沢村 達也 (サワムラ タツヤ)   

学術研究院(医学系)

先鋭領域融合研究群 バイオメディカル研究所 

教授 

学位

  • 医学博士, 筑波大学大学院

研究分野

  • 生理学, 生理学一般
  • 医療薬学, 分子病態学

ホームページURL

経歴

  • 2010年 - 2014年
    独立行政法人国立循環器病研究センター 血管生理学部部長
  • 2003年 - 2010年
    国立循環器病センター 脈管生理部部長
  • 1998年 - 2003年
    国立循環器病センター バイオサイエンス部細胞生物学研究室長
  • 1992年 - 1997年
    京都大学医学部助手
  • 1991年 - 1992年
    学術振興会特別研究員

学歴

  • 1992年, 筑波大学

受賞

  • 2016年
    文部科学大臣表彰 科学技術賞(開発部門)
  • 2009年
    日本学術振興会賞
  • 2008年
    バイオビジネスコンペJAPAN優秀賞
  • 2008年
    日本心血管内分泌代謝学会 第12回高峰譲吉研究奨励賞
  • 2001年
    日本薬理学会学術奨励賞
  • 2000年
    成人血管病研究振興財団 岡本研究奨励賞
  • 2000年
    日本生化学会奨励賞

論文

  • LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen.
    Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.
    Hypertens Res, 46, 63-74, 2023年, 査読有り
  • NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
    Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
    Cardiovasc Res, 119, 1008-1020, 2023年, 査読有り
  • Lectin-like oxidized low-density lipoprotein receptor-1 attenuates pneumonia-induced lung injury.
    Korkmaz, F.T., Shenoy, A.T., Symer, E., Baird, L.A., Odom, C.V., Arafa, E., Dimbo, E.L., Na, E., Molina-Arocho, W., Brudner, M., Standiford, T.J., Mehta, J.L., Sawamura, T., Jones, M.R., Mizgerd, J.P., Traber, K.T. and Quinton, L.J.
    JCI Insight, 7, e149955, 2022年, 査読有り
  • Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study.
    Sata, M., Kakino, A., Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.
    Eur J Prev Cardiol, 29, e193-e195, 2022年
  • Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2.
    Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.
    Viruses, 13, 2137, 2021年
  • Lectin-like oxidized LDL receptor-1 (LOX-1): A crucial driver of atherosclerotic cardiovascular disease.
    Akhmedov, A., Sawamura, T., Chen, C.H., Kraler, S., Vdovenko, D. and Lüscher, T.F.
    Eur Heart J, 42, 1797-1807, 2021年
  • Autoimmune rheumatic diseases: An update on the role of atherogenic electronegative LDL and potential therapeutic strategies.
    Chen, D.Y., Sawamura, T., Dixon, R.A.F., Sanchez-Quesada, J.L. and Chen, C.H.
    J Clin Med, 10, 1992, 2021年
  • Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
    Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.
    Sci Rep, 11, 15675, 2021年
  • Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
    Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and Sawamura, T.
    J Lipid Res, 62, 100001, 2021年
  • The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor.
    Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H
    ISCIENCE, 24, 102076, 2021年
  • Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using with direct-acting antivirals.
    Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.
    Hepatol Res, 51, 758-766, 2021年
  • RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
    Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.
    Sci Rep, 11, 5759, 2021年
  • The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men.
    Hirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K., Ueshima, H. and Group, S.R.
    Atherosclerosis, 313, 20-25, 2020年
  • Role of lectin-like oxidized LDL receptor-1 and syncytiotrophoblast extracellular vesicles in the vascular reactivity of mouse uterine arteries during pregnancy.
    Spaans, F., Quon, A., Kirschenman, R., Morton, J.S., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
    Sci Rep, 10, 6046, 2020年
  • High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: Potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
    Sáez, T., Spaans, F., Kirschenman, R., Sawamura, T. and Davidge, S.T.
    Clin Sci (Lond), 134, 2295-2313, 2020年
  • Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits K ATP channels through CaMKII activation
    Ma, Y., Cheng, N., Sun, J., Lu, J.X., Abbasi, S., Wu, G., Lee, A.S., Sawamura, T., Cheng, J., Chen, C.H. and Xi Y.
    Lipids Health Dis, 19, 189, 2020年
  • LOX-1 deletion has protective effects on stroke in the genetic background of stroke-prone spontaneously hypertensive rat.
    Liang, Y.Q., Kakino, A., Matsuzaka, Y., Mashimo, T., Isono, M., Akamatsu, T., Shimizu-Furusawa, H., Tajima, M., Kaneko, T., Li, L., Takeuchi, F., Sawamura, T. and Kato, N.
    Stroke, 51, 1835-1843, 2020年
  • LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.
    Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.
    J Cell Sci, 133, jcs243840, 2020年
  • Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction.
    Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.
    J Am Heart Assoc, 9, e014008, 2020年
  • Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1.
    Cimmino, G., Cirillo, P., Conte, S., Pellegrino, G., Barra, G., Maresca, L., Morello, A., Cali, G., Loffredo, F., Palma, R., Arena, G., Sawamura, T., Ambrosio, G. and Golino, P.
    Cardiovasc Res, 116, 1125-1135, 2020年
  • Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.
    Tian, K., Ogura, S., Little, P.J., Xu, S.W. and Sawamura, T.
    Ann N Y Acad Sci, 1443, 34-53, 2019年
  • A novel cell-free, non-fluorescent method to measure LOX-1- binding activity corresponding to the functional activity of HDL.
    Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.
    J Atheroscler Thromb, 26, 947-958, 2019年
  • Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.
    Shih, C.M., Lin, F.Y., Yeh, J.S., Lin, Y.W., Loh, S.H., Tsao, N.W., Nakagami, H., Morishita, R., Sawamura, T., Li, C.Y., Lin, C.Y. and Huang, C.Y.
    Transl Res, 205, 17-32, 2019年
  • Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries.
    Spaans, F., Quon, A., Rowe, S.R., Morton, J.S., Kirschenman, R., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
    Clin Sci (Lond), 132, 2369-2381, 2018年
  • Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.
    Komiyama, M., Wada, H., Ono, K., Yamakage, H., Satoh-Asahara, N., Shimada, S., Akao, M., Morimoto, T., Shimatsu, A., Takahashi, Y., Sawamura, T. and Hasegawa, K.
    Heart Vessels, 33, 9-16, 2018年
  • 123I-labeled oxLDL is widely distributed throughout the whole body in mice.
    Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.
    Nucl Med Mol Imaging, 52, 144-153, 2018年
  • Ecrg4 peptide is the ligand of multiple scavenger receptors.
