ITO KEN-ICHI

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

School of Medicine Department of Surgery Division of Breast and Endocrine Surgery 

Professor 

Researcher Information

Degree

  • Doctor of Medicine

Field Of Study

  • General surgery and pediatric surgery, Breast and Thyroid Surgery

Educational Background

  • 1988, Kanazawa University, Faculty of Medicine
Research activity information

Paper

  • Changes in the pathophysiology of primary hyperparathyroidism and analysis of postoperative recurrence cases at a regional core hospital in Japan: experience of 35 years in Shinshu University Hospital.
    Kanai T, Oba T, Morikawa H, Amitani M, Chino T, Shimizu T, Ono MT, Maeno K, Ito KI, Ito T.
    Ann Palliat Med., 2023電子ジャーナル
  • Significance of skeletal muscle index-to-body mass index ratio as a predictor of postsurgical bleeding after mastectomy in patients with breast cancer.
    6. Morikawa H, Oba T, Kiyosawa N, Iji R, Amitani M, Chino T, Shimizu T, Ono M, Kanai T, Maeno K, Ito KI.
    Breast Cancer., 2023電子ジャーナル
  • Development of a predictive score for post-hemithyroidectomy hypothyroidism using skeletal muscle index, remnant thyroid index, and thyroid-stimulating hormone levels: a retrospective cohort study.
    5. Amitani M, Oba T, Kiyosawa N, Iji R, Morikawa H, Chino T, Shimizu T, Ono M, Kanai T, Maeno K, Ito KI.
    Quant Imaging Med Surg, 2023電子ジャーナル
  • Eribulin promotes proliferation of CD8+ T cells and potentiates T cell-mediated anti-tumor activity against triple-negative breast cancer cells.
    Shimizu T, Oba T, Oshi M, Ito KI.
    Breast Cancer Res Treat., 2023電子ジャーナル
  • The Advantage of Using an Optical See-Through Head-Mounted Display in Ultrasonography-Guided Needle Biopsy Procedures: A Prospective Randomized Study.
    Shimizu T, Oba T, Ito KI.
    J Clin Med, 2023電子ジャーナル
  • Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.
    Oba T, Long M, Ito KI, Ito F.
    Sci Rep, 2023電子ジャーナル
  • Neutrophil-to-lymphocyte ratio is associated with the proportion of poorly differentiated components in papillary thyroid carcinoma
    Neutrophil-to-lymphocyte ratio is associated with the proportion of poorly differentiated components in papillary thyroid carcinoma
    J Surg Res, 2023電子ジャーナル
  • 甲状腺未分化癌治療における最近の進歩
    伊藤研一、森川大樹、網谷正統、清水忠史、大場崇旦、伊藤勅子、金井敏晴
    日本外科学会誌, 2023
  • 人生100年時代の外科医療
    2. 伊藤研一、山本雄造
    日本臨床外科学会誌, 2023
  • A Case of a Cystic Parathyroid Adenoma with Marked Hyperparathyroidism but Difficult Preoperative Diagnostic Imaging
    KUBOTA Satoshi, SHIMADA Yasuho, TAKAYAMA Shohei, OBA Takaaki, ITO Ken-ichi, KOMATSU Mitsuhisa
    The Shinshu Medical Journal, 70(3), 189-194, Jun. 2022電子ジャーナル
  • Surgical resection of the primary tumor prevents an undesirable locoregional condition and improves the quality of life in patients with anaplastic thyroid cancer.
    Kanai T, Ito T, Morikawa H, Amitani M, Shimizu T, Ohno K, Ono M, Oba T, Maeno K, Ito KI
    Surg Today, 2022電子ジャーナル
  • Epidermal growth factor receptor activation confers resistance to lenvatinib in thyroid cancer cells.
    Ohno K, Shibata T, Ito KI.
