TAKESHITA TOSHIKAZU｜Shinshu University Researcher List

Academic Assembly　School of Medicine and Health Sciences　Institute of Medicine

School of Medicine　Department of Pathology　

Professor　

Researcher Information

Research activity information

MK-6, a novel not-alpha IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance
Kobayashi, Maki; Kojima, Katsuhiko; Murayama, Kazutaka; Amano, Yuji; Koyama, Takashi; Ogama, Naoko; Takeshita, Toshikazu; Fukuhara, Tatsuro; Tanaka, Nobuyuki;
CANCER SCIENCE, 112(11), 4478-4489, Nov. 2021

Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases.
Yuichiro Ide, Ryu Yanagisawa, Jun Kobayashi, Kazutoshi Komori, Kazuyuki Matsuda, Yuji Amano, Yozo Nakazawa, Toshikazu Takeshita, Kazuo Sakashita, Minoru Tozuka
Blood Transfusion, 03 Feb. 2021, Refereed

A low-frequency IL-4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.
Amano Y., Akazawa K., Yasuda J., Yoshino K., Kojima K., Kobayashi K., Matsuzaki S., Nakasaki M.,Kawai Y., Minegishi N., Ishida N., Motoki N.,Hachiya A.,Nakazawa Y.,Yamamoto M., Koike K. Takeshita T
Pediatr Rheumatol, (17(1):34), 03 Jul. 2019

Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, 2018

Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
Kashihara, Toshihide; Nakada, Tsutomu; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
JOURNAL OF PHYSIOLOGY-LONDON, 595(13), 4207-4225, 2017

Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1
Funadani R, Sogame Y, Kojima K, Takeshita T, Yamamoto K, Tsujizono T, Suizu F, Miyata S, Yagyu KI, Suzuki T, Arikawa M, Matsuoka T
FEMS Microbiol Lett, 363(18), fnw203, Sep. 2016

ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule(STAM) and the complex formation with STAM promotes its endosomal dissociation (vol 289, pg 33296, 2014)
Kojima, Katsuhiko; Amano, Yuji; Yoshino, Kazuhisa; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(13), 8065-8066, 2015

ESCRT-0 Protein Hrs Is Targeted to Endosomes Independent of STAM and the Complex Formation with STAM Promotes Its Endosomal Dissociation.
1. Kojima K., Amano Y., Yoshino K., Tanaka N., Sugamura K., Takeshita T.
JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 33296-33310, 2014

A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal.
Amano Y., Yoshino K, Kojima K., Takeshita T
Biochem Biophys Res Commun, 441, 164-168, 2013

Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins
Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Sigeki Fujiwara, Seiji Miyata, Eiji Kinoshita, Tatsuomi Matsuoka
FEMS Microbiology Letters (in press), 2012

Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
Yuji Amano, Yuki Yamashita, Katsuhiko Kojima, Kazuhisa Yoshino, Nobuyuki Tanaka, Kazuo Sugamura and Toshikazu Takeshita
JOURNAL OF BIOLOGICAL CHEMISTRY, 286(17), 15458-15472, 2011

Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
Yamada, Koichiro; Tsukahara, Tomonori; Yoshino, Kazuhisa; Kojima, Katsuhiko; Agawa, Hideyuki; Yamashita, Yuki; Amano, Yuji; Hatta, Mariko; Matsuzaki, Yasunori; Kurotori, Naoki; Wakui, Keiko; Fukushima, Yoshimitsu; Osada, Ryosuke; Shiozawa, Tanri; Sakashita, Kazuo; Koike, Kenichi; Kumaki, Satoru; Tanaka, Nobuyuki; Takeshita, Toshikazu
RETROVIROLOGY, 6, 79,, Sep. 2009

Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain
Yamashita, Yuki; Kojima, Katsuhiko; Tsukahara, Tomonori; Agawa, Hideyuki; Yamada, Koichiro; Amano, Yuji; Kurotori, Naoki; Tanaka, Nobuyuki; Sugamura, Kazuo; Takeshita, Toshikazu;
JOURNAL OF CELL SCIENCE, 121(10), 1727-1738, 2008

Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line.
Tsukahara T., Agawa H., Matsumoto S., Matsuda M., Ueno S., YamashitaY., Yamada K., Tanaka N., Kojima K., Takeshita T
Biochem Biophys Res Commun., 345, 1099-1107,, 2006

Deborah Brancho（他９名）Davis.: Mechanism of p38 MAP kinase activation in vivo.2.
Genes Dev., 17, 1969-1978,, 2003

Cloning of the gamma chain of human IL-2 receptor
Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Tanaka, N., Munakata, H., Nakamura, M., Sugamura, K.
science, 257, 379-382, 1992, Refereed
Lead