    Moriguchi, T., Takeda, S., Iwashita, S., Enomoto, K., Sawamura, T., Koshimizu, U. and Kondo, T.
    Sci Rep, 8, 4048, 2018年
  • Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
    Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.
    Aging Cell, 17, e12792, 2018年
  • L5: an LDL fraction in which pathogenic activity of LDL is concentrated.
    Sawamura, T., Fujita, Y., Horiuchi, S. and Kakino, A.
    Trends Cardiovasc Med, 27, 247-248, 2017年
  • LOX-1 in ischemic stroke.
    Sawamura, T., Fujita, Y., Horiuchi, S. and Kakino, A.
    J Atheroscler Thromb, 24, 566-568, 2017年
  • A consensus definitive classification of scavenger receptors and their roles in health and disease.
    PrabhuDas, M.R., Baldwin, C.L., Bollyky, P.L., Bowdish, DM.E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., McVicker, B., Means, T.K., Moestrup, S.K., Post, S.R., Sawamura, T., Silverstein, S., Speth, R.C., Telfer, J.C., Thiele, G.M., Wang, X.Y., Wright, S.D. and El Khoury, J.
    J Immunol, 198, 3775-3789, 2017年
  • Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
    Spaans, F., Kao, C.K., Morton, J.S., Quon, A.L., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
    PLOS ONE, 12, e0180364, 2017年
  • Electronegative low-density lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.
    Ke, L.Y., Chan, H.C., Chan, H.C., Kalu, F.C.U., Lee, H.C., Lin, I.L., Jhuo, S.J., Lai, W.T., Tsao, C.R., Sawamura, T., Dixon, R.A., Chen, C.H., Chu, C.S. and Shin, S.J.
    J Clin Endocrinol Metab, 102, 4615-4625, 2017年
  • Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis.
    Stancel, N., Chen, C.C., Ke, L.Y., Chu, C.S., Lu, J., Sawamura, T. and Chen, C.H.
    Clin Chem, 62, 320-327, 2016年
  • Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
    Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.
    BLOOD, 127, 1336-1345, 2016年
  • Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese.
    Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.
    J Clin Lipidol, 10, 172-180, 2016年
  • Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
    Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.
    Scand J Rheumatol, 45, 412-422, 2016年
  • High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
    Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
    J Atheroscler Thromb, 23, 1222-1226, 2016年
  • Deletion of LOX-1 protects against heart failure induced by doxorubicin.
    Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.
    PLOS ONE, 11, e0154994, 2016年
  • Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
    Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.
    Blood Cells Mol Dis, 60, 44-48, 2016年
  • Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
    Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.
    Circ J, 80, 2541-2549, 2016年
  • Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis.
    Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.
    Medicine (Baltimore), 95, e2265, 2016年WebofScienceリポジトリ電子ジャーナル
  • Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
    Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.
    J Mol Cell, 84, 36-44, 2015年
  • Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
    Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.
    Am J Physiol Regul Integr Comp Physiol, 308, R163-172, 2015年
  • Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
    Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
    BONE, 75, 170-182, 2015年
  • Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
    Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.
    FASEB J, 29, 3342-3356, 2015年
  • The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE Study.
    Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.
    J Atheroscler Thromb, 22, 499-508, 2015年
  • LOX-1 in atherosclerotic disease.
    Sawamura, T., Wakabayashi, I. and Okamura, T.
    Clin Chim Acta, 440, 157-163, 2015年
  • Cross-talk between LOX-1 and PCSK9 in vascular tissues.
    Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.
    Cardiovasc Res, 107, 556-567, 2015年
  • Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.
    Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.
    PLOS ONE, 10, e0118835, 2015年WebofScienceリポジトリ電子ジャーナル
  • High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
    Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.
    Lipids Health Dis, 14, 6, 2015年WebofScienceリポジトリ電子ジャーナル
  • The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells.
    Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.
    PLOS ONE, 10, e0123971, 2015年WebofScienceリポジトリ電子ジャーナル
  • Standardizing scavenger receptor nomenclature.
    Prabhudas, M., Bowdish, D., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., Means, T.K., Moestrup, S.K., Post, S., Sawamura, T., Silverstein, S., Wang, X.Y. and El Khoury, J.
    J Immunol, 192, 1997-2006, 2014年
  • Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis.
    Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.
    Am J Physiol Heart Circ Physiol, 306, H1700-1707, 2014年
  • Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients.
    Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.
    Int J Cardiol, 176, 1230-1232, 2014年
  • Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.
    Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.
    Biomed Res Int, 2014, 649185, 2014年WebofScienceリポジトリ電子ジャーナル
  • LOX-1 plays an important role in ischemia-induced angiogenesis of limbs.
    Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.
    PLOS ONE, 9, e114542, 2014年WebofScienceリポジトリ電子ジャーナル
  • Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells.
    Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.
    J Biol Chem, 288, 29595-29603, 2013年
  • Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
    Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.
    J Atheroscler Thromb, 20, 585-590, 2013年
  • LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
    Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.
    Atherosclerosis, 229, 240-245, 2013年
  • Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia.