    Cancer Science., 2022電子ジャーナル
  • Neutrophil-to-Lymphocyte Ratio Is Associated With the Proportion of Poorly Differentiated Components in Papillary Thyroid Carcinoma.
    Oba T, Kazuma M, Kiyosawa N, Morikawa H, Amitani M, Chino T, Shimizu T, Ono M, Ito T, Kanai T, Ito KI.
    J Surg Res., 2022電子ジャーナル
  • Hypercalcemic crisis caused by primary hyperparathyroidism in a 11-year-old boy: a rare case report and review of the literature
    Hayashi S, Oba T, Ichikawa K, Nakamura C, Hara Y, Kanai T, Sato Y, Uehara T, Ito KI.
    Gland Surgery, 2022電子ジャーナル
  • Skeletal muscle loss during neoadjuvant chemotherapy predicts poor prognosis in patients with breast cancer.
    Amitani M, Oba T, Kiyosawa N, Morikawa H, Chino T, Soma A, Shimizu T, Ohno K, Ono M, Ito T, Kanai T, Maeno K, Ito KI.
    BMC CANCER, 2022電子ジャーナル
  • The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time
    Ono, Mayu; Oba, Takaaki; Shibata, Tomohiro; Ito, Ken-Ichi;
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 147(11), 3211-3224, Nov. 2021WebofScience電子ジャーナル
  • HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells
    Oba, Takaaki; Ono, Mayu; Matoba, Hisanori; Uehara, Takeshi; Hasegawa, Yoshie; Ito, Ken-ichi;
    Breast Cancer Research and Treatment, 186(1), 37-51, Feb. 2021WebofScience電子ジャーナル
  • Concomitant use of F-18-FDG PET-CT SUVmax is useful in the assessment of Ki67 labeling index in core-needle biopsy specimens of breast cancer
    Nakajima, Hiroki; Maeno, Kazuma; Ito, Tokiko; Kanai, Toshiharu; Oba, Takaaki; Ono, Mayu; Takayama, Fumiyoshi; Uehara, Tsuyoshi; Ito, Ken-ichi;
    Gland Surgery, 10(1), 1-9, Jan. 2021WebofScience電子ジャーナル
  • Prognostic Nutritional Index Is Superior to Neutrophil-to-lymphocyte Ratio as a Prognostic Marker in Metastatic Breast Cancer Patients Treated With Eribulin
    Oba, Takaaki; Maeno, Kazuma; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Ito, Ken-ichi;
    Anticancer Research, 41(1), 445-452, Jan. 2021WebofScience電子ジャーナル
  • Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer
    Watanabe, Takayuki; Oba, Takaaki; Tanimoto, Keiji; Shibata, Tomohiro; Kamijo, Shinobu; Ito, Ken-ichi;
    PLOS ONE, 16(6), e0252822, 2021WebofScience電子ジャーナル
  • Surgical treatment for mediastinal lymph node metastasis of thyroid cancer
    Kanai Toshiharu;Amitani Masatugu;Shimizu Tadafumi;Ohno Koichi;Ono Mayu;Oba Takaaki;Ito Tokiko;Maeno Kazuma;Ito Ken-ichi
    Official Journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery, 38(2), 63-67, 2021電子ジャーナル
  • Bone morphogenetic protein-7 expression reflects the high proliferative ability and aggressiveness of thymic epithelial tumors
    Miura, Kentaro; Hamanaka, Kazutoshi; Uehara, Tsuyoshi; Momose, Masanobu; Kanai, Yukiko; Matsuoka, Shunichiro; Takeda, Tetsu; Agatsuma, Hiroyuki; Hyogotani, Akira; Ito, Ken-ichi;
    JOURNAL OF THORACIC DISEASE, 12(3), 448-456, Mar. 2020WebofScience電子ジャーナル
  • Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer
    Oba, Takaaki; Maeno, Kazuma; Takekoshi, Daiya; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Ito, Ken-ichi;
    BMC CANCER, 20(1), 2020WebofScience電子ジャーナル
