor antagonist and phosphodiesterase 5 inhibitor mitigated cold stress-induced detrusor overactivity through resiniferatoxin-sensitive nerves in bladder outlet obstructed rats.
Shinshu Med J,70(2):81-90 2022(Apr.)
Author:Suzuki, A., Imamura, T., Hara, H., Ueno, M., Minagawa, T., Ogawa, T., Ishizuka, O.

Influence of background characteristics in responders of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence
Low Urine Tract Symptoms,14(4):273-280 2022
Author:Yamanishi, T., Ishizuka,O., Shimizu, S., Kobayashi, Y., Kinoshita, F., Yamamoto, T., Mizokami, A., Narimoto, K., Toriyama, K., Kamei,Y., Kuwatsuka,Y., Mizuno,M., Gotoh, M.

Autologous bilaered adipose-dereived mesenchymal cell-gelatin sheets reconstruct ureters in rabbits
Tissue Eng. Part A,28(19-20):855-866 2022
Author:Ogawa, N., Imamura, T., Minagawa, T., Ogawa, T., Ishizuka, O.

A pilot prospective randomized trial with cancer fatigue scale and Juzentaihoto for cancer-related fatigue during cisplatin-based chemotherapy for advanced urothelial carcinoma
Shinshu Med J,70(5):275-284 2022
Author:Domen, T., Minagawa, T., Hara, H., Suzuki, A., Ogawa, T., Ishizuka, O.

Successful management of testicular primitive neuroectodermal tumor with multiple bone metastases.
Int J Urol Case Rep,5(3):1479-1482 2022
Author:Takasawa, T., Minagawa, T., Domen, T., Fusushima, T., Fujii, Y., Iwaya, M., Koizumi, T., Ogawa, T., Ishizuka, O.

UDSで捉えるLUTS
排尿障害プラクティス,30(1):4-12 2022
Author:小川輝之、岸蔭貴裕、北原　梓、齋藤徹一、今村哲也、皆川倫範、石塚　修

Impact of low-dose tadalafil on adverse events after low-dose-rate brachytherapy for prostate cancer: A bi-center randomized open-label trial
Int. J.Urol. 2021(Feb. 07)
Author:Minagawa, T., Oguchi, T., Saitou, T., Fukazawa, A., Hashida, I., Koiwai, K., Iijima, K., Kato, H., Ogawa, T., Ishizuka, O.

Pleural and pulmonary metastases from nonseminomatous germ cell tumors successfully managed by extrapleural pneumonectomy
IJU case reports,4(1) 2021
Author:Matsuda, H., Minagawa, T., Agatsuma, H., Uehara, T., Utazu, H., Ogawa, T., Yoshida, K., Ishizuka, O.

Clinical Guidelines for Female Lower Urinary Tract Symptoms (second edition)
Int. J. Urol 2021
Author:Satoru Takahashi, Mineo Takei, Hirotaka Asakura, Momokazu Gotoh, Osamu Ishizuka, Kumiko Kato, Masayasu Koyama, Masami Takeyama, Hikaru Tomoe, Tomonori Yamanishi,Osamu Yokoyama, Masaki Yoshida, Yasukuni Yoshimura and Tsuyoshi Yoshizawa

Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model.
Am J Physiol Renal Physiol,321:F26-F32 2021
Author:Saito, T., Gotoh, D., Wada, N., Tyagi, P., Minagawa, T., Ogawa, T., Ishizuka, O., Yoshimura, N.

Effect of oxybutynin patch versus mirabegron on nocturia-related quality of life in female overactive bladder patients: A multicenter randomized trial.
Int.J.Urol.,28(9):944-949 2021
Author:Suzuki T, Minagawa T, Saito T, Nakagawa T, Suzuki T, Furuhata M, Hosaka K, Ogawa T, Ishizuka O.

Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate.
Sci Rep,11(1) 2021
Author:Saito T, Hitchens TK, Foley LM, Singh N, Mizoguchi S, Kurobe M, Gotoh D, Ogawa T, Minagawa T, Ishizuka O, Chermansky C, Kaufman J, Yoshimura N, Tyagi P.

Recovery of cryo-injured rabbit urethra by biofabricated c-shaped adipose-derived mesenchymal cell structures
Shinshu Med J,68(6):357-370 2020(Dec.)
Author:Sudha, S.G., Imamura, T., Shimamura, M., Minagawa, T., Nakazawa, M., Ogawa, T., Ishizuka, O.

Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study
Int J Urol 2020(Jul. 30)
Author:Gotoh, M., Shimizu, S., Yamamoto, T., Ishizuka, O., Yamanishi, T., Mizokami, A., Narimoto, K., Toriyama, K., Kamei, Y., Nakayama, S., Kuwatsuka, Y., Mizuno, M., Hirakawa, A.

Salvage radiotherapy versus hormone therapy for prostate-specific antigen failure after radical prostatectomy: A randomized, multicenter, open-label, phase 3 trial (JCOG401).
Eur Urol,77(6):689 2020
Author:Yokomizo, A., Wakabayashi,M., Satoh, T., Hashine, K., Inoue,T., Fujimoto,K., Egawa,S., Habuchi,T., Kawashima,K., Ishizuka,O., Shinohara,N., Sugimoto,M., Yoshino,Y., Nihei,K., Fukuda,H., Tobisu, K., Ke

Safety and efficacy of cabazitaxel in Japanese patients with castration-resistant prostate cancer.
Prostate International,8:27 2020
Author:Yamamoto, T., Ishizuka, O., Oike, H., Shiozaki, M., Haba, T., Oguchi, T., Iijima, K., Kato, H.

Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study
Renal Replacement Therapy 2020
Author:Hashimoto, K., Harada, M., Yamada, Y., Sugano, M., Minagawa, T., Ogawa, T., Ishizuka, O., Kamijo, Y

The therepeutic effect of Choreito, a traditional Japanese (Kampo) medicine in Japan, on overactive bladder induced by acetic acid in the rats.
LUTS 2020
Author:Ueno, M., Minagawa, T., Saito, T., Imamura, T., Nagai, T., Ogawa, T., Ishizuka, O.

Vorticity in lower urinary tract can be assessed and associates with urinary tract morphology in men
Neurourol Urodyn,39(1):286 2020
Author:Minagawa, T., Tezuka, M., Ogawa, T., Ishizuka, O.

Fluid dynamic assessment of the lower urinary tract: Exploratory research to observe vorticity in the prostatic urethra after transurethral enucleation.
Int J Urol,26(8):853 2019
Author:Minagawa, T., Ogawa, T., Ishizuka, O.

Intraoperative detection of inferior vena caval tumor thrombus extending from metastatic lymph node of renal cell carcinoma using ultrasonography
J Med Ultrason,11(2):4-10 2019
Author:Minagawa, T., Fukui, D., Shingu, K., Ogawa,T., et al.

Morphological and clinical evaluation of prostatic urethra using modified sonourethrography with retrograde jelly injection.
LUTS,11(2):4 2019
Author:Minagawa, T., Daimon, H., Ogawa, N., Saito, T., Suzuki, T., Domen, T., Nagai, T.,

Nicotine-induced hypoxia in rat urotherium deteriorates bladder storage funcitons.
Neurourol Urodyn,38(6):1560 2019
Author:Nagai, T., Imamura, T., Ogawa, T., Minagawa,T., Domen,T., Suzuki, T., Ueno, M., Ishizuka, O.