    English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.
    Am J Hypertens, 26, 279-286, 2013年
  • Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
    Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.
    BLOOD, 122, 3632-3641, 2013年
  • Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
    Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.
    J Atheroscler Thromb, 20, 195-203, 2013年
  • Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor.
    Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.
    PLOS ONE, 8, e70533, 2013年WebofScienceリポジトリ電子ジャーナル
  • LOX-1: a multiligand receptor at the crossroads of response to danger signals.
    Sawamura, T., Kakino, A. and Fujita, Y.
    Curr Opin Lipidol, 23, 439-445, 2012年
  • Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
    Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.
    J Atheroscler Thromb, 19, 986-998, 2012年
  • Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
    Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.
    Hypertension, 59, 1014-1020, 2012年
  • Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
    Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
    Arthritis Rheum, 64, 1024-1034, 2012年
  • LOX-1: a new target for therapy for cardiovascular diseases.
    Mehta, J. L., Khaidakov, M., Hermonat, P. L., Mitra, S., Wang, X., Novelli, G., and Sawamura, T.
    Cardiovasc Drugs Ther, 25, 495-500, 2011年
  • The discovery of LOX-1, its ligands and clinical significance.
    Yoshimoto, R., Fujita, Y., Kakino, A., Iwamoto, S., Takaya, T. and Sawamura, T.
    Cardiovasc Drugs Ther, 25, 379-391, 2011年
  • Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
    Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.
    Clin Chim Acta, 412, 1643-1647, 2011年
  • Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
    Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
    Proc Jpn Acad Ser B Phys Biol Sci, 87, 104-113, 2011年
  • An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
    Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
    J Atheroscler Thromb, 18, 818-828, 2011年
  • Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
    Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
    Clin Chem, 57, 1398-1405, 2011年
  • LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.
    Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.
    Infect Immun, 79, 2865-2870, 2011年
  • Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells.
    Taye, A., Sawamura, T. and Morawietz, H.
    Pharmacol Rep, 62, 311-318, 2010年
  • Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.
    Takanabe-Mori, R., Ono, K., Sowa, N., Wada, H., Takaya, T., Horie, T., Satoh-Asahara, N., Shimatsu, A., Fujita, M., Sawamura, T. and Hasegawa, K.
    Biochem Biophys Res Commun, 398, 576-580, 2010年
  • Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development.
    Qiu, Y., Yanase, T., Hu, H., Tanaka, T., Nishi, Y., Liu, M., Sueishi, K., Sawamura, T. and Nawata, H.
    Endocrinology, 151, 3307-3316, 2010年
  • High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules.
    Matsutake, T., Sawamura, T. and Srivastava, P.K.
    Cancer Immun, 10, 7, 2010年
  • Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress.
    Kishimoto, H., Akagi, M., Zushi, S., Teramura, T., Onodera, Y., Sawamura, T. and Hamanishi, C.
    Osteoarthritis Cartilage, 18, 1284-1290, 2010年
  • Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
    Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
    Lipids, 45, 329-335, 2010年
  • LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
    Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
    Clin Chem, 56, 550-558, 2010年
  • Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
    Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T. and Hasegawa, K.
    Circ J, 74, 723-729, 2010年
  • C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
    Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.
    Clin Chem, 56, 478-481, 2010年
  • LOX-1 mediates vascular lipid retention under hypertensive state.
    Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.
    J Hypertens, 28, 1273-1280, 2010年
  • New Idol of cholesterol reduction?
    Sawamura,T.
    Clin Chem, 55, 2082-2084, 2009年
  • LOX-1: the multifunctional receptor underlying cardiovascular dysfunction.
    Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R. and Sawamura, T.
    Circ J, 73, 1993-1999, 2009年
  • Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
    Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.
    Circ Res, 104, 619-627, 2009年
  • A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
    Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T.
    J Hypertens, 27, 508-516, 2009年
  • Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
    Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.
    Clin Chem, 55, 285-294, 2009年
  • Generation and characterization of chicken monoclonal antibodies against human LOX-1.
    Iwamoto, S., Nishimichi, N., Tateishi, Y., Sato, Y., Horiuchi, H., Furusawa, S., Sawamura, T. and Matsuda, H.
    MAbs, 1, 357-363, 2009年
  • Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1.
    Zushi, S., Akagi, M., Kishimoto, H., Teramura, T., Sawamura, T. and Hamanishi, C.
    Arthritis Rheum, 60, 3007-3016, 2009年
  • Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
    Sankaralingam, S., Xu, H., Jiang, Y., Sawamura, T. and Davidge, S.T.
    Hypertension, 54, 897-904, 2009年
  • Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet.
    Eichhorn, B., Muller, G., Leuner, A., Sawamura, T., Ravens, U. and Morawietz, H.
    Cardiovasc Res, 82, 493-502, 2009年
  • Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells.
    Sakamoto, N., Ishibashi, T., Sugimoto, K., Sawamura, T., Sakamoto, T., Inoue, N., Saitoh, S., Kamioka, M., Uekita, H., Ohkawara, H., Suzuki, K., Teramoto, T., Maruyama, Y. and Takeishi, Y.
    J Cell Physiol, 220, 706-715, 2009年
  • LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
    Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.
    Cardiovasc Res, 84, 127-136, 2009年
  • LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma.