  • Comparative efficacy and safety of tyrosine kinase inhibitors for thyroid cancer: a systematic review and meta-analysis
    Oba, Takaaki; Chino, Tatsunori; Soma, Ai; Shimizu, Tadafumi; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi;
    Endocrine journal, 67(12), 1215-1226, 2020WebofScience
  • 癌微小環境研究up-date(第5回)癌微小環境に基づいた乳癌治療
    伊藤 研一
    Cancer board of the breast = キャンサーボードオブザブレスト, 5(2), 102-104, Sep. 2019
  • A Case of Hereditary Breast and Ovarian Cancer Syndrome with Serous Tubal Intraepithelial Lesions in Bilateral Fimbriae Resected by Laparoscopic Risk-reducing Salpingo-oophorectomy
    KASHIMA Hiroyasu, OKA Kenji, SHINAGAWA Manaka, YAMANAKA Sakura, ONO Motoki, TAKEUCHI Hodaka, IDA Koichi, HIGUCHI Shotaro, YAMADA Yasushi, KOBARA Hisanori, KIKUCHI Norihiko, MIYAMOTO Tsutomu, TACHIBANA Ryota, FUKUSHIMA Yoshimitsu, KOSHO Tomoki, IESATO Asumi, ITO Ken-ichi, ASAKA Shiho, UEHARA Takeshi, SHIOZAWA Tanri
    The Shinshu Medical Journal, 67(3), 209-215, Jun. 2019リポジトリ電子ジャーナル
  • FGF2-FGFR1 pathway activation together with thymidylate synthase upregulation is induced in pemetrexed-resistant lung cancer cells
    Miura K, Oba T, Hamanaka K, Ito K
    Oncotarget, 10, 1171-1192, 2019
  • 甲状腺乳頭癌の再発リスク分類
    金井敏晴、伊藤研一、千野辰徳、小野真由、大野晃一、伊藤勅子、前野一真
    日本内分泌外科学会雑誌, 36(4), 209-212, 2019
  • Clinical features and long-term results of poorly differentiated carcinoma of thyroid ~single-center analysis
    Maeno Kazuma;Ito Ken-ichi;Shimizu Tadafumi;Soma Ai;Takekoshi Daiya;Ono Mayu;Oba Takaaki;Ito Tokiko;Kanai Toshiharu;Uehara Takeshi
    Official Journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery, 36(4), 235-239, 2019電子ジャーナル
  • Lenvatinib (VEGFR inhibitor) : Results of clinical trials and its proper use
    伊藤 研一;清水 忠史;相馬 藍;竹腰 大也;小野 真由;大場 崇旦;伊藤 勅子;金井 敏晴;前野 一真
    腫瘍内科 = Clinical oncology, 22(4), 404-409, Oct. 2018
  • A Retrospective Study of the Efficacy of Perioperative Oral Management on Prevention of Postoperative Pneumonia Associated with Lung Cancer Surgery
    KAJIHARA Ryo, YAMADA Shin-ichi, NISHIMAKI Fumihiro, KONDO Eiji, KAMATA Takahiro, KOYAMA Tsutomu, MATSUOKA Shunichiro, TAKEDA Tetsu, MIURA Kentaro, YAMADA Kyoko, HAMANAKA Kazutoshi, ITO Ken-ichi, KURITA Hiroshi
    The Shinshu Medical Journal, 66(4), 249-256, Aug. 2018リポジトリ電子ジャーナル
  • Small molecule inhibitor : Lenvatinib
    伊藤 勅子;伊藤 研一
    腫瘍内科 = Clinical oncology, 21(6), 675-682, Jun. 2018
  • Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition.
    Oba T, Ito KI.
    Oncotarget, 9(33), 22986-23002, May 2018電子ジャーナル
  • Increased Expression of Y-Box-Binding Protein-1 in Hind-Limb Muscles During Regeneration from Ischemic Injury in Mice
    Fuke, Megumi; Narita, Makoto; Wada, Yuko; Seto, Tatsuichiro; Okada, Kenji; Nakayama, Jun; Izumi, Hiroto; Ito, Ken-ichi;
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 244(1), 53-62, Jan. 2018WebofScience電子ジャーナル
  • Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors.
    Hamanaka K, Koyama T, Matsuoka S, Takeda T, Miura K, Yamada K, Hyogotani A, Seto T, Okada K, Ito KI.
    Gen Thorac Cardiovasc Surg, in press, 2018電子ジャーナル
