Shinshu University Researcher Directory｜Shinshu University Online system of General Academic Resources SOAR

Academic Organization	Academic Assembly　School of Medicine and Health Sciences　Institute of Medicine	TEL	+81-263-37-2578
Education and Research Organization	Interdisciplinary Cluster for Cutting Edge Research　Institute for Biomedical Sciences	FAX	+81-263-37-3437
Position	Professor	Mail Address	tshindo＠shinshu-u.ac.jp
Address	3-1-1 Asahi, Matsumoto, 390-862, Japan,	Web site	http://www7a.biglobe.ne.jp/~shindo/

Profile

Assigned Class: School of Medicine　Department of Cardiovascular Research

Research Field: Cardiovascular medicine
Endocrinology
Keywords:Cardiovascular Research , 発生工学 , Mice Gene Engineering

Current Subject: Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.
Keywords:atherosclerosis , hypertension , heart failure , renal failure , liver failure
Pathophysiological roles of vasoactive peptides and their receptor system.
Keywords:vasoactive peptide , receptor , pathophysiology
Regenerative medicine of blood vessel.
Keywords:blood vessel , regenerative medicine
Generation of novel genetically engineerd mice.
Keywords:geen engineering , mice
Development of novel technique for genome editing
Keywords:genome editing

Academic Background: Graduate School
University of Tokyo , 1998

College
University of Tokyo , 1991

Degree
Ph.D. in Cardiovascular Science , University of Tokyo

Research Career: Research Career
2004- , Professor, Department of Cardiovascular Research, Shinshu University, School of Medicine
2002- , Assistant Professor, Department of Cardiovascular Medicine, University of Tokyo

Research

Books, Articles, etc.: Books
Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line., Methods Mol Biol. 1874 , 257-271
2019
Author:Sakurai T, Kamiyoshi A, Ohtsuka M, Gurumurthy CB, Sato M, Shindo T.

Noninheritable maternal factors useful for genetic manipulation in mammals., Results Probl Cell Differ. 63 , 495-510
2017
Author:Sakurai T, Shindo T, Sato M.

Oocytes Maternal information and functions, Springer , 495-510
2017
Author:Sakurai T, Shindo T, Sato M

Knockout mice and transgenic mice. Nishikimi T eds: Adrenomedullin in Cardiovascular Disease, pp 167-173
Springer, New Jersey 2005

Articles
An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility.
Sci Rep.,12(1):8844 2022
Author:Negishi K, Aizawa K, Shindo T, Suzuki T, Sakurai T, Saito Y, Miyakawa T, Tanokura M, Kataoka Y, Maeda M, Tomida S, Morita M, Kario K, Nagai R, Imai Y.

Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin.
Biology.,11(5):788 2022
Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.

Studies on safety and efficacy of particles containing a mixture of hydroxyapatite-argentum-titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: II. Cellular, in vivo, and clinical studies.
Eur Arch Otorhinolaryngol.,279(9):4425-4433 2022
Author:Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.

Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice.
Neurosci Lett.,778:136615 2022
Author:Ishida K, Tanaka S, Shen D, Matsui S, Fuseya S, Shindo, Kawamata M.

Studies on safety and efficacy of particles containing a mixture of hydroxyapatite–argentum–titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: I. In vitro studies.
The Allergy in Practice,42(3):37-46 2022
Author:Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.

Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts.
Endocrinology.,162(8):1-22 2021
Author:Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui1 N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.

Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress.
Endocrinology.,162(3):1-20 2021
Author:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.

Production of single- and multiple-gene-modified mice via maternal SpCas9-based gene editing.
STAR Protoc.,2(2):100509 2021
Author:Sakurai T, Shindo T.

Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration.
Am J Pathol. ,191(4):652-668 2021
Author:Tanaka M, Kakihara S, Hirabayashi K. Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata M, Shindo T.

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study.
Sci Rep. ,11(1):305 2021
Author:Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M, Shindo T, Uehara R.

Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina.
Graefes Arch Clin Exp Ophthalmol. ,285(5):1039-1047 2020
Author:Hirabayashi K, Kakihara S, Tanaka M, Shindo T, Murata T.

Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Oncogene. ,39(9):1914-1930 2020
Author:Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.

Production of genetically engineered mice with higher efficiency, lower mosaicism, and mulitiplexing capability using maternally expressed Cas9.
Sci Rep.,10(1):1091, 2020
Author:Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.

Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Biomedical Research.,41(1):1–12 2020
Author:Yamauchi A. Tone T, Tokedo A, Igarashi K, Sugimoto K, Miyai H, Deng D, Nakamura J, Lim HS, Kaku T, Hirano E, Shindo T.

Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice
Heliyon.,5(10):e02655. 2019
Author:Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T.

Porcine placental extract facilitates memory and learning in aged mice.
Food Sci Nutr. ,(7):2995–3005 2019
Author:Yamauchi A, Tone T, Sugimoto K, Lim HS, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E.

Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation.
Am J Pathol. ,189(12):2487-2502 2019
Author:Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.

Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Heliyon.,10;5(5):e01637 2019
Author:Yamauchi A. Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism

Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
Peptides.,111:55-61 2019
Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T

Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-RAMP2 system
Am J Pathol.,189(2):449-466 2019
Author:Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T

Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sci Rep,9:9923. 2019
Author:Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M , Shindo T.

Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline
J Hypertens.,36(4):876-891 2018
Author:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A,Igarashi K, Shindo T

RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
Peptides.,110:10-18 2018
Author:Liu T, Kamiyoshi A, Tanaka M, Iida S, Sakurai T, Ichikawa-Shindo Y, Kawate H, Hirabayashi K, Dai K, Cui N, Tanaka M, Wei Y, Nakamura K, Matsui S, Yamauchi A, Shindo T

Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells
Heliyon. 2017
Author:Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T

Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and Inflammation in retinopath
Am J Phthol.,187(5):999-1015 2017
Author:Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T"

Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells.
Endocrinology.,158(5):1359−1372 2017
Author:Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.

Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice.
Endocrinology.,158(5):1194-1206 2017
Author:Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques.
Sci Rep,6:35861 2016(Oct.)
Author:Uemura T, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K.

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.
Cardiovasc Res,111(4):398-409 2016(Sep.)
Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T.

Adrenomedullin: A potential therapeutic target for retinochoroidal disease.
Prog Retin Eye Res,52:112-29 2016(May)
Author:Iesato Y, Yuda K, Chong KT, Tan X, Murata T, Shindo T, Yanagi Y.

Effects of Adrenomedullin on Doxorubicin-Induced Cardiac Damage in Mice.
Biol Pharm Bull,39(5):737-46 2016(May)
Author:Yoshizawa T, Takizawa S, Shimada S, Tokudome T, Shindo T, Matsumoto K.

Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development.
Endocrinology,157(1):358-67 2016(Jan.)
Author:Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.
Hypertension,67(1):99-106 2016(Jan.)
Author:Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T.

A non-inheritable maternal Cas9-based multiple-gene editing system in mice.
Sci Rep,6:20011 2016(Jan.)
Author:Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T.

Adrenomedullin-RAMP2 system in vascular endothelial cells
J. Atheroscler. Thromb,22(7):647-653 2015
Author:Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T.

Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases
Am J Pathol.,185(6):1783-1794 2015
Author:Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T.

Pathophysiological roles of adrenomedullin and its receptor activity modifying system.
Folia Pharmacol. Jpn,143(5):232-235 2014
Author:Shindo T, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Koyama T.

Functional differentiation of RAMP2 and RAMP3 in their regulation of vascular system
J Mol Cell Cardiol.,77:73-85 2014
Author:Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.

Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Peptides.,62:21-31 2014
Author:Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.

Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain.
Anesthesiology.,121(5):1068-79 2014
Author:Ishida K, Kawamata T, Tanaka S, Shindo T, Kawamata M.

Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection
PLoS One,9(2):e87667 2014
Author:Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T.

A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice.
BMC Biotechnol.,14(1):69 2014
Author:Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T.

Regulation of adrenomedullin and its family peptide by RAMP system
Curr Prot Pept Sci.,14(5):347-367 2013
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S.

Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
J Mol Cell Cardiol.,59:55-66 2013
Author:Yang　L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T.

Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis
Am J Pathol.,182(6):2380-2390 2013
Author:Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T

Novel regulation of cardiac ｍetabolism and homeostasis by the adrenomedullin-RAMP2 system
Hypertension,61(2):341-351 2013
Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Circulation,127(7):842-853 2013
Author:Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams R.H, Kawakami H, Mochizuki N, Martínez A, Shindo T

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
Protein Sci.,21:199-210 2012
Author:Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S.

Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Curr Hypertens Rev.,7(4):217-227 2011
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y.

Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Peptides,32(9):1855-1865 2011
Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.

Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
PEPTIDES,31(5):865-871 2010(May)
Author:Iinuma, Nobuyoshi; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Arai, Takuma; Yoshizawa, Takahiro; Koyama, Teruhide; Uetake, Ryuichi; Kawate, Hisaka; Muto, Shin-ichi; Tagawa, Yoh-ichi; Miyagawa, Shinichi; Shindo, Takayuki

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
J Clin Invest.,120(1):254-65 2010
Author:Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Nagai R.　

Regulation of angiogenesis and vascular integrity by adrenomedullin-RAMP2 system.
J Soc Circ Res.,32(2):33-35 2009
Author:Shindo Y, Sakurai T, Kamiyoshi A, Koyma T, Yoshizawa T, Shindo T.　

Endogenous a-CGRP mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A.
Liver International.,29(5):642-9 2009
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y. Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.

Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.: Shinoda Y, Ogata N,
J Biol Chem.,283(36):24682-9 2008
Author:Higashikawa A, Manabe I,Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain
Protein Sci.,17(11):1907-14 2008
Author:Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, ShindoT, Yokoyama S.

Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution.
Transgenic Res.,17:149-55 2008
Author:Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T.

GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
J Clin Invest.,(118):29-39 2008
Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.　

Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice.
J Appl Physiol.,102(6):2361-8 2007
Author:Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y

Endogenous alpha CGRP protects against concanavalin A-induced hepatitis in mice
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,343(1):152-158 2006
Author:Kainiyoshi, A; Sakurai, T; Ichikawa-Shindo, Y; Fukuchi, J; Kawate, H; Muto, S; Tagawa, Y; Shindo, T

The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,26(5):1177-1183 2006
Author:Takeda, N; Manabe, I; Shindo, T; Iwata, H; Iimuro, S; Kagechika, H; Shudo, K; Nagai, R

Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice.
CIRCULATION,114(18):13-13 2006
Author:Shindo, T; Niu, P; Kamiyoshi, A; Sakurai, T; Ichikawa, Y; Iinuma, N; Kawate, H

Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
Cell Metabolism,1:27-29 2005
Author:Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R

Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5
Circ Res,97:1132-1141 2005
Author:Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R

Significance of the transcription factor KLF5 in cardiovascular remodeling
J ThrombHaemost,343:1569-1576 2005
Author:Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa
Eur J Pharmacol,502:243-252 2004
Author:Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M

Angiogenic effects of adrenomedullin in ischemia and tumor growth
Circ Res,95:415-423 2004
Author:Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R

Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis and renal damage
Circulation,109:1789-1794 2004
Author:Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R

Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Hypertens Res,26:S79-84 2003
Author:Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R

Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.
Hypertens Res,26:S105-8 2003
Author:Kurihara H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T

Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice.
Eur J Pharmacol,468(1):47-58 2003
Author:Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T, Omata M, Nagai R, Kurihara H, Asano T

Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Hypertens Res,26:731-736 2003
Author:Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R

KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Adv Exp Med Biol,538:57-65 2003
Author:Nagai R, Shindo T, Manabe I, Suzuki T, Kurabayashi M

Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.
J. Mol. Med,80(2):105-16 2002
Author:Shindo T, Kurihara H, MaemuraK, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R, Kimura K

Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury. Studies on transgenic/knockout mice of adrenomedullin gene.
Circ Res,90:657-63 2002
Author:Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R

Regulation of angiogenesis by the aging suppressor gene klotho.
Biochem Biophys Res Commun,293:332-7 2002
Author:Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R

Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice.
Arterioscler Thromb Vasc Biol,22(8):1310-5 2002
Author:Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature Medicine,8(8):856-63 2002
Author:Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R

Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
Am J Physiol Lung Cell Mol Physiol,283(5):L963-70 2002
Author:Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy.
Nephrol Dial Transplant,17:39-41 2002
Author:Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K

Protective effect of adrenomedullin against cardiac hypertrophy and renal damage.
J Cardiac Failure,8:S221 2002
Author:Niu P, Shindo T, Ebihara A, Zhang Y, Kawanami D, Imai Y, Amaki T, Suematsu Y, Nagai R

Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy.
Circ Res,27:1103-1113 2002
Author:Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy.

Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Circulation,103(1):133-9 2001
Author:Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y, Nagai R

Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice.
Circ Res,89(1):55-62 2001
Author:Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S

Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Circulation,104:1964-71 2001
Author:Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H

Elevated sympathetic nervous activity in mice deficient in aCGRP.
Circ Res,89:983-90 2001
Author:Oh-hashi Y,* Shindo T* (*double 1st author), Kurihara Y, Imai T, Wang Y, Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, Kurihara H

Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.
Ann N Y Acad Sci,947:26-33 2001
Author:Imai Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H

Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases.
Atherosclerosis,149(2):435-42 2000
Author:Imai Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y

Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing
Circulation,101(19):2309-16 2000
Author:Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y

ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphologyand function.
J Clin Invest,105(10):1345-52 2000
Author:Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K

Polymorphism of the methionine synthase gene : association with homocysteine metabolism and late-onset vascular diseases in the Japanese population.
Arterioscler Thromb Vasc Biol,19(2):298-302 1999
Author:Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y

Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.
Hypertens Res,22(1):11-6 1999
Author:Morita H, Kurihara H, Kurihara Y, Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y

Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese.
Arterioscler Thromb Vasc Biol,18(9):1465-9 1998
Author:Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y

Systemic and renal response to salt loading in endothelin-1 knockout mice.
J Cardiovasc Pharmacol,(31):S557-60 1998
Author:Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y

Cardiac sarcoidosis.
Circulation,97(13):1306-7 1998
Author:Shindo T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H, Yamaoki K, Yazaki Y

Upregulation of endothelin-1 and adrenomedullin gene expression in the mouse endotoxin shock model.
J Cardiovasc Pharmacol,31:S541-4 1998
Author:Shindo T, Kurihara H, Kurihara Y, Morita H, Yazaki Y

Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor forcoronary artery disease.
Circulation,95(8):2032-6 1997
Author:Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines.
Cardiovasc Res,29(6):813-9 1995
Author:Shindo T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K

Nitric oxide synthesis in rat cardiac myocytes and fibroblasts.
Life Sci.,55(14):1101-8 1994
Author:Shindo T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y, Yokoyama M, Kasahara T, Shimada K

Presentations
Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis.
The Association for Research in Vision and Ophthalmology (ARVO) 2022 2022(May 14)
Presenter:Matsuda　Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo, Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T.

Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model.
The Association for Research in Vision and Ophthalmology (ARVO) 2022 2022(May 14)
Presenter:Kakihara K, Sakurai T, Kamiyoshi A, Tanaka M, Kawate H, Ichikawa-Shindo Y, Zhao Y, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Murata T, Shindo T.

Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization.
The Association for Research in Vision and Ophthalmology (ARVO) 2021 2021(May 01)
Presenter:Kakihara S, Tanaka M, Hirabayash K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Kawate H, Ichikawa-Shindo Y, Tanaka M, Murata T, Shindo T.

Adrenomedullin-RAMP2 and RAMP3 systems regulate cardiac homeostasis against cardiovascular stresses
Asian Pacific Society of Cardiology Congress 2020 (APSC2020) 2020(Jul. 27)
Presenter:Cui N, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Tanaka M, Dai K, Wei Y, Tanaka M. Kakihara S, Matsui S, Shindo T.

Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration
Association for research in Vision and Ophthalmology 2019(Apr. 28)
Presenter:Masaaki Tanaka, Kazutaka Hirabayashi, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Toshinori Murata, Takayuki Shindo

Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin
Congress of Asia-Pacific Academy of Ophthalmology 2019(Mar. 06)
Presenter:Kazutaka Hirabayashi, Toshinori Murata, Takayuki Shindo, Masaaki Tanaka, Akira Imai

Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion
The Association for Research in Vision and Ophthalmology 2018(Apr. 28)
Presenter:Kazukata Hirabayashi, Toshinori Murata, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Masaaki Tnanaka, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Takayuki Shindo

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium 2014(Sep. 11)
Presenter:Shindo T.

Pathophysiological roles and potential applications of vasoactive peptides and their receptor regulation system.
2010
Presenter:新藤隆行

Vasoactive peptides and their receptor regulation system.
2010
Presenter:新藤隆行

Pathophysiological roles of Adrenomedullin-RAMP system in cardiovascular diseases
2008
Presenter:新藤隆行

Adrenomedullin and cardiovascular disease　-Lessons from knockout mice-
2005
Presenter:新藤隆行

Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
2003
Presenter:新藤隆行

Patents: Patents
RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , JP
RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , EP
RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , US
代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , JP
代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , CN
代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , US
代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , EP

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SHINDO TAKAYUKI

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SHINDO　TAKAYUKI