    Schaeffer, D.F., Riazy, M., Parhar, K.S., Chen, J.H., Duronio, V., Sawamura, T. and Steinbrecher, U.P.
    J Lipid Res, 50, 1676-1684, 2009年
  • Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice.
    Inomata, Y., Fukushima, M., Hara, R., Takahashi, E., Honjo, M., Koga, T., Kawaji, T., Satoh, H., Takeya, M., Sawamura, T. and Tanihara, H.
    Invest Ophthalmol Vis Sci, 50, 3970-3976, 2009年
  • Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes.
    Akagi, M., Ueda, A., Teramura, T., Kanata, S., Sawamura, T. and Hamanishi, C.
    Osteoarthritis Cartilage, 17, 271-275, 2009年
  • Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite.
    Sankaralingam, S., Xu, Y., Sawamura, T. and Davidge, S.T.
    Hypertension, 53, 270-277, 2009年
  • LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin II.
    Kang, B.Y., Hu, C., Prayaga, S., Khaidakov, M., Sawamura, T., Seung, K.B. and Mehta, J.L.
    Biochem Biophys Res Commun, 379, 395-399, 2009年
  • LDL protein nitration: implication for LDL protein unfolding.
    Hamilton, R.T., Asatryan, L., Nilsen, J.T., Isas, J.M., Gallaher, T.K., Sawamura, T. and Hsiai, T.K.
    Arch Biochem Biophys, 479, 1-14, 2008年
  • Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas.
    Satoh, H., Kiyota, E., Terasaki, Y., Sawamura, T., Takagi, K., Mizuta, H. and Takeya, M.
    J Histochem Cytochem, 56, 773-784, 2008年
  • Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
    Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K. and Katoh-Fukui, Y.
    Mol Reprod Dev, 75, 1361-1371, 2008年
  • Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion.
    Hu, C., Dandapat, A., Sun, L., Marwali, M.R., Inoue, N., Sugawara, F., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Hermonat, P.L., Sawamura, T. and Mehta, J.L.
    Hypertension, 52, 556-562, 2008年
  • LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet.
    Hu, C., Dandapat, A., Sun, L., Chen, J., Marwali, M.R., Romeo, F., Sawamura, T. and Mehta, J.L.
    Cardiovasc Res, 79, 287-293, 2008年
  • Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.
    Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.
    Circulation, 118, 75-83, 2008年
  • Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
    Yao, E.H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H. and Sawamura, T.
    Hypertension, 52, 86-92, 2008年
  • Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells.
    Honjo, T., Otsui, K., Shiraki, R., Kawashima, S., Sawamura, T., Yokoyama, M. and Inoue, N.
    Endothelium, 15, 137-141, 2008年
  • Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB.
    Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H. and Sawamura, T.
    Atherosclerosis, 200, 303-309, 2008年
  • Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1.
    Tang, D., Lu, J., Walterscheid, J.P., Chen, H.H., Engler, D.A., Sawamura, T., Chang, P.Y., Safi, H.J., Yang, C.Y. and Chen, C.H.
    J Lipid Res, 49, 33-47, 2008年
  • LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.
    Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P.L., Sawamura, T. and Mehta, J.L.
    J Mol Cell Cardiol, 44, 76-83, 2008年
  • Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor: Its versatile functions and human diseases.
    Inoue, N. and Sawamura, T.
    Methods, 43, 218-222, 2007年
  • LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion.
    Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T. and Mehta, J.L.
    Cardiovasc Res, 76, 292-302, 2007年
  • Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.
    Marwali, M.R., Hu, C.P., Mohandas, B., Dandapat, A., Deonikar, P., Chen, J., Cawich, I., Sawamura, T., Kavdia, M. and Mehta, J.L.
    J Pharmacol Exp Ther, 322, 1324-1332, 2007年
  • Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
    Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.
    Circ Res, 100, 1634-1642, 2007年
  • Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis.
    Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T. and Hamanishi, C.
    Osteoarthritis Cartilage, 15, 281-290, 2007年
  • Endothelin and endothelial dysfunction.
    Masaki,T. and Sawamura,T.
    Proc Jpn Acad Ser B Phys Biol Sci, 82, 17-24, 2006年
  • Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.
    Oka, K., Yasuhara, M., Suzumura, K., Tanaka, K. and Sawamura, T.
    J Cardiovasc Pharmacol, 48, 177-183, 2006年
  • Low-density lipoprotein oxidized to various degrees activates ERK1/2 through LOX-1.
    Tanigawa, H., Miura, S., Zhang, B., Uehara, Y., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.
    Atherosclerosis, 188, 245-250, 2006年
  • Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma.
    Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H. and Hamanishi, C.
    Biochem Biophys Res Commun, 348, 1003-1010, 2006年
  • Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized ldl receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis.
    Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H. and Hamanishi, C.
    J Orthop Res, 24, 1782-1790, 2006年
  • Dominant-negative LOX-1 blocks homodimerization of wild-type LOX-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation.
    Tanigawa, H., Miura, S., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.
    Hypertension, 48, 294-300, 2006年
  • Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase.
    Ma, F.X., Zhou, B., Chen, Z., Ren, Q., Lu, S.H., Sawamura, T. and Han, Z.C.
    J Lipid Res, 47, 1227-1237, 2006年
  • LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells.
    Murphy, J.E., Tacon, D., Tedbury, P.R., Hadden, J.M., Knowling, S., Sawamura, T., Peckham, M., Phillips, S.E., Walker, J.H. and Ponnambalam, S.
    Biochem J, 393, 107-115, 2006年
  • Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model.
    Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M. and Sawamura, T.
    Cardiovasc Res, 69, 263-271, 2006年
  • LOX-1 unlocked.
    Sawamura, T.
    Structure (Camb), 13, 834-835, 2005年
  • Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects.
    Bruni, F., Pasqui, A.L., Pastorelli, M., Bova, G., Cercignani, M., Palazzuoli, A., Sawamura, T., Gioffre, W.R., Auteri, A. and Puccetti, L.