  • A case of mixed type squamous cell carcinoma of the breast with enlarged squamous component during neoadjuvant chemotherapy
    Kanai Toshiharu;Oba Takaaki;Ito Tokiko;Maeno Kazuma;Ito Ken-ichi;Tamada Hisashi
    Official Journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery, 35(4), 282-287, 2018電子ジャーナル
  • A Case of Juvenile Fibroadenoma of the Breast Enlarging Rapidly Soon after Menarche in a 14-year-old Girl
    IKEHARA Tomohiko;OBA Takaaki;MAENO Kazuma;ITO Ken-ichi;KOBAYASHI Sho;UEHARA Takeshi
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 79(6), 1187-1192, 2018電子ジャーナル
  • Chylous leakage after axillary lymph node dissection in a patient with breast cancer
    Oba, Takaaki; Ono, Mayu; Iesato, Asumi; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi;
    BREAST JOURNAL, 24(3), 438-440, 2018WebofScience電子ジャーナル
  • A Case of Adenomyoepithelioma of the Breast Showing Strong Uptake of (18) F-Fluorodeoxyglucose on a Positron Emission Tomography.
    Oba T, Maeno K, Ono M, Iesato A, Ito T, Kanai T, Mochizuki Y, Ito KI, Yoshizawa A, Takayama F.
    Breast J, 23(2), 220-224, Mar. 2017電子ジャーナル
  • Case of painless thyroiditis that developed during adjuvant chemotherapy for breast cancer.
    Iesato A, Oba T, Ono K, Watanabe T, Ito T, Kanai T, Maeno K, Ito K.
    Int Cancer Conf J, 6(4), 184-187, 2017
  • PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells
    Iesato, Asumi; Nakamura, Teruo; Izumi, Hiroto; Uehara, Takeshi; Ito, Ken-Ichi;
    Oncotarget, 8(47), 82754-82772, 2017WebofScience電子ジャーナル
  • Human 3 beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations
    Hanamura, Toru; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Shimojo, Yasuyo; Uehara, Takeshi; Suzuki, Takashi; Hayashi, Shin-ichi; Ito, Ken-ichi;
    CANCER MEDICINE, 5(7), 1405-1415, Jul. 2016WebofScience電子ジャーナル
  • 女性のがん患者の生活・生命の質(QOL)の実態調査 : 術後1年間のQOL調査結果から
    増樺京子, 竹内沙弥香, 所真由美, 執印抄枝子, 青柳美恵子, 伊藤勅子, 伊藤研一, 樋口正太郎, 塩沢丹里
    信州大学医学部附属病院看護研究集録, 45(1), 1-6, Mar. 2016リポジトリ
  • Significance of sentinel lymph nodes with low gamma counts in breast cancer patients via radioisotopic sentinel lymph node biopsy
    Maeno K, Ito T, Koyama H, Kanai T, Mochizuki Y, Ito K
    Arch Surg Oncol, 2, 1, 2016
  • ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines
    Oba, Takaaki; Izumi, Hiroto; Ito, Ken-ichi;
    Oncotarget, 7(43), 70011-70027, 2016WebofScience電子ジャーナル
  • Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review
    Oba, Takaaki; Ono, Mayu; Iesato, Asumi; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi; Tateishi, Ayako; Yoshizawa, Akihiko; Takayama, Fumiyoshi;
    OncoTargets and Therapy, 9, 1641-1646, 2016WebofScience電子ジャーナル
  • Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature
    Iesato, Asumi; Oba, Takaaki; Ono, Mayu; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ishizaka, Katsuhiko; Kitabatake, Hiroyuki; Takeuchi, Daisuke; Suzuki, Akira; Nakayama, Jun; Ito, Ken-ichi;
    OncoTargets and Therapy, 8, 91-97, 2015WebofScience電子ジャーナル
  • Coexpression of EpCAM, CD44 Variant Isoforms and Claudin-7 in Anaplastic Thyroid Carcinoma
