野村 亘 (ノムラ ワタル)
助教（テニュア・トラック）
研究者情報
研究キーワード
- 酵母, シグナル伝達, 代謝物, 脂肪細胞
経歴
研究活動情報
論文
- Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae.
Wataru Nomura; Yoshiharu Inoue
Communications biology, 7(1), 722-722, 2024年06月, 査読有り
筆頭著者, 責任著者
- Metabolome analysis reveals that cyclic adenosine diphosphate ribose contributes to the regulation of differentiation in mice adipocyte.
Haruya Takahashi; Kento Nishitani; Satoko Kawarasaki; Agustin Martin-Morales; Hiroyuki Nagai; Hidetoshi Kuwata; Motohiro Tokura; Haruka Okaze; Shinsuke Mohri; Takeshi Ara; Tetsuro Ito; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(1), e23391, 2024年01月, 査読有り - Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae.
#Momoko Hayashida; #Wataru Nomura; Atsushi Shiojiri; Yoshiharu Inoue
Biochemical and biophysical research communications, 685, 149157-149157, 2023年10月, 査読有り
筆頭著者, 責任著者 - Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
European journal of pharmacology, 947, 175682-175682, 2023年05月, 査読有り - 8-Prenyl daidzein and 8-prenyl genistein from germinated soybean modulate inflammatory response in activated macrophages.
Huei-Fen Jheng; Miho Takase; Satoko Kawarasaki; Zheng Ni; Shinsuke Mohri; Kanako Hayashi; Atsushi Izumi; Kuni Sasaki; Yu Shinyama; Jungin Kwon; Su-Ping Ng; Haruya Takahashi; Wataru Nomura; Rina Yu; Koji Ochiai; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 87(7), 747-757, 2023年04月, 査読有り - Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
Jungin Kwon; Yu-Sheng Yeh; Satoko Kawarasaki; Hiroto Minamino; Yoshihito Fujita; Yuko Okamatsu-Ogura; Haruya Takahashi; Wataru Nomura; Shigenobu Matsumura; Rina Yu; Kazuhiro Kimura; Masayuki Saito; Nobuya Inagaki; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
iScience, 26(3), 106161-106161, 2023年03月, 査読有り - Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
#Su-Ping Ng; #Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto; Yoshiharu Inoue
The Biochemical journal, 479(21), 2279-2296, 2022年11月, 査読有り
筆頭著者, 責任著者 - Metabolomics reveals inosine 5'-monophosphate is increased during mice adipocyte browning.
Haruya Takahashi; Motohiro Tokura; Satoko Kawarasaki; Hiroyuki Nagai; Mari Iwase; Kento Nishitani; Haruka Okaze; Shinsuke Mohri; Tetsuro Ito; Takeshi Ara; Huei-Fen Jheng; Wataru Nomura; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
The Journal of biological chemistry, 298(10), 102456-102456, 2022年09月, 査読有り - Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae.
Wataru Nomura; Su-Ping Ng; Terunao Takahara; Tatsuya Maeda; Teruo Kawada; Tsuyoshi Goto; Yoshiharu Inoue
Journal of cell science, 135(17), 2022年09月, 査読有り
筆頭著者, 責任著者 - Screening of flavor compounds using Ucp1-luciferase reporter beige adipocytes identified 5-methylquinoxaline as a novel UCP1-inducing compound.
Satoko Kawarasaki; Kazuki Matsuo; Hidetoshi Kuwata; Lanxi Zhou; Jungin Kwon; Zheng Ni; Haruya Takahashi; Wataru Nomura; Hisanori Kenmotsu; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 86(3), 380-389, 2022年02月, 査読有り - Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.
Su-Ping Ng; Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Biochemistry and biophysics reports, 28, 101127-101127, 2021年12月, 査読有り
責任著者 - Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae.
Wataru Nomura; Ryota Futamata; Yoshiharu Inoue
Biochimica et biophysica acta. General subjects, 129853-129853, 2021年01月, 査読有り
筆頭著者, 責任著者 - Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.
