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ISHIZUKA OSAMU|Shinshu University Researcher List

ISHIZUKA OSAMU

Shinshu University Hospital Clinical Division of Urology 

Honorary professor Professor 

Degree

  • Doctor of Philosophy, Lund University
  • Doctor of Medicine, Shinshu University

Research Keyword

    Neurourology

Field Of Study

  • Urology, Tissue Engineering for Lower Urinary Tract System
  • Urology, Urological Minimal Invasive Surgery
  • Urology, Neurourology

TEL

    +81 263 372661

Career

  • 2014 - 2023
    信州大学医学部 泌尿器科学教室 教授
  • 2012 - 2014
    信州大学医学部附属病院泌尿器科 診療教授
  • 2007 - 2012
    信州大学医学部 泌尿器科学教室 准教授
  • 2001 - 2007
    信州大学医学部 泌尿器科学教室 助教授
  • 1996 - 2001
    信州大学医学部附属病院 泌尿器科 講師
  • 1996 - 1996
    信州大学医学部附属病院 泌尿器科 助手
  • 1995 - 1996
    市立甲府病院泌尿器科 医長
  • 1992 - 1995
    信州大学医学部 泌尿器科学教室 助手
  • 1990 - 1992
    佐久総合病院泌尿器科 医師
  • 1988 - 1990
    信州大学医学部附属病院 泌尿器科 助手
  • 1987 - 1988
    篠ノ井総合病院 泌尿器科 医師
  • 1986 - 1987
    信州大学医学部附属病院 泌尿器科 助手
  • 1985 - 1986
    山梨県立中央病院 泌尿器科 研修医
  • 1984 - 1985
    信州大学医学部附属病院 泌尿器科 研修医

Educational Background

  • 1993 - 1995, Department of Urology, Lund University, Sweden
  • 1984, Shinshu University, Faculty of Medicine

Member History

  • 2022 - 2022
    President, The 87th Annual Meeting of Japan Urological Associaion Western Section
  • 2017 - 2019
    理事, 長野県医師会
  • 2017 - 2018
    運営委員長, 信州医学会
  • 2015
    理事, 長野県アイバンク・臓器移植推進協会
  • 2006
    委員, 長野県健康づくり事業団 前立腺がん検診委員会

Award

  • 2020
    LUTS Journal, LUTS Best Reviewer Award for 2019
  • 2017
    日本泌尿器科学会, IJU Reviewers of the Year 2017
  • 2016
    日本排尿機能学会, LUTS Best Reviewer Award for 2015-16
  • 2015
    日本泌尿器科学会, IJU Reviewers of the Year 2015
  • 2007
    Japanese Urological Society, Japanese Urological Society Research Grant
  • 2007
    日本漢方生薬製剤協会, 日本漢方生薬製剤協会研究助成
  • 2004
    Pfizer, Detrol LA Research Grants 2004
  • 2002
    信州医学振興会, 信州医学振興会研究費助成
  • 2001
    Abott Laboratories, Abbott Laboratories Erectile Dysfunction Research Awards
  • 2000
    日本泌尿器科学会信州地方会, 日本泌尿器科学会信州地方会賞
  • 1997
    笹川医学医療研究財団, 高齢者の医学医療に関する研究助成