    Okada, Toshihiro; Nakamura, Teruo; Watanabe, Takayuki; Onoda, Naoyoshi; Ashida, Atsuko; Okuyama, Ryuhei; Ito, Ken-ichi;
    PLOS ONE, 9(4), e94487, 2014WebofScience電子ジャーナル
  • Expression of Polypeptide N-Acetylgalactosaminyl Transferase-3 and Its Association with Clinicopathological Factors in Thyroid Carcinomas
    Mochizuki, Yasuhiro; Ito, Ken-ichi; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun;
    THYROID, 23(12), 1553-1560, 2013WebofScience電子ジャーナル
  • Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclitaxel combination therapy in a case of advanced breast cancer
    Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Murayama, Koichi; Koyama, Hiroshi; Maeno, Kazuma; Mochizuki, Yasuhiro; Iesato, Asumi; Hanamura, Toru; Okada, Toshihiro; Watanabe, Takayuki; Ito, Ken-ichi;
    OncoTargets and Therapy, 6, 1393-1398, 2013WebofScience電子ジャーナル
  • Association of Nuclear YB-1 Localization With Lung Resistance-related Protein and Epidermal Growth Factor Receptor Expression in Lung Cancer
    Hyogotani, Akira; Ito, Ken-ichi; Yoshida, Kazuo; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun;
    CLINICAL LUNG CANCER, 13(5), 375-384, Sep. 2012WebofScience電子ジャーナル
  • Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer
    Ito, Tokiko; Kamijo, Shinobu; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun; Ito, Ken-ichi;
    Breast Cancer Research and Treatment, 133(1), 145-159, May 2012WebofScience電子ジャーナル
  • Multimodality therapeutic outcomes In anaplastic thyroid carcinoma: Improved survival in subgroups of patients with localized primary tumors
    Ito, Ken-ichi; Hanamura, Toru; Murayama, Koichi; Okada, Toshihiro; Watanabe, Takayuki; Harada, Michihiko; Ito, Tokiko; Koyama, Hiroshi; Kanai, Toshiharu; Maeno, Kazuma; Mochizuki, Yasuhiro; Amano, Jun;
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 34(2), 230-237, Feb. 2012WebofScience電子ジャーナル
  • Full-thickness chest-wall resection followed by thorax reconstruction for recurrent malignant phyllodes tumor
    Ito, Tokiko; Ito, Ken-ichi; Okada, Toshihiro; Murayama, Koichi; Hanamura, Toru; Kanai, Toshiharu; Maeno, Kazuma; Mochizuki, Yasuhiro; Kondo, Ryoichi; Amano, Jun; Osada, Yoshiro; Asano, Koji;
    International journal of clinical oncology, 16(2), 156-160, Apr. 2011WebofScience電子ジャーナル
  • Upregulation of the apoptosis-related inflammasome in cardiac allograft rejection
    Seto, Tatsuichiro; Kamijo, Shinobu; Wada, Yuko; Yamaura, Kazuhiro; Takahashi, Kohei; Komatsu, Kazunori; Otsu, Yoshinori; Terasaki, Takamitsu; Fukui, Daisuke; Amano, Jun; Taniguchi, Shun'ichiro; Sagara, Junji; Ito, Ken-ichi;
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(3), 352-359, Mar. 2010WebofScience電子ジャーナル
  • ENDOSCOPIC-ASSISTED SKIN-SPARING MASTECTOMY COMBINED WITH SENTINEL NODE BIOPSY
    Ito, Ken-Ichi; Kanai, Toshiharu; Gomi, Kuniyuki; Watanabe, Takayuki; Ito, Tokiko; Komatsu, Akira; Fujita, Tomoyuki; Amano, Jun;
    ANZ JOURNAL OF SURGERY, 78(10), 894-898, Oct. 2008WebofScience電子ジャーナル
  • Hepatocyte growth factor prevents pulmonary ischernia-reperfusion injury in mice
    Makiuchi, Akiko; Yamaura, Kazuhiro; Mizuno, Shinya; Matsumoto, Kunio; Nakamura, Toshikazu; Amano, Jun; Ito, Ken-ichi;