    Clin Appl Thromb Hemost, 11, 417-428, 2005年
  • Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina.
    Cominacini, L., Anselmi, M., Garbin, U., Fratta Pasini, A., Stranieri, C., Fusaro, M., Nava, C., Agostoni, P., Keta, D., Zardini, P., Sawamura, T. and Lo Cascio, V.
    J Am Coll Cardiol, 46, 799-806, 2005年
  • Adhesion molecule expression in fibroblasts: alteration in fibroblast biology after transfection with LOX-1 plasmids.
    Chen, K., Chen, J., Liu, Y., Xie, J., Li, D., Sawamura, T., Hermonat, P.L. and Mehta, J.L.
    Hypertension, 46, 622-627, 2005年
  • Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1).
    Chen, M. and Sawamura, T.
    J Mol Cell Cardiol, 39, 553-561, 2005年
  • Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice.
    Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.
    Circ Res, 97, 176-184, 2005年
  • Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway.
    Limor, R., Kaplan, M., Sawamura, T., Sharon, O., Keidar, S., Weisinger, G., Knoll, E., Naidich, M. and Stern, N.
    Am J Hypertens, 18, 299-307, 2005年
  • Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells.
    Theriault, J.R., Mambula, S.S., Sawamura, T., Stevenson, M.A. and Calderwood, S.K.
    FEBS Lett, 579, 1951-1960, 2005年
  • Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation.
    Pasini, A.F., Garbin, U., Nava, M.C., Stranieri, C., Davoli, A., Sawamura, T., Lo Cascio, V. and Cominacini, L.
    J Hypertens, 23, 589-596, 2005年
  • Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients.
    Puccetti, L., Sawamura, T., Pasqui, A.L., Pastorelli, M., Auteri, A. and Bruni, F.
    Eur J Clin Invest, 35, 47-51, 2005年
  • LOX-1, a lectin-like oxidized LDL receptor identified form endothelial cells, in endothelial dysfunction.
    Sawamura, T.
    International Congress Series, 1262, 531-534, 2004年
  • Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
    Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. and Daida, H.
    Circulation, 110, 3329-3334, 2004年
  • Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascularization.
    Honjo, M., Sawamura, T., Hinagata, J., Nakamura, K., Sanada, N., Tanihara, H., Honda, Y. and Kiryu, J.
    Arch Ophthalmol, 122, 2004年
  • Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1).
    Sakurai, K., Cominacini, L., Garbin, U., Fratta Pasini, A., Sasaki, N., Takuwa, Y., Masaki, T. and Sawamura, T.
    J Cardiovasc Pharmacol, 44, S173-180, 2004年
  • Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
    Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.
    Arthritis Rheum, 50, 3495-3503, 2004年
  • Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts.
    Suga, M., Sawamura, T., Nakatani, T. and Kitamura, S
    Transplant Proc, 36, 2440-2442, 2004年
  • C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction.
    Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.
    Circ Res, 95, 877-883, 2004年
  • Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors.
    Pavan, L., Hermouet, A., Tsatsaris, V., Therond, P., Sawamura, T., Evain-Brion, D. and Fournier, T.
    Endocrinology, 145, 4583-4591, 2004年
  • Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency.
    Smirnova, I.V., Sawamura, T. and Goligorsky, M.S.
    Am J Physiol Renal Physiol, 287, F25-32, 2004年
  • Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB.
    Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.
    Osteoarthritis Cartilage, 12, 568-576, 2004年
  • Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction.
    Imanishi, T., Hano, T., Sawamura, T. and Nishio, I.
    Clin Exp Pharmacol Physiol, 31, 407-413, 2004年
  • Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
    Smirnova, I.V., Kajstura, M., Sawamura, T. and Goligorsky, M.S.
    287, H782-790, 2004年
  • Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
    Li, L., Sawamura, T. and Renier, G.
    Circ Res, 94, 892-901, 2004年
  • Stress and vascular responses: endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: close relationships with oxidative stress.
    Sakurai, K. and Sawamura, T.
    J Pharmacol Sci, 91, 182-186, 2003年
  • Modulation of endothelial Ca(2+)-activated K(+) channels by oxidized LDL and its contribution to endothelial proliferation.
    Kuhlmann, C.R., Schafer, M., Li, F., Sawamura, T., Tillmanns, H., Waldecker, B. and Wiecha, J.
    Cardiovasc Res, 60, 626-634, 2003年
  • The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells.
    Cominacini, L., Fratta Pasini, A., Garbin, U., Pastorino, A., Rigoni, A., Nava, C., Davoli, A., Lo Cascio, V. and Sawamura, T.
    J Am Coll Cardiol, 41, 499-507, 2003年
  • Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia.
    Chade, A.R., Best, P.J., Rodriguez-Porcel, M., Herrmann, J., Zhu, X., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.
    Kidney Int, 64, 962-969, 2003年
  • Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells.
    Hu, B., Li, D., Sawamura, T. and Mehta, J.L.
    Biochem Biophys Res Commun, 307, 1008-1012, 2003年
  • Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium.
    Li, L., Sawamura, T. and Renier, G.
    DIABETES, 52, 1843-1850, 2003年
  • Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis.
    Chade, A.R., Rodriguez-Porcel, M., Grande, J.P., Zhu, X., Sica, V., Napoli, C., Sawamura, T., Textor, S.C., Lerman, A. and Lerman, L.O.
    Arterioscler Thromb Vasc Biol, 23, 1295-1301, 2003年
  • Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature.
    Rodriguez-Porcel, M., Lerman, A., Herrmann, J., Schwartz, R.S., Sawamura, T., Condorelli, M., Napoli, C. and Lerman, L.O.
    Cardiovasc Res, 58, 213-221, 2003年
  • Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function.
    Rodriguez-Porcel, M., Lerman, L.O., Herrmann, J., Sawamura, T., Napoli, C. and Lerman, A.
    Arterioscler Thromb Vasc Biol, 23, 885-891, 2003年
  • Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
    Wilson, S.H., Chade, A.R., Feldstein, A., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.
    Nephrol Dial Transplant, 18, 703-709, 2003年
  • LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells.
    Li, D., Liu, L., Chen, H., Sawamura, T. and Mehta, J.L.