エンザルタミド導入後の全身倦怠感に対して補中益気湯を使用下去勢抵抗性前立腺癌３症例の検討
日泌尿会誌,110(2):86-91 2019
Author:皆川倫範、道面尚久、鈴木都史郎、上野　学ら

腎移植ドナー適応判定におけるクレアチニンクリアランスの妥当性について.腎と透析
腎と透析,86(6):67-71 2019
Author:上條祐司、橋本幸始、川崎健治、菅野光俊ら

Intestinal injury by heat conduction from surgical sealing devices.
JSLS 2019
Author:Suzuki, T., Hattori, R., Minagawa, T., Uehara, T., Ogawa, T., Ishizuka, O.

Primary Bladder Choriocarcinoma : A Case Report and Review of Literature
Shinshu Medical Journal,66(6):451-455 2018(Dec. 10)
Author:DOMEN Takahisa, INOUE Takahiro, HARA Hiroaki, NAGAI Takashi, ISHIZUKA Osamu

Biofabricated structures reconstruct functional urinary bladders in radiation -injured rat bladders
Tissue Eng Part A,24(21-22):1574-1587 2018
Author:Imamura, T., Shimamura, S., Ogawa, T., Minagawa, T., et al.

FGF2 has distinct molecular functions from GDNF in the mouse germline niche
Stem Cell Reports,10(6):1782 2018
Author:Masaki, K., Sakai, M., Kuroki, S., Jo, JI, Hoshina, K., Fujimori, Y., Oka, K., Amano, T.,

Surgical management of neurogenic bladder after spinal cord injury.
World J Urol,36(10):1569 2018
Author:Wyndaele, J.J., Birch, B., Boarau, A., Burks, F., Catrro-Diaz, D., Chartier-Kastler, E., Drake, M., Ishizuka, O., Minagawa, T., Opisso, E., Peters, K., Padilla-Fernandez, B., Reus, C., Sekido, N.

Pharmacological management of interstitial cystitis/bladder pain syndrome and the role cyclosporine and other immunomodulating drugs play.
Expert Rev Clin Pharmacol,11(5):495 2018
Author:Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P, Chancellor, M.B., Yoshimura, N.

Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol.
BMC Urology,17:89 2017
Author:Shimizu, S., Yamamoto, T., Nakayama, S., et al.

Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol.
2017
Author:Shimizu, S., Yamamoto, T., Nakayama, S., Hirakawa, A., Kuwatsuka, Y., Funahashi, Y., Matsuoka, Y., Takanari, K., Toriyama, K., Kamei, Y., Narimoto, K., Yamanishi, T., Ishizuka, O., Mizuno, M., Gotoh, M.

Implantation of autologous bone marrow-derived cells improve erectile dysfunction in spontaneously hypertensive rats
Shinshu Medical Journal,65(1):37-44 2017
Author:Ishikawa, M., Imamura, T., Nishizawa, O., Ishizuka,O.

Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy.
Nat. Rev. Urol.,14:79-89 2017
Author:Ogawa, T., Sakakibara, R., Kuno,S., Ishizuka,O., Kitta,T., Yoshimura, N

Engineered Bone Marrow-Derived Cell Sheets Restore Structure and Function of Radiation-Injured Rat Urinary Bladders
Tissue Eng. Part A,21(9-10):1600-1610 2015(Mar. 26)
Author:Imamura, Tetsuya; Ogawa, Teruyuki; Minagawa, Tomonori; Yokoyama, Hitoshi; Nakazawa, Masaki; Nishizawa, Osamu; Ishizuka, Osamu

高齢者の過活動膀胱に対するオキシブチニン塩酸塩経皮吸収型製剤の有効性および安全性　－2つのランダム化比較試験の併合データを用いたサブグループ解析
泌外,28(7):1229-1237 2015
Author:吉田正貴、山口秋人、後藤百万、武田正之

Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS)
Expert Opin. Emerging Drugs,20(4):1 2015
Author:Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P., Chancellor, M.B., Yoshimura, N.