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 26(9), 935-943, Sep. 2007WebofScience電子ジャーナル
  • Stimulation of P19CL6 with multiple reagents induces pulsating particles in vivo
    Ohtsu Y, Johkura K, Ito K, Akashima T, Asanuma K, Ogiwara N, Oka T, Komuro I, Sasaki K, Amano J
    CURRENT MEDICAL RESEARCH AND OPINION, 21(5), 795-803, 2005WebofScience
  • Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with paclitaxel
    Fujita T, Ito K, Izumi H, Kimura M, Sano M, Nakagomi H, Maeno K, Hama Y, Shingu K, Tsuchiya S, Kohno K, Fujimori M
    CLINICAL CANCER RESEARCH, 11(24), 8837-8844, 2005WebofScience
  • Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation - Induction of tolerance and prevention of cardiac allograft vasculopathy
    Yamaura, K; Ito, K; Tsukioka, K; Wada, Y; Makiuchi, A; Sakaguchi, M; Akashima, T; Fujimori, M; Sawa, Y; Morishita, R; Matsumoto, K; Nakamura, T; Suzuki, J; Amano, J; Isobe, M
    Circulation, 110(12), 1650-1657, 2004WebofScience
  • Mutation of proline residues in the NH2-terminal region of the multidrug resistance protein, MRP1(ABCC1): effects on protein expression, membrane localization, and transport function.
    Ito K, Weigl LE, Deeley RG, Cole SPC.
    Biochim Biophys Acta-Biomember1615, 103-114, 2003
  • Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer
    Maeno K, Ito K, Hama Y, Shingu K, Kimura M, Sano M, Nakagomi H, Tsuchiya S, Fujimori M
    Cancer Letters, 198(1), 89-97, 2003WebofScience
  • Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport
    K. Ito/ S. Cole
    J. Biol. Chem, 276, 15616-15624, 2001
  • Mutation of Trp1254 in the multispecific organic anion transporter, MRP2 (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity
    Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG, Cole SPC
    J. Biol. Chem, 276, 38108-38114, 2001
  • 上皮小体の位置診断における⁹⁹mTc MIBIシンチグラムの有用性 : 局在画像診断法の検討
    中村 俊幸;小林 信や;藤森 実;新宮 聖士;伊藤 研一;浜 善久;天野 純;橋爪 潔志;伊藤 敦子;小松 誠;山岸 喜代文
    信州医学雑誌, 46(5), 331-335, 10 Oct. 1998
  • Clinical significance of the increased multidrug resistance-associated protein (MRP) gene expression in patients with primary breast cancer
    K. Ito/ M. Fujimori/ J. Amano
    Oncol Res, 10, 99-109, 1998
  • Expression of tissue-type plasminogen activator and its inhibitor couples with development of capillary network by human microvascular endothelial cells on Matrigel
    Ito K, Ryuto M, Ushiro S, Ono M, Sugenoya A, Kuraoka A, Shibata Y, Kuwano M
    J. Cell. Physiol, 162, 213-024, 1995
  • anti-angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvasucular endothelial cells and neovascularization in mice.
    Ito k, Abe T, Tomita M, Morimoto A, Kohno K, Mori T, Ono M, Sugenoya A, Nishihira T, Kuwano M.
    Int J Cancer, 55(4), 660-666, 1993WebofScience

Research Themes

  • 遺伝子変異解析と網羅的遺伝子発現解析を用いた甲状腺未分化癌発症の分子機構の解明
    科学研究費補助金, 基盤研究(C)
    2020 - 2022
  • 網羅的遺伝子発現解析に基づいた甲状腺未分化癌の分子機構の解明と新規治療戦略の開発
    科学研究費補助金, 基盤研究(C)
    2017 - 2019
  • 甲状腺未分化癌の分子標的開発に向けたEpCAMの機能解析
    科学研究費補助金, 基盤研究(C)
    2013 - 2015
  • 抗癌剤感受性試験を用いた、臨床乳癌における抗癌剤治療効果予測因子の解析
    科学研究費補助金, 基盤研究(C)
    2005 - 2006