Haruya Takahashi; Koji Ochiai; Kuni Sasaki; Atsushi Izumi; Yu Shinyama; Shinsuke Mohri; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
PloS one, 16(7), e0254190, 2021年, 査読有り - Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae.
Wataru Nomura; Miho Aoki; Yoshiharu Inoue
Scientific reports, 10(1), 13887-13887, 2020年08月, 査読有り, 招待無し
筆頭著者, 責任著者 - Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes.
Mari Iwase; Soshi Tokiwa; Shigeto Seno; Takako Mukai; Yu-Sheng Yeh; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Sigenobu Matsumura; Tatsuya Kusudo; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
The Journal of biological chemistry, 295(20), 7033-7045, 2020年05月, 査読有り, 招待無し - Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
Huei-Fen Jheng; Kanako Hayashi; Yasuki Matsumura; Teruo Kawada; Shigeto Seno; Hideo Matsuda; Kazuo Inoue; Wataru Nomura; Haruya Takahashi; Tsuyoshi Goto
Molecular nutrition & food research, 64(10), e2000015, 2020年05月, 査読有り, 招待無し - Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes.
Mari Iwase; Shoko Sakai; Shigeto Seno; Yu-Sheng Yeh; Tony Kuo; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Paul Horton; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 84(2), 305-313, 2020年02月, 査読有り, 招待無し - Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Su-Ping Ng; Jungin Kwon; Shinsuke Mohri; Mari Iwase; Huei-Fen Jheng; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 4353-4359, 2020年, 査読有り - Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae.
Nomura W; Inoue Y
Small GTPases, 10(6), 449-455, 2019年11月, 査読有り, 招待無し
筆頭著者 - Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes.
Ng SP; Nomura W; Mohri S; Takahashi H; Jheng HF; Ara T; Nagai H; Ito T; Kawada T; Goto T
Bioscience, biotechnology, and biochemistry, 83(9), 1782-1789, 2019年09月, 査読有り, 招待無し
責任著者 - A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
Kawarasaki S; Kuwata H; Sawazaki H; Sakamoto T; Nitta T; Kim CS; Jheng HF; Takahashi H; Nomura W; Ara T; Takahashi N; Tomita K; Yu R; Kawada T; Goto T
FEBS letters, 593(11), 1201-1212, 2019年06月, 査読有り, 招待無し - Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
Kiriyama K; Goto T; Yamamoto H; Ara T; Takahashi H; Jheng HF; Nomura W; Inoue H; Nakata R; Kawada T
Journal of Functional Foods, 54, 529-535, 2019年03月, 査読有り, 招待無し - Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.
Yuliana A; Daijo A; Jheng HF; Kwon J; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 20(2), 2019年01月, 査読有り, 招待無し - Lactobacillus amylovorus CP1563株由来10-Hydroxyoctadecanoic Acidが脂質代謝および脂肪蓄積に及ぼす影響
青木 ゆめこ; 菅原 智詞; 柳原 沙恵; 高橋 春弥; 野村 亘; Jheng Huei-Fen; 荒 武; 後藤 剛; 河田 照雄; 澤田 大輔
応用薬理, 95(3/4), 73-82, 2018年11月, 査読有り, 招待無し - The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
Takeda K; Sawazaki H; Takahashi H; Yeh YS; Jheng HF; Nomura W; Ara T; Takahashi N; Seno S; Osato N; Matsuda H; Kawada T; Goto T
FEBS open bio, 8(11), 1782-1793, 2018年11月, 査読有り, 招待無し - The Mevalonate Pathway Is Indispensable for Adipocyte Survival.
Yeh YS; Jheng HF; Iwase M; Kim M; Mohri S; Kwon J; Kawarasaki S; Li Y; Takahashi H; Ara T; Nomura W; Kawada T; Goto T
iScience, 9, 175-191, 2018年11月, 査読有り, 招待無し - β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
Yuliana A; Jheng HF; Kawarasaki S; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 19(8), 2018年08月, 査読有り, 招待無し - Toxicity of dihydroxyacetone is exerted through formation of methylglyoxal in Saccharomyces cerevisiae : effects on actin polarity and nuclear division.