Transient receptor channel superfamily: Role in lower urinary tract function.
Int J Urol,22(11):994 2015
Author:Ogawa, T., Imamura, T., Nakazawa, M., Hiragata, S., Nagai, T., Minagawa, T., Yokoyama, H., Ishikawa, M., Domen, T., Ishizuka, O.

Status of urological Kampo-medicine: a narrative review and future vision.
Int J Urol,22(3):254 2015
Author:Minagawa, T., Ishizuka, O.

Two Cases of Kidney Cancer Treated with Hand-assisted Laparoscopic Surgery
Shinshu Med J,62(5):303-308 2014(Oct.)
Author:YOKOYAMA Hitoshi, ISHIZUKA Osamu, OGAWA Teruyuki, NISHIZAWA Osamu

Living Renal Transplantation for a Patient with an Artificial Ear Using Energy-Based Sealing Devices without Monopolar Electrocautery
Shinshu Med J,62(1):45-49 2014(Feb.)
Author:OGAWA Teruyuki, ISHIZUKA Osamu, YOKOYAMA Hitoshi, KAMIJO Yuji, HIGUCHI Makoto, NISHIZAWA Osamu

Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra.
Tissue Eng. Part A,20(13-14):1971-1979 2014
Author:Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.

Cold stress induces lower urinary tract symptoms
INTERNATIONAL JOURNAL OF UROLOGY,20(7):661-669 2013(Jul.)
Author:Imamura, T; Ishizuka, O; Nishizawa, O

Male lower urinary tract symptoms and α1D-adrenoceptors
Int J Urol,20(1):73-78 2013
Author:Ishizuka O, Imamura T, Kurizaki Y, Nishizawa O, Andersson KE

Relationship between expression of ss 3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms
NEUROUROLOGY AND URODYNAMICS,32(1):88-91 2013
Author:Kurizaki, Y; Ishizuka, O; Imamura, T; Ishikawa, M; Ichino, M; Ogawa, T; Nishizawa, O; Andersson, KE

The Relationship between α1-AdrenergicReceptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress inOvariectomized Rats.
J.Urol.,189(5):1975-1981 2012(Oct. 12)
Author:Noguchi W, Ishizuka O, Imamura T, Kurizaki Y, Yamagishi T, Yokoyama H, Lei Z,Silwal SG, Nishizawa O, Andersson KE

Bonemarrow-derived cells implanted into radiation-injured urinary bladdersreconstruct functional bladder tissues in rats.
Tissue Eng Part A,18(15-16):1698-709 2012(Aug.)
Author:Imamura T, Ishizuka O, Lei Z, Hida S, Sudha GS, Kato H, Nishizawa O

Relationship between expression of β3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms.
Neurourol Urodyn,32(1):88-91 2012(Jun. 12)
Author:Kurizaki Y, Ishizuka O, Imamura T, Ishikawa M, Ichino M, Ogawa T, Nishizawa O,Andersson KE

Comparison of efficacy and safety of 1-and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer
Int J Clin Oncol,18(3):524-530 2012(Mar. 03)
Author:Ishizuka O, Nishizawa O, Nishizawa S, Satoh T, Wajiki M, Kiyokawa H, Inoue Y,

Advantages of self-tailored mesh for vaginal prolapse
Int J Urol,19(6):494-5 2012
Author:Nishizawa O, Kato H, Ishizuka O

Analysis of the pressure-flow study in weak detrusor patients with benign prostatic hypertrophy.
LUTS,3:109-112 2011
Author:Tanabe T, Ishizuka O, Ichino M, Ogawa T, Imamura T, Kurizaki Y, Iijima K, Nishizawa O

Early efficacy of an alpha 1 adrenoceptor antagonist, naftopidil,againt lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
LUTS,3:79-85 2011
Author:Ishizuka O, Nishizawa O, Takeda M, Nomura T, Kagawa S

Effect of apomorphine on intracavernous pressure and blood pressure in conscious, spinalized rats.
Int.J.Imp.Res.,14(2):128-132 2002
Author:Ishizuka, O., Gu, B.-J., Nishizawa, O., Mizusawa, H., Andersson, K.-E.

