SHINDO TAKAYUKI
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Professor
Researcher Information
Research Keyword
- Cardiovascular Research, Gene Engineering
TEL
- +81-263-37-2578
Mail Address
- tshindo★shinshu-u.ac.jp
Career
Research activity information
Books and other publications
- Methods Mol Biol. 1874
Sakurai T, Kamiyoshi A, Ohtsuka M, Gurumurthy CB, Sato M, Shindo T., Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line.
257-271 2019Oocytes Maternal information and functions
Sakurai T, Shindo T, Sato M, Noninheritable Maternal Factors Useful for Genetic Manipulation in Mammals
Springer, 495-510 2017
Results Probl Cell Differ. 63
Sakurai T, Shindo T, Sato M., Noninheritable maternal factors useful for genetic manipulation in mammals.
495-510 2017Knockout mice and transgenic mice. Nishikimi T eds: Adrenomedullin in Cardiovascular Disease
Springer, New Jersey, pp 167-173 2005Lectures, oral presentations, etc.
- Vascular homeostasis by the AM-RAMP2 system promotes T cell recruitment, prevents cancer cell migration, and suppresses lymph node metastasis.
Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Kasahara T, Shindo T
第88回日本循環器学会, 08 Mar. 2024Protective effects of adrenomedullin 2 against heart failure by regulating the metabolism of cardiac myocytes
Zhao Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Kasahara T, Shindo T
第88回日本循環器学会, 08 Mar. 2024Metabolic regulation by the adrenomedullin2-RAMP3 system
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Tanaka M, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Kasahara T, Shindo T
第88回日本循環器学会, 08 Mar. 2024アドレノメデュリン2は、心筋細胞のミトコンドリア機能と代謝系シグナルを制御し、心保護に働く
Zhao Yunlu、桜井敬之、神吉昭子、新藤優佳、河手久香、田中愛、松田順繁、Zhang Yan、Guo Qianqian、Li Peixuan、星山健、Li Jiake、大西菜穂、林真倫那、笠原智貴、新藤隆行
第53回日本心脈管作動物質学会, 09 Feb. 2024アドレノメデュリンの受容体活性調節システムを標的とした癌転移の制御
田中愛、新藤隆行
第53回日本心脈管作動物質学会, 09 Feb. 2024Adrenomedullin 2/intermedin is produced in response to pressure stress and protects cardiac function by regulating cardiomyocyte metabolism
Zhao Y､Shindo T
第40回国際心臓研究学会, 09 Dec. 2023閉経後代謝障害におけるRAMP1、RAMP3の病態生理学的意義の検討
大西菜穂、神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、Yunlu Zhao、松田順繁、Yan Zhang、QianQian Guo、Peixuan Li、星山健、林真倫那、Li Jiake、新藤隆行
第44回日本肥満学会, 25 Nov. 2023脂肪肝および肝癌発症における、アドレノメデュリン2(AM2)の病態生理学的意義
神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、Zhao Yunlu、松田順繁、Zhang Yan、Guo Qianqian、Li Peixuan、大西菜穂、星山健、林真倫那、Li Jiake、新藤隆行
第44回日本肥満学会, 25 Nov. 2023AM-RAMP2系は、高内皮細静脈(HEV)の恒常性を制御し、リンパ節転移を抑制する
田中愛、桜井敬之、神吉昭子、新藤優佳、河手久香、ZHAO YUNLU、松田順繁、ZHANG YAN、GUO QIANQIAN、星山健、LI PEIXUAN、LI JIAKE、大西菜穂、林真倫那、笠原智貴、甲斐健佑、新藤隆行
第6回日本腫瘍循環器学会 , 30 Sep. 2023AM-RAMPシステムによる生体内恒常性制御
新藤隆行
第55回日本動脈硬化学会, 09 Jul. 2023アドレノメデュリンの投与による、ぶどう膜炎の病態改善効果
松田順繁、柿原伸次、桜井敬之、神吉昭子、 市川優佳、田中愛、 河手久香、村田敏規、新藤隆行
第55回日本眼炎症学会, 07 Jul. 2023RAMPシステムによる生体内恒常性制御機構の解明と応用展開
新藤隆行
第41回内分泌代謝学サマーセミナー 松尾賞受賞講演, 07 Jul. 2023AM-RAMPシステムによる生体内恒常性制御
新藤隆行
第96回日本内分泌学会, 01 Jun. 2023Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis.
Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T
The Association for Research in Vision and Ophthalmology (ARVO) 2023, 23 Apr. 2023Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular AMD.
Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Murata T, Shindo T
FujiRetina2023 , 25 Mar. 2023Endogenous adrenomedullin 2 /intermedin exerts cardioprotective effects against pressure overload.
Zhao Y, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Tanaka M, Kakihara S, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Adrenomedullin-2/intermedin ameliorates pathological angiogenesis and associated inflammation and fibrotic lesions via Meox2.
Kakihara S, Matsuda Y, Sakurai T, Kamiyoshi K, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Vascular homeostatic function of the AM-RAMP2 system and its application to the regulation of lymph node metastasis.
Tanaka M, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Kakihara S, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model.
Kakihara K, Sakurai T, Kamiyoshi A, Tanaka M, Kawate H, Ichikawa-Shindo Y, Zhao Y, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2022, 14 May 2022Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis.
Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo, Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2022, 14 May 2022Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization.
Kakihara S, Tanaka M, Hirabayash K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Kawate H, Ichikawa-Shindo Y, Tanaka M, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2021, 01 May 2021Adrenomedullin-RAMP2 and RAMP3 systems regulate cardiac homeostasis against cardiovascular stresses
Cui N, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Tanaka M, Dai K, Wei Y, Tanaka M. Kakihara S, Matsui S, Shindo T.
Asian Pacific Society of Cardiology Congress 2020 (APSC2020), 27 Jul. 2020Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration
Masaaki Tanaka, Kazutaka Hirabayashi, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Toshinori Murata, Takayuki Shindo
Association for research in Vision and Ophthalmology, 28 Apr. 2019Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin
Kazutaka Hirabayashi, Toshinori Murata, Takayuki Shindo, Masaaki Tanaka, Akira Imai
Congress of Asia-Pacific Academy of Ophthalmology, 06 Mar. 2019Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion
Kazukata Hirabayashi, Toshinori Murata, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Masaaki Tnanaka, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Takayuki Shindo
The Association for Research in Vision and Ophthalmology, 28 Apr. 2018Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Shindo T.
The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium, 11 Sep. 2014Vasoactive peptides and their receptor regulation system.
新藤隆行
2010Pathophysiological roles and potential applications of vasoactive peptides and their receptor regulation system.
新藤隆行
2010Pathophysiological roles of Adrenomedullin-RAMP system in cardiovascular diseases
新藤隆行
2008Adrenomedullin and cardiovascular disease -Lessons from knockout mice-
新藤隆行
2005Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
新藤隆行
2003Research Themes
- Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.
- Pathophysiological roles of vasoactive peptides and their receptor system.
- Regenerative medicine of blood vessel.
- Generation of novel genetically engineerd mice.
- Development of novel technique for genome editing
Industrial Property Rights
- RAMP2を標的とする血管構造の安定化剤及び血管新生剤, EP1900374, Patent right
新藤隆行 - RAMP2を標的とする血管構造の安定化剤及び血管新生剤, US 9,072,777B2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, CNZL200880117473.2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, US 8,858,915 B2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, EP2221065, Patent right
- RAMP2を標的とする血管構造の安定化剤及び血管新生剤, 4993606, 304422, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, 5099856, 071212 , Patent right
新藤隆行