Paper

  • Development of Bilayered Bone Marrow-derived Cell-Gelatin Grafts for Augmentation Cystoplasty and Reconstruction of Bladder Tissues in Rats
    Inoue, Yoshihiro; Imamura, Tetsuya; Ogawa, Noriyuki; Hara, Hiroaki; Matsumoto, Yuki; Ueno, Manabu; Minagawa, Tomonori; Ogawa, Teruyuki; Ishizuka, Osamu
    shinshu med J, 71(3), 167-177, 10 Jun. 2023リポジトリ電子ジャーナル
  • 過活動膀胱
    斎藤徹一、石塚 修
    日本臨床, 80(6), 959-964, Jun. 2023, Refereed
  • Initial clinical results of fluid dynamic approach for lower urinary tract function using a high-speed video camera.
    Minagawa, T., Saito, T, Ueno, M., Ogawa, T., Ishizuka, O.
    Int J Urol, Dec. 2022, Refereed電子ジャーナル
  • Cold stress-induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of a M3-musucarinic antagonist and a β3-adrenergic agonist.
    Hara, H., Imamura, T., Suzuki, A., Ueno, M., Minagawa, T., Ogawa, T., Ishizuka, O.
    Low Urin Tract Symptoms, Dec. 2022電子ジャーナル
  • A pilot prospective randomized trial with cancer fatigue scale and Juzentaihoto for cancer-related fatigue during cisplatin-based chemotherapy for advanced urothelial carcinoma
    Domen Takahisa, Minagawa Tomonori, Hara Hiroaki, Suzuki Ataru, Ogawa Teruyuki, Ishizuka Osamu
    Shinshu Medical Journal, 70(5), 275-284, Oct. 2022電子ジャーナル
  • The Combination of α1-adrenergic Receptor Antagonist and Phosphodiesterase 5 Inhibitor Mitigates Cold Stress-induced Detrusor Overactivity through Resiniferatoxin-Sensitive Nerves in Bladder Outlet Obstructed Rats
    Suzuki Ataru, Imamura Tetsuya, Hara Hiroyuki, Ueno Manabu, Minagawa Tomonori, Ogawa Teruyuki, Ishizuka Osamu
    Shinshu Medical Journal, 70(2), 81-90, Apr. 2022電子ジャーナル
  • The combination of a1-adrenergic receptor antagonist and phosphodiesterase 5 inhibitor mitigated cold stress-induced detrusor overactivity through resiniferatoxin-sensitive nerves in bladder outlet obstructed rats.
    Suzuki, A., Imamura, T., Hara, H., Ueno, M., Minagawa, T., Ogawa, T., Ishizuka, O.
    shinshu med J, 70(2), 81-90, Apr. 2022, Refereedリポジトリ電子ジャーナル
  • UDSで捉えるLUTS
    小川輝之、岸蔭貴裕、北原 梓、齋藤徹一、今村哲也、皆川倫範、石塚 修
    排尿障害プラクティス, 30(1), 4-12, 2022
  • Successful management of testicular primitive neuroectodermal tumor with multiple bone metastases.
    Takasawa, T., Minagawa, T., Domen, T., Fusushima, T., Fujii, Y., Iwaya, M., Koizumi, T., Ogawa, T., Ishizuka, O.
    Int J Urol Case Rep, 5(3), 1479-1482, 2022
  • Autologous bilaered adipose-dereived mesenchymal cell-gelatin sheets reconstruct ureters in rabbits
    Ogawa, N., Imamura, T., Minagawa, T., Ogawa, T., Ishizuka, O.
    Tissue Eng. Part A, 28(19-20), 855-866, 2022, Refereed
  • Influence of background characteristics in responders of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence
    Yamanishi, T., Ishizuka,O., Shimizu, S., Kobayashi, Y., Kinoshita, F., Yamamoto, T., Mizokami, A., Narimoto, K., Toriyama, K., Kamei,Y., Kuwatsuka,Y., Mizuno,M., Gotoh, M.
    Low Urine Tract Symptoms, 14(4), 273-280, 2022, Refereed
  • A pilot prospective randomized trial with cancer fatigue scale and Juzentaihoto for cancer-related fatigue during cisplatin-based chemotherapy for advanced urothelial carcinoma
    Domen, T., Minagawa, T., Hara, H., Suzuki, A., Ogawa, T., Ishizuka, O.
    shinshu med J, 70(5), 275-284, 2022, Refereedリポジトリ電子ジャーナル
  • Impact of low-dose tadalafil on adverse events after low-dose-rate brachytherapy for prostate cancer: A bi-center randomized open-label trial
    Minagawa, T., Oguchi, T., Saitou, T., Fukazawa, A., Hashida, I., Koiwai, K., Iijima, K., Kato, H., Ogawa, T., Ishizuka, O.
    Int. J.Urol., 07 Feb. 2021, Refereed
  • Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate.
    Saito T, Hitchens TK, Foley LM, Singh N, Mizoguchi S, Kurobe M, Gotoh D, Ogawa T, Minagawa T, Ishizuka O, Chermansky C, Kaufman J, Yoshimura N, Tyagi P.
    Sci Rep, 11(1), 2021, Refereed
  • Effect of oxybutynin patch versus mirabegron on nocturia-related quality of life in female overactive bladder patients: A multicenter randomized trial.
    Suzuki T, Minagawa T, Saito T, Nakagawa T, Suzuki T, Furuhata M, Hosaka K, Ogawa T, Ishizuka O.