    Arterioscler Thromb Vasc Biol, 23, 816-821, 2003年
  • Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction.
    Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Romeo, F. and Mehta, J.L.
    J Am Coll Cardiol, 41, 1048-1055, 2003年
  • Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
    Tatsuguchi, M., Furutani, M., Hinagata, J., Tanaka, T., Furutani, Y., Imamura, S., Kawana, M., Masaki, T., Kasanuki, H., Sawamura, T. and Matsuoka, R.
    Biochem Biophys Res Commun, 2003年
  • Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation.
    Cominacini, L., Fratta Pasini, A., Garbin, U., Nava, C., Davoli, A., Criscuoli, M., Crea, A., Sawamura, T. and Lo Cascio, V.
    J Am Coll Cardiol, 42, 1838-1844, 2003年
  • LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells.
    Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S. and Mehta, J.L.
    Circulation, 107, 612-617, 2003年
  • Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation.
    Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T. and Sawamura, T.
    Proc Natl Acad Sci U S A, 100, 1274-1279, 2003年
  • LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
    Kataoka, K., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Iwai-Kanai, E., Kawamura, T., Hirai, T., Kita, T. and Nohara, R.
    Biochem Biophys Res Commun, 300, 656-660, 2003年
  • LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
    Chen, M., Masaki, T. and Sawamura, T.
    Pharmacol Ther, 95, 89, 2002年
  • LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt.
    Nakagawa, T., Yasuda, T., Hoshikawa, H., Shimizu, M., Kakinuma, T., Chen, M., Masaki, T., Nakamura, T. and Sawamura, T.
    Biochem Biophys Res Commun, 299, 91-97, 2002年
  • Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells.
    Imanishi, T., Hano, T., Sawamura, T., Takarada, S. and Nishio, I.
    Circ J, 66, 1060-1064, 2002年
  • LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation.
    Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T. and Mehta, J.L
    Am J Physiol Heart Circ Physiol,, 283, H1795-1801, 2002年
  • Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis.
    Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T. and Sawamura, T.
    Arthritis Rheum, 46, 2486-2494, 2002年
  • Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.
    Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J. and Jeannin, P.
    Immunity, 17, 353-362, 2002年
  • Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1
    Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.
    Clin Sci (Lond), 48, 9S-12S, 2002年
  • A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes.
    Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.
    Exp Eye Res, 75, 135-142, 2002年
  • Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1.
    Li, D., Chen, H., Romeo, F., Sawamura, T., Saldeen, T. and Mehta, J.L.
    J Pharmacol Exp Ther, 302, 601-605, 2002年
  • Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE).
    Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T. and Horiuchi, S.
    FEBS Lett, 511, 170-174, 2002年
  • Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.
    Honjo, M., Tanihara, H., Nishijima, K., Kiryu, J., Honda, Y., Yue, B.Y. and Sawamura, T
    Arch Ophthalmol, 120, 1707-1713, 2002年
  • Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.
    Iwai-Kanai, E., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Toyokuni, S., Adachi, S., Kihara, Y. and Sasayama, S.
    Circulation, 104, 2948-2954, 2001年
  • Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE.
    Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T. and Sawamura, T.
    Biochem Biophys Res Commun, 287, 962-968, 2001年
  • Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
    Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.
    Arch Ophthalmol, 119, 1171-1178, 2001年
  • Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein.
    Chen, M., Inoue, K., Narumiya, S., Masaki, T. and Sawamura, T.
    FEBS Lett, 499, 215-219, 2001年
  • Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells.
    Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.
    Biochem Biophys Res Commun, 284, 961-965, 2001年
  • 8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells.
    Halvorsen, B., Staff, A.C., Henriksen, T., Sawamura, T. and Ranheim, T.
    Hypertension, 37, 1184-1190, 2001年
  • LOX-1 supports adhesion of gram-positive and gram-negative bacteria.
    Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.
    J Immunol, 166, 5108-5114, 2001年
  • Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.
    Chen, M., Narumiya, S., Masaki, T. and Sawamura, T.
    Biochem J, 355, 289-296, 2001年
  • The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.
    Cominacini, L., Rigoni, A., Pasini, A.F., Garbin, U., Davoli, A., Campagnola, M., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.
    J Biol Chem, 276, 13750-13755, 2001年
  • Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: identification by a novel enzyme immunoassay.
    Kakutani, M., Ueda, M., Naruko, T., Masaki, T. and Sawamura, T.
    Biochem Biophys Res Commun, 282, 180-185, 2001年
  • Activation-dependent surface expression of LOX-1 in human platelets.
    Chen, M., Kakutani, M., Naruko, T., Ueda, M., Narumiya, S., Masaki, T. and Sawamura, T.
    Biochem Biophys Res Commun,, 282, 153-158, 2001年
  • Redox-sensitive regulation of lox-1 gene expression in vascular endothelium.
    Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T. and Fujita, T.
    Biochem Biophys Res Commun, 281, 720-725, 2001年
  • Identification of peptides that target the endothelial cell-specific LOX-1 receptor.
    White, S.J., Nicklin, S.A., Sawamura, T. and Baker, A.H.
    Hypertension, 37, 449-455, 2001年
  • Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway.
    Iwakura, A., Fujita, M., Hasegawa, K., Toyokuni, S., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.
    J Mol Cell Cardiol, 33, 419-430, 2001年
  • Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
    Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Narumiya, S. and Honda, Y.
    Invest Ophthalmol Vis Sci, 42, 137-144, 2001年
  • Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin.
    Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.
    FEBS Lett, 504, 65-68, 2001年
  • Regeneration of cardiac muscle in normal adult C57BL/6 mice.
    Jiang, H., Hidaka, K., Sawamura, T., Arai, Y., Takihara, Y., Ota, A. and Morisaki, T.
    Cardiac and Vascular Regeneration, 1, 268-273, 2000年
  • Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
    Araki, M., Hasegawa, K., Iwai-Kanai, E., Fujita, M., Sawamura, T., Kakita, T., Wada, H., Morimoto, T. and Sasayama, S.
    J Am Coll Cardiol, 36, 1411-1418, 2000年
  • Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan.
    Chen, H., Li, D., Sawamura, T., Inoue, K. and Mehta, J.L.
    Biochem Biophys Res Commun, 276, 1100-1104, 2000年
  • Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis.
    Nagase, M., Kaname, S., Nagase, T., Wang, G., Ando, K., Sawamura, T. and Fujita, T.
    J Am Soc Nephrol, 11, 1826-1836,, 2000年
  • Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells.
    Yoneda, T., Fujita, M., Kihara, Y., Hasegawa, K., Sawamura, T., Tanaka, T., Inanami, M., Nohara, R. and Sasayama, S.
    Jpn Circ J, 64, 495-498, 2000年
  • Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions.
    Kataoka, H., Kume, N., Minami, M., Moriwaki, H., Sawamura, T., Masaki, T. and Kita, T.
    Ann N Y Acad Sci, 902, 328-335, 2000年
  • Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells.
    Kume, N., Moriwaki, H., Kataoka, H., Minami, M., Murase, T., Sawamura, T., Masaki, T. and Kita, T.
    Ann N Y Acad Sci, 902, 323-327, 2000年
  • Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis.
    Iwakura, A., Fujita, M., Hasegawa, K., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.
    J Am Coll Cardiol, 35, 1785-1790, 2000年
  • Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1.
    Minami, M., Kume, N., Kataoka, H., Morimoto, M., Hayashida, K., Sawamura, T., Masaki, T. and Kita, T.
    Biochem Biophys Res Commun,, 272, 357-361, 2000年
  • Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species.
    Cominacini, L., Pasini, A.F., Garbin, U., Davoli, A., Tosetti, M.L., Campagnola, M., Rigoni, A., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.
    J Biol Chem, 275, 12633-12638, 2000年
  • Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
    Chen, M., Kakutani, M., Minami, M., Kataoka, H., Kume, N., Narumiya, S., Kita, T., Masaki, T. and Sawamura, T.
    Arterioscler Thromb Vasc Biol, 20, 1107-1115,, 2000年
  • Identification of soluble forms of lectin-like oxidized LDL receptor-1.
    Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T. and Kita, T.
    Arterioscler Thromb Vasc Biol, 20, 2000年
  • Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding.
    Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.
    J Biol Chem, 275, 6573-6579, 2000年
  • LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells.
    Aoyama, T., Chen, M., Fujiwara, H., Masaki, T. and Sawamura, T.
    FEBS Lett, 467, 217-220, 2000年
  • A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1.
    Kakutani, M., Masaki, T. and Sawamura, T.
    Proc Natl Acad Sci U S A, 97, 360-364, 2000年
  • Subcellular mechanisms of endothelin action in vascular system.
    Masaki, T., Miwa, S., Sawamura, T., Ninomiya, H and Okamoto, Y.
    Eur J Pharmacol, 375, 133-138, 1999年
  • Northern blot analysis to quantify gene expression in vascular diseases.
    Chen M. and Sawamura, T.
    Methods in Molecular Biology, 30, 181-188, 1999年
  • Subcellular mechanisms of endothelin action in vascular system.
    Masaki, T., Miwa, S., Sawamura, T., Ninomiya, H. and Okamoto, Y.
    Eur J Pharmacol, 375, 133-138, 1999年
  • Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.
    Aoyama, T., Fujiwara, H., Masaki, T. and Sawamura, T.
    J Mol Cell Cardiol, 31, 2101-2114, 1999年
  • Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein.
    Morawietz, H., Rueckschloss, U., Niemann, B., Duerrschmidt, N., Galle, J., Hakim, K., Zerkowski, H.R., Sawamura, T. and Holtz, J.
    Circulation, 100, 899-902, 1999年
  • Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.
    Hosokawa, H., Ninomiya, H., Sawamura, T., Sugimoto, Y., Ichikawa, A., Fujiwara, K. and Masaki, T.
    Brain Res, 838, 158-165, 1999年
  • Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
    Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Moriwaki, H., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.
    Circulation, 99, 3110-3117, 1999年
  • Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation.
    Li, D.Y., Zhang, Y.C., Philips, M.I., Sawamura, T. and Mehta, J.L.
    Circ Res, 84, 1043-1049, 1999年
  • Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.
    Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M.C., Fujiwara, H. and Masaki, T.
    Biochem J, 339, 177-184, 1999年
  • The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
    Kaburagi, S., Hasegawa, K., Morimoto, T., Araki, M., Sawamura, T., Masaki, T. and Sasayama, S.
    Circulation, 99, 292-298, 1999年
  • Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
    Murase, T., Kume, N., Korenaga, R., Ando, J., Sawamura, T., Masaki, T. and Kita, T.
    Circ Res, 83, 328-333, 1998年
  • Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.
    Nicholson, B., Sawamura, T., Masaki, T. and MacLeod, C.L.
    J Biol Chem, 273, 14663-14666, 1998年
  • Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
    1Moriwaki, H., Kume, N., Kataoka, H., Murase, T., Nishi, E., Sawamura, T., Masaki, T. and Kita, T.
    FEBS Lett, 440, 29-32, 1998年
  • High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine.
    Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N. and Masaki, T.
    Circ Res, 83, 1088-1096, 1998年
  • Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.
    Moriwaki, H., Kume, N., Sawamura, T., Aoyama, T., Hoshikawa, H., Ochi, H., Nishi, E., Masaki, T. and Kita, T.
    Arterioscler Thromb Vasc Biol, 18, 1541-1547, 1998年
  • Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.
    Zhang, X.F., Komuro, T., Miwa, S., Minowa, T., Iwamuro, Y., Okamoto, Y., Ninomiya, H., Sawamura, T. and Masaki, T.
    Eur J Pharmacol, 352, 237-245, 1998年
  • Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
    Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T. and Kita, T.
    Circ Res, 83, 322-327, 1998年
  • Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells.
    Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.
    Proc Natl Acad Sci U S A, 95, 9535-9540, 1998年
  • Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
    Hasegawa, H., Hiki, K., Sawamura, T., Aoyama, T., Okamoto, Y., Miwa, S., Shimohama, S., Kimura, J. and Masaki, T.
    FEBS Lett, 428, 304-308, 1998年
  • The processing pathway of endothelin-1 production.
    Kido, T., Sawamura, T. and Masaki, T.
    J Cardiovasc Pharmacol, 31, S13-15, 1998年
  • High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1).
    Hoshikawa, H., Sawamura, T., Kakutani, M., Aoyama, T., Nakamura, T. and Masaki, T.
    Biochem Biophys Res Commun, 245, 841-846, 1998年
  • Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.
    Fujita, M., Ikemoto, M., Tanaka, T., Tamaki, S., Yamazato, A., Sawamura, T., Hasegawa, K., Kihara, Y., Nohara, R. and Sasayama, S.
    Angiogenesis, 2, 105-108, 1998年
  • Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta.
    Komuro, T., Miwa, S., Zhang, X.F., Minowa, T., Enoki, T., Kobayashi, S., Okamoto, Y., Ninomiya, H., Sawamura, T., Kikuta, K., Iwamuro, Y., Furutani, H., Hasegawa, H., Uemura, Y., Kikuchi, H. and Masaki, T.
    J Cardiovasc Pharmacol, 30, 504-509, 1997年
  • Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats.
    Nagase, M., Hirose, S., Sawamura, T., Masaki, T. and Fujita, T.
    Biochem Biophys Res Commun, 237, 496-498, 1997年
  • Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo.
    Kido, T., Sawamura, T., Hoshikawa, H., D'Orleans-Juste, P., Denault, J.B., Leduc, R., Kimura, J. and Masaki, T.
    Eur J Biochem, 244, 520-526, 1997年
  • An endothelial receptor for oxidized low-density lipoprotein.
    Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T.
    Nature, 386, 73-77, 1997年
  • Cloning and characterization of a brain-specific cationic amino acid transporter.
    Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S. and Masaki, T.
    J Biol Chem, 272, 8717-8722, 1997年
  • Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1.
    Matsuoka, R., Sawamura, T., Yamada, K., Yoshida, M., Furutani, Y., Ikura, T., Shiraki, T., Hoshikawa, H., Shimada, K., Tanzawa, K. and Masaki, T.
    Cytogenet Cell Genet, 72, 322-324, 1996年
  • Processing of proendothelin-1 by human furin convertase.
    Denault, J.B., Claing, A., D'Orleans-Juste, P., Sawamura, T., Kido, T., Masaki, T. and Leduc, R.
    FEBS Lett, 362, 276-280, 1995年
  • cDNA cloning and expression of bovine endothelin converting enzyme.
    Ikura, T., Sawamura, T., Shiraki, T., Hosokawa, H., Kido, T., Hoshikawa, H., Shimada, K., Tanzawa, K., Kobayashi, S., Miwa, S. and Masaki, T.
    Biochem Biophys Res Commun, 203, 1417-1422, 1994年
  • Genetic transfer of endothelin converting enzyme activity to CHO-K1 cells: detection of positive cells by reverse hemolytic plaque assay.
    Shiraki, T., Sawamura, T., Ikura, T., Kobayashi, S., Miwa, S. and Masaki, T.
    FEBS Lett, 351, 197-200, 1994年
  • Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
    Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. and Masaki,
    J Biol Chem, 268, 8547-8553, 1993年
  • Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
    Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
    Biochim Biophys Acta, 1161, 295-302, 1993年
  • Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells.
    Sawamura, T., Kasuya, Y., Matsushita, Y., Suzuki, N., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
    Biochem Biophys Res Commun, 174, 779-784, 1991年
  • Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung.
    Giaid, A., Polak, J.M., Gaitonde, V., Hamid, Q.A., Moscoso, G., Legon, S., Uwanogho, D., Roncalli, M., Shinmi, O., Sawamura, T., Kimura, S., Yanagisawa, M., Masaki, T. and Springal, D.R.
    Am J Respir Cell Mol Biol, 4, 50-58, 1991年
  • Analysis of big endothelin-1 digestion by cathepsin D.
    Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
    Biochem Biophys Res Commun, 172, 883-889, 1990年
  • Detection of endothelin immunoreactivity and mRNA in pulmonary tumours.
    Giaid, A., Hamid, Q.A., Springall, D.R., Yanagisawa, M., Shinmi, O., Sawamura, T., Masaki, T., Kimura, S., Corrin, B. and Polak, J.M.
    J Pathol, 162, 15-22, 1990年
  • Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid.
    Usuki, S., Saitoh, T., Sawamura, T., Suzuki, N., Shigemitsu, S., Yanagisawa, M., Goto, K., Onda, H., Fujino, M. and Masaki, T.
    Gynecol Endocrinol, 4, 85-97, 1990年
  • Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells.
    Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Kobayashi, M., Mitsui, Y., Yanagisawa, M., Goto, K. and Masaki, T.
    Biochem Biophys Res Commun, 169, 1138-1144, 1990年
  • Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme.
    Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
    Biochem Biophys Res Commun, 168, 1230-1236, 1990年
  • Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination.
    Shinmi, O., Kimura, S., Yoshizawa, T., Sawamura, T., Uchiyama, Y., Sugita, Y., Kanazawa, I., Yanagisawa, M., Goto, K. and Masaki, T.
    Biochem Biophys Res Commun, 162, 340-346, 1989年
  • Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.
    Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kanazawa, I.
    Biochem Biophys Res Commun, 164, 587-593, 1989年
  • Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.
    Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. and Masaki, T.
    Biochem Biophys Res Commun, 162, 1287-1294, 1989年
  • Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1.
    Kimura, S., Kasuya, Y., Sawamura, T., Shinimi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
    J Cardiovasc Pharmacol, 13, S5-7, 1989年
  • Structure-activity relationships of endothelin: importance of the C-terminal moiety.
    Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
    Biochem Biophys Res Commun, 156, 1182-1186, 1988年

所属学協会

  • 日本生化学会
  • 日本薬理学会
  • 日本生理学会
  • 日本循環器学会
  • 日本動脈硬化学会
  • 日本循環薬理学会
  • 日本心血管内分泌代謝学会
  • 高血圧関連疾患モデル学会
  • 国際心臓研究学会