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SAWAMURA Tatsuya

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research Institute for Biomedical SciencesFAX
PositionProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Profile

Assigned Class
School of Medicine Department of Molecular Pathophysiology
Research Field
Research Fieldmolecular pathophysiology
Physiology
Academic Background
Graduate School
1992

Degree
Doctor of Medicine

Research

Books, Articles, etc.
Articles
Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.
Transl Res,205:17-32 2019
Author:Shih, C.M., Lin, F.Y., Yeh, J.S., Lin, Y.W., Loh, S.H., Tsao, N.W., Nakagami, H., Morishita, R., Sawamura, T., Li, C.Y., Lin, C.Y. and Huang, C.Y.


A novel cell-free, non-fluorescent method to measure Lox-1- binding activity corresponding to the functional activity of HDL.
J Atheroscler Thromb 2019
Author:Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.


Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.
Ann N Y Acad Sci,1443:34-53 2019
Author:Tian, K., Ogura, S., Little, P.J., Xu, S.W. and Sawamura, T.


Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
Aging Cell,:e12792 2018
Author:Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.


Ecrg4 peptide is the ligand of multiple scavenger receptors. Sci Rep
Sci Rep,8:4048 2018
Author:Moriguchi, T., Takeda, S., Iwashita, S., Enomoto, K., Sawamura, T., Koshimizu, U. and Kondo, T.


123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nucl Med Mol Imaging,52:144-153 2018
Author:Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.


Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.
Heart Vessels,33:9-16 2018
Author:Komiyama, M., Wada, H., Ono, K., Yamakage, H., Satoh-Asahara, N., Shimada, S., Akao, M., Morimoto, T., Shimatsu, A., Takahashi, Y., Sawamura, T. and Hasegawa, K.


Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries.
Clin Sci (Lond),132:2369-2381 2018
Author:Spaans, F., Quon, A., Rowe, S.R., Morton, J.S., Kirschenman, R., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.


Electronegative Low-density Lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.
J Clin Endocrinol Metab,102:4615-4625 2017
Author:Ke, L.Y., Chan, H.C., Chan, H.C., Kalu, F.C.U., Lee, H.C., Lin, I.L., Jhuo, S.J., Lai, W.T., Tsao, C.R., Sawamura, T.


Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
PLoS One,12:e0180364 2017
Author:Spaans, F., Kao, C.K., Morton, J.S., Quon, A.L., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.


Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Circ J 2016
Author:Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.


Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
Blood Cells Mol Dis,60:44-48 2016
Author:Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.


Deletion of LOX-1 protects against heart failure induced by doxorubicin.
PLoS One,11:e0154994 2016
Author:Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.


High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
J Atheroscler Thromb,23:1222-1226 2016
Author:Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.


Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis.
Medicine (Baltimore),95:e2265 2016
Author:Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.


Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Scand J Rheumatol,45:412-422 2016
Author:Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.


Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese.
J Clin Lipidol,10:172-180 2016
Author:Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.


Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Blood,127:1336-1345 2016
Author:Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell Cardiol,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Cardiovasc Res,107:556-567 2015
Author:Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.


The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells.
PLoS One,10:e0123971 2015
Author:Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.


LOX-1 in atherosclerotic disease.
Clin Chim Acta,440:157-163 2015
Author:Sawamura, T., Wakabayashi, I. and Okamura, T.


The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE Study.
J Atheroscler Thromb,22:499-508 2015
Author:Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.


High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
Lipids Health Dis,14:6 2015
Author:Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.


Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
FASEB J,29:3342-3356 2015
Author:Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.


Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.
PLoS One,10:e0118835 2015
Author:Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.


Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Bone,75:170-182 2015
Author:Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.


Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
Am J Physiol Regul Integr Comp Physiol,308:R163-172 2015
Author:Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients.
Int J Cardiol,176:1230-1232 2014
Author:Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.


LOX-1 plays an important role in ischemia-induced angiogenesis of limbs.
PLoS One,9:e114542 2014
Author:Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.


Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.
Biomed Res Int,2014:649185 2014
Author:Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.


Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis.
Am J Physiol Heart Circ Physiol,306:H1700-1707 2014
Author:Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.


Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
J Atheroscler Thromb,20:195-203 2013
Author:Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.


Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
Blood,122(22):3632-3641 2013
Author:Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.


Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor.
PLoS One,8:e70533 2013
Author:Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.


Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia.
Am J Hypertens,26:279-286 2013
Author:English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.


LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Atherosclerosis,229:240-245 2013
Author:Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.


Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
J Atheroscler Thromb,20:585-590 2013
Author:Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.


Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells.
J Biol Chem,288:29595-29603 2013
Author:Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.:


Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis Rheum,64:1024-1034 2012
Author:Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.


Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
Hypertension,59:1014-1020 2012
Author:Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.


Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
J Atheroscler Thromb,19:986-998 2012
Author:Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.


LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.
Infect Immun,79:2865-2870 2011
Author:Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.


Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Clin Chem,57:1398-1405 2011
Author:Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.


An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb,18:818-828 2011
Author:Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.


Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Proc Jpn Acad Ser B Phys Biol Sci,87:104-113 2011
Author:Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.


Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
Clin Chim Acta,412:1643-1647 2011
Author:Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.


LOX-1 mediates vascular lipid retention under hypertensive state.
J Hypertens,28:1273-1280 2010
Author:Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.


Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Clin Chem,55:285-294 2009
Author:Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.


A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
J Hypertens,27:508-516 2009
Author:Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T


Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
Circ Res,104:619-627 2009
Author:Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.