    Int.J.Urol., 28(9), 944-949, 2021, Refereed
  • Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model.
    Saito, T., Gotoh, D., Wada, N., Tyagi, P., Minagawa, T., Ogawa, T., Ishizuka, O., Yoshimura, N.
    Am J Physiol Renal Physiol, 321, F26-F32, 2021, Refereed, Not invited
  • Pleural and pulmonary metastases from nonseminomatous germ cell tumors successfully managed by extrapleural pneumonectomy
    Matsuda, H., Minagawa, T., Agatsuma, H., Uehara, T., Utazu, H., Ogawa, T., Yoshida, K., Ishizuka, O.
    IJU case reports, 4(1), 2021
  • Clinical Guidelines for Female Lower Urinary Tract Symptoms (second edition)
    Satoru Takahashi, Mineo Takei, Hirotaka Asakura, Momokazu Gotoh, Osamu Ishizuka, Kumiko Kato, Masayasu Koyama, Masami Takeyama, Hikaru Tomoe, Tomonori Yamanishi,Osamu Yokoyama, Masaki Yoshida, Yasukuni Yoshimura and Tsuyoshi Yoshizawa
    Int. J. Urol, 2021電子ジャーナル
  • Recovery of cryo-injured rabbit urethra by biofabricated c-shaped adipose-derived mesenchymal cell structures
    Sudha, S.G., Imamura, T., Shimamura, M., Minagawa, T., Nakazawa, M., Ogawa, T., Ishizuka, O.
    shinshu med J, 68(6), 357-370, Dec. 2020リポジトリ電子ジャーナル
  • Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study
    Gotoh, M., Shimizu, S., Yamamoto, T., Ishizuka, O., Yamanishi, T., Mizokami, A., Narimoto, K., Toriyama, K., Kamei, Y., Nakayama, S., Kuwatsuka, Y., Mizuno, M., Hirakawa, A.
    Int J Urol, 30 Jul. 2020, Refereed電子ジャーナル
  • Vorticity in lower urinary tract can be assessed and associates with urinary tract morphology in men
    Minagawa, T., Tezuka, M., Ogawa, T., Ishizuka, O.
    Neurourol Urodyn, 39(1), 286, 2020, Refereed
  • Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study
    Hashimoto, K., Harada, M., Yamada, Y., Sugano, M., Minagawa, T., Ogawa, T., Ishizuka, O., Kamijo, Y
    Renal Replacement Therapy, 2020, Refereed
  • Safety and efficacy of cabazitaxel in Japanese patients with castration-resistant prostate cancer.
    Yamamoto, T., Ishizuka, O., Oike, H., Shiozaki, M., Haba, T., Oguchi, T., Iijima, K., Kato, H.
    Prostate International, 8, 27, 2020, Refereed
  • Salvage radiotherapy versus hormone therapy for prostate-specific antigen failure after radical prostatectomy: A randomized, multicenter, open-label, phase 3 trial (JCOG401).
    Yokomizo, A., Wakabayashi,M., Satoh, T., Hashine, K., Inoue,T., Fujimoto,K., Egawa,S., Habuchi,T., Kawashima,K., Ishizuka,O., Shinohara,N., Sugimoto,M., Yoshino,Y., Nihei,K., Fukuda,H., Tobisu, K., Ke
    Eur Urol, 77(6), 689, 2020, Refereed電子ジャーナル
  • The therepeutic effect of Choreito, a traditional Japanese (Kampo) medicine in Japan, on overactive bladder induced by acetic acid in the rats.
    Ueno, M., Minagawa, T., Saito, T., Imamura, T., Nagai, T., Ogawa, T., Ishizuka, O.
    LUTS, 2020, Refereed電子ジャーナル
  • 腎移植ドナー適応判定におけるクレアチニンクリアランスの妥当性について.腎と透析
    上條祐司、橋本幸始、川崎健治、菅野光俊ら
    腎と透析, 86(6), 67-71, 2019
  • エンザルタミド導入後の全身倦怠感に対して補中益気湯を使用下去勢抵抗性前立腺癌3症例の検討
    皆川倫範、道面尚久、鈴木都史郎、上野 学ら
    日泌尿会誌, 110(2), 86-91, 2019
  • Intraoperative detection of inferior vena caval tumor thrombus extending from metastatic lymph node of renal cell carcinoma using ultrasonography
    Minagawa, T., Fukui, D., Shingu, K., Ogawa,T., et al.
    J Med Ultrason, 11(2), 4-10, 2019
  • Nicotine-induced hypoxia in rat urotherium deteriorates bladder storage funcitons.
    Nagai, T., Imamura, T., Ogawa, T., Minagawa,T., Domen,T., Suzuki, T., Ueno, M., Ishizuka, O.
    Neurourol Urodyn, 38(6), 1560, 2019
  • Morphological and clinical evaluation of prostatic urethra using modified sonourethrography with retrograde jelly injection.
    Minagawa, T., Daimon, H., Ogawa, N., Saito, T., Suzuki, T., Domen, T., Nagai, T.,
    LUTS, 11(2), 4, 2019
  • Fluid dynamic assessment of the lower urinary tract: Exploratory research to observe vorticity in the prostatic urethra after transurethral enucleation.
    Minagawa, T., Ogawa, T., Ishizuka, O.
    Int J Urol, 26(8), 853, 2019
  • Intestinal injury by heat conduction from surgical sealing devices.