Functional role of central muscarinic receptors for micturition in normal conscious rats
J.Urol.,168(5):2258-2262 2002
Author:Ishizuka,O., Gu, B.-J., Young, Z.-X, Nishizawa, O., Andersson, K.-E.

Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats
Neurourol.Urodyn.,19(1):101-109 2000
Author:Ishizuka, O. et al.

Effects of spinal a1 adrenoceptors blockade on bladder activity induced by apomorphine in conscious rats with and without outlet obstruction.
Neurourol.Urodyn,16:191-200 1997
Author:Ishizuka O. et al.

Stimulation of bladder activity byvolume, l-dopa and capsaicin in normal conscious rats - effects of spinal a1-adrenoceptors blockade.
Naunyn-Schmiedeberg's Arch. Pharmacol.,,355:787-793 1997
Author:Ishizuka O et al.

Micturition in conscious rats with and without outlet obstruction: role of spinal α1 adrenoceptors.
Br J Pharmacol,117:962 1996
Author:Ishizuka O. et al.

Facilitatory effect of pituitary adenylate cyclase activating polypeptide on micturition on normal, conscious rats.
Neuroscience,66:1009 1995
Author:Ishizuka O. et al.

Tachykinin effects on bladderactivity in conscious, normal rats.
J.Urol.,154:257-261 1995
Author:Ishizuka,O., Mattiasson, A. and Andersson, K.-E.

Capsaicin-induced bladderhyperactivity in normal conscious rats.
J.Urol.,152:525-530 1994
Author:Ishizuka,O., Igawa,Y., Mattiasson, A. and Andersson, K.-E.

Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.
Br J Pharmacol,113(1):111-116 1994
Author:Ishizuka O et al.

Presentations
「おしっこが近い」と相談されたらどうしますか？　-排尿障害の診断と治療について-　最近の排尿障害治療について.
日医障害教育講座学術講演会 2021(Sep. 14)
Presenter:石塚　修

Neurourology and Tissue Engineering: Past and Future in Shinshu, 会長発言.
第28回日本排尿機能学会 2021(Sep. 09)
Presenter:石塚　修

最近の排尿障害治療について.
第911回松本市医師会生涯教育講座第7回 Web Lecture 2021(May 27)
Presenter:石塚　修

Implantation of biofabricated autologous adipose derived cell C-type structures regenerate cryo-injured urethra.
The 51th Annual Meeting of the International Continence Society 2019(Sep. 06)
Presenter:Gautam Silwal S, Imamura, T., Shimamura, M., Minagawa, T., Manabu, U., Ogawa, T., Ishizuka, O.

Observation of vorticity in evacuated urine stream from male urethra using high-speed video-camera.
The 51th Annual Meeting of the International Continence Society. 2019(Sep. 06)
Presenter:Minagawa, T., Tezuka, M., Ogawa, T., Ishizuka, O.

Psychological stress induced by water avoidance stress increases urothelial permeability and bladder pain sensation in rats.
The 51th Annual Meeting of the International Continence Society 2019(Sep. 05)
Presenter:Saito, T., Tyagi, P., Hitchens, T., Shimizu, T., Mizoguchi, S., Kurobe, M., Gotoh, D., Shimizu, N., Ishizuka, O., Yoshimura, N.

Ivermectin-induced activation of mutant glycine receptors delivered to A-fiber bladder afferents by herpes simplex virus vectors driven by a subpopulation-specific neurofilament promoter improves det
The 51th Annual Meeting of the International Continence Society 2019(Sep. 05)
Presenter:Saito, T., Shimizu, N., Goins, W., Suzuki, T., Shimizu, T., Wada, N., Ishizuka, O., Glorioso, J., Yoshimura, N.