Nomura W; Aoki M; Inoue Y
The Biochemical journal, 475(16), 2637-2652, 2018年07月, 査読有り, 招待無し
筆頭著者 - Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
Ha-Eun Yang; Yongjia Li; Akira Nishimura; Huei-Fen Jheng; Ana Yuliana; Ryuji Kitano-Ohue; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada; Tsuyoshi Goto
MOLECULAR NUTRITION & FOOD RESEARCH, 61(10), 2017年10月, 査読有り, 招待無し
- Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae
Wataru Nomura; Kazuhiro Maeta; Yoshiharu Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(36), 15039-15048, 2017年09月, 査読有り, 招待無し
筆頭著者 - Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation.
Iwase M; Yamamoto T; Nishimura K; Takahashi H; Mohri S; Li Y; Jheng HF; Nomura W; Takahashi N; Kim CS; Yu R; Taniguchi M; Baba K; Murakami S; Kawada T; Goto T
Lipids, 52(7), 657-664, 2017年07月, 査読有り, 招待無し - The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice.
Goto T; Hirata M; Aoki Y; Iwase M; Takahashi H; Kim M; Li Y; Jheng HF; Nomura W; Takahashi N; Kim CS; Yu R; Seno S; Matsuda H; Aizawa-Abe M; Ebihara K; Itoh N; Kawada T
The Journal of biological chemistry, 292(22), 9175-9190, 2017年06月, 査読有り, 招待無し - Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae
Wataru Nomura; Yusuke Ito; Yoshiharu Inoue
CELLULAR SIGNALLING, 31, 146-153, 2017年02月, 査読有り, 招待無し
筆頭著者 - 4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells.
Li Y; Goto T; Yamakuni K; Takahashi H; Takahashi N; Jheng HF; Nomura W; Taniguchi M; Baba K; Murakami S; Kawada T
Lipids, 51(7), 787-795, 2016年07月, 査読有り, 招待無し - 代謝ストレスによるTORシグナルの活性化
野村 亘; 井上善晴
化学と生物, 54(4), 273-280, 2016年04月, 査読有り, 招待無し
筆頭著者 - Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae
Wataru Nomura; Yoshiharu Inoue
MOLECULAR AND CELLULAR BIOLOGY, 35(7), 1269-1280, 2015年04月, 査読有り, 招待無し
筆頭著者 - 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.
Goto T; Kim YI; Furuzono T; Takahashi N; Yamakuni K; Yang HE; Li Y; Ohue R; Nomura W; Sugawara T; Yu R; Kitamura N; Park SB; Kishino S; Ogawa J; Kawada T
Biochemical and biophysical research communications, 459(4), 597-603, 2015年04月, 査読有り, 招待無し - 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor γ in adipocytes.
Takahashi H; Hara H; Goto T; Kamakari K; Wataru N; Mohri S; Takahashi N; Suzuki H; Shibata D; Kawada T
Lipids, 50(1), 3-12, 2015年01月, 査読有り, 招待無し - Reduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiae
Aya Yoshida; Dandan Wei; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY, 287(1), 701-711, 2012年01月, 査読有り, 招待無し - Glyoxalase system in yeasts: Structure, function, and physiology
Yoshiharu Inoue; Kazuhiro Maeta; Wataru Nomura
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 22(3), 278-284, 2011年05月, 査読有り, 招待無し - Methylglyoxal activates Gcn2 to phosphorylate eIF2 alpha independently of the TOR pathway in Saccharomyces cerevisiae
Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 86(6), 1887-1894, 2010年05月, 査読有り, 招待無し
筆頭著者 - Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae
Yoshifumi Takatsume; Takumi Ohdate; Kazuhiro Maeta; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
BIOCHEMICAL JOURNAL, 427(2), 275-287, 2010年04月, 査読有り, 招待無し - Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2 alpha
Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(4), 738-742, 2008年11月, 査読有り, 招待無し
筆頭著者 - Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol
Yoko Takeuchi; Wataru Nomura; Takumi Ohdate; Shogo Tamasu; Hiroshi Masutani; Kazuo Murata; Shingo Izawa; Junji Yodoi; Yoshiharu Inoue
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 75(6), 1393-1399, 2007年07月, 査読有り, 招待無し - Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol
Yoshiharu Inoue; Wataru Nomura; Yoko Takeuchi; Takumi Ohdate; Shogo Tamasu; Atsushi Kitaoka; Yoshifumi Kiyokawa; Hiroshi Masutani; Kazuo Murata; Yoshinori Wakai; Shingo Izawa; Junji Yodoi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(5), 1672-1675, 2007年03月, 査読有り, 招待無し - Green tea polyphenols function as prooxidants to activate oxidative-stress-responsive transcription factors in yeasts
Kazuhiro Maeta; Wataru Nomura; Yoshifumi Takatsume; Shingo Izawa; Yoshiharu Inoue
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(2), 572-580, 2007年01月, 査読有り, 招待無し
書籍等出版物
- 脂肪酸および脂肪酸代謝物が褐色脂肪組織機能に及ぼす影響～ω-3脂肪酸を中心に～
後藤剛; 岩瀬麻里; 川原崎聡子; 高橋春弥; 野村亘; 井上和生; 河田照雄, 共著
BIO INDUSTRY (シーエムシー出版), 2020年10月 - 脂肪組織機能を制御する食品由来成分に関する研究
岩瀬麻里; 川原崎聡子; 毛利晋輔; 高橋春弥; 野村亘; Huei-Fen Jheng; 井上和生; 河田照雄; 後藤剛, 共著
日本機能性食品医用学会, 2020年 - The Yeast Role in Medical Applications
Yoshiharu Inoue; Wataru Nomura, 分担執筆, TOR signaling in budding yeast
InTechOpen, 2018年01月
講演・口頭発表等
- 酵母の細胞壁ストレスを感知するCWI経路は細胞膜健全性に寄与するTORC2シグナルを負に制御する
野村 亘; 井上善晴
第46回日本分子生物学会年会 シンポジウム, 2023年12月 - 膜ストレスを感知するTORシグナルの制御機構
野村 亘
生理化学研究ユニット第10回シンポジウム, 2020年12月 - 出芽酵母のストレス応答におけるPKCシグナルの制御機構
野村 亘
酵母研究会 第85回講演会, 2018年07月 - 酵母のストレス応答におけるPKCシグナル制御機構に関する研究
野村 亘
第65回 日本生化学会近畿支部例会 近畿支部奨励賞受賞記念講演, 2018年05月 - 解糖系代謝物によるTORC2シグナルの活性化
野村 亘; 河田照雄; 井上善晴
第36回 日本分子生物学会年会 ワークショップ, 2013年12月
担当経験のある科目_授業
共同研究・競争的資金等の研究課題
- 酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御
科学研究費助成事業 基盤研究(C), 日本学術振興会, 基盤研究(C)
京都大学
2022年04月01日 - 2025年03月31日 - TORC2シグナルの活性化に寄与する細胞膜脂質の作用機序の解析
科学研究費助成事業 基盤研究(C), 日本学術振興会, 基盤研究(C)
京都大学
2019年04月01日 - 2022年03月31日 - ホスファチジルセリンによるTOR複合体2シグナル制御機構の解明
科学研究費助成事業 若手研究(B), 日本学術振興会, 若手研究(B)
京都大学
2017年04月01日 - 2019年03月31日 - 糖尿病病態における解糖系代謝物の関与：新規インスリン抵抗性獲得モデルの立証
科学研究費助成事業 挑戦的萌芽研究, 日本学術振興会, 挑戦的萌芽研究
京都大学
2014年04月01日 - 2016年03月31日 - メタボリックシグナリング：解糖系代謝物によるＴＯＲＣ２の新規活性化機構の解明
科学研究費助成事業 特別研究員奨励費, 日本学術振興会, 特別研究員奨励費
京都大学
2012年04月01日 - 2015年03月31日