    Suzuki, T., Hattori, R., Minagawa, T., Uehara, T., Ogawa, T., Ishizuka, O.
    JSLS, 2019電子ジャーナル
  • Primary Bladder Choriocarcinoma : A Case Report and Review of Literature
    DOMEN Takahisa, INOUE Takahiro, HARA Hiroaki, NAGAI Takashi, ISHIZUKA Osamu
    Shinshu Medical Journal, 66(6), 451-455, 10 Dec. 2018電子ジャーナル
  • Pharmacological management of interstitial cystitis/bladder pain syndrome and the role cyclosporine and other immunomodulating drugs play.
    Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P, Chancellor, M.B., Yoshimura, N.
    Expert Rev Clin Pharmacol, 11(5), 495, 2018, Refereed
  • Surgical management of neurogenic bladder after spinal cord injury.
    Wyndaele, J.J., Birch, B., Boarau, A., Burks, F., Catrro-Diaz, D., Chartier-Kastler, E., Drake, M., Ishizuka, O., Minagawa, T., Opisso, E., Peters, K., Padilla-Fernandez, B., Reus, C., Sekido, N.
    World J Urol, 36(10), 1569, 2018, Refereed
  • FGF2 has distinct molecular functions from GDNF in the mouse germline niche
    Masaki, K., Sakai, M., Kuroki, S., Jo, JI, Hoshina, K., Fujimori, Y., Oka, K., Amano, T.,
    Stem Cell Reports, 10(6), 1782, 2018, Refereed
  • Biofabricated structures reconstruct functional urinary bladders in radiation -injured rat bladders
    Imamura, T., Shimamura, S., Ogawa, T., Minagawa, T., et al.
    Tissue Eng Part A, 24(21-22), 1574-1587, 2018
  • Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol.
    Shimizu, S., Yamamoto, T., Nakayama, S., Hirakawa, A., Kuwatsuka, Y., Funahashi, Y., Matsuoka, Y., Takanari, K., Toriyama, K., Kamei, Y., Narimoto, K., Yamanishi, T., Ishizuka, O., Mizuno, M., Gotoh, M.
    2017, Refereed
  • Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol.
    Shimizu, S., Yamamoto, T., Nakayama, S., et al.
    BMC Urology, 17, 89, 2017
  • Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy.
    Ogawa, T., Sakakibara, R., Kuno,S., Ishizuka,O., Kitta,T., Yoshimura, N
    Nat. Rev. Urol., 14, 79-89, 2017
  • Implantation of autologous bone marrow-derived cells improve erectile dysfunction in spontaneously hypertensive rats
    Ishikawa, M., Imamura, T., Nishizawa, O., Ishizuka,O.
    Shinshu Medical Journal, 65(1), 37-44, 2017, Refereed電子ジャーナル
  • Engineered Bone Marrow-Derived Cell Sheets Restore Structure and Function of Radiation-Injured Rat Urinary Bladders
    Imamura, Tetsuya; Ogawa, Teruyuki; Minagawa, Tomonori; Yokoyama, Hitoshi; Nakazawa, Masaki; Nishizawa, Osamu; Ishizuka, Osamu
    Tissue Eng. Part A, 21(9-10), 1600-1610, 26 Mar. 2015WebofScienceリポジトリ電子ジャーナル
  • Status of urological Kampo-medicine: a narrative review and future vision.
    Minagawa, T., Ishizuka, O.
    Int J Urol, 22(3), 254, 2015, Refereed
  • Transient receptor channel superfamily: Role in lower urinary tract function.
    Ogawa, T., Imamura, T., Nakazawa, M., Hiragata, S., Nagai, T., Minagawa, T., Yokoyama, H., Ishikawa, M., Domen, T., Ishizuka, O.
    Int J Urol, 22(11), 994, 2015, Refereed
  • Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS)
    Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P., Chancellor, M.B., Yoshimura, N.
    Expert Opin. Emerging Drugs, 20(4), 1, 2015, Refereed
  • 高齢者の過活動膀胱に対するオキシブチニン塩酸塩経皮吸収型製剤の有効性および安全性 -2つのランダム化比較試験の併合データを用いたサブグループ解析
    吉田正貴、山口秋人、後藤百万、武田正之
    泌外, 28(7), 1229-1237, 2015
  • Two Cases of Kidney Cancer Treated with Hand-assisted Laparoscopic Surgery
    YOKOYAMA Hitoshi, ISHIZUKA Osamu, OGAWA Teruyuki, NISHIZAWA Osamu
    shinshu med J, 62(5), 303-308, Oct. 2014電子ジャーナル
  • Living Renal Transplantation for a Patient with an Artificial Ear Using Energy-Based Sealing Devices without Monopolar Electrocautery
    OGAWA Teruyuki, ISHIZUKA Osamu, YOKOYAMA Hitoshi, KAMIJO Yuji, HIGUCHI Makoto, NISHIZAWA Osamu
    shinshu med J, 62(1), 45-49, Feb. 2014電子ジャーナル
  • Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra.
    Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.
    Tissue Eng. Part A, 20(13-14), 1971-1979, 2014WebofScienceリポジトリ電子ジャーナル
  • Cold stress induces lower urinary tract symptoms
    Imamura, T; Ishizuka, O; Nishizawa, O