Impact of low dose tadalafil, phosphodiesterase-5 inhibitor, on adverse events after low dose rate brachytherapy for prostate cancer – a multi center randomized open label trial -.
The 51th Annual Meeting of the International Continence Society. 2019(Sep. 03)
Presenter:Oguchi, T., Minagawa, T., Saitoh, T., Fukazawa, A., Hashida, I., Koiwai, K., Iijima, K., Kato, H., Ogawa, T., Ishizuka, O.

Bladder outlet obstruction significantly correlates with detrusor overactivity in patients with benign prostatic hyperplasia.
The 51th Annual Meeting of the International Continence Society 2019(Sep. 03)
Presenter:Ogawa, T., Kitahara, A., Imamura, T., Ueno, M., Suzuki, T., Domen, T., Minagawa, T., Ishizuka, O.

Efficacy of ao-dake-humi, Japanese traditional bamboo foot stimulator, on lower urinary tract symptoms, constipation, and hypersensitivity to cold: a multi center cross-over trial.
The 51th Annual Meeting of the International Continence Society 2019(Sep. 03)
Presenter:Minagawa, T., Inoue, Y., Hara, H., Kitahara, A., Suzuki, A., Suzuki, T., Ueno, M., Domen, T., Nagai, T., Ogawa, T., Ishizuka, O.

Combination of alpha 1 blocker and PDE5 inhibitor mediates detrusor overactivity induced by cold stress in rats with bladder outlet obstruction.
The 14th Pan-pacific continence society annual meeting 2019(Jul. 13)
Presenter:Suzuki, A., Imamura, T., Ueno, M., Nagai, T., Ogawa, T., Ishizuka, O.

Combined treatment with beta-3 adrenergic receptor agonist and muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in diabetic disease rats.
The 14th Pan-pacific continence society annual meeting 2019(Jul. 13)
Presenter:Hara, H., Imamura, T., Ueno, M., Suzuki, A., Nagai, T., Ogawa, T., Ishizuka, O.

Biofabricated autologous adipose derived C-type cell structure regenerates cryo-injured urethra in rabbits.
The 14th Pan-pacific continence society annual meeting 2019(Jul. 13)
Presenter:Sudha, G.S., Imamura, T., Minagawa, T., Ogawa, T., Ishizuka, O.

Effects of tadalafil on improving hypoxic environment of urothelium and on restoring bladder storage function in the nicotine-treated rat.
The 13th Pan-pacific continence society annual meeting. 2018(Oct. 18)
Presenter:Nagai, T., Imamura, T., Ueno, M., Suzuki, T., Domen, T., Minagawa, T., Ogawa, T., Nishizawa, O., Ishizuka, O.

Nocturia QOL evaluation in OAB patients treated with oxybutynin and mirabegron study: NEOXY study.
The 13th Pan-pacific continence society annual meeting 2018(Oct. 18)
Presenter:Suzuki, T., Saitoh, T., Furuhata, M., Nakagawa, T., Daimon, H., Hosaka, K., Minagawa, T., Ogawa, T., Ishizuka, O.

Biofabricated bone marrow-derived cell structures recover radiation-injured bladders in rats.
The 13th Pan-pacific continence society annual meeting 2018(Oct. 18)
Presenter:mamura, T., Ogawa, T., Nagai, T., Ueno, M., Minagawa, T., Sudha, SG., Nishizawa, O., Ishizuka, O.

Decrease of estrogen influences vessel damage and increase skin temperature receptor channesl which will provoke cold stress related frequency.
The 50th Annual Meeting of the International Continence Society 2018(Aug. 31)
Presenter:Saito, T., Imamura, T., Nagai, T., Minagawa, T., Ogawa, T., Ishizuka, O.