    INTERNATIONAL JOURNAL OF UROLOGY, 20(7), 661-669, Jul. 2013WebofScienceリポジトリ電子ジャーナル
  • Relationship between expression of ss 3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms
    Kurizaki, Y; Ishizuka, O; Imamura, T; Ishikawa, M; Ichino, M; Ogawa, T; Nishizawa, O; Andersson, KE
    NEUROUROLOGY AND URODYNAMICS, 32(1), 88-91, 2013WebofScienceリポジトリ電子ジャーナル
  • Male lower urinary tract symptoms and α1D-adrenoceptors
    Ishizuka O, Imamura T, Kurizaki Y, Nishizawa O, Andersson KE
    Int J Urol, 20(1), 73-78, 2013WebofScienceリポジトリ電子ジャーナル
  • The Relationship between α1-AdrenergicReceptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress inOvariectomized Rats.
    Noguchi W, Ishizuka O, Imamura T, Kurizaki Y, Yamagishi T, Yokoyama H, Lei Z,Silwal SG, Nishizawa O, Andersson KE
    J.Urol., 189(5), 1975-1981, 12 Oct. 2012WebofScienceリポジトリ電子ジャーナル
  • Bonemarrow-derived cells implanted into radiation-injured urinary bladdersreconstruct functional bladder tissues in rats.
    Imamura T, Ishizuka O, Lei Z, Hida S, Sudha GS, Kato H, Nishizawa O
    Tissue Eng Part A, 18(15-16), 1698-709, Aug. 2012WebofScienceリポジトリ電子ジャーナル
  • Relationship between expression of β3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms.
    Kurizaki Y, Ishizuka O, Imamura T, Ishikawa M, Ichino M, Ogawa T, Nishizawa O,Andersson KE
    Neurourol Urodyn, 32(1), 88-91, 12 Jun. 2012WebofScienceリポジトリ電子ジャーナル
  • Comparison of efficacy and safety of 1-and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer
    Ishizuka O, Nishizawa O, Nishizawa S, Satoh T, Wajiki M, Kiyokawa H, Inoue Y,
    Int J Clin Oncol, 18(3), 524-530, 03 Mar. 2012WebofScienceリポジトリ電子ジャーナル
  • Advantages of self-tailored mesh for vaginal prolapse
    Nishizawa O, Kato H, Ishizuka O
    Int J Urol, 19(6), 494-5, 2012WebofScienceリポジトリ電子ジャーナル
  • Early efficacy of an alpha 1 adrenoceptor antagonist, naftopidil,againt lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
    Ishizuka O, Nishizawa O, Takeda M, Nomura T, Kagawa S
    LUTS, 3, 79-85, 2011
  • Analysis of the pressure-flow study in weak detrusor patients with benign prostatic hypertrophy.
    Tanabe T, Ishizuka O, Ichino M, Ogawa T, Imamura T, Kurizaki Y, Iijima K, Nishizawa O
    LUTS, 3, 109-112, 2011
  • Functional role of central muscarinic receptors for micturition in normal conscious rats
    Ishizuka,O., Gu, B.-J., Young, Z.-X, Nishizawa, O., Andersson, K.-E.
    J.Urol., 168(5), 2258-2262, 2002WebofScience
  • Effect of apomorphine on intracavernous pressure and blood pressure in conscious, spinalized rats.
    Ishizuka, O., Gu, B.-J., Nishizawa, O., Mizusawa, H., Andersson, K.-E.
    Int.J.Imp.Res., 14(2), 128-132, 2002WebofScience
  • Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats
    Ishizuka, O. et al.
    Neurourol.Urodyn., 19(1), 101-109, 2000WebofScience
  • Stimulation of bladder activity byvolume, l-dopa and capsaicin in normal conscious rats - effects of spinal a1-adrenoceptors blockade.
    Ishizuka O et al.
    Naunyn-Schmiedeberg's Arch. Pharmacol.,, 355, 787-793, 1997
  • Effects of spinal a1 adrenoceptors blockade on bladder activity induced by apomorphine in conscious rats with and without outlet obstruction.
    Ishizuka O. et al.
    Neurourol.Urodyn, 16, 191-200, 1997
  • Micturition in conscious rats with and without outlet obstruction: role of spinal α1 adrenoceptors.
    Ishizuka O. et al.
    Br J Pharmacol, 117, 962, 1996
  • Tachykinin effects on bladderactivity in conscious, normal rats.
    Ishizuka,O., Mattiasson, A. and Andersson, K.-E.
    J.Urol., 154, 257-261, 1995
  • Facilitatory effect of pituitary adenylate cyclase activating polypeptide on micturition on normal, conscious rats.
    Ishizuka O. et al.
    Neuroscience, 66, 1009, 1995
  • Capsaicin-induced bladderhyperactivity in normal conscious rats.
    Ishizuka,O., Igawa,Y., Mattiasson, A. and Andersson, K.-E.
    J.Urol., 152, 525-530, 1994
  • Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.
    Ishizuka O et al.
    Br J Pharmacol, 113(1), 111-116, 1994WebofScience

Books and other publications

  • 信州大学医学部附属病院編著, よりよい医療を届けたい― 信大病院の最新治療
    石塚 修, 腹腔鏡手術がさらに進化 ロボット支援下による前立腺がん・腎がん手術. 第3部 さらなる高みを目指して―高度設備と最新の技術.
    バリューメディカル, 106-107 2021
  • A Joint SIU-ICUD International consultation
    Wyndaele, J.J., Birch, B., Burks, F., Catrro-Diaz, D., Chartier-Kastler, E., Drake, M., Ishizuka, O., Minagawa, T., Opisso, E., Padilla-Fernandez, B., Peters, K., Reus, C., Sekido, N., Joint work, Surgical management of neurogenic bladder after spinal cord injury
    209 2017

Lectures, oral presentations, etc.

  • 「おしっこが近い」と相談されたらどうしますか? -排尿障害の診断と治療について- 最近の排尿障害治療について.
    石塚 修
    日医障害教育講座学術講演会, 14 Sep. 2021
  • Neurourology and Tissue Engineering: Past and Future in Shinshu, 会長発言.
    石塚 修
    第28回日本排尿機能学会, 09 Sep. 2021
  • 最近の排尿障害治療について.
    石塚 修
    第911回松本市医師会生涯教育講座 第7回 Web Lecture, 27 May 2021
  • Implantation of biofabricated autologous adipose derived cell C-type structures regenerate cryo-injured urethra.
    Gautam Silwal S, Imamura, T., Shimamura, M., Minagawa, T., Manabu, U., Ogawa, T., Ishizuka, O.
    The 51th Annual Meeting of the International Continence Society, 06 Sep. 2019
  • Observation of vorticity in evacuated urine stream from male urethra using high-speed video-camera.
    Minagawa, T., Tezuka, M., Ogawa, T., Ishizuka, O.
    The 51th Annual Meeting of the International Continence Society., 06 Sep. 2019
  • Psychological stress induced by water avoidance stress increases urothelial permeability and bladder pain sensation in rats.
    Saito, T., Tyagi, P., Hitchens, T., Shimizu, T., Mizoguchi, S., Kurobe, M., Gotoh, D., Shimizu, N., Ishizuka, O., Yoshimura, N.
    The 51th Annual Meeting of the International Continence Society, 05 Sep. 2019
  • Ivermectin-induced activation of mutant glycine receptors delivered to A-fiber bladder afferents by herpes simplex virus vectors driven by a subpopulation-specific neurofilament promoter improves det
    Saito, T., Shimizu, N., Goins, W., Suzuki, T., Shimizu, T., Wada, N., Ishizuka, O., Glorioso, J., Yoshimura, N.
    The 51th Annual Meeting of the International Continence Society, 05 Sep. 2019
  • Efficacy of ao-dake-humi, Japanese traditional bamboo foot stimulator, on lower urinary tract symptoms, constipation, and hypersensitivity to cold: a multi center cross-over trial.
    Minagawa, T., Inoue, Y., Hara, H., Kitahara, A., Suzuki, A., Suzuki, T., Ueno, M., Domen, T., Nagai, T., Ogawa, T., Ishizuka, O.
    The 51th Annual Meeting of the International Continence Society, 03 Sep. 2019
  • Bladder outlet obstruction significantly correlates with detrusor overactivity in patients with benign prostatic hyperplasia.
    Ogawa, T., Kitahara, A., Imamura, T., Ueno, M., Suzuki, T., Domen, T., Minagawa, T., Ishizuka, O.
    The 51th Annual Meeting of the International Continence Society, 03 Sep. 2019
  • Impact of low dose tadalafil, phosphodiesterase-5 inhibitor, on adverse events after low dose rate brachytherapy for prostate cancer – a multi center randomized open label trial -.
    Oguchi, T., Minagawa, T., Saitoh, T., Fukazawa, A., Hashida, I., Koiwai, K., Iijima, K., Kato, H., Ogawa, T., Ishizuka, O.
    The 51th Annual Meeting of the International Continence Society., 03 Sep. 2019
  • Combined treatment with beta-3 adrenergic receptor agonist and muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in diabetic disease rats.
    Hara, H., Imamura, T., Ueno, M., Suzuki, A., Nagai, T., Ogawa, T., Ishizuka, O.
    The 14th Pan-pacific continence society annual meeting, 13 Jul. 2019
  • Biofabricated autologous adipose derived C-type cell structure regenerates cryo-injured urethra in rabbits.
    Sudha, G.S., Imamura, T., Minagawa, T., Ogawa, T., Ishizuka, O.
    The 14th Pan-pacific continence society annual meeting, 13 Jul. 2019
  • Combination of alpha 1 blocker and PDE5 inhibitor mediates detrusor overactivity induced by cold stress in rats with bladder outlet obstruction.
    Suzuki, A., Imamura, T., Ueno, M., Nagai, T., Ogawa, T., Ishizuka, O.
    The 14th Pan-pacific continence society annual meeting, 13 Jul. 2019
  • Biofabricated bone marrow-derived cell structures recover radiation-injured bladders in rats.
    mamura, T., Ogawa, T., Nagai, T., Ueno, M., Minagawa, T., Sudha, SG., Nishizawa, O., Ishizuka, O.
    The 13th Pan-pacific continence society annual meeting, 18 Oct. 2018
  • Effects of tadalafil on improving hypoxic environment of urothelium and on restoring bladder storage function in the nicotine-treated rat.
    Nagai, T., Imamura, T., Ueno, M., Suzuki, T., Domen, T., Minagawa, T., Ogawa, T., Nishizawa, O., Ishizuka, O.
    The 13th Pan-pacific continence society annual meeting., 18 Oct. 2018
  • Nocturia QOL evaluation in OAB patients treated with oxybutynin and mirabegron study: NEOXY study.
    Suzuki, T., Saitoh, T., Furuhata, M., Nakagawa, T., Daimon, H., Hosaka, K., Minagawa, T., Ogawa, T., Ishizuka, O.
    The 13th Pan-pacific continence society annual meeting, 18 Oct. 2018
  • Biofabricated autologous adipose derived cell structures reconstruct cryo-injured urethra in rabbits.
    Gautam Silwal S, Imamura, T., Shimamura, M., Minagawa, T., Takashi, N., Manabu, U., Nakazawa, M., Ogawa, T., Ishizuka, O.
    The 50th Annual Meeting of the International Continence Society, 31 Aug. 2018
  • Decrease of estrogen influences vessel damage and increase skin temperature receptor channesl which will provoke cold stress related frequency.
    Saito, T., Imamura, T., Nagai, T., Minagawa, T., Ogawa, T., Ishizuka, O.
    The 50th Annual Meeting of the International Continence Society, 31 Aug. 2018
  • Fluid dynamical assessment of lower urinary tract: Exploratory research to observe vorticity in male lower urinary tract using color dopper ultrasonography.
    Minagawa, T., Ogawa, T., Ishizuka, O.
    The 50th Annual Meeting of the International Continence Society, 30 Aug. 2018
  • Exploratory research to observe vorticity in male lower urinary tract using color dopper ultrasonography.
    Minagawa, T., Ogawa, T., Ishizuka, O.
    The 50th Annual Meeting of the International Continence Society., 30 Aug. 2018
  • Results of treatment with abrateron acetate in Japanese castration resistant prostate cancer patients: Deterimining a prognostic factor of long term response
    Ogawa, N., Saito, T., Kitahara, R., Hagimito, T., Utazu, H., Takeda, Y., Ueno, M., Suzuki, T., Domen, T., Nagai, T., Ogawa, T., Ishizuka, O.
    7th congress of the Societe Internationale d’Urologie, 22 Oct. 2017
  • Long term adherence to combination of mirabegron and antimuscarinic drug on overactive bladder symptoms.
    Ogawa, T., Ogawa, N., Saito, T., Nagai, T., Yokoyama, H., Imamura, T., Minagawa, T., Ishizuka, O.
    22 Oct. 2017
  • Fluid dynamical assessment of lower urinary tract: exploratory research to observe voricity in prostatic urethra after transurethral enuclation using color dopper ultrasonography.
    Minagawa, T., Ogawa, N., Daimon, H., Saito, T., Ogawa, T., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society., 15 Sep. 2017
  • Correlation between prostatic volume change and lower urinary tract symptoms after low-dose rate brachytherapy for prostate cancer.
    Daimon, H., Minagawa, T., Matsutaka, J., Ogawa, N., Saito, T., Suzuki, T., Domen, N., Ishikawa, M., Hiragata, S., Nagai, T., Ogawa, T., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society., 14 Sep. 2017
  • A prospective randomized trial to evaluate the prophylactic use of tadalafil versus tamsulosin for lower urinary tract symptoms and erectile dysfunction after low-dose-rate brachytherapy for prostate
    Minagawa, T., Oguchi, T., Daimon, H., Koiwai, K., Kato, H., Hashida, I., Ogawa, T., Kadoya, M., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society., 13 Sep. 2017
  • The effect and mechanism of change in neuroreceptors in the bladder and skin with ovarectomised rats.
    Saito, T., Imamura, T., Nagai, T., Gautam Silwal, S., Minagawa, T., Ogawa, T., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society., 13 Sep. 2017
  • The hypoxic environment decreased both aquaporin 3 and uroplakin 3 expressions and bladder storage functions in spontaneous hypertensive rats.
    Nagai, T., Imamura, T., Saito, T., Ogawa T., Minagawa, T., Domen, T., Suzuki, T., Ogawa, N., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society., 13 Sep. 2017
  • The impact of Dai-ken-chu-tou on cold-stress induced detrusor overactivity and neurological receptors in the bladder.
    Saito, T., Minagawa, T., Imamura, T., Gautam Silwal S, Nagai, T., Ogawa, T., Ishizuka, O.
    The 49th Annual Meeting of the International Continence Society, 13 Sep. 2017
  • Role of α1D/A antagonist-Naftopidil-for Male LUTS. Focusing on a α1D adrenoceptor subtype and 5-HT.
    Ishizuka O
    4th Innovative symposium for urological excellence, 2015
  • LUTS資料の最近の話題 ―信州大学における研究を中心としてー.
    石塚 修
    第16回静岡県LUTS研究会

Affiliated academic society

  • SocieteInterationale d'Urologie
  • International Society for sexual and impotence research
  • 日本排尿機能学会
  • 日本泌尿器科学会
  • 日本癌治療学会
  • 日本超音波医学会
  • 日本移植学会
  • 日本臨床腎移植学会
  • 日本内視鏡外科学会
  • 日本泌尿器内視鏡学会
  • 日本ロボット外科学会
  • 日本性感染症学会
  • 老年泌尿器科学会
  • 日本性機能学会
  • 日本泌尿器腫瘍学会
  • 日本内分泌外科学会
  • Endourological Society
  • 日本脊髄障害医学会
  • 日本メンズヘルス医学会
  • 日本ミニマム創泌尿器内視鏡学会

Research Themes

  • 微小循環改善を介した漢方薬による下部尿路症状治療薬剤の探索
    受託研究, ツムラ
    2017 - 2017
  • 末梢血液循環障害を誘発させた自然発症高血圧ラットモデルを利用した冷えストレス排尿筋過活動に対するタダラフィルの薬理効果の考察
    受託研究, 日本新薬
    2017 - 2017
  • ヒト膀胱平滑筋におけるセロトニン受容体の検索およびセロトニン誘発収縮に対するナフトピジルの作用
    受託研究, 旭化成ファーマ
    2012 - 2013
  • 冷えストレスによる頻尿とホルモンバランスの研究
    受託研究, 旭化成ファーマ
    2012 - 2012
  • 夜間頻尿に対するハルンケアの改善効果
    受託研究, 大鵬薬品工業
    2011 - 2011
  • 加齢に伴う尿道障害に対する生薬エキスHの改善効果検討
    受託研究, 大鵬薬品工業
    2010 - 2010
  • 自然発症高血圧ラットにおける下部尿路組織の形態学的変化およびa1交感神経受容体の関与に関する研究
    受託研究, 旭化成ファーマ
    2010 - 2010
  • 下部尿路閉塞病態ラットにおける下部尿路組織の形態学的変化およびα1交感神経受容体の関与に関する研究
    受託研究, 旭化成ファーマ
    2009 - 2009
  • 生薬エキスHの下部尿路病態への改善効果の検討(その3)
    受託研究, 大鵬薬品工業
    2008 - 2008
  • 生薬エキスHの下部尿路病態への改善効果の検討(その2)
    受託研究, 大鵬薬品工業
    2007 - 2007
  • 生薬エキスHの下部尿路病態への改善効果の検討
    受託研究, 大鵬薬品工業
    2006 - 2006
  • 冷えによる膀胱過活動に対するナフトピジルの抑制効果
    受託研究, 旭化成ファーマ
    2006 - 2006
  • 膀胱過活動を有する高血圧ラットもおける膀胱内無髄C線維に対する生薬エキスHの影響の検討
    受託研究, 大鵬薬品工業
    2005 - 2005
  • 冷えによるラットの膀胱過活動に対する生薬エキスHの有効性の検討
    受託研究, 大鵬薬品工業
    2004 - 2004
  • 尿失禁患者における塩酸プロピベリンのQOL改善の検討
    受託研究, 大鵬薬品工業
    2004 - 2004
  • Detrol LA Research Grants 2004 (Pfizer) “Functional roles of anti-muscarinic drugs and the roles of muscarinic receptor subtypes for centrally induced overactive bladder”
    2004 - 2004
  • 下部尿路閉塞ラットに対するハルンケアの効果
    受託研究, 大鵬薬品工業
    2003 - 2003
  • 脊髄損傷による膀胱過活動に対するトルテロジンの効果
    受託研究, ファイザー製薬
    2003 - 2003
  • Abbott Laboratories Erectile Dysfunction Research Awards 2001 “Effects of spinal and peripheral dopamine receptor stimulation on intracavenous pressure and blood pressure in conscious rats with and wi
    2001 - 2001
  • Tissue Engineering for Lower Urinary Tract
  • 排尿における神経伝達物質の役割
  • 腹腔鏡下泌尿器科手術の研究
  • ロボット支援手術の技術改良

Academic Contribution Activities

  • Planning etc
    第33回日本超音波医学会関東甲信越地方会, 松本市, 16 Oct. 2021 - 17 Oct. 2021
  • Planning etc
    Pan-Pacific Continence Society Meeting 2021, 松本市, 11 Sep. 2021 - 12 Sep. 2021
  • Planning etc
    第28回日本排尿機能学会, 松本市, 09 Sep. 2021 - 11 Sep. 2021
  • Others
    LUTS, 11 May 2021
  • Others
    日本泌尿器科学会編集委員会, Jun. 2011 - Apr. 2013

Acceptance of research students

  • 01 Apr. 2020 - 30 Sep. 2020, Gautam Silwal Sudha, Nepal, Tissue Engineering for lower urinary tract