Biofabricated autologous adipose derived cell structures reconstruct cryo-injured urethra in rabbits.
The 50th Annual Meeting of the International Continence Society 2018(Aug. 31)
Presenter:Gautam Silwal S, Imamura, T., Shimamura, M., Minagawa, T., Takashi, N., Manabu, U., Nakazawa, M., Ogawa, T., Ishizuka, O.

Exploratory research to observe vorticity in male lower urinary tract using color dopper ultrasonography.
The 50th Annual Meeting of the International Continence Society. 2018(Aug. 30)
Presenter:Minagawa, T., Ogawa, T., Ishizuka, O.

Fluid dynamical assessment of lower urinary tract: Exploratory research to observe vorticity in male lower urinary tract using color dopper ultrasonography.
The 50th Annual Meeting of the International Continence Society 2018(Aug. 30)
Presenter:Minagawa, T., Ogawa, T., Ishizuka, O.

Results of treatment with abrateron acetate in Japanese castration resistant prostate cancer patients: Deterimining a prognostic factor of long term response
7th congress of the Societe Internationale d’Urologie 2017(Oct. 22)
Presenter:Ogawa, N., Saito, T., Kitahara, R., Hagimito, T., Utazu, H., Takeda, Y., Ueno, M., Suzuki, T., Domen, T., Nagai, T., Ogawa, T., Ishizuka, O.

Long term adherence to combination of mirabegron and antimuscarinic drug on overactive bladder symptoms.
2017(Oct. 22)
Presenter:Ogawa, T., Ogawa, N., Saito, T., Nagai, T., Yokoyama, H., Imamura, T., Minagawa, T., Ishizuka, O.

Fluid dynamical assessment of lower urinary tract: exploratory research to observe voricity in prostatic urethra after transurethral enuclation using color dopper ultrasonography.
The 49th Annual Meeting of the International Continence Society. 2017(Sep. 15)
Presenter:Minagawa, T., Ogawa, N., Daimon, H., Saito, T., Ogawa, T., Ishizuka, O.

Correlation between prostatic volume change and lower urinary tract symptoms after low-dose rate brachytherapy for prostate cancer.
The 49th Annual Meeting of the International Continence Society. 2017(Sep. 14)
Presenter:Daimon, H., Minagawa, T., Matsutaka, J., Ogawa, N., Saito, T., Suzuki, T., Domen, N., Ishikawa, M., Hiragata, S., Nagai, T., Ogawa, T., Ishizuka, O.

The impact of Dai-ken-chu-tou on cold-stress induced detrusor overactivity and neurological receptors in the bladder.
The 49th Annual Meeting of the International Continence Society 2017(Sep. 13)
Presenter:Saito, T., Minagawa, T., Imamura, T., Gautam Silwal S, Nagai, T., Ogawa, T., Ishizuka, O.

The hypoxic environment decreased both aquaporin 3 and uroplakin 3 expressions and bladder storage functions in spontaneous hypertensive rats.
The 49th Annual Meeting of the International Continence Society. 2017(Sep. 13)
Presenter:Nagai, T., Imamura, T., Saito, T., Ogawa T., Minagawa, T., Domen, T., Suzuki, T., Ogawa, N., Ishizuka, O.

The effect and mechanism of change in neuroreceptors in the bladder and skin with ovarectomised rats.
The 49th Annual Meeting of the International Continence Society. 2017(Sep. 13)
Presenter:Saito, T., Imamura, T., Nagai, T., Gautam Silwal, S., Minagawa, T., Ogawa, T., Ishizuka, O.

A prospective randomized trial to evaluate the prophylactic use of tadalafil versus tamsulosin for lower urinary tract symptoms and erectile dysfunction after low-dose-rate brachytherapy for prostate
The 49th Annual Meeting of the International Continence Society. 2017(Sep. 13)
Presenter:Minagawa, T., Oguchi, T., Daimon, H., Koiwai, K., Kato, H., Hashida, I., Ogawa, T., Kadoya, M., Ishizuka, O.

Role of α1D/A antagonist-Naftopidil-for Male LUTS. Focusing on a α1D adrenoceptor subtype and 5-HT.
4th Innovative symposium for urological excellence 2015
Presenter:Ishizuka　O

LUTS資料の最近の話題　―信州大学における研究を中心としてー.
第16回静岡県LUTS研究会
Presenter:石塚　修

Themes for Joint Research: New drug for overactive bladder
Tissue Engineering for Lower Urinary Tract

Research Grants: Cooperative research with industry
2017 - 2017 , 末梢血液循環障害を誘発させた自然発症高血圧ラットモデルを利用した冷えストレス排尿筋過活動に対するタダラフィルの薬理効果の考察
2017 - 2017 , 微小循環改善を介した漢方薬による下部尿路症状治療薬剤の探索
2012 - 2013 , ヒト膀胱平滑筋におけるセロトニン受容体の検索およびセロトニン誘発収縮に対するナフトピジルの作用
2012 - 2012 , 冷えストレスによる頻尿とホルモンバランスの研究
2011 - 2011 , 夜間頻尿に対するハルンケアの改善効果
2010 - 2010 , 加齢に伴う尿道障害に対する生薬エキスＨの改善効果検討
2010 - 2010 , 自然発症高血圧ラットにおける下部尿路組織の形態学的変化およびa1交感神経受容体の関与に関する研究
2009 - 2009 , 下部尿路閉塞病態ラットにおける下部尿路組織の形態学的変化およびα１交感神経受容体の関与に関する研究
2008 - 2008 , 生薬エキスＨの下部尿路病態への改善効果の検討（その３）
2007 - 2007 , 生薬エキスＨの下部尿路病態への改善効果の検討（その２）
2006 - 2006 , 生薬エキスＨの下部尿路病態への改善効果の検討
2006 - 2006 , 冷えによる膀胱過活動に対するナフトピジルの抑制効果
2005 - 2005 , 膀胱過活動を有する高血圧ラットもおける膀胱内無髄Ｃ線維に対する生薬エキスＨの影響の検討
2004 - 2004 , 冷えによるラットの膀胱過活動に対する生薬エキスＨの有効性の検討
2004 - 2004 , 尿失禁患者における塩酸プロピベリンのＱＯＬ改善の検討
2003 - 2003 , 下部尿路閉塞ラットに対するハルンケアの効果
2003 - 2003 , 脊髄損傷による膀胱過活動に対するトルテロジンの効果

Other
2004 - 2004 , Detrol LA Research Grants 2004 (Pfizer) “Functional roles of anti-muscarinic drugs and the roles of muscarinic receptor subtypes for centrally induced overactive bladder”
2001 - 2001 , Abbott Laboratories Erectile Dysfunction Research Awards 2001 “Effects of spinal and peripheral dopamine receptor stimulation on intracavenous pressure and blood pressure in conscious rats with and wi

Research Activities: Journal Editorial Board
2021- , LUTS , Associate Editor
2011-2013 , 日本泌尿器科学会編集委員会

Education

Researcher Receipt: 2020-2020 , Tissue Engineering for lower urinary tract

Social Activities

Social Activitie: Organization of Conferences and/or Symposia
20211016 - 20211017 , 第33回日本超音波医学会関東甲信越地方会 , 大会長
20210911 - 20210912 , Pan-Pacific Continence Society Meeting 2021 , 大会長
20210909 - 20210911 , 第28回日本排尿機能学会 , 大会長

Professional Affiliations and Activities
20170617 - 20190615 , 長野県医師会 , 理事
20170101 - 20181231 , 信州医学会 , 運営委員長
20150401 - , 長野県アイバンク・臓器移植推進協会 , 理事
20060308 - , 長野県健康づくり事業団　前立腺がん検診委員会 , 委員

Shinshu University Researcher Directory

ISHIZUKA OSAMU

Profile

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ISHIZUKA　